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  • Henry W Lim

    Prominent publications by Henry W Lim

    KOL Index score: 12887

    The effects of ultraviolet radiation, visible light, and infrared radiation on cutaneous erythema, immediate pigment darkening, persistent pigment darkening, and delayed tanning are affected by a variety of factors. Some of these factors include the depth of cutaneous penetration of the specific wavelength, the individual skin type, and the absorption spectra of the different chromophores in the skin. UVB is an effective spectrum to induce erythema, which is followed by delayed tanning. ...

    Also Ranks for: Visible Light |  infrared radiation |  skin erythema |  pigment darkening |  ultraviolet rays
    KOL Index score: 11368

    Recent genome scans have established the presence of a major psoriasis-susceptibility locus in the human leukocyte antigen (HLA) complex on chromosome 6p21.3. To narrow the interval for candidate gene testing, we performed a linkage-disequilibrium analysis of 339 families, with the use of 62 physically mapped microsatellite markers spanning the major histocompatibility complex (MHC). As detected by use of the transmission/disequilibrium test (TDT), individual markers yielded significant ...

    Also Ranks for: Linkage Disequilibrium |  kb interval |  susceptibility locus |  corneodesmosin gene |  risk haplotype
    KOL Index score: 10391

    To investigate the functional heterogeneity of mouse mast cells, we extracted and purified cutaneous and peritoneal mast cells from 10- to 18-week-old BALB/c mice and compared their responses to secretagogues. Cutaneous mast cells (CMC) were extracted from mouse ears after digestion with hyaluronidase and collagenase in MEM containing 25% fetal calf serum and purified on a discontinuous Percoll gradient. The histamine content of cells obtained from the 30/40% interface was 1.0 +/- 0.1 ...

    Also Ranks for: Mast Cells |  histamine release |  cmc pmc |  calcium cell |  balb mice
    KOL Index score: 10145

    Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin and joint manifestations affecting approximately 2% of the population. In this fifth of 6 sections of the guidelines of care for psoriasis, we discuss the use of ultraviolet (UV) light therapy for the treatment of patients with psoriasis. Treatment should be tailored to meet individual patients' needs. We will discuss in detail the efficacy and safety as well as offer recommendations for the use of ...

    Also Ranks for: Psoriatic Arthritis |  treatment psoriasis |  phototherapy photochemotherapy |  efficacy safety |  excimer laser
    KOL Index score: 9902

    Psoriasis is a common, chronic, inflammatory, multi-system disease with predominantly skin and joint manifestations affecting approximately 2% of the population. In this third of 6 sections of the guidelines of care for psoriasis, we discuss the use of topical medications for the treatment of psoriasis. The majority of patients with psoriasis have limited disease (<5% body surface area involvement) and can be treated with topical agents, which generally provide a high efficacy-to-safety ...

    Also Ranks for: Psoriatic Arthritis |  topical therapies |  treatment psoriasis |  combination humans |  guidelines management
    KOL Index score: 9872

    BACKGROUND: Cutaneous reactions after messenger RNA (mRNA)-based COVID-19 vaccines have been reported but are not well characterized.

    OBJECTIVE: To evaluate the morphology and timing of cutaneous reactions after mRNA COVID-19 vaccines.

    METHODS: A provider-facing registry-based study collected cases of cutaneous manifestations after COVID-19 vaccination.

    RESULTS: From December 2020 to February 2021, we recorded 414 cutaneous reactions to mRNA COVID-19 vaccines from Moderna (83%) and ...

    Also Ranks for: Cutaneous Reactions |  covid19 vaccination |  vaccines drug eruptions |  messenger rna |  registrybased study
    KOL Index score: 9658

    Skin cancer is less prevalent in people of color than in the white population. However, when skin cancer occurs in non-whites, it often presents at a more advanced stage, and thus the prognosis is worse compared with white patients. The increased morbidity and mortality associated with skin cancer in patients of color compared with white patients may be because of the lack of awareness, diagnoses at a more advanced stage, and socioeconomic factors such as access to care barriers. ...

    Also Ranks for: Skin Cancer |  people color |  white patients |  hispanic americans |  advanced stage
    KOL Index score: 9586

    To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci ...

    Also Ranks for: Innate Immunity |  susceptibility loci |  candidate genes |  stat3 transcription |  new psoriasis
    KOL Index score: 9479

    Psoriasis is a common inflammatory and hyperproliferative skin disease with a multifactorial genetic basis. A recent study reported that psoriasis was associated with the IL12B haplotype rs3212227 (3'-untranslated region)-rs6887695 (60 kb, 5') and the IL23R haplotype rs7530511 (L310P)-rs11209026 (Q381R). We examined these four single-nucleotide polymorphisms (SNPs) for association with psoriasis in two groups of North American and German Caucasians: (1) 1,810 cases and 2,522 controls; ...

    Also Ranks for: Il23r Genes |  association psoriasis |  il12b markers |  single nucleotide |  case control
    KOL Index score: 9386

    Previous studies have narrowed the interval containing PSORS1, the psoriasis-susceptibility locus in the major histocompatibility complex (MHC), to an approximately 300-kb region containing HLA-C and at least 10 other genes. In an effort to identify the PSORS1 gene, we cloned and completely sequenced this region from both chromosomes of five individuals. Two of the sequenced haplotypes were associated with psoriasis (risk), and the other eight were clearly unassociated (nonrisk). ...

