KOL | Haibing ChenDepartment of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, China | Department of Endocrinology and ... |
KOL Resume for Haibing Chen
| Year | |
|---|---|
| 2022 | Department of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, China |
| 2021 | Department of Endocrinology and Metabolism, Shanghai 10th People’s Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai 200072, China |
| 2020 | Department of Endocrinology and Metabolism, Shanghai Eighth People’s Hospital, 200233, Shanghai, China |
| 2019 | Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China. |
| 2018 | Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, China |
| 2017 | Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600Yishan road, 200233, Shanghai, China |
| 2016 | Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao tong University Affiliated Sixth People’s Hospital, Shanghai, China |
| 2015 | Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiaotong University Affiliated Sixth People's Hospital Shanghai 200233, China. Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Key Laboratory of Diabetes Shanghai China |
| 2014 | Department of Endocrinology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China |
| 2012 | Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China |
| 2011 | Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China |
| 2010 | Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Ophthalmology, Shanghai Jiaotong University Affiliated First People’s Hospital of Shanghai, Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China |
| 2009 | Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China |
| 2008 | Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Department of Endocrinology and Metabolism of Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, China |
| 2006 | Shanghai Diabetic Institute, Shanghai Jiaotong University Affiliated No. 6 People Hospital, 600 Yishan Road, Shanghai 200233, China |
Haibing Chen: Influence Statistics
| Concept | World rank |
|---|---|
| pcdna3pgc1α diabetic rats | #1 |
| pgc1α dn | #1 |
| abnormal vpt age | #1 |
| gout 442 patients | #1 |
| pcdna3pgc1α pgc1α | #1 |
| pcdna3pgc1α | #1 |
| gout vpt | #1 |
| pgc1αoverexpressing plasmid | #1 |
| 269 tophaceous gout | #1 |
| uric acid deposition | #1 |
| esr vpt | #1 |
| pgc1α diabetic nephropathy | #1 |
| patients abnormal vpt | #1 |
| 442 patients gout | #1 |
| ros pcdna3pgc1α | #1 |
| longer gout duration | #1 |
| development kidney damage | #1 |
| nail urate patients | #2 |
| nail urate level | #2 |
| urate human fingernails | #2 |
| 31–45 years patients | #2 |
| diabetes 31–45 years | #2 |
| 31–45 years | #2 |
| gout patients fingernails | #2 |
| onset 31–45 | #2 |
| study nail urate | #2 |
| age 31–45 | #2 |
| age 31–45 years | #2 |
| diabetes onset development | #2 |
| damaged network structure | #2 |
| fingernail represents | #2 |
| serum ficolin3 levels | #2 |
| 31–45 years age | #2 |
| urate levels body | #2 |
| urate nail | #2 |
| nail urate | #2 |
| dkd chinese | #3 |
| hole vegf | #3 |
| tiit | #3 |
| brecs stat3 | #3 |
| cmh2dcfda fluorescent probes | #3 |
| stat3 cultured endothelium | #3 |
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Prominent publications by Haibing Chen
Inhibition of JAK2/STAT3-Mediated VEGF Upregulation under High Glucose Conditions by PEDF through a Mitochondrial ROS Pathway In Vitro
[ PUBLICATION ]
PURPOSE: Hyperglycemia-induced mitochondrial reactive oxygen species (ROS) production plays an important role in the development of complications of diabetes such as retinopathy. However, whether pigment epithelium-derived factor (PEDF) can decrease ROS production remains uncertain. The aim of this study was to clarify whether PEDF can decrease mitochondria-derived ROS generation and subsequently downregulate vascular endothelial growth factor (VEGF) expression; the authors also ...
| Known for Mitochondrial Ros | Pedf Expression | Protein Ucp2 | Cultured Endothelium | Stat3 Vegf |
OBJECTIVE: This study aimed to verify whether the decreased vascular endothelial growth factor (VEGF)-to-pigment epithelium-derived factor (PEDF) ratio can serve as an indicator for the protective effect of angiotensin-converting enzyme inhibitors (ACEIs) on diabetic retinopathy (DR) and to investigate the role of mitochondrial reactive oxygen species (ROS) in the downregulated VEGF-to-PEDF ratio.
RESEARCH DESIGN AND METHODS: Diabetic rats and control animals were randomly assigned to ...
| Known for Diabetic Retinopathy | Growth Factor | Vascular Endothelial | Pigment Epithelium | Vegf Pedf |
OBJECTIVE: Mitochondrial reactive oxygen species (ROS) plays a key role in diabetic retinopathy (DR) pathogenesis. However, whether simvastatin decreases diabetes-induced mitochondrial ROS production remains uncertain. The aim of this study was to clarify the beneficial effects and mechanism of action of simvastatin against diabetes-induced retinal vascular damage.
