Prominent publications by Alberto G Ayala

KOL Index score: 18738

PURPOSE: We assessed whether complexed prostate specific antigen (PSA) and complexed PSA referenced variables would enhance prostate cancer detection in men with serum total PSA between 2.5 and 4.0 ng./ml.

MATERIALS AND METHODS: Transition zone and total prostate gland volumes were determined in 151 men who underwent prostate biopsy using an 11 core biopsy strategy. In addition to measuring the Bayer section sign complexed PSA assay, we also calculated 2 computed complexed PSA values ...

Also Ranks for: Complexed Prostate |  total psa |  specific antigen |  cancer detection |  ng ml
KOL Index score: 14892

OBJECTIVES: To evaluate whether the presence of, or the number of cores containing, high-grade prostatic intraepithelial neoplasia (PIN) found in men who underwent initial extended multisite biopsy could predict which men would have prostate cancer on subsequent repeat biopsies.

METHODS: Between June 1997 and January 2003, 1086 men underwent initial prostate biopsy for early detection of prostate cancer using an extended multisite biopsy scheme. Of these, 175 men without cancer underwent ...

Also Ranks for: Repeat Biopsy |  intraepithelial neoplasia |  highgrade pin |  prostate cancer |  predictive tests
KOL Index score: 14504

BACKGROUND: The incidence of testicular carcinoma in the United States has increased significantly over the last two decades. Germ cell tumors form the majority of malignant testicular tumors. With advances in diagnosis and therapeutic approaches, germ cell tumors are now highly sensitive to treatment, providing long-term survival. It has been speculated that the incidence of bilateral germ cell tumors may increase due to the improved survival of patients with unilateral germ cell ...

Also Ranks for: Cell Tumors |  testicular germ |  patients seminoma |  multiple primary neoplasms |  incidence bilateral
KOL Index score: 13836

Clear cell papillary renal cell carcinoma (CCP-RCC) has recently been recognized as a distinct subtype of renal cell carcinoma (RCC) due to its unique morphologic, immunohistochemical, and genetic features and indolent clinical behavior. However, the incidence of this tumor in a nephrectomy series for renal mass has not been fully investigated. Twelve cases of CCP-RCC were identified from a total of 290 consecutive partial (n = 137) or radical nephrectomies (n = 153) for RCC from 2010 to ...

Also Ranks for: Clear Cell |  papillary renal |  tumor carcinoma |  cases ccprcc |  distinct subtype
KOL Index score: 13197

BACKGROUND: Contemporary therapy for osteosarcoma is comprised of initial treatment with chemotherapy and surgical extirpation of the primary tumor in the affected bone. In view of the major advances forged by chemotherapy in the treatment of the primary tumor, an attempt was made to destroy the tumor exclusively with this therapeutic modality and abrogate surgery.

METHODS: Thirty-one consecutive patients were treated. All had localized disease (absence of metastases) at the time of ...

Also Ranks for: Patients Osteosarcoma |  pulmonary metastases |  primary tumor |  chemotherapy treatment |  free disease
KOL Index score: 12988

Eighteen cases of transitional cell carcinoma (TCC) of the urinary bladder containing a micropapillary component (MPC) (> 90%, three cases; 50-90%, nine cases; < 50%, six cases) are presented. The patients' mean age was 66.6 years (range, 47-81 years) with a male predominance (male-to-female ratio of 5:1). The MPC was part of the surface noninvasive TCC in 16 cases and part of the invasive portion of the TCC in all 18 cases. Eight patients had metastases, each with a predominant (> or = ...

Also Ranks for: Micropapillary Variant |  transitional cell carcinoma |  urinary bladder |  surface mpc |  cases 50
KOL Index score: 12783

PURPOSE: It is common practice to histologically grade adenocarcinoma of the prostate using the Gleason system. Whereas the prognostic utility of this grading is well known, few studies have comprehensively evaluated it for patients undergoing definitive radiation therapy and generally accepted guidelines as to which Gleason grades should be "lumped" have not been established. This study reports the results of univariate and multivariate evaluation of the prognostic significance of ...

