KOL | Krista F HuybrechtsDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts | Division of ... |
KOL Resume for Krista F Huybrechts
| Year | |
|---|---|
| 2022 | Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts |
| 2021 | Division of Pharmacoepidemiology & Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA |
| 2020 | Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts |
| 2019 | Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Department of Epidemiology, School of Public Health, Boston University, Boston, Massachusetts |
| 2018 | Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Boston, MA, 02120, USA. Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (B.T.B., K.F.H.). |
| 2017 | Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA |
| 2016 | Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, 02120, Boston, MA, USA |
| 2015 | Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts |
| 2014 | Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, the Department of Epidemiology, Harvard School of Public Health, and the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. |
| 2013 | Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02120, USA |
| 2012 | Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston 02120, MA, United States |
| 2011 | Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., USA. |
| 2010 | Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, 02118, Boston, MA, USA |
| 2008 | United Biosource Corporation (formerly Caro Research Institute), Lexington, Mass., USA;, Faculty of Medicine and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Que., Canada;, Department of Clinical Therapeutics, Acute-Stroke Unit, Alexandra Hospital, Athens, Greece |
| 2007 | Caro Research Institute, Concord, MA, |
Krista F Huybrechts: Influence Statistics
| Concept | World rank |
|---|---|
| 1 year countries | #1 |
| marketscan clinformatics datamart | #1 |
| major hemorrhage hrs | #1 |
| longacting formulations countries | #1 |
| longacting formulations persistence | #1 |
| 1403240 patients | #1 |
| caserta claims database | #1 |
| risperidone united | #1 |
| 5935 42 | #1 |
| balance clinical parameters | #1 |
| labeling rule | #1 |
| 12 months doacs | #1 |
| schizophrenic disorder | #1 |
| 19588 apixaban initiators | #1 |
| usresultsthe frequency | #1 |
| warfarin marketscan | #1 |
| smr weighting | #1 |
| prescription episode | #1 |
| emr database spain | #1 |
| years publicly | #1 |
| newborn mood abnormalities | #1 |
| 35520 rivaroxaban | #1 |
| ehr data matching | #1 |
| medicaid analytic extract | #1 |
| linked ehr data | #1 |
| 2 claims databases | #1 |
| participants medicaid | #1 |
| 95 atypical aps | #1 |
| schizophrenic disorder italy | #1 |
| quetiapine 95 | #1 |
| clinformatics datamart | #1 |
| patient characteristics balance | #1 |
| 29448 dabigatran | #1 |
| databases warfarin | #1 |
| italy emr database | #1 |
| 140187 patients | #1 |
| initiators pooled | #1 |
| initiating atypical | #1 |
| development cohort subgroups | #2 |
| variation antipsychotic | #2 |
| 1 367 hospitals | #2 |
| sevelamer 1 year | #2 |
| 5080 medium | #2 |
| 228316 patients | #2 |
| matching paradox | #2 |
| sevelamer canada | #2 |
| risk cardiac defects | #2 |
| pregnancies tretinoin exposure | #2 |
| 38120 women | #2 |
| versus thromboembolism | #2 |
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Prominent publications by Krista F Huybrechts
Use of antidepressants near delivery and risk of postpartum hemorrhage: cohort study of low income women in the United States
[ PUBLICATION ]
OBJECTIVE: To determine whether use of serotonin or non-serotonin reuptake inhibitors near to delivery is associated with postpartum hemorrhage.
DESIGN: Cohort study.
SETTING: 2000-07 nationwide Medicaid data (Medicaid Analytic eXtract).
POPULATION: 106,000 pregnant women aged 12-55 with a diagnosis of mood or anxiety disorder. Women were categorized into four mutually exclusive exposure groups according to pharmacy dispensing data: current (delivery date), recent (1-30 days before ...
| Known for Postpartum Hemorrhage | Reuptake Inhibitors | United States | Delivery Risk | Exposure Serotonin |
Persistent opioid use following cesarean delivery: patterns and predictors among opioid-naïve women
[ PUBLICATION ]
BACKGROUND: The incidence of opioid-related death in women has increased 5-fold over the past decade. For many women, their initial opioid exposure will occur in the setting of routine medical care. Approximately 1 in 3 deliveries in the United States is by cesarean, and opioids are commonly prescribed for postsurgical pain management.
