• Disease
  • Diabetic
  • Diabetic Ketoacidosis
  • Abbas Eghbal Kitabchi

    Prominent publications by Abbas Eghbal Kitabchi

    KOL Index score: 17144

    PURPOSE: To compare the efficacy and safety of subcutaneous insulin lispro with that of a standard low-dose intravenous infusion protocol of regular insulin in patients with uncomplicated diabetic ketoacidosis.

    METHODS: In this prospective, randomized open trial, 20 patients treated with subcutaneous insulin lispro were managed in regular medicine wards (n=10) or an intermediate care unit (n=10), while 20 patients treated with the intravenous protocol were managed in the intensive care ...

    Also Ranks for: Diabetic Ketoacidosis |  subcutaneous insulin |  intravenous regular |  intensive unit |  correction hyperglycemia
    KOL Index score: 16198

    BACKGROUND: Impaired glucose tolerance is associated with increased rates of cardiovascular disease and conversion to type 2 diabetes mellitus. Interventions that may prevent or delay such occurrences are of great clinical importance.

    METHODS: We conducted a randomized, double-blind, placebo-controlled study to examine whether pioglitazone can reduce the risk of type 2 diabetes mellitus in adults with impaired glucose tolerance. A total of 602 patients were randomly assigned to receive ...

    Also Ranks for: Impaired Glucose Tolerance |  pioglitazone placebo |  weight gain |  diabetes prevention |  mellitus type
    KOL Index score: 15382

    BACKGROUND: Findings from the Look AHEAD trial showed no significant reductions in the primary outcome of cardiovascular disease incidence in adults with type 2 diabetes randomly assigned to an intensive lifestyle intervention for weight loss compared with those randomly assigned to diabetes support and education (control). We examined whether the incidence of cardiovascular disease in Look AHEAD varied by changes in weight or fitness.

    METHODS: Look AHEAD was a randomised clinical trial ...

    Also Ranks for: Weight Loss |  ahead study |  cardiovascular disease |  secondary outcome |  physical fitness
    KOL Index score: 15357

    CONTEXT: The frequency of remission of type 2 diabetes achievable with lifestyle intervention is unclear.

    OBJECTIVE: To examine the association of a long-term intensive weight-loss intervention with the frequency of remission from type 2 diabetes to prediabetes or normoglycemia.

    DESIGN, SETTING, AND PARTICIPANTS: Ancillary observational analysis of a 4-year randomized controlled trial (baseline visit, August 2001-April 2004; last follow-up, April 2008) comparing an intensive lifestyle ...

    Also Ranks for: Lifestyle Intervention |  remission type |  4 years |  6 months |  dse participants
    KOL Index score: 14707

    Insulin resistance and beta-cell dysfunction, two factors central to the pathogenesis of type 2 diabetes, were studied in relation to the development of diabetes in a group of participants with impaired glucose tolerance in the Diabetes Prevention Program (DPP) at baseline and after specific interventions designed to prevent diabetes. Participants were randomly assigned to placebo (n = 1,082), metformin (850 mg twice a day) (n = 1,073), or intensive lifestyle intervention (n = 1,079). ...

    Also Ranks for: Insulin Secretion |  diabetes prevention program |  lifestyle intervention |  1 year |  type 2
    KOL Index score: 13301

    Acute and chronic hyperglycemia are proinflammatory states, but the status of proinflammatory cytokines and markers of oxidative stress and cardiovascular risks is not known in hyperglycemic crises of diabetic ketoacidosis (DKA) and nonketotic hyperglycemia (NKH). We studied 20 lean and 28 obese patients with DKA, 10 patients with NKH, and 12 lean and 12 obese nondiabetic control subjects. We measured 1) proinflammatory cytokines (tumor necrosis factor-alpha, interleukin [IL]-6, ...

