Prominent publications by Mark E Molitch

KOL Index score: 17055

BACKGROUND: An impaired glomerular filtration rate (GFR) leads to end-stage renal disease and increases the risks of cardiovascular disease and death. Persons with type 1 diabetes are at high risk for kidney disease, but there are no interventions that have been proved to prevent impairment of the GFR in this population.

METHODS: In the Diabetes Control and Complications Trial (DCCT), 1441 persons with type 1 diabetes were randomly assigned to 6.5 years of intensive diabetes therapy ...

Known for Diabetes Therapy |  Filtration Rate |  Type 1 |  Estimated Gfr |  Edic Study
KOL Index score: 14232

Importance: Recent studies have yielded conflicting results as to whether testosterone treatment increases cardiovascular risk.

Objective: To test the hypothesis that testosterone treatment of older men with low testosterone slows progression of noncalcified coronary artery plaque volume.

Design, Setting, and Participants: Double-blinded, placebo-controlled trial at 9 academic medical centers in the United States. The participants were 170 of 788 men aged 65 years or older with an ...

Known for Testosterone Treatment |  Coronary Artery |  Plaque Volume |  12 Months |  Cardiovascular Risk
KOL Index score: 14211

OBJECTIVE: To determine if glucose management in postcardiothoracic surgery patients with a combined intravenous (IV) and subcutaneous (SC) insulin regimen reduces mortality and morbidity in patients with diabetes and stress-induced hyperglycemia.

RESEARCH DESIGN AND METHODS: Retrospective review of 614 consecutive patients who underwent cardiothoracic (CT) surgery in 2005 was performed to evaluate the incidence and treatment of postoperative hyperglycemia and operative morbidity and ...

Known for Diabetic Patients |  Cardiac Surgery |  Subcutaneous Insulin |  Surgical Mortality |  Intravenous Injections
KOL Index score: 14210

Diabetes is the most frequent cause of chronic kidney disease (CKD), leading to nearly half of all cases of kidney failure requiring replacement therapy. The principal cause of death among patients with diabetes and CKD is cardiovascular disease (CVD). Sodium/glucose cotransporter 2 (SGLT2) inhibitors were developed to lower blood glucose levels by inhibiting glucose reabsorption in the proximal tubule. In clinical trials designed to demonstrate the CVD safety of SGLT2 inhibitors in type ...

Known for Cardiovascular Disease |  Sglt2 Inhibitors |  2 Diabetes |  Patients Ckd |  Scientific Workshop
KOL Index score: 13873

BACKGROUND: Microalbuminuria is a common diagnosis in the clinical care of patients with type 1 diabetes mellitus. Long-term outcomes after the development of microalbuminuria are variable.

METHODS: We quantified the incidence of and risk factors for long-term renal outcomes after the development of microalbuminuria in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. The DCCT randomly assigned 1441 persons with type ...

Known for Diabetes Control |  Renal Outcomes |  Type 1 |  Development Microalbuminuria |  Progression Macroalbuminuria
KOL Index score: 13728

OBJECTIVE: The objective of this study was to determine whether high levels of HDL cholesterol are associated with a lower prevalence of albuminuria

RESEARCH DESIGN AND METHODS: We analyzed the lipid profiles of patients with type 1 diabetes of > or = 20 years duration in 42 patients with albuminuria (28 microalbuminuria and 14 macroalbuminuria) and 65 patients without increased albumin excretion before any interventions with either statins or ACE inhibitors.

RESULTS: Several ...

Known for Hdl Cholesterol |  Type 1 Diabetes |  Albuminuria Patients |  Decreased Likelihood |  Lipid Profiles
KOL Index score: 13270

OBJECTIVE: This multicenter study examined the impact of albumin excretion rate (AER) on the course of estimated glomerular filtration rate (eGFR) and the incidence of sustained eGFR <60 ml/min/1.73 m(2) in type 1 diabetes up to year 14 of the Epidemiology of Diabetes Interventions and Complications (EDIC) study (mean duration of 19 years in the Diabetes Control and Complications Trial [DCCT]/EDIC).

RESEARCH DESIGN AND METHODS: Urinary albumin measurements from 4-h urine collections were ...

Known for Diabetes Interventions |  Type 1 |  Renal Insufficiency |  Complications Study |  Serum Creatinine
KOL Index score: 12578

BACKGROUND: Diabetes mellitus and hypertension are closely linked, but the long-term blood pressure effects of glucose-lowering therapy and hyperglycemia are not clear.

METHODS: We examined the effects of intensive insulin therapy and hyperglycemia on the development of hypertension in the Diabetes Control and Complications Trial (DCCT) and its observational follow-up, the Epidemiology of Diabetes Intervention and Complications (EDIC) study. Incident hypertension was defined as 2 ...

Known for Diabetes Mellitus |  Insulin Therapy |  Type 1 |  Incident Hypertension |  Blood Pressure
KOL Index score: 11831

BACKGROUND: Optimal treatment for patients with both type 2 diabetes mellitus and stable ischemic heart disease has not been established.

METHODS: We randomly assigned 2368 patients with both type 2 diabetes and heart disease to undergo either prompt revascularization with intensive medical therapy or intensive medical therapy alone and to undergo either insulin-sensitization or insulin-provision therapy. Primary end points were the rate of death and a composite of death, myocardial ...

Known for Type 2 Diabetes |  Major Cardiovascular Events |  Insulin Sensitization |  Rates Death |  Coronary Artery
KOL Index score: 11749

OBJECTIVE: To determine the optimal dose of insulin glargine needed to maintain glycemic control in patients undergoing conversion from intravenous regular insulin infusions to a subcutaneous insulin regimen.