OBJECTIVE: The objective of this study was to determine the risk that opioid-naïve women prescribed opioids after cesarean delivery will subsequently ...
| Known for Cesarean Delivery | Persistent Opioid | 95 Confidence Interval | Adjusted Odds Ratio | Patterns Predictors |
Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: cohort study
[ PUBLICATION ]
Objectives To assess the impact of in utero co-exposure to psychotropic medications and opioids on the incidence and severity of neonatal drug withdrawal.Design Observational cohort study.Setting Nationwide sample of pregnancies in publicly insured women in the US, nested in the Medicaid Analytic eXtract (2000-10).Participants 201 275 pregnant women with public insurance who were exposed to opioids around the time of delivery and their liveborn infants.Interventions In utero exposure to ...
| Known for Psychotropic Medications | Utero Exposure Opioids | Drug Withdrawal | Benzodiazepines Gabapentin | Opioid Disorders |
Safety and effectiveness of dabigatran and warfarin in routine care of patients with atrial fibrillation
[ PUBLICATION ]
The RE-LY study demonstrated the safety and efficacy of dabigatran relative to warfarin for stroke prevention in non-valvular atrial fibrillation. It is important to further evaluate safety and effectiveness of drugs in routine care. This study used a sequential cohort design with propensity score matching to compare dabigatran with warfarin among patients in two commercial health insurance databases. New users of these anticoagulants were followed from initiation until discontinuation, ...
| Known for Dabigatran Warfarin | Atrial Fibrillation | Safety Effectiveness | Stroke Prevention | Study Outcome |
BACKGROUND: Whether the use of selective serotonin-reuptake inhibitors (SSRIs) and other antidepressants during pregnancy is associated with an increased risk of congenital cardiac defects is uncertain. In particular, there are concerns about a possible association between paroxetine use and right ventricular outflow tract obstruction and between sertraline use and ventricular septal defects.
METHODS: We performed a cohort study nested in the nationwide Medicaid Analytic eXtract for the ...
| Known for Cardiac Defects | Pregnancy Risk | Antidepressants Trimester | Women Depression | Congenital Humans Infant |
Importance: Given the rapidly increasing use of stimulant medications during pregnancy and among women of reproductive age who may become pregnant inadvertently, there is a need to better understand their safety.
Objective: To examine the risk of congenital malformations associated with intrauterine exposure to stimulants.
Design, Setting, and Participants: Cohort study of the Medicaid-insured population in the United States nested in the 2000-2013 US Medicaid Analytic eXtract, with ...
| Known for Congenital Malformations | United States | Pregnancy Risk | Reproductive Age | Newborn Methylphenidate |
BACKGROUND: Despite safety-related concerns, psychotropic medications are frequently prescribed to manage behavioural symptoms in older adults, particularly those with dementia. We assessed the comparative safety of different classes of psychotropic medications used in nursing home residents.
METHODS: We identified a cohort of patients who were aged 65 years or older and had initiated treatment with psychotropics after admission to a nursing home in British Columbia between 1996 and ...
| Known for Nursing Homes | Psychotropic Medications | Medical Events | Atypical Antipsychotics | Antidepressants Benzodiazepines |
IMPORTANCE: The frequency of antipsychotic (AP) use during pregnancy has approximately doubled during the last decade. However, little is known about their safety for the developing fetus, and concerns have been raised about a potential association with congenital malformations.
OBJECTIVE: To examine the risk for congenital malformations overall and cardiac malformations associated with first-trimester exposure to APs.
DESIGN, SETTING, AND PARTICIPANTS: This nationwide sample of ...
| Known for Congenital Malformations | Pregnancy Risk | 95 Risperidone | 1 Prescription | Adult Antipsychotic |
Association of Maternal First-Trimester Ondansetron Use With Cardiac Malformations and Oral Clefts in Offspring.
[ PUBLICATION ]
Importance: Evidence for the fetal safety of ondansetron, a 5-HT3 receptor antagonist that is commonly prescribed for nausea and vomiting during pregnancy, is limited and conflicting.
Objective: To evaluate the association between ondansetron exposure during pregnancy and risk of congenital malformations.
Design, Setting, and Participants: A retrospective cohort study nested in the 2000-2013 nationwide Medicaid Analytic eXtract. The cohort consisted of 1 816 414 pregnancies contributed ...
| Known for Oral Clefts | Trimester Ondansetron | Congenital Malformations | Pregnancy Risk | 10 000 |
OBJECTIVE: To report the prevalence of prescription opioid use and evaluate the trends in a large cohort of Medicaid-enrolled pregnant women.
