Prominent publications by Richard B Lipton

KOL Index score: 23496

BACKGROUND: The strikingly higher prevalence of migraine in females compared with males is one of the hallmarks of migraine. A large global body of evidence exists on the sex differences in the prevalence of migraine with female to male ratios ranging from 2:1 to 3:1 and peaking in midlife. Some data are available on sex differences in associated symptoms, headache-related disability and impairment, and healthcare resource utilization in migraine. Few data are available on corresponding ...

Also Ranks for: Severe Headache |  migraine prevalence |  females males |  sex difference |  healthcare resource utilization
KOL Index score: 21193

OBJECTIVE: This study assessed the efficacy of sumatriptan 50- and 100-mg tablets in the treatment of migraine attacks while the pain is mild rather than moderate/severe.

BACKGROUND: Results from The Spectrum Study suggested that early treatment of migraine attacks with sumatriptan 50-mg tablets while the pain is mild might enhance pain-free response and reduce headache recurrence.

METHODS: Retrospective analyses of headaches treated during mild pain were performed using data from 3 ...

Also Ranks for: Migraine Pain |  early intervention |  sumatriptan 50 |  2 hours |  free response
KOL Index score: 20975

OBJECTIVE: To evaluate and compare healthcare resource use and related costs in chronic migraine and episodic migraine in the USA and Canada.

BACKGROUND: Migraine is a common neurological disorder that produces substantial disability for sufferers around the world. Several studies have quantified overall costs associated with migraine in general, with recent estimates ranging from $581 to $7089 per year. Although prior studies have characterized the clinical and humanistic burden of ...

Also Ranks for: Episodic Migraine |  international burden |  usa canada |  costs chronic |  healthcare resource
KOL Index score: 19556

OBJECTIVE: To assess the effectiveness of the nonprescription combination of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain.

DESIGN: Three double-blind, randomized, parallel-group, single-dose, placebo-controlled studies.

SETTING: Private practice, referral centers, and general community.

PATIENTS: Migraineurs with moderate or severe headache pain who met International Headache Society diagnostic criteria for migraine with aura or without aura. The most ...

Also Ranks for: Migraine Headache |  aspirin caffeine |  patients pain |  nonprescription combination |  nausea photophobia
KOL Index score: 19196

OBJECTIVE: To assess the efficacy, safety, and tolerability of onabotulinumtoxinA (BOTOX) as headache prophylaxis in adults with chronic migraine.

BACKGROUND: Chronic migraine is a prevalent, disabling, and undertreated neurological disorder. Few preventive treatments have been investigated and none is specifically indicated for chronic migraine.

METHODS: The 2 multicenter, pivotal trials in the PREEMPT: Phase 3 REsearch Evaluating Migraine Prophylaxis Therapy clinical program each ...

Also Ranks for: Chronic Migraine |  headache frequency |  onabotulinumtoxina placebo |  baseline week |  preempt clinical
KOL Index score: 17456

OBJECTIVE: The objective of this study was to evaluate the efficacy, safety, and tolerability of DFN-02 - a nasal spray comprising sumatriptan 10 mg and a permeation-enhancing excipient (0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside [DDM]) - for the acute treatment of migraine with or without aura in adults.

BACKGROUND: Prior work has shown that DFN-02, which contains only half the recommended adult dose of sumatriptan found in the original formulation (10 mg vs 20 mg), is more rapidly absorbed ...

Also Ranks for: Acute Treatment |  nasal spray |  dfn02 placebo |  permeation enhancer |  sumatriptan 10
KOL Index score: 16972

BACKGROUND: Benefits of calcitonin-gene related peptide (CGRP) inhibition have not been established in chronic migraine. Here we assess the safety, tolerability, and efficacy of two doses of TEV-48125, a monoclonal anti-CGRP antibody, in the preventive treatment of chronic migraine.

METHODS: In this multicentre, randomised, double-blind, double-dummy, placebo-controlled, parallel-group phase 2b study, we enrolled men and women (aged 18-65 years) from 62 sites in the USA who had chronic ...

Also Ranks for: Preventive Treatment |  chronic migraine |  patients placebo |  safety tolerability |  675 225
KOL Index score: 16966

BACKGROUND: Calcitonin gene-related peptide (CGRP) is crucial in the pathophysiology of migraine. We assessed the safety, tolerability, and efficacy of ALD403, a genetically engineered humanised anti-CGRP antibody, for migraine prevention.