    Also Ranks for: Proinflammatory Cytokines |  hyperglycemic crises |  lipid peroxidation |  oxidative stress |  cardiovascular risk
    KOL Index score: 12994

    Aims/hypothesisThe aim of the study was to examine the determinants of oral glucose tolerance in 602 persons with impaired glucose tolerance (IGT) who participated in the Actos Now for Prevention of Diabetes (ACT NOW) study.MethodsIn addition to the 602 IGT participants, 115 persons with normal glucose tolerance (NGT) and 50 with impaired fasting glucose (IFG) were identified during screening and included in this analysis. Insulin secretion and insulin sensitivity indices were derived ...

    Also Ranks for: Glucose Tolerance |  ngt igt |  insulin secretion |  prevention diabetes |  2 plasma
    KOL Index score: 12742

    Admission hyperglycemia has been associated with increased hospital mortality in critically ill patients; however, it is not known whether hyperglycemia in patients admitted to general hospital wards is associated with poor outcome. The aim of this study was to determine the prevalence of in-hospital hyperglycemia and determine the survival and functional outcome of patients with hyperglycemia with and without a history of diabetes. We reviewed the medical records of 2030 consecutive ...

    Also Ranks for: Undiagnosed Diabetes |  patients hospital |  hyperglycemia length |  independent marker |  medical records
    KOL Index score: 12653

    OBJECTIVE: Rates of severe obesity (BMI ≥40 kg/m(2)) are on the rise, and effective treatment options are needed. We examined the effect of an intensive lifestyle intervention (ILI) on weight loss, cardiovascular disease (CVD) risk, and program adherence in participants with type 2 diabetes who were severely obese compared with overweight (BMI 25 to <30 kg/m(2)), class I (BMI 30 to <35 kg/m(2)), and class II (BMI 35 to <40 kg/m(2)) obese participants.


    Also Ranks for: Severe Obesity |  2 diabetes |  lifestyle interventions |  class bmi |  obese participants
    KOL Index score: 12398

    OBJECTIVE: The effectiveness of intentional weight loss in reducing cardiovascular disease (CVD) events in type 2 diabetes is unknown. This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events.

    RESEARCH DESIGN AND METHODS: This study consisted of a multicentered, randomized, controlled trial of 5,145 individuals with type 2 diabetes, aged 45-74 years, with BMI ...

    Also Ranks for: Type 2 Diabetes |  ili dse |  ahead trial |  cardiovascular disease |  weight loss
    KOL Index score: 12335

    OBJECTIVE: Restoration of normal glucose regulation (NGR) in people with prediabetes significantly decreases the risk of future diabetes. We sought to examine whether regression to NGR is also associated with a long-term decrease in cardiovascular disease (CVD) risk.

    RESEARCH DESIGN AND METHODS: The Framingham (2008) score (as an estimate of the global 10-year CVD risk) and individual CVD risk factors were calculated annually for the Diabetes Prevention Program Outcomes Study years 1-10 ...

    Also Ranks for: Cardiovascular Risk |  normal glucose regulation |  diabetes prevention program |  regression ngr |  blood glucose
    KOL Index score: 11963

    OBJECTIVE: To study the effects of high-protein versus high-carbohydrate diets on various metabolic end points (glucoregulation, oxidative stress [dichlorofluorescein], lipid peroxidation [malondialdehyde], proinflammatory cytokines [tumor necrosis factor-α and interleukin-6], adipokines, and resting energy expenditure [REE]) with high protein-low carbohydrate (HP) and high carbohydrate-low protein (HC) diets at baseline and after 6 months of dietary intervention.


    Also Ranks for: Oxidative Stress |  lipid peroxidation |  premenopausal women |  carbohydrate diets |  6 months
    KOL Index score: 11943

    BACKGROUND: Weight loss is recommended for overweight or obese patients with type 2 diabetes on the basis of short-term studies, but long-term effects on cardiovascular disease remain unknown. We examined whether an intensive lifestyle intervention for weight loss would decrease cardiovascular morbidity and mortality among such patients.

    METHODS: In 16 study centers in the United States, we randomly assigned 5145 overweight or obese patients with type 2 diabetes to participate in an ...

