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    • Stephen M Smith

      Stephen M Smith

      Wellcome Centre for Integrative Neuroimaging, Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom | ...



      KOL Resume for Stephen M Smith


      Wellcome Centre for Integrative Neuroimaging, Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom


      Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, Oxford, UK

      Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany


      Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford. John Radcliffe Hospital, Oxford, UK

      Oxford University


      Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK

      University of Oxford, ;

      Donders Institute


      Department of Pathology, Yale School of Medicine, New Haven, CT

      The Wellcome Centre for Integrative Neuroimaging, University of Oxford, UK

      Wellcome Centre for Integrative Neuroimaging - Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), University of Oxford, Oxford, United Kingdom.

      Oxford Centre for Functional MRI of the Brain, University of Oxford, Oxford, United Kingdom


      Oxford Centre for Functional MRI of the Brain, University of Oxford, Oxford, UK

      Department of Pathology, The Ohio State University, Columbus, OH, 43210, USA


      Department of Pathology and Laboratory Medicine, Wexner Medical Center at The Ohio State University, 410 West 10th Avenue, 43210, Columbus, OH, USA

      FMRIB Centre, University of Oxford, Oxford, United Kingdom



      Stephen M Smith: Influence Statistics

      Sample of concepts for which Stephen M Smith is among the top experts in the world.
      Concept World rank
      multistudy data #1
      148 replicated clusters #1
      disambiguating brain #1
      aging comprises #1
      stable neural architecture #1
      standard pca variables #1
      cca image processing #1
      multisubject fmri analysis #1
      confounds essential step #1
      method frequency sensitivity #1
      loci handedness #1
      rsns oscillatory activity #1
      ssrt spatial maps #1
      realtime motion segmentation #1
      temporal features ica #1
      standard clusterbased methods #1
      autocorrelation correction #1
      faster permutation inference #1
      unfixed post #1
      canonical variates discovery #1
      substrate execution #1
      brain volumetric development #1
      inexpensive computing #1
      ica state fmri #1
      respect local gyral #1
      labelled cortical regions #1
      scanner site variability #1
      fine scaled patterns #1
      particle scalespace particles #1
      statistical neurons phantoms #1
      early cortical recruitment #1
      cluster leaking #1
      existing expertcurated idps #1
      idps brain #1
      nbv siena #1
      pam joint bam #1
      ukb data #1
      nidps idps #1
      hcpya #1
      massive parallel processors #1
      fast transient networks #1
      local tract directionality #1
      rs199512 #1
      population norms aspects #1
      brainorganizational motif #1
      task activity model #1
      crease features #1
      simple conceptual explanation #1
      n1d stack #1
      vitamin b12 05 #1


      Prominent publications by Stephen M Smith

      KOL-Index: 14922

      Task-functional magnetic resonance imaging studies have shown that early cortical recruitment exists in multiple sclerosis, which can partly explain the discrepancy between conventional magnetic resonance imaging and clinical disability. The study of the brain 'at rest' may provide additional information, because task-induced metabolic changes are relatively small compared to the energy use of the resting brain. We therefore questioned whether functional changes exist at rest in the ...

      Known for Clinically Isolated Syndrome | State Networks | Multiple Sclerosis | Remitting Patients | Cortical Reorganization
      KOL-Index: 14733

      Though mild cognitive impairment is an intermediate clinical state between healthy aging and Alzheimer's disease (AD), there are very few whole-brain voxel-wise diffusion MRI studies directly comparing changes in healthy control, mild cognitive impairment (MCI) and AD subjects. Here we report whole-brain findings from a comprehensive study of diffusion tensor indices and probabilistic tractography obtained in a very large population of healthy controls, MCI and probable AD subjects. As ...

      Known for Diffusion Anisotropy | White Matter | Dti Measures | Crossing Fibres | Probabilistic Tractography
      KOL-Index: 14048

      BACKGROUND: Increased brain atrophy rates are common in older people with cognitive impairment, particularly in those who eventually convert to Alzheimer disease. Plasma concentrations of omega-3 (ω-3) fatty acids and homocysteine are associated with the development of brain atrophy and dementia.

