Prominent publications by Rodrigo Hasbun

KOL Index score: 16997

CONTEXT: Complicated, left-sided native valve endocarditis causes significant morbidity and mortality in adults. The presumed benefits of valve surgery remain unproven due to lack of randomized controlled trials.

OBJECTIVE: To determine whether valve surgery is associated with reduced mortality in adults with complicated, left-sided native valve endocarditis.

DESIGN AND SETTING: Retrospective, observational cohort study conducted from January 1990 to January 2000 at 7 Connecticut ...

Known for Valve Surgery |  Propensity Analysis |  Reduced Mortality |  Sided Native |  Heart Failure
KOL Index score: 10720

BACKGROUND: Large epidemiologic studies evaluating the etiologies, management decisions and outcomes of infants and children with meningitis and encephalitis in the United States are lacking.

METHODS: Children 0-17 years of age with meningitis or encephalitis as assessed by International Classification of Diseases, Ninth Revision, codes available in the Premier Healthcare Database during 2011-2014 were analyzed.

RESULTS: Six thousand six hundred sixty-five patients with meningitis or ...

Known for United States |  Meningitis Encephalitis |  Antibiotic Therapy |  Adjunctive Steroids |  Hospitalization Humans
KOL Index score: 10478

BACKGROUND: In adults with suspected meningitis clinicians routinely order computed tomography (CT) of the head before performing a lumbar puncture.

METHODS: We prospectively studied 301 adults with suspected meningitis to determine whether clinical characteristics that were present before CT of the head was performed could be used to identify patients who were unlikely to have abnormalities on CT. The Modified National Institutes of Health Stroke Scale was used to identify neurologic ...

Known for Suspected Meningitis |  Computed Tomography |  Lumbar Puncture |  Clinical Characteristics |  60 Years
KOL Index score: 10126

PurposeAlthough the antistaphylococcal penicillins remain the drugs of choice for methicillin-susceptible Staphylococcus aureus (MSSA) infections, cefazolin and ceftriaxone are often prescribed due to their less frequent dosing and reduced cost. The purpose of this study was to compare clinical outcomes and adverse events in patients receiving outpatient parenteral antimicrobial therapy (OPAT) with ceftriaxone or cefazolin for the treatment of MSSA infections.Methods A retrospective ...

Known for Cefazolin Ceftriaxone |  Mssa Infections |  Staphylococcus Aureus |  Outpatient Parenteral |  Antimicrobial Therapy
KOL Index score: 9645

CONTEXT: Complicated left-sided native valve endocarditis causes significant morbidity and mortality in adults. Lack of valid data regarding estimation of prognosis makes management of this condition difficult.

OBJECTIVE: To derive and externally validate a prognostic classification system for adults with complicated left-sided native valve endocarditis.

DESIGN, SETTING, AND PATIENTS: Retrospective observational cohort study conducted from January 1990 to January 2000 at 7 Connecticut ...

Known for Valve Endocarditis |  Sided Native |  Mortality Adults |  Staphylococcus Aureus |  6 Months
KOL Index score: 9600

To determine the diagnostic accuracy of Kernig's sign, Brudzinski's sign, and nuchal rigidity for meningitis, 297 adults with suspected meningitis were prospectively evaluated for the presence of these meningeal signs before lumbar puncture was done. Kernig's sign (sensitivity, 5%; likelihood ratio for a positive test result [LR(+)], 0.97), Brudzinski's sign (sensitivity, 5%; LR(+), 0.97), and nuchal rigidity (sensitivity, 30%; LR(+), 0.94) did not accurately discriminate between ...

Known for Suspected Meningitis |  Nuchal Rigidity |  Csf Patients |  Kernigs Sign |  Lumbar Puncture
KOL Index score: 9450

BACKGROUND: Aseptic meningitis represents a common diagnostic and management dilemma to clinicians.

