David J Quenelle

Among the histologic parameters described by Jakobsson, only the stage (depth) of invasion appears to be of value in predicting lymph node metastases. Early carcinomas of the FOM examined in our institution (T1 and some T2) grew in a superficial or horizontal manner and none developed metastases or local recurrence. Larger neoplasms (some T2 and all T3 and T4) had extensive submucosal and deep soft tissue infiltration and a corresponding high frequency of regional lymph node metastases. ...

The hemilaryngectomy procedure includes the entire hemithyroid cartilage with the extent of the cartilage cut beyond the midline determined by endoscopy and cord cut determined after anterolateral pharyngotomy to minimize or maximize the procedure according to tumor size. Hypopharyngeal or piriform sinus mucosa was used to reconstruct the resected hemilarynx. There were 56 male subjects and one female subject. The mean age was 59 years. All had squamous cell carcinoma. There were 25 T1 ...

Epidermoid carcinoma of the tonsil region is one of the most common malignancies of the upper aerodigestive tract, equal in frequency to laryngeal carcinoma at the University of Cincinnati Medical Center. This paper reviews the author's experience in treating these lesions with a combination of 5000 rads preoperatively followed by composite resection. The overall two-year crude survival is 58%. A 60% two-year survival for T3 lesions compares favorably with other series for treatment of T3 lesions.

In order to test the hypothesis that there is air streaming through the upper airways to the ipsilateral lung, and that reflex hypoventilation of the ipsilateral lung may occur in unilateral nasal obstruction, 11 volunteers and three patients were examined for these phenomena, employing Xenon-133 (133Xe) and a special mask permitting inhalation of the gas through one nostril at a time. Patients with deviated nasal septa were also examined, one of these before and after surgery. There was ...

Excellent speech can be produced by diverting expired pulmonary air to the pharynx through a tracheopharyngeal fistula. This study contributes basic information regarding the selection and fate of autogenous skin-lined tubes created for this purpose in a standardized fashion in pigs. Our specific objectives were to determine (1) the best cutaneous autograft for constructing a 6- to 7-cm skin-lined tube, (2) the airflow resistance of surviving skin-lined tubes, and (3) the effect of ...