      OBJECTIVE: We investigated whether plasma ω-3 fatty acid concentrations (eicosapentaenoic acid and docosahexaenoic acid) modify the treatment effect of homocysteine-lowering B vitamins on brain ...

      Known for Brain Atrophy | Fatty Acids | Vitamin Status | Docosahexaenoic Acid | Controlled Trial
      KOL-Index: 13466

      BACKGROUND: An increased rate of brain atrophy is often observed in older subjects, in particular those who suffer from cognitive decline. Homocysteine is a risk factor for brain atrophy, cognitive impairment and dementia. Plasma concentrations of homocysteine can be lowered by dietary administration of B vitamins.

      OBJECTIVE: To determine whether supplementation with B vitamins that lower levels of plasma total homocysteine can slow the rate of brain atrophy in subjects with mild ...

      Known for Mild Cognitive Impairment | Brain Atrophy | Controlled Trial | Alzheimers Disease | Treatment Homocysteine
      KOL-Index: 12372

      Adolescent-onset schizophrenia provides an exceptional opportunity to explore the neuropathology of schizophrenia free from the potential confounds of prolonged periods of medication and disease interactions with age-related neurodegeneration. Our aim was to investigate structural grey and white matter abnormalities in adolescent-onset schizophrenia. Whole-brain voxel-wise investigation of both grey matter topography and white matter integrity (Fractional Anisotropy) were carried out on ...

      Known for White Matter | Adolescentonset Schizophrenia | Adolescent Age | Anisotropy Brain | Structural Grey
      KOL-Index: 12032

      Increasing age and carrying an APOE ε4 allele are well established risk factors for Alzheimer's disease (AD). The earlier age of onset of AD observed in ε4-carriers may reflect an accelerated aging process. We recently reported that APOE genotype modulates brain function decades before the appearance of any cognitive or clinical symptoms. Here we test the hypothesis that APOE influences brain aging by comparing healthy ε4-carriers and non-carriers, using the same imaging protocol in ...

      Known for Apoe Genotype | Brain Function | Differential Effects | Ε4 Carriers | Interaction Age
      KOL-Index: 11665

      BACKGROUND: Converging evidence from several theories of the development of incentive-sensitization to smoking-related environmental stimuli suggests that the ventral striatum plays an important role in the processing of smoking-related cue reactivity.

      METHODS: Twenty-six healthy right-handed volunteers (14 smokers and 12 nonsmoking controls) underwent functional magnetic resonance imaging (fMRI) during which neutral and smoking-related images were presented. Region of interest analyses ...

      Known for Ventral Striatum | Nucleus Accumbens | Magnetic Resonance | Smokers Nonsmokers | Image Processing
      KOL-Index: 11086

      Temporal fluctuations in functional Magnetic Resonance Imaging (fMRI) have been profitably used to study brain activity and connectivity for over two decades. Unfortunately, fMRI data also contain structured temporal "noise" from a variety of sources, including subject motion, subject physiology, and the MRI equipment. Recently, methods have been developed to automatically and selectively remove spatially specific structured noise from fMRI data using spatial Independent Components ...

      Known for Temporal Ica | Global Noise | Fmri Data | Functional Mri | Brain Activity
      KOL-Index: 11059

      PURPOSE: To investigate intercenter agreement of brain volume (change) measurement in multiple sclerosis (MS) using structural image evaluation using normalization of atrophy (SIENA) and the cross-sectional version of SIENA (SIENAX) with additional manual editing to correct for inadequate brain extraction.

      MATERIALS AND METHODS: Baseline and follow-up T1-weighted MR images of 20 MS patients were dispatched to five centers. Each center performed fully-automated and manually-edited ...