OBJECTIVES: To compare the clinical epidemiology, diagnostic evaluations, management, and outcomes between adults and children with aseptic meningitis.

STUDY DESIGN: We conducted a retrospective study from January 2005 through September 2010 at 9 Memorial Hermann Hospitals in Houston, TX. Patients age≥2months who presented with community-acquired aseptic meningitis with a CSF white blood ...

Known for Aseptic Meningitis |  Adults Children |  Meningeal Symptoms |  Newborn Male |  Hospitalization Humans
KOL Index score: 9294

Background: Large epidemiological studies evaluating the etiologies, management decisions, and outcomes of adults with meningitis or encephalitis in the United States (US) are lacking.

Methods: Adult patients (≥18 years) with meningitis or encephalitis by International Classification of Diseases, Ninth Revision codes available in the Premier Healthcare Database during 2011-2014 were analyzed.

Results: A total of 26429 patients with meningitis or encephalitis were identified. The median ...

Known for United States |  Meningitis Encephalitis |  International Classification |  Management Decisions |  Premier Healthcare Database
KOL Index score: 8924

BACKGROUND: Daptomycin has become a front-line antibiotic for multidrug-resistant Enterococcus faecium bloodstream infections (BSIs). We previously showed that E. faecium strains with daptomycin minimum inhibitory concentrations (MICs) in the higher end of susceptibility frequently harbor mutations associated with daptomycin resistance. We postulate that patients with E. faecium BSIs exhibiting daptomycin MICs of 3-4 µg/mL treated with daptomycin are more likely to have worse clinical ...

Known for Enterococcus Faecium |  Daptomycin Mics |  Minimum Inhibitory Concentration |  Microbiologic Failure |  Initial Isolates
KOL Index score: 8418

Chronic immune activation is a major complication of antiretroviral therapy (ART) for HIV infection and can cause a devastating immune reconstitution inflammatory syndrome (IRIS) in the brain. The mechanism of T-cell activation in this population is not well understood. We found HIV-Tat protein and IL-17-expressing mononuclear cells in the brain of an individual with IRIS. Tat was also present in the CSF of individuals virologically controlled on ART. Hence we examined if Tat protein ...

Known for Tat Protein |  Cell Activation |  Gene Products |  Hiv Infection |  Antiretroviral Therapy
KOL Index score: 8266

ObjectivesTo describe the clinical manifestations, cerebrospinal fluid (CSF) characteristics, imaging studies and prognostic factors of adverse clinical outcomes (ACO) among adults with herpes simplex virus (HSV) or varicella zoster virus (VZV) CNS infections.MethodsRetrospective review of adult patients with positive HSV or VZV polymerase chain reaction on CSF from an observational study of meningitis or encephalitis in Houston, TX (2004–2014), and New Orleans, LA ...

Known for Herpes Simplex |  Cns Infections |  Vzv Meningitis |  Varicella Zoster |  Hsv Encephalitis
KOL Index score: 8244

BACKGROUND: Bacterial meningitis continues to be a substantial cause of morbidity and mortality, but the epidemiological trends after adjunctive dexamethasone recommendations are unknown in the USA. We aimed to describe the changing patterns among the most common bacterial causes in the USA after conjugate vaccination and to assess the association between adjunctive dexamethasone and mortality.

METHODS: For this population-based observational study, we searched information available from ...

Known for Bacterial Meningitis |  Child Child |  Adjunctive Dexamethasone |  100 000 |  Conjugate Vaccination
KOL Index score: 7906

The Houston West Nile Cohort (HWNC) was founded in 2002 when West Nile virus (WNV) reached Houston, TX. The long-term outcomes following WNV infection are still mostly unknown, though neurological abnormalities up to 1 year postinfection have been documented. We report an observational study of neurological abnormalities at 1-3 and 8-11 years following WNV infection in the HWNC. We conducted standard neurological examinations at two separate time points to assess changes in neurological ...

