Prominent publications by Samir R Kapadia

KOL Index score: 24254

Importance: Transcatheter aortic valve replacement (TAVR) indications are expanding, leading to an increasing number of patients with bicuspid aortic stenosis undergoing TAVR. Pivotal randomized trials conducted to obtain US Food and Drug Administration approval excluded bicuspid anatomy.

Objective: To compare the outcomes of TAVR with a balloon-expandable valve for bicuspid vs tricuspid aortic stenosis.

Design, Setting, and Participants: Registry-based prospective cohort study of ...

Also Ranks for: Aortic Stenosis |  valve replacement |  patients bicuspid |  1 year |  mortality stroke
KOL Index score: 20497

Importance: In patients with severe aortic stenosis (AS) at intermediate surgical risk, treatment with transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) results in similar 2-year survival. The effect of TAVR vs SAVR on health status in patients at intermediate surgical risk is unknown.

Objective: To compare health-related quality of life among intermediate-risk patients with severe AS treated with either TAVR or SAVR.

Design, Setting, and ...

Also Ranks for: Intermediate Surgical Risk |  tavr patients |  severe aortic stenosis |  aortic valve |  2 years
KOL Index score: 19023

BACKGROUND: Prosthetic valve endocarditis (PVE) is a rare but critical mechanism of valve failure and death after transcatheter and surgical aortic valve replacement (TAVR, SAVR) warranting further analysis in modern aortic valve replacement experience. We characterize the incidence, risk factors, microbiological profile and outcomes of PVE from the PARTNER trials and registries (Placement of Aortic Transcatheter Valve).

METHODS: We analyzed a pooled cohort of all patients in PARTNER 1 ...

Also Ranks for: Pve Tavr |  prosthetic valve endocarditis |  aortic valve |  1 year |  incidence risk factors
KOL Index score: 17204

BACKGROUND: Transcatheter aortic valve replacement (TAVR) with the SAPIEN 3 valve demonstrates good 30 day clinical outcomes in patients with severe aortic stenosis who are at intermediate risk of surgical mortality. Here we report longer-term data in intermediate-risk patients given SAPIEN 3 TAVR and compare outcomes to those of intermediate-risk patients given surgical aortic valve replacement.

METHODS: In the SAPIEN 3 observational study, 1077 intermediate-risk patients at 51 sites in ...

Also Ranks for: Aortic Valve |  intermediaterisk patients |  propensity score analysis |  tavr sapien |  1 year
KOL Index score: 16723

IMPORTANCE: Limited data exist on clinical characteristics and outcomes of patients who had infective endocarditis after undergoing transcatheter aortic valve replacement (TAVR).

OBJECTIVE: To determine the associated factors, clinical characteristics, and outcomes of patients who had infective endocarditis after TAVR.

DESIGN, SETTING, AND PARTICIPANTS: The Infectious Endocarditis after TAVR International Registry included patients with definite infective endocarditis after TAVR from 47 ...

Also Ranks for: Infective Endocarditis |  patients tavr |  valve replacement |  transcatheter aortic |  heart failure
KOL Index score: 16627

BACKGROUND: The Placement of Aortic Transcatheter Valves (PARTNER) trial showed that mortality at 1 year, 2 years, and 3 years is much the same with transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) for high-risk patients with aortic stenosis. We report here the 5-year outcomes.

METHODS: We did this randomised controlled trial at 25 hospitals, in Canada (two), Germany (one), and the USA (23). We used a computer-generated randomisation sequence to ...

Also Ranks for: Aortic Valve |  surgical risk |  year outcomes |  savr tavr |  randomised controlled
KOL Index score: 16626

CONTEXT: Statins reduce low-density lipoprotein cholesterol (LDL-C) levels and slow progression of coronary atherosclerosis. However, no data exist describing the relationship between statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and disease progression.

OBJECTIVE: To investigate the relationship between changes in LDL-C and HDL-C levels and atheroma burden.

DESIGN, SETTING, AND PATIENTS: Post-hoc analysis combining raw data from 4 prospective randomized trials ...

Also Ranks for: Lipoprotein Cholesterol |  ldlc hdlc |  hdl levels |  clinical events |  ldl coronary
KOL Index score: 16542

OBJECTIVES: The aim of this study was to examine the independent association of short-term complications of transcatheter aortic valve replacement (TAVR) with survival and quality of life at 1 year.

BACKGROUND: Prior studies have examined the mortality and cost implications of various complications of TAVR. However, many of these complications may primarily affect patients' quality of life after TAVR, which has not been previously studied.

METHODS: Among patients at intermediate or high ...

