• Disease
  • Acute
  • Acute Lung
  • Acute Lung Injury
  • Leonard D Hudson

    Prominent publications by Leonard D Hudson

    KOL Index score: 19848

    OBJECTIVE: Alcohol is one of the most commonly used drugs in the world and causes dysfunction in many vital organs. However, the effects of chronic alcohol abuse on acute lung injury and nonpulmonary organ dysfunction are relatively unexplored. The goal of this study was to determine the effects of chronic alcohol abuse on the incidence and severity of the acute respiratory distress syndrome and multiple organ dysfunction syndrome in patients with septic shock.

    DESIGN: Multicenter ...

    Also Ranks for: Chronic Alcohol Abuse |  septic shock |  respiratory distress |  increased incidence |  multiple organ
    KOL Index score: 16850

    OBJECTIVE: To determine whether bronchoalveolar lavage fluid (BALF) from patients either at risk for the acute respiratory distress syndrome (ARDS) or with sustained ARDS modulates neutrophil apoptosis; to measure the BALF concentrations of the apoptosis inhibitors granulocyte colony-stimulating factor (G-CSF) and granulocyte/macrophage colony-stimulating factor (GM-CSF) before and after the onset of ARDS; and to determine whether the BALF concentrations of G-CSF and/or GM-CSF are ...

    Also Ranks for: Neutrophil Apoptosis |  patients ards |  stimulating factor |  granulocyte colony |  respiratory distress
    KOL Index score: 14549

    The effects of bacterial endotoxin (lipopolysaccharide, LPS) are amplified by lipopolysaccharide binding protein (LBP) and CD14, resulting in cellular activation at very low concentrations of LPS. To investigate the importance of this pathway in acute lung injury, we measured LPS, LBP, and soluble CD14 (sCD14) in the bronchoalveolar lavage fluid (BAL) of 82 patients with acute respiratory distress syndrome (ARDS). LBP and sCD14 increased markedly in BAL of patients with ARDS. sCD14 and ...

    Also Ranks for: Soluble Cd14 |  patients ards |  respiratory distress |  lps lbp |  total protein
    KOL Index score: 14325

    OBJECTIVE: Studies describing predictors of mortality in patients with acute lung injury were primarily derived from selected academic centers. We sought to determine the predictors of mortality in a population-based cohort of patients with acute lung injury and to characterize the performance of current severity of illness scores in this population.

    DESIGN: Secondary analysis of a prospective, multicenter, population-based cohort.

    SETTING: Twenty-one hospitals in Washington ...

    Also Ranks for: Acute Lung Injury |  hospital mortality |  apache iii |  cohort patients |  secondary analysis
    KOL Index score: 13905

    The goal of this study was to determine the changes that occur in surfactant-associated proteins in bronchoalveolar lavage fluid (BAL) and serum of patients at risk for ARDS and during the course of ARDS. We found that the concentrations of SP-A and SP-B were low in the BAL of patients at risk for ARDS before the onset of clinically defined lung injury, whereas the concentration of SP-D was normal. In patients with established ARDS, BAL SP-A and SP-B concentrations were low during the ...

    Also Ranks for: Patients Ards |  spd serum |  pulmonary surfactant |  spa spb |  proteins lung
    KOL Index score: 13781

    OBJECTIVE: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are known to be associated with increased mortality and costs in trauma patients. We estimated the independent impact of these conditions on mortality and cost, beyond the severity of injury with which they are correlated.

    DESIGN: One-year prospective cohort.

    PATIENTS AND SETTING: All trauma patients admitted to the intensive care unit in a level I center were evaluated daily for ALI/ARDS using the ...

    Also Ranks for: Trauma Patients |  ali ards |  respiratory distress |  acute lung injury |  95 confidence interval
    KOL Index score: 13197

    Acute respiratory distress syndrome (ARDS) involves an intense inflammatory response in the lungs, with accumulation of both pro- and antiinflammatory cytokines in bronchoalveolar lavage fluid (BALF). Our goal was to determine how the balance between pro- and antiinflammatory mediators in the lungs changes before and after the onset of ARDS. We identified 23 patients at risk for ARDS and 46 with established ARDS and performed serial bronchoalveolar lavage (BAL). We used immunoassays to ...

    Also Ranks for: Tumor Necrosis Factor |  onset ards |  type receptors |  respiratory distress |  antiinflammatory cytokines
    KOL Index score: 13129

    Nitric oxide (NO) end-products (nitrate and nitrite) are present in bronchoalveolar lavage (BAL) fluid of patients with inflammatory lung diseases. Reactive oxygen-nitrogen intermediates damage macromolecules by oxidation or nitration of critical residues in proteins. The goal of this study was to measure NO end-products (nitrate+ nitrite), in BAL fluid before and after the onset of acute respiratory distress syndrome (ARDS) and to determine if these products are associated with ...

    Also Ranks for: Nitric Oxide |  ards patients |  distress syndrome |  bal fluid |  acute respiratory
    KOL Index score: 11790

    OBJECTIVE: Recent estimates of acute respiratory distress syndrome (ARDS) incidence have varied from 1.3 to 22 per 100,000 person years (105 person.years); the incidence of acute lung injury (ALI) has varied from 17.9 to 34 cases per 105 person.years. Potential reasons for this wide range include differences in the definition of the syndrome, in the populations sampled, and in the assumptions made to estimate incidence. We hypothesized that careful, prospective, protocol-driven case ...