Known for West Nile |  Infected Patients |  Wnv Infection |  Term Neurological |  Encephalitis Viral
KOL Index score: 7236

BACKGROUND: The treatment of vancomycin-resistant enterococcal (VRE) bacteraemia remains challenging. Daptomycin is a new antibiotic with bactericidal activity against VRE, but available clinical data are limited.

METHODS: A retrospective study was performed on 98 adult patients with VRE bacteraemia admitted to two hospitals between September 2003 and December 2007 to compare the efficacy of daptomycin with that of linezolid. Multivariable analyses were performed to compare the ...

Known for Daptomycin Linezolid |  Vre Bacteraemia |  Resistant Enterococcal |  Bactericidal Activity |  Clinical Data
KOL Index score: 7100

The Infectious Diseases Society of America (IDSA) Standards and Practice Guidelines Committee collaborated with partner organizations to convene a panel of 10 experts on healthcare-associated ventriculitis and meningitis. The panel represented pediatric and adult specialists in the field of infectious diseases and represented other organizations whose members care for patients with healthcare-associated ventriculitis and meningitis (American Academy of Neurology, American Association of ...

Known for Infectious Diseases |  Clinical Practice Guidelines |  Patients Meningitis |  Head Trauma |  Healthcare Ventriculitis


Rodrigo Hasbun: Influence Statistics

Sample of concepts for which Rodrigo Hasbun is among the top experts in the world.
Concept World rank
cerebrospinal abnormalities #1
meningitis usa #1
549 adults #1
patients hcamv #1
fungal 82 #1
evidence hcamv #1
cmv meningoencephalitis patients #1
meningoencephalitis aseptic meningitis #1
treatment mssa infections #1
3 baseline variables #1
bacterial usa #1
66 patients hcavm #1
low bactericidal concentration #1
communityacquired meningitis january #1
meningococcal meningitis usa #1
lp 549 patients #1
cmv aseptic meningitis #1
healthcare meningitis #1
vzv aco #1
incidence meningeal pathogens #1
comparison meningitis #1
mortality decrease introduction #1
availability pneumoniae #1
successful outcomes cns #1
hcavm gcs #1
outcome hcamv #1
mizrahi colleagues #1
meningitis retrospective #1
antinmda receptor antibody #1
adults meningitis #1
unknown etiologies majority #1
subacute community #1
enterovirus enterovirus pcr #1
csf gold standard #1
ninth icd9 codes #1
magnetic resonance antinmda #1
lymphocytepredominant csf #1
implantation successful outcomes #1
viral middle #1
universal testing cdc #1

Key People For Bacterial Meningitis

Top KOLs in the world
Diederik van de Beek
bacterial meningitis brain abscess acute stroke
William Michael SCHELD
bacterial meningitis brain abscess severe sepsis
Allan R Tunkel
bacterial meningitis food insecurity central nervous
George H McCracken
bacterial meningitis newborn infant haemophilus influenzae
Jan de Gans
bacterial meningitis aids dementia complex cerebrospinal fluid
Sheldon L Kaplan
staphylococcus aureus united states bacterial meningitis

Rodrigo Hasbun:Expert Impact

Concepts for whichRodrigo Hasbunhas direct influence:Bacterial meningitis,  West nile,  Adverse clinical outcome,  West nile virus,  Pediatric patients,  Suspected meningitis,  Patients meningitis,  Diagnostic tests.

Rodrigo Hasbun:KOL impact

Concepts related to the work of other authors for whichfor which Rodrigo Hasbun has influence:Bacterial meningitis,  Infective endocarditis,  Central nervous,  Cerebrospinal fluid,  Lumbar puncture,  Early surgery,  Streptococcus pneumoniae.



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Section of Infectious Diseases, UT Health Mc Govern Medical School, Houston, Texas, USA | Department of Medicine, University of Texas Health Science Center at Houston. | Department of Medicine, University of Texas Health Science Center, Houston, TX,

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