      Known for Multiple Sclerosis | Manual Editing | Brain Atrophy | Nbv Pbvc | Sienax Siena
      KOL-Index: 10829

      Although multiple sclerosis (MS) is an inflammatory demyelinating disease, there can be substantial axonal injury and loss. We therefore hypothesized that adaptive cortical changes may contribute to limiting functional impairment, particularly in the early stages of the disease. To test our hypothesis, we used functional magnetic resonance imaging (MRI) to characterize the localization and volumes of activation in the motor cortex during simple flexion-extension finger movements. There ...

      Known for Motor Cortex | Adaptive Functional | Multiple Sclerosis | Brain Injury | Cortical Activation
      KOL-Index: 10762

      Many sources of fluctuation contribute to the fMRI signal, and this makes identifying the effects that are truly related to the underlying neuronal activity difficult. Independent component analysis (ICA) - one of the most widely used techniques for the exploratory analysis of fMRI data - has shown to be a powerful technique in identifying various sources of neuronally-related and artefactual fluctuation in fMRI data (both with the application of external stimuli and with the subject "at ...

      Known for Independent Component | Functional Mri Data | Fmri Signal | Analysis Ica | Spatial Maps
      KOL-Index: 10751

      Echo planar imaging (EPI) is an MRI technique of particular value to neuroscience, with its use for virtually all functional MRI (fMRI) and diffusion imaging of fiber connections in the human brain. EPI generates a single 2D image in a fraction of a second; however, it requires 2-3 seconds to acquire multi-slice whole brain coverage for fMRI and even longer for diffusion imaging. Here we report on a large reduction in EPI whole brain scan time at 3 and 7 Tesla, without significantly ...

      Known for Diffusion Imaging | Brain Fmri | Echo Planar | 3 Tesla | Epi Time
      KOL-Index: 10736

      Previous studies have established the clinical relevance of hypointense lesions (“black holes”) on T1-weighted MRI as a surrogate marker for pathological change [36]. In contrast to measuring the volume of “black holes”, the direct measurement of T1 values allows an objective assessment of the changes contributing to hypointensity both in the focal lesions and in the normal appearing white matter (NAWM). The aims of this study were first, to determine the relationship between T1 values ...

      Known for White Matter | Multiple Sclerosis | Values Nawm | Black Holes | Hypointense Lesions
      KOL-Index: 10361

      BACKGROUND: The cerebellum is of potential interest for understanding adaptive responses in motor control in patients with multiple sclerosis because of the high intrinsic synaptic plasticity of this brain region.

      OBJECTIVE: To assess the relative roles of interactions between the neocortex and the cerebellum using measures of functional connectivity.

      METHODS: A role for altered neocortical-cerebellar functional connectivity in adaptive responses to injury from multiple sclerosis was ...

      Known for Functional Connectivity | Multiple Sclerosis | Motor Cortex | Magnetic Resonance | Adaptive Responses
      KOL-Index: 10286

      OBJECTIVES: To investigate the relationship between markers of vitamin B(12) status and brain volume loss per year over a 5-year period in an elderly population.

      METHODS: A prospective study of 107 community-dwelling volunteers aged 61 to 87 years without cognitive impairment at enrollment. Volunteers were assessed yearly by clinical examination, MRI scans, and cognitive tests. Blood was collected at baseline for measurement of plasma vitamin B(12), transcobalamin (TC), ...

      Known for Vitamin B12 | Brain Volume | Thcy Holotc | Cognitive Impairment | Elderly Population

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      Stephen M Smith:Expert Impact

      Concepts for whichStephen M Smithhas direct influence:Uk biobank,  Functional connectivity,  Multiple sclerosis,  White matter,  Human connectome project,  Brain atrophy,  Fmri data,  Magnetic resonance.

      Stephen M Smith:KOL impact

      Concepts related to the work of other authors for whichfor which Stephen M Smith has influence:White matter,  Functional connectivity,  Magnetic resonance,  Multiple sclerosis,  Brain regions,  Diffusion tensor imaging,  Cognitive impairment.



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      Wellcome Centre for Integrative Neuroimaging, Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom | Wellcome Centre for Integrative Neuroimaging (WIN FMRIB), University of Oxford, O

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