METHODS: In this randomised, double-blind, placebo-controlled, exploratory, proof-of-concept phase 2 trial, patients aged 18-55 years with five to 14 migraine days per 28-day period were randomly assigned (1:1) via an interactive web response system to ...

Also Ranks for: Migraine Patients |  2 trial |  calcitonin gene |  placebo patient |  adverse event
KOL Index score: 16907

BACKGROUND: US Headache Consortium Guidelines state that persons with migraine with headache-related disability should receive certain acute treatments including migraine-specific and other medications. However, many eligible individuals do not receive these therapies. Individuals with migraine may experience barriers to receiving minimal appropriate care. We aimed to identify barriers to care in a population sample of individuals with episodic migraine. We assessed barriers at 3 levels: ...

Also Ranks for: Individuals Migraine |  headache features |  acute treatments |  midas score |  diagnosis 3
KOL Index score: 16868

BACKGROUND: Calcitonin gene-related peptide (CGRP) is a validated target for the treatment of episodic migraine. Here we assess the safety, tolerability, and efficacy of TEV-48125, a monoclonal anti-CGRP antibody, in the preventive treatment of high-frequency episodic migraine.

METHODS: In this multicentre, randomised, double-blind, placebo-controlled, phase 2b study, we enrolled men and women (aged 18-65 years) from 62 sites in the USA who had migraine headaches 8-14 days per month. ...

Also Ranks for: Preventive Treatment |  episodic migraine |  safety tolerability |  phase 2b study |  patients placebo
KOL Index score: 16693

OBJECTIVE: To evaluate the efficacy and safety of topiramate (100 mg/day) compared with placebo for the treatment of chronic migraine.

METHODS: This was a randomized, placebo-controlled, parallel-group, multicenter study consisting of 16 weeks of double-blind treatment. Subjects aged 18 to 65 years with 15 or more headache days per month, at least half of which were migraine/migrainous headaches, were randomized 1:1 to either topiramate 100 mg/day or placebo. An initial dose of ...

Also Ranks for: Chronic Migraine |  placebo treatment |  safety topiramate |  100 day |  baseline monthly
KOL Index score: 16581

OBJECTIVE: To determine the extent to which variation in the Migraine Disability Assessment (MIDAS) score is associated with headache frequency, pain intensity, headache symptoms, gender, and employment status.

BACKGROUND: The MIDAS questionnaire is a 7-item questionnaire (with 5 scored items) designed to measure headache-related disability, to improve physician-patient communication, and to identify patients with high treatment needs.

METHODS: Data from 3 population-based studies (total ...

Also Ranks for: Headache Frequency |  pain intensity |  migraine disability |  midas score |  united kingdom
KOL Index score: 16393

OBJECTIVE: To compare the effects of oral rizatriptan, sumatriptan, naratriptan, and zolmitriptan on the relief and emergence of nausea during a migraine attack.

METHODS: Data from five randomized, placebo-controlled, double-blind clinical trials in which oral rizatriptan 10 mg was directly compared with oral sumatriptan 100 mg (N = 772), 50 mg (N = 1168), 25 mg (N = 1180), naratriptan 2.5 mg (N = 406), or zolmitriptan 2.5 mg (N = 571) for the acute treatment of a migraine attack were ...

Also Ranks for: 2 Hours |  patients nausea |  oral rizatriptan |  migraine attack |  sumatriptan 50
KOL Index score: 16229

OBJECTIVE: To evaluate the association between migraine and cardiovascular disease, including stroke, myocardial infarction, and death due to cardiovascular disease.

DESIGN: Systematic review and meta-analysis.

DATA SOURCES: Electronic databases (PubMed, Embase, Cochrane Library) and reference lists of included studies and reviews published until January 2009. Selection criteria Case-control and cohort studies investigating the association between any migraine or specific migraine ...

Also Ranks for: Cardiovascular Disease |  association migraine |  myocardial infarction |  women risk |  ischaemic stroke

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Richard B Lipton:Expert Impact

Concepts for whichRichard B Liptonhas direct influence:Chronic migraine,  Episodic migraine,  United states,  Acute treatment,  Incident dementia,  Migraine prevalence,  Pain intensity,  Cognitive decline.

Richard B Lipton:KOL impact

Concepts related to the work of other authors for whichfor which Richard B Lipton has influence:Chronic migraine,  Cognitive impairment,  Alzheimer disease,  Physical activity,  Headache disorders,  Acute treatment,  Gait speed.



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Department of Neurology, Epidemiology and Population Health, and the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York, USA | Department of Neurology, Albert Einstein College of Medicine, Bronx, Ne