Prominent publications by Catharine R Gale

KOL Index score: 16884

OBJECTIVE: To examine whether the 1-year prevalence of major depressive disorder (MDD), generalized anxiety disorder (GAD), and their comorbidity were associated with subsequent all-cause and cardiovascular disease (CVD) mortality during 15 years in Vietnam veterans.

METHODS: Participants (N = 4256) were from the Vietnam Experience Study. Service, sociodemographic, and health data were collected from service files, telephone interviews, and a medical examination. One-year prevalence of ...

Also Ranks for: Cardiovascular Mortality |  generalized anxiety disorder |  mdd gad |  major depressive |  united states
KOL Index score: 16391

OBJECTIVE: We investigated the effects of head growth prenatally, during infancy, and during later periods of development on cognitive function at the ages of 4 and 8 years.

METHODS: We studied 633 term-born children from the Avon Longitudinal Study of Parents and Children cohort whose head circumference was measured at birth and at regular intervals thereafter. Their cognitive function was assessed with the Wechsler Preschool and Primary Scale of Intelligence at the age of 4 years and ...

Also Ranks for: Head Growth |  8 years |  children age |  brain volume |  cognitive function
KOL Index score: 15330

Background: loneliness and social isolation have been associated with mortality and with functional decline in older people. We investigated whether loneliness or social isolation are associated with progression of frailty.

Methods: participants were 2,817 people aged ≥60 from the English Longitudinal Study of Ageing. Loneliness was assessed at Wave 2 using the Revised UCLA scale (short version). A social isolation score at Wave 2 was derived from data on living alone, frequency of ...

Also Ranks for: Social Isolation |  loneliness frailty |  english longitudinal study |  older people |  longitudinal studies
KOL Index score: 12874

Cross-sectional studies show that higher blood concentrations of inflammatory markers tend to be more common in frail older people, but longitudinal evidence that these inflammatory markers are risk factors for frailty is sparse and inconsistent. We investigated the prospective relation between baseline concentrations of the inflammatory markers C-reactive protein (CRP) and fibrinogen and risk of incident frailty in 2,146 men and women aged 60 to over 90 years from the English ...

Also Ranks for: Incident Frailty |  inflammatory markers |  crp fibrinogen |  english longitudinal study |  crosssectional studies
KOL Index score: 12273

CONTEXT: Lower cognitive ability is a risk factor for some forms of psychopathology, but much of the evidence for risk is based on individuals who required specialist care. It is unclear whether lower ability influences the risk of particular patterns of comorbidity.

OBJECTIVE: To examine the relation between premorbid cognitive ability in early adulthood and the risk of major depression, generalized anxiety disorder (GAD), posttraumatic stress disorder (PTSD), alcohol and other drug ...

Also Ranks for: Cognitive Ability |  early adulthood |  vietnam experience study |  middle age |  major depression
KOL Index score: 12011

BACKGROUND: Vitamin D insufficiency is common in women of childbearing age and increasing evidence suggests that the risk of osteoporotic fracture in adulthood could be determined partly by environmental factors during intrauterine and early postnatal life. We investigated the effect of maternal vitamin D status during pregnancy on childhood skeletal growth.

METHODS: In a longitudinal study, we studied 198 children born in 1991-92 in a hospital in Southampton, UK; the body build, ...

Also Ranks for: Childhood Bone |  maternal vitamin |  late pregnancy |  9 years |  osteoporotic fracture
KOL Index score: 11845

BACKGROUND: The English NHS Bowel Cancer Screening Programme has offered biennial faecal occult blood testing to people aged 60-69 years since 2006, and to those aged 60-74 years since 2010. Analysis of the first 2.6 million screening invitations found that 54% of eligible people took up the invitation. The reasons for this low uptake are unclear. We investigated whether participation in screening varies according to cognitive ability and personality.

METHODS: Participants were members ...

Also Ranks for: Cognitive Ability |  cancer screening |  english longitudinal study |  early detection |  health literacy
KOL Index score: 11652

Neuroticism is a personality trait of fundamental importance for psychological well-being and public health. It is strongly associated with major depressive disorder (MDD) and several other psychiatric conditions. Although neuroticism is heritable, attempts to identify the alleles involved in previous studies have been limited by relatively small sample sizes. Here we report a combined meta-analysis of genome-wide association study (GWAS) of neuroticism that includes 91 370 participants ...