Also Ranks for: Gleason Grade |  radiation therapy |  prostatic adenocarcinoma |  neoplasm recurrence |  10 years
KOL Index score: 12778

Extranodal follicular dendritic cell (FDC) sarcoma of the head and neck region is uncommon, with 16 well-documented cases previously reported (four in the tonsil, four in the pharynx, two in the palate, five in the soft tissue, and one in the thyroid). We here report an additional three cases of extranodal FDC sarcoma in the tonsil (two cases) and pharynx (one case). In these new cases, the neoplastic cells were arranged in diffuse, fascicular, and vaguely whorled growth patterns. A ...

Also Ranks for: Extranodal Follicular |  new cases |  neck region |  cell sarcoma |  complement receptors
KOL Index score: 12624

Carcinomas with micropapillary features have been described in the breast, urinary bladder, lung, and ovary. They are characterized by the presence of micropapillary tufts in clear spaces. Unequivocal vascular invasion is usually present at the periphery of the tumor. Consequently, these tumors have a high propensity for lymph node metastases and high-stage disease. The metastatic carcinoma can consist exclusively of the micropapillary component, which may elicit an erroneous diagnosis ...

Also Ranks for: Micropapillary Carcinoma |  urinary bladder |  estrogen receptor |  lymph node metastases |  differential diagnosis
KOL Index score: 12108

The aim of this study was to analyze the clinicopathological features of patients with flat epithelial atypia, diagnosed in directional vacuum-assisted biopsy targeting microcalcifications, to identify upgrade rate to in situ ductal or invasive breast carcinoma, and determine factors predicting carcinoma in the subsequent excision. We retrospectively evaluated the histological, clinical, and mammographic features of 69 cases from 65 women, with directional vacuum-assisted ...

Also Ranks for: Flat Epithelial Atypia |  surgical excision |  breast carcinoma |  upgrade rate |  atypical ductal hyperplasia
KOL Index score: 12032

PURPOSE: We determine if histopathological factors of the primary penile tumor can stratify the risk of the development of inguinal lymph node metastases.

MATERIALS AND METHODS: Clinical records of 48 consecutive patients with squamous cell carcinoma of the penis who underwent resection of the primary lesion and either inguinal lymph node dissection or were observed for signs of recurrence (median followup 59 months) were reviewed. Parameters examined included pathological tumor stage, ...

Also Ranks for: Vascular Invasion |  lymph node |  tumor stage |  penile squamous |  aged neoplasm
KOL Index score: 12019

Cases filed as vascular tumor of bone other than ordinary hemangioma were reviewed. They were included in the study if there was adequate histologic material and clinical information, clear evidence of bone origin, and at least 5 years follow-up. The study group comprised 17 cases, of which 13 were categorized as hemangioendothelioma of bone, 1 as epithelioid hemangioendothelioma, and 3 as high-grade angiosarcoma. Hemangioendothelioma of bone had growth patterns varying from ...

Also Ranks for: Epithelioid Hemangioendothelioma |  vascular tumors |  bone patients |  highgrade angiosarcomas |  soft tissue
KOL Index score: 11985

BACKGROUND: The outcome of radiation therapy for localized prostate cancer depends on many pretreatment variables that are interrelated in complex ways. A multivariate analysis of 874 cases of prostate cancer treated between 1966 and 1988 was conducted. The median length of the follow-up period after radiation therapy was 6.7 years.

METHODS: The disease outcome and rate of survival was analyzed with the proportional hazards model for patients with stage A2 (104), stage B (168), or stage ...

Also Ranks for: Radiation Therapy |  prostate cancer |  stage grade |  10 years |  transurethral resection

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Alberto G Ayala:Expert Impact

Concepts for whichAlberto G Ayalahas direct influence:Urinary bladder,  Cell carcinoma,  Germ cell,  Renal cell carcinoma,  Prostate cancer,  Adjuvant chemotherapy,  Intraluminal crystalloids,  Small cell carcinoma.

Alberto G Ayala:KOL impact

Concepts related to the work of other authors for whichfor which Alberto G Ayala has influence:Prostate cancer,  Urinary bladder,  Cell carcinoma,  Neoadjuvant chemotherapy,  Differential diagnosis,  Soft tissue,  Radiation therapy.



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Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA | Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA; Weill Medical College of Cornell University (WCMC), New Yor