Also Ranks for: Aortic Valve |  complications tavr |  1 year |  quality life |  factors transcatheter
KOL Index score: 16329

BACKGROUND: Patients with severe aortic stenosis due to BAV are excluded from transcatheter aortic valve replacement (TAVR) due to concern for asymmetric expansion and valve dysfunction. We sought to characterize the aortic root and annulus in bicuspid aortic valve (BAV) and tricuspid aortic valves (TAV).

METHODS AND RESULTS: We identified patients with severe AS who underwent multi-detector computed tomographic (MDCT) imaging prior to surgical aortic valve replacement (SAVR, n = 200) ...

Also Ranks for: Aortic Annulus |  bav tav |  heart valve |  stenosis bicuspid |  basal ring
KOL Index score: 16191

BACKGROUND: Among patients with aortic stenosis who are at intermediate or high risk for death with surgery, major outcomes are similar with transcatheter aortic-valve replacement (TAVR) and surgical aortic-valve replacement. There is insufficient evidence regarding the comparison of the two procedures in patients who are at low risk.

METHODS: We randomly assigned patients with severe aortic stenosis and low surgical risk to undergo either TAVR with transfemoral placement of a ...

Also Ranks for: Tavr Surgery |  death stroke |  patients low risk |  valve replacement |  transcatheter aortic
KOL Index score: 16114

OBJECTIVES: The study aimed to evaluate the impact of chronic lung disease (CLD) on outcomes of severe aortic stenosis patients across all treatment modalities.

BACKGROUND: Outcomes of patients with CLD undergoing transcatheter aortic valve replacement (TAVR) have not been systematically examined.

METHODS: All patients who underwent TAVR in the PARTNER (Placement of AoRTic TraNscathetER Valve) trial, including the continued access registry (n = 2,553; 1,108 with CLD), were evaluated ...

Also Ranks for: Tavr Patients |  aortic valve |  chronic lung disease |  standard therapy |  hazard ratio
KOL Index score: 15830

OBJECTIVES: The purpose of this study was to determine the safety and effectiveness of the SAPIEN XT versus SAPIEN systems (Edwards Lifesciences, Irvine, California) in patients with symptomatic, severe aortic stenosis (AS) who were not candidates for surgery.

BACKGROUND: Transcatheter aortic valve replacement (TAVR) has become the standard of care for inoperable patients with severe, symptomatic AS. In the PARTNER (Placement of Aortic Transcatheter Valves) IB trial, a reduction in ...

Also Ranks for: Aortic Stenosis |  heart valve |  patients sapien |  vascular complications |  allcause mortality
KOL Index score: 15617

OBJECTIVES: This study sought to compare clinical outcomes in a contemporary acute coronary syndrome (ACS) percutaneous coronary intervention (PCI) cohort stratified by chronic kidney disease (CKD) status.

BACKGROUND: Patients with CKD exhibit high risks for both thrombotic and bleeding events, thus complicating decision making regarding antiplatelet therapy in the setting of ACS.

METHODS: The PROMETHEUS study was a multicenter observational study comparing outcomes with prasugrel versus ...

Also Ranks for: Chronic Kidney Disease |  patients ckd |  acute coronary |  1 year |  myocardial infarction
KOL Index score: 15605

BACKGROUND: Based on the early results of the Placement of Aortic Transcatheter Valves (PARTNER) trial, transcatheter aortic valve replacement (TAVR) is an accepted treatment for patients with severe aortic stenosis who are not suitable for surgery. However, little information is available about the late clinical outcomes in such patients.

METHODS: We did this randomised controlled trial at 21 experienced valve centres in Canada, Germany, and the USA. We enrolled patients with severe ...

Also Ranks for: Aortic Valve |  5 years |  tavr patients |  randomised controlled trial |  risk mortality
KOL Index score: 15186

Importance: The frequency of baseline renal impairment among high-risk and inoperable patients with severe aortic stenosis undergoing a transcatheter aortic valve replacement (TAVR) and the effect of TAVR on subsequent renal function are, to our knowledge, unknown.

Objective: To determine the effect of TAVR among patients with baseline renal impairment.

Design, Setting, and Participants: This substudy of patients with baseline renal impairment (estimated glomerular filtration rate ...

Also Ranks for: Renal Function |  aortic valve |  tavr patients |  egfr baseline |  1 year

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Samir R Kapadia:Expert Impact

Concepts for whichSamir R Kapadiahas direct influence:Aortic valve,  Valve replacement,  Aortic stenosis,  Transcatheter aortic,  United states,  Mitral valve,  Myocardial infarction,  Atrial fibrillation.

Samir R Kapadia:KOL impact

Concepts related to the work of other authors for whichfor which Samir R Kapadia has influence:Aortic valve,  Heart failure,  Coronary artery,  Myocardial infarction,  Mitral regurgitation,  Atrial fibrillation,  Patients tavr.



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Department of Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, OH, USA. | Cleveland Clinic, Cleveland, Ohio, USA. | Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cl