Also Ranks for: Wide Analysis |  neuroticism mdd |  genetic loci |  personality trait |  individuals identifies
KOL Index score: 11532

OBJECTIVE: To examine the cross-sectional associations between generalized anxiety disorder (GAD) and major depressive disorder (MDD), their comorbidity, and hypertension.

METHODS: Participants (n = 4180) were drawn from a cohort of men who were members of the U.S. army during the Vietnam war era. Occupational, sociodemographic, and health data were collected from military service files, telephone interviews, and medical examinations. Hypertension status was defined by the presence of ...

Also Ranks for: Generalized Anxiety |  gad mdd |  depressive disorders |  hypertension status |  antihypertensive medication
KOL Index score: 11370

BACKGROUND: Cross-sectional surveys of older people commonly find associations between higher levels of depressive symptoms and poorer cognitive performance, but the direction of effect is unclear. We examined whether there was a bidirectional relationship between depressive symptoms and general cognitive ability in non-demented older people, and explored the role of physical health, smoking, exercise, social class and education as potential confounders of this association and as ...

Also Ranks for: Depressive Symptoms |  older people |  cognitive ability |  bidirectional relationship |  english longitudinal study
KOL Index score: 11330

OBJECTIVES: To determine whether vitamin C status, as measured by dietary intake and plasma ascorbic acid concentration, is related to mortality from stroke and coronary heart disease in people aged 65 and over.

DESIGN: A 20 year follow up study of a cohort of randomly selected elderly people living in the community who had taken part in the 1973-4 Department of Health and Social Security nutritional survey and for whom dietary and other data had been recorded.

SETTING: Eight areas in ...

Also Ranks for: Coronary Heart Disease |  elderly people |  risk death |  dietary intake |  nutritional survey
KOL Index score: 11160

BACKGROUND: Maternal nutrition during pregnancy has been linked with fetal brain development and psychopathology in the offspring. We examined for associations of maternal folate status and dietary intake during pregnancy with brain growth and childhood behavioural difficulties in the offspring.

METHODS: In a prospective cohort study, maternal red blood cell folate (RCF) was measured at 14 weeks of pregnancy and total folate intake (TFI) from food and supplements was assessed in early ...

Also Ranks for: Early Pregnancy |  maternal folate |  peer problems |  offspring associations |  brain growth
KOL Index score: 11036

BACKGROUND: Physical activity, diet, smoking, and alcohol consumption have been shown to be related to mortality. We examined prospectively the individual and combined influence of these risk factors on total and cause-specific mortality.

METHODS: The prospective cohort study included 4886 individuals at least 18 years old from a United Kingdom-wide population in 1984 to 1985. A health behavior score was calculated, allocating 1 point for each poor behavior: smoking; fruits and ...

Also Ranks for: United Kingdom |  health behaviors |  specific mortality |  diet smoking |  alcohol consumption
KOL Index score: 10945

BACKGROUND: Several studies in older people have shown that grip strength predicts all-cause mortality. The mechanisms are unclear. Muscle strength declines with age, accompanied by a loss of muscle mass and an increase in fat, but the role that body composition plays in the association between grip strength and mortality has been little explored. We investigated the relation between grip strength, body composition, and cause-specific and total mortality in 800 men and women aged 65 and ...

Also Ranks for: Grip Strength |  body composition |  cardiovascular disease |  united kingdom |  cancer women
KOL Index score: 10942

OBJECTIVE: To examine the relationship between locus of control at age 10 years and self-reported health outcomes (overweight, obesity, psychological distress, health, and hypertension) and health behaviors (smoking and physical activity) at age 30, controlling for sex, childhood IQ, educational attainment, earnings, and socioeconomic position.

METHODS: Participants were members of the 1970 British Cohort Study, a national birth cohort. At age 10, 11,563 children took tests to measure ...

Also Ranks for: Locus Control |  health outcomes |  10 years |  childhood risk |  psychological distress

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Catharine R Gale:Expert Impact

Concepts for whichCatharine R Galehas direct influence:Uk biobank,  Cognitive ability,  Cognitive function,  Metabolic syndrome,  Vietnam experience study,  Older people,  General cognitive function,  Psychological distress.

Catharine R Gale:KOL impact

Concepts related to the work of other authors for whichfor which Catharine R Gale has influence:Physical activity,  Grip strength,  Birth weight,  Cognitive function,  Uk biobank,  Depressive symptoms,  Metabolic syndrome.



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MRC Lifecourse Epidemiology Unit, University of Southampton, UK, Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, UK | MRC Lifecourse Epidemiology Unit, University of Southampton, UK | Medical Research Council Lifecourse Epid