    Also Ranks for: United States |  incidence ali |  acute lung injury |  syndrome ards |  prospective cohort study
    KOL Index score: 11673

    The acute respiratory distress syndrome (ARDS) frequently results in a fibroproliferative response that precludes effective alveolar repair. Transforming growth factor-alpha (TGF-alpha), a potent epithelial and mesenchymal cell mitogen, may modulate the response to lung injury. In this study, we determined whether bronchoalveolar lavage fluid (BALF) concentrations of TGF-alpha are increased during the first 2 wk after the onset of ARDS and, if so, whether increased TGF-alpha levels in ...

    Also Ranks for: Lavage Fluid |  patients ards |  growth factor |  respiratory distress |  tgf alpha
    KOL Index score: 11537

    OBJECTIVE: No studies have explored the barriers to implementing lung-protective ventilation in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Our objective was to identify barriers to using lung-protective ventilation in patients with ALI/ARDS.

    DESIGN: Survey with content analysis of open-ended responses.

    SETTING: Medical center.

    PARTICIPANTS: Experienced intensive care unit nurses and respiratory therapists network identified through purposive ...

    Also Ranks for: Protective Ventilation |  ali ards |  acute lung |  respiratory therapists |  physician recognition
    KOL Index score: 11230

    Despite a great deal of information about the risk factors, prognostic variables, and hospital mortality in the acute respiratory distress syndrome (ARDS), very little is known about the long-term outcomes of patients with this syndrome. We conducted a prospective, matched, parallel cohort study with the goals of describing the survival of patients with ARDS after hospital discharge and comparing the long-term survival of patients with ARDS and that of a group of matched controls. The ...

    Also Ranks for: Patients Ards |  respiratory distress |  hospital discharge |  sepsis trauma |  longterm survival
    KOL Index score: 11122

    OBJECTIVES: : To investigate if light sedation favorably affects subsequent patient mental health compared with deep sedation. Symptoms of posttraumatic stress disorder are common in patients after they have undergone prolonged mechanical ventilation and are associated with sedation depth.

    DESIGN: : Randomized, open-label, controlled trial.

    SETTING: : Single tertiary care center.

    PATIENTS: : Adult patients requiring mechanical ventilation.

    INTERVENTIONS: : Patients were randomized to ...

    Also Ranks for: Deep Sedation |  mental health |  anxiety depression |  intensive unit |  posttraumatic stress disorder
    KOL Index score: 11096

    To characterize the evolution of inflammation in the adult respiratory distress syndrome (ARDS) and test the hypothesis that sustained alveolar inflammation is associated with a poor outcome in patients with ARDS, we performed fiberoptic bronchoscopy and bronchoalveolar lavage (BAL) in 125 patients and compared BAL cells and protein concentrations in survivors and nonsurvivors. ARDS followed sepsis syndrome in 35 patients, major trauma in 41, and other causes in 49. When possible, BAL ...

    Also Ranks for: Patients Ards |  adult respiratory |  distress syndrome |  bronchoalveolar lavage bal |  major trauma


    Leonard D Hudson: Influence Statistics

    Sample of concepts for which Leonard D Hudson is among the top experts in the world.
    Concept World rank
    quantitative culture criteria #1
    early reports patients #1
    ards older patients #1
    asbestos‐related pleural disease #1
    smoke trachea #1
    ventilatory support parameters #1
    distress syndrome1–3 #1
    ali cases #1
    psb severity #1
    methylphenidate abusers #1
    peep incidence #1
    ali incidence #1
    acute episode arf #1
    proximal onehalf trachea #1
    hospitalization records year #1
    true incidence outcome #1
    smokes radiant furnace #1
    remaining 160 patients #1
    control surfactant instillation #1
    ards age #1
    ards 25 #1
    marax ephedrine #1
    pulmonary tissue reactions #1
    ards hospital discharge #1
    ards prospective study #1
    ards sepsis syndrome #1
    fiftynine study patients #1
    entry 44 patients #1
    etiologies morbidity #1
    defined ards #1
    ards improvement #1
    admitted bed #1
    discharged beds #1
    terbutaline bronchodilator combination #1
    spontaneous variability pao2 #1
    ards clinical risks #1
    clinical risks trauma #1
    treatment antituberculous drugs #1
    response smoke injury #1
    copd combination ethics #1
    unresponsive patient #1
    ards proportion #1
    8 organ systems #1
    188 402 #1

    Key People For Acute Lung Injury

    Top KOLs in the world
    Michael Anthony Matthay
    acute lung injury pulmonary edema respiratory distress
    Leonard D Hudson
    acute lung injury patients ards distress syndrome
    Gordon R MD Bernard
    severe sepsis drotrecogin alfa acute lung injury
    Arthur S MD Slutsky
    mechanical ventilation lung injury respiratory distress
    Lorraine B Ware
    acute lung injury lung transplantation primary graft dysfunction
    Boyd Taylor Thompson
    acute lung injury septic shock distress syndrome

    Leonard D Hudson:Expert Impact

    Concepts for whichLeonard D Hudsonhas direct influence:Acute lung injury,  Patients ards,  Distress syndrome,  Respiratory distress,  Death rounds,  Transbronchial biopsy,  Chronic alcohol abuse,  Sepsis syndrome.

    Leonard D Hudson:KOL impact

    Concepts related to the work of other authors for whichfor which Leonard D Hudson has influence:Lung injury,  Respiratory distress,  Mechanical ventilation,  Patients ards,  Septic shock,  Critical illness,  Severe sepsis.



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    From the Division of Pulmonary & Critical Care Medicine (CRC), University of Michigan, Ann Arbor, MI; Robert Wood Johnson Foundation Clinical Scholars Program (CRC), University of Michigan, Ann Arbor, MI; Pulmonary & Critical Care Medicine (S