    Also Ranks for: Type 2 Diabetes |  intensive lifestyle |  cardiovascular effects |  weight loss |  intervention control
    KOL Index score: 11490

    Isolated adrenal cells from vitamin E-deficient and control rats were prepared by a trypsin digestion method. Corticosterone formation and lipid peroxidation in vitro were measured in these cells in response to adrenocorticotropin (ACTH) and dibutyryl cyclic adenosine 3′, 5′-monophosphate ((bt)2 cAMP) in the presence and absence of ascorbate. The addition of ascorbate to adrenal cells of vitamin E-deficient rats stimulated lipid peroxidation in the presence and absence of ACTH or (bt)2 ...

    Also Ranks for: Adrenal Cells |  ascorbic acid |  lipid peroxidation |  ascorbate acth |  α tocopherol


    Abbas Eghbal Kitabchi: Influence Statistics

    Sample of concepts for which Abbas Eghbal Kitabchi is among the top experts in the world.
    Concept World rank
    extreme superfasted state #1
    beef proinsulin intermediates #1
    generation intermediate products #1
    controls transcriptomes #1
    bt2 camp steroidogenesis #1
    diarginineinsulin #1
    0003 nmol 01 #1
    insulin pco patients #1
    tocopherol deficient rat #1
    beta ketoacidosis #1
    degraded a14 #1
    vitamin investigations #1
    activated tcells t2dm #1
    hplc a14125iinsulin #1
    kitabchi #1
    peroxidation vitro #1
    pork biological #1
    14 weightmatched controls #1
    testosterone insulin metabolism #1
    height stimulation #1
    pdh degradation #1
    epinephrine lipid peroxidation #1
    therapeutic discussion #1
    novo emergence #1
    pha activated tlymphocytes #1
    insulin activated pdc #1
    irp glucose administration #1
    partly protein nature #1
    rising incidence dka #1
    dcamp cyclic nucleotides #1
    insulin beef proinsulin #1
    hhs unanswered questions #1
    insulin activated lymphocytes #1
    adt receipt #1
    muscles streptozotocindiabetic rats #1
    bacitracin phenylarsine oxide #1
    insulin intermediate #1
    incubation haec #1
    partly protein constitution #1
    insulin lysine residue #1
    glucagon enzyme #1
    hc diet remission #1
    dkaassociated morbidity #1
    activity proinsulin #1
    adrenal ascorbate #1
    ketoacidosis female humans #1
    proteinlow carbohydrate #1
    receipt vitamin #1
    diabetic patient evidence #1
    emergence insulin #1

    Key People For Diabetic Ketoacidosis

    Top KOLs in the world
    Abbas Eghbal Kitabchi
    diabetic ketoacidosis type 2 diabetes hyperglycemic crises
    Guillermo E UMPIERREZ†
    type 2 diabetes diabetic ketoacidosis hospitalized patients
    Nicole S Glaser
    diabetic ketoacidosis cerebral edema early remission
    Joseph I Wolfsdorf
    diabetic ketoacidosis type 1 diabetes glycemic control
    Mark A Sperling
    growth hormone diabetes mellitus diabetic ketoacidosis
    Ragnar Hanas
    type 1 diabetes diabetic ketoacidosis indwelling catheters

    Abbas Eghbal Kitabchi:Expert Impact

    Concepts for whichAbbas Eghbal Kitabchihas direct influence:Diabetic ketoacidosis,  Type 2 diabetes,  Insulin resistance,  Hyperglycemic crises,  Lipid peroxidation,  Diabetes mellitus,  Diabetes prevention program,  Type 2.

    Abbas Eghbal Kitabchi:KOL impact

    Concepts related to the work of other authors for whichfor which Abbas Eghbal Kitabchi has influence:Type 2 diabetes,  Weight loss,  Diabetic ketoacidosis,  Insulin resistance,  Metabolic syndrome,  Bariatric surgery,  Glycemic control.



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    The University of Tennessee Health Science Center, Memphis, Tennessee, USA | From the Weight Control and Diabetes Research Center (McCaffery, Wing), The Miriam Hospital and Warren Alpert School of Medicine at Brown University, Providence, RI; The Bio