METHODS: A cohort of pregnancies was identified using data from the Medicaid Analytical eXtract for the period of 2000-2007. Dispensing of opioids, as a class and separately for individual agents, was evaluated using claims from filled prescriptions. Variations in patterns of prescription opioid fills were examined by demographic characteristics, ...
| Known for Prescription Opioid | Women Cohort | Demographic Characteristics | Geographic Region | Pregnancy Medicaid |
Background: Apixaban and rivaroxaban are the most commonly prescribed direct oral anticoagulants for adults with atrial fibrillation, but head-to-head data comparing their safety and effectiveness are lacking.
Objective: To compare the safety and effectiveness of apixaban versus rivaroxaban for patients with nonvalvular atrial fibrillation.
Design: New-user, active-comparator, retrospective cohort study.
Setting: A U.S. nationwide commercial health care claims database from 28 December ...
| Known for Atrial Fibrillation | Apixaban Rivaroxaban | Effectiveness Safety | Ischemic Stroke | Systemic Embolism |
Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study
[ PUBLICATION ]
OBJECTIVE: To assess risks of mortality associated with use of individual antipsychotic drugs in elderly residents in nursing homes.
DESIGN: Population based cohort study with linked data from Medicaid, Medicare, the Minimum Data Set, the National Death Index, and a national assessment of nursing home quality.
SETTING: Nursing homes in the United States.
PARTICIPANTS: 75,445 new users of antipsychotic drugs (haloperidol, aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone). ...
| Known for Nursing Homes | Antipsychotic Drugs | Risk Mortality | Haloperidol Quetiapine | United States |
Antidepressant Use Late in Pregnancy and Risk of Persistent Pulmonary Hypertension of the Newborn
[ PUBLICATION ]
IMPORTANCE: The association between selective serotonin reuptake inhibitor (SSRI) antidepressant use during pregnancy and risk of persistent pulmonary hypertension of the newborn (PPHN) has been controversial since the US Food and Drug Administration issued a public health advisory in 2006.
OBJECTIVE: To examine the risk of PPHN associated with exposure to different antidepressant medication classes late in pregnancy.
DESIGN AND SETTING: Cohort study nested in the 2000-2010 Medicaid ...
| Known for Pregnancy Risk | Persistent Pulmonary | Newborn Pphn | Ssri Antidepressant | Infants Exposed |
Brief Report: Patterns and Secular Trends in Use of Immunomodulatory Agents During Pregnancy in Women With Rheumatic Conditions
[ PUBLICATION ]
OBJECTIVE: To describe patterns and secular trends in the use of immunomodulatory agents in pregnant women with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), psoriatic arthritis (PsA), or ankylosing spondylitis (AS).
METHODS: We identified a cohort of women with SLE, RA, PsA, or AS enrolled in public (Medicaid, 2001-2010) or private (Optum Clinformatics, 2004-2012) health insurance, and we included women filling prescriptions for immunomodulatory agents (including ...
| Known for Pregnancy Women | Psoriatic Arthritis | Secular Trends | Biologic Agents | Systemic Lupus Erythematosus |
Harnessing the Medicaid Analytic eXtract (MAX) to Evaluate Medications in Pregnancy: Design Considerations
[ PUBLICATION ]
BACKGROUND: In the absence of clinical trial data, large post-marketing observational studies are essential to evaluate the safety and effectiveness of medications during pregnancy. We identified a cohort of pregnancies ending in live birth within the 2000-2007 Medicaid Analytic eXtract (MAX). Herein, we provide a blueprint to guide investigators who wish to create similar cohorts from healthcare utilization data and we describe the limitations in detail.
METHODS: Among females ages ...
| Known for Medicaid Analytic Extract | Medications Pregnancy | Live Birth | Cohort Pregnancies | Private Insurance |
Key People For United States
Krista F Huybrechts:Expert Impact
Concepts for whichKrista F Huybrechtshas direct influence:United states, Congenital malformations, Pregnant women, Cardiac malformations, Oral clefts, Neurodevelopmental disorders, Prescription opioids, Vaginal delivery.
Krista F Huybrechts:KOL impact
Concepts related to the work of other authors for whichfor which Krista F Huybrechts has influence:Pregnant women, United states, Cesarean delivery, Atrial fibrillation, Severe maternal morbidity, Medication adherence, Postmenopausal osteoporosis.
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