    Also Ranks for: Psoriasis Risk |  hla cw6 |  psors1 gene |  haplotype analysis |  kb region
    KOL Index score: 9140

    BACKGROUND: Few large-scale studies have quantified the burden of comorbid autoimmune diseases in patients with vitiligo.

    OBJECTIVE: We sought to determine the prevalence of comorbid autoimmune diseases in patients with vitiligo.

    METHODS: We conducted a manual chart review on a cohort of 1873 patients with vitiligo seen between January 2002 and October 2012 at the Henry Ford Health System in Detroit, MI. Patients were excluded if they had fewer than 2 dermatology notes (N = 595) or if ...

    Also Ranks for: Autoimmune Diseases |  patients vitiligo |  alopecia areata |  thyroid disease |  pernicious anemia
    KOL Index score: 8989

    Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin and joint manifestations affecting approximately 2% of the population. In this fourth of 6 sections of the guidelines of care for psoriasis, we discuss the use of traditional systemic medications for the treatment of patients with psoriasis. Treatment should be tailored to meet individual patients' needs. We will discuss in detail the efficacy and safety, and offer recommendations for the use of the ...

    Also Ranks for: Psoriatic Arthritis |  guidelines psoriasis |  systemic agents |  management treatment |  efficacy safety
    KOL Index score: 8961

    BACKGROUND: Ultraviolet light (UVL) is a long established treatment for mycosis fungoides (MF) and Sézary syndrome (SS), subtypes of cutaneous T-cell lymphoma (CTCL). Treatments have traditionally included broadband, narrowband ultraviolet B light (UVB) and psoralen plus ultraviolet A light photochemotherapy (PUVA), but more recently, treatment options have expanded to include UVA1 and excimer laser. UVL is used either as monotherapy or as an adjuvant to systemic therapy, demonstrating ...

    Also Ranks for: Mycosis Fungoides |  sézary syndrome |  cutaneous lymphoma |  phototherapy mf |  united states
    KOL Index score: 8870

    In this study, demethylchlortetracycline was used as a prototype of exogenous phototoxic substances. In vitro, exposure of serum containing demethylchlortetracycline to ultraviolet-A irradiation resulted in the diminution of total complement hemolytic activity and C4, C2, C3, and C5 activities. In addition, chemotactic activity for human polymorphonuclear cells was generated, which was thermostable and antigenically related to human C5 but not human C3. In vivo, phototoxic lesions were ...

    Also Ranks for: Guinea Pigs |  induced phototoxicity |  maximal response |  phototoxic lesions |  human c5
    KOL Index score: 8658

    BackgroundUV-based therapies, which include narrow-band (NB) UVB, broad-band (BB) UVB, and psoralen and UVA (PUVA), are well known treatment options for moderate to severe plaque psoriasis. However, there are limited evidence-based reviews on their efficacy, short-term safety, and tolerability.AimThe aim of the study was to evaluate the efficacy, short-term safety, and tolerability of UV-based therapy in the treatment of adults with moderate to severe plaque psoriasis.MethodsWe performed ...

    Also Ranks for: Uvb Puva |  therapy psoriasis |  randomized controlled |  safety tolerability |  severe plaque


    Henry W Lim: Influence Statistics

    Sample of concepts for which Henry W Lim is among the top experts in the world.
    Concept World rank
    tregs nsv #1
    serum histamine histologic #1
    public education sunscreens #1
    option localized vitiligo #1
    summarymitochondrial #1
    models straps #1
    73 puva #1
    reviewto update readers #1
    ezbsa #1
    publics nonadherence #1
    vl sunscreens #1
    common photodermatosis individuals #1
    sunburn protective efficacy #1
    15 2 uvc #1
    subacute phototoxicity addition #1
    uvr vl #1
    therapy suppuration #1
    historically loss #1
    photoprotection vitamin levels #1
    138 466 #1
    hematoporphyrin antagonists humans #1
    eruption pmle #1
    1 micronthick #1
    density atpasepositive cells #1
    cutaneous photobiology studies #1
    nbuvb excimer laser #1
    vehicle cream 28 #1
    photodermatoses males #1
    nonpigmentary influences #1
    repigmentation mktp #1
    druginduced photosensitivity photosensitivity #1
    risks sunburn #1
    measure repigmentation #1
    localized phototherapy #1
    experience uva1 phototherapy #1
    cpp pih #1
    factors mm detection #1
    standard spf testing #1
    puva option #1
    indoor tanning equipment #1
    skin conditions illness #1
    370700 nm #1
    tcainduced pih model #1
    porphyrin levels patients #1
    narrowband uvb nbuvb #1
    ebv infection hypersensitivity #1
    demethylchlortetracycline ultravioleta irradiation #1
    8 weeks colorimetry #1
    chalky white appearance #1
    longterm repigmentation #1

    Key People For Visible Light

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    Henry W Lim:Expert Impact

    Concepts for whichHenry W Limhas direct influence:Visible light,  United states,  Ultraviolet radiation,  Polymorphous light eruption,  Skin disease,  Chronic actinic dermatitis,  Guinea pigs,  African americans.

    Henry W Lim:KOL impact

    Concepts related to the work of other authors for whichfor which Henry W Lim has influence:Skin cancer,  Psoriatic arthritis,  Atopic dermatitis,  Mycosis fungoides,  Psoriasis patients,  Actinic keratosis,  Photodynamic therapy.



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    Department of Dermatology, Henry Ford Health System, Detroit, MI, USA | Department of Dermatology, Henry Ford Health System, Detroit, MI, United States | Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA. | Department of Dermatology, H