RESEARCH DESIGN AND METHODS: Diabetic rats and control animals were randomly assigned to receive simvastatin or vehicle for ...
| Known for Diabetic Rats | Retinal Vascular | Oxygen Species | Peroxisome Proliferator | Mitochondrial Reactive |
Nuclear factor (NF)-κB and signal transducer and activator of transcription 3 (STAT3) play a critical role in diabetic nephropathy (DN). Sirtuin-1 (SIRT1) regulates transcriptional activation of target genes through protein deacetylation. Here, we determined the roles of Sirt1 and the effect of NF-κB (p65) and STAT3 acetylation in DN. We found that acetylation of p65 and STAT3 was increased in both mouse and human diabetic kidneys. In human podocytes, advanced glycation end products ...
| Known for Diabetic Kidney Disease | Kidney Injury | Db Db Mice | Stat3 Sirt1 | Nfκb P65 |
AIMS: To assess the involvement of peripheral nerve dysfunction in asymptomatic patients with latent autoimmune diabetes of adults (LADA) or type 2 diabetes (T2DM), and compare nerve conduction (NC) parameters between the two groups.
METHODS: A total of 1635 patients without symptoms and signs relevant to diabetic polyneuropathy (1275 with T2DM and 360 with LADA) were included and were further categorized into 3 groups according to diabetes duration: <5years, 5-14 years and ≥15years. All ...
| Known for Latent Autoimmune Diabetes | Peripheral Nerve | Type 2 | Lada Patients | Conduction Studies |
Sirtuin 1–Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin
[ PUBLICATION ]
Cellular metabolic memory occurs in diabetic microvascular and macrovascular complications, but the underlying mechanisms remain unclear. Here, we investigate the role of sirtuin 1 (SIRT1) and metformin in this phenomenon. In bovine retinal capillary endothelial cells (BRECs) and retinas of diabetic rats, the inflammatory gene, nuclear factor-κB (NF-κB), and the proapoptotic gene, Bax, induced by hyperglycemia, remained elevated after returning to normoglycemia. BRECs with small ...
| Known for Cellular Metabolic Memory | Sirtuin 1 | Therapeutic Effects | Metformin Nf | Diabetic Rats |
Prevalence of chronic kidney disease and associated factors in Chinese individuals with type 2 diabetes: Cross-sectional study
[ PUBLICATION ]
AIMS: This cross-sectional study aimed to determine the prevalence and associated risk factors of chronic kidney disease (CKD) in Chinese type 2 diabetic patients.
METHODS: A total of 3301 patients with type 2 diabetes were included in this study. Anthropometric parameters and biochemical indices were measured. The main outcome measures were detection of CKD, albuminuria and estimated glomerular filtration rate (eGFR).
RESULTS: The prevalence of CKD and albuminuria in Shanghai Chinese ...
| Known for Chronic Kidney Disease | Type 2 Diabetes | Prevalence Ckd | Crosssectional Study | Diabetic Kidney |
Vascular endothelial growth factor (VEGF) plays a pivotal role in diabetic retinopathy (DR) and hypertension has been identified as an independent risk factor for DR. The aim of the present study was to: (1) explore whether beta-adrenergic blockers influence retinal VEGF expression; (2) determine the effect of angiotensin-converting enzyme inhibitors (ACEI) on retinal VEGF expression independently of their anti-hypertensive actions; and (3) investigate the correlation between retinal ...
| Known for Diabetic Rats | Growth Factor | Vascular Endothelial | Converting Enzyme | Mrna Expression |
miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signalling pathway
[ PUBLICATION ]
Aims/hypothesisThe mechanisms underlying the cellular metabolic memory induced by high glucose remain unclear. Here, we sought to determine the effects of microRNAs (miRNAs) on metabolic memory in diabetic retinopathy.MethodsThe miRNA microarray was used to examine human retinal endothelial cells (HRECs) following exposure to normal glucose (N) or high glucose (H) for 1 week or transient H for 2 days followed by N for another 5 days (H→N). Levels of sirtuin 1 (SIRT1) and ...
| Known for Metabolic Memory | Diabetic Retinopathy | Signalling Pathway | Sirt1 Expression | Normal Glucose |
PURPOSE: To investigate the relationship of ficolin-3 with inflammatory and angiogenic factors, namely, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF), in the vitreous of eyes with proliferative diabetic retinopathy (PDR).
DESIGN: Case-control study.