METHODS: Seventy-five hospitalized patients receiving continuous insulin infusions were randomized to receive 40%, 60%, or 80% of their total daily insulin requirement, calculated from the rate during the final 6 hours of the infusion, as insulin glargine at the time of conversion ...

Known for Insulin Glargine |  60 80 |  Patients Hyperglycemia |  Intravenous Injections |  Glycemic Control
KOL Index score: 11682

Importance: Most cognitive functions decline with age. Prior studies suggest that testosterone treatment may improve these functions.

Objective: To determine if testosterone treatment compared with placebo is associated with improved verbal memory and other cognitive functions in older men with low testosterone and age-associated memory impairment (AAMI).

Design, Setting, and Participants: The Testosterone Trials (TTrials) were 7 trials to assess the efficacy of testosterone treatment in ...

Known for Testosterone Treatment |  Cognitive Function |  12 Months |  Memory Impairment |  1 Year
KOL Index score: 11555

CONTEXT: In the absence of panhypopituitarism and low serum IGF-I levels, the diagnosis of adult GH deficiency (AGHD) requires confirmation with a GH stimulation test. Macimorelin is a novel, orally active ghrelin mimetic that stimulates GH secretion.

OBJECTIVE: The objective of the study was to determine the diagnostic efficacy and safety of macimorelin in AGHD.

DESIGN: This was a multicenter open-label study comparing the diagnostic accuracy of oral macimorelin with that of ...

Known for Growth Hormone |  Adult Gh Deficiency |  Macimorelin Aghd |  Stimulation Test |  Gh Secretion
KOL Index score: 11536

BACKGROUND AND OBJECTIVES: In trials of people with type 2 diabetes, albuminuria reduction with renin-angiotensin system inhibitors is associated with lower risks of cardiovascular events and CKD progression. We tested whether progression or remission of microalbuminuria is associated with cardiovascular and renal risk in a well characterized cohort of type 1 diabetes.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We studied 1441 participants in the Diabetes Control and Complications ...

Known for Type 1 Diabetes |  Microalbuminuria Normoalbuminuria |  Cardiovascular Events |  Renal Outcomes |  Adult Albuminuria
KOL Index score: 11392

To assess the utility and precision of GFR measurements in multicenter trials, the test performance and variability of GFR were analyzed in 2,250 patients enrolled in 44 clinical centers participating in either the Modification of Diet in Renal Disease (MDRD) Study or the Diabetes Control and Complications Trial (DCCT). GRF was measured as the renal clearance of [125I]iothalamate after an sc injection without epinephrine. The studies used similar protocols for obtaining blood and urine, ...

Known for Renal Disease Study |  Gfr Measurements |  Diabetes Control |  Glomerular Filtration |  Modification Diet


Mark E Molitch: Influence Statistics

Sample of concepts for which Mark E Molitch is among the top experts in the world.
Concept World rank
ghrharg united states #1
nephropathy years #1
infertility primary indication #1
secreted ectopically #1
ideal target hemoglobin #1
prolactin hyperprolactinemic #1
hypothyroidism childbirth #1
recombinant ghrh #1
90 lanreotide week #1
bromocriptine metaanalysis #1
inpatient setting insulin #1
agent detailed guidance #1
primary indication treatment #1
14 macroalbuminuria #1
edw data #1
27 carbidopaldopa #1
grant 5t32amo7039–5 #1
measures diabetesrelated complications #1
expected finding patients #1
irradiation macroadenomas #1
cardiovascular risk nephropathy #1
week igf1 levels #1
ld acromegaly #1
hyperglycemia glulisine #1
experience bromocriptine #1
microadenomas 10 mm #1
increase tumor size #1
microadenomas 23 #1
cortisol normal response #1
cardiovascular disease multidisciplinary #1
dopamine agonist reduction #1
fsh tsh levels #1
sex meld score #1
patients chacm01 #1
compromise large #1
timing special concerns #1
sensitive radioimmunoassays tumors #1
hypothalamic generation #1
normalize prl #1
20 drip #1
treatment decisionmaking outcomes #1
inpatient setting studies #1
nephropathy reduction #1
purposethis 2year analysis #1
incidence sheehan syndrome #1
glulisine hospitalized subjects #1
surgery fetal development #1
shock appendectomy #1
management nfas observation #1
pituitary incidentalomas hypersecretion #1

Key People For Type 1 Diabetes

Top KOLs in the world
John M Lachin
type 1 diabetes cardiovascular disease complications trial
David Matthew Nathan
type 2 diabetes insulin resistance cardiovascular disease
William V Tamborlane
type 1 diabetes young children growth hormone
Patricia A Cleary
type 1 diabetes optic neuritis intensive therapy
George S Eisenbarth
type 1 diabetes nod mice celiac disease
Marian J Rewers
type 1 diabetes islet autoimmunity celiac disease

Mark E Molitch:Expert Impact

Concepts for whichMark E Molitchhas direct influence:Type 1 diabetes,  Lymphocytic hypophysitis,  Diabetes mellitus,  Dopamine agonists,  Pituitary tumors,  Pituitary adenomas,  Growth hormone,  Kidney disease.

Mark E Molitch:KOL impact

Concepts related to the work of other authors for whichfor which Mark E Molitch has influence:Type 2 diabetes,  Diabetic nephropathy,  Chronic kidney disease,  Growth hormone,  Pituitary adenomas,  Patients acromegaly,  Blood pressure.



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Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL. | Endocrinology, Metabolism & Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. | Division of

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