METHODS: Vitreous fluid and serum samples were obtained at the time of vitreoretinal surgery from 21 eyes of 21 patients with PDR and from 16 eyes of 16 nondiabetic patients with idiopathic macular ...
| Known for Growth Factor | Diabetic Retinopathy | Vascular Endothelial | Idiopathic Macular Hole | Ficolin3 Levels |
Diabetes Onset at 31–45 Years of Age is Associated with an Increased Risk of Diabetic Retinopathy in Type 2 Diabetes
[ PUBLICATION ]
This hospital-based, cross-sectional study investigated the effect of age of diabetes onset on the development of diabetic retinopathy (DR) among Chinese type 2 diabetes mellitus (DM) patients. A total of 5,214 patients with type 2 DM who were referred to the Department of Ophthalmology at the Shanghai First People’s Hospital from 2009 to 2013 was eligible for inclusion. Diabetic retinopathy status was classified using the grading system of the Early Treatment Diabetic Retinopathy Study ...
| Known for Diabetic Retinopathy | Type 2 | Age Diabetes | Independent Risk | Hospital Based |
Protective Role of PGC-1α in Diabetic Nephropathy Is Associated with the Inhibition of ROS through Mitochondrial Dynamic Remodeling
[ PUBLICATION ]
The overproduction of mitochondrial reactive oxygen species (ROS) plays a key role in the pathogenesis of diabetic nephropathy (DN). However, the underlying molecular mechanism remains unclear. Our aim was to investigate the role of PGC-1α in the pathogenesis of DN. Rat glomerular mesangial cells (RMCs) were incubated in normal or high glucose medium with or without the PGC-1α-overexpressing plasmid (pcDNA3-PGC-1α) for 48 h. In the diabetic rats, decreased PGC-1α expression was ...
| Known for Diabetic Nephropathy | Protective Role | Pgc1α Expression | Oxidative Stress | Mitochondrial Ros |
Serum betatrophin concentrations are significantly increased in overweight but not in obese or type 2 diabetic individuals
[ PUBLICATION ]
OBJECTIVE: In this study, circulating serum betatrophin levels were quantitated and their relationships with insulin resistance (IR) and other metabolic parameters in Chinese subjects with varying degrees of obesity and glucose tolerance were examined.
METHODS: Serum betatrophin levels were determined using ELISA in 60 subjects with normal glucose tolerance (NGT: 17 lean, 23 overweight, and 20 obese subjects) and 56 subjects with type 2 diabetes mellitus (T2DM: 14 lean, 23 overweight, ...
| Known for Serum Betatrophin | Type 2 | Insulin Resistance | Glucose Tolerance | Obese Subjects |
Oral Supplementation with Cholecalciferol 800 IU Ameliorates Albuminuria in Chinese Type 2 Diabetic Patients with Nephropathy
[ PUBLICATION ]
BACKGROUND: Low vitamin D levels can be associated with albuminuria, and vitamin D analogs are effective anti-proteinuric agents. The aim of this study was to investigate differences in vitamin D levels between those with micro- and those with macroalbuminuria, and to determine whether low dose cholecalciferol increases vitamin D levels and ameliorates albuminuria.
METHODS: Two studies were performed in which 25-OH vitamin D(3) (25(OH)D(3)) concentrations were determined by ...
| Known for Type 2 | Diabetic Patients | Vitamin Levels | Longitudinal Studies | Micro Macroalbuminuria |
Prevalence and risk of diabetes based on family history in the Shanghai High‐Risk Diabetic Screen (SHiDS) study
[ PUBLICATION ]
AIMS: To evaluate the prevalence and risk of diabetes based on family history in high-risk subjects and also to evaluate insulin sensitivity and insulin secretion in these subjects.
METHODS: Data were analysed from 9756 participants in the Shanghai High-Risk Diabetic Screen (SHiDS) Project. Family history of diabetes was classified according to parental and sibling diabetes status. The prevalence and odds ratios were calculated for each grouping after adjusting for other risk factors. ...
| Known for Risk Diabetes | Insulin Secretion | Prevalence Rates | Glucose Tolerance | Mellitus Type |
Key People For Type 2 Diabetes
Haibing Chen:Expert Impact
Concepts for whichHaibing Chenhas direct influence:Type 2 diabetes, Diabetic retinopathy, Diabetic nephropathy, Uric acid, Type 2, 2 diabetes, Diabetic rats, Chinese patients.
Haibing Chen:KOL impact
Concepts related to the work of other authors for whichfor which Haibing Chen has influence:Diabetic retinopathy, Type 2 diabetes, Oxidative stress, Kidney disease, Insulin resistance, Uric acid, Metabolic memory.
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