Prominent publications by Robert H Young

KOL Index score: 25984

AIMS: In the female genital tract CD10 has been used to assist in the evaluation of mesenchymal tumours of the uterus and in determining whether endometrial stroma is present. CD10 positivity has also been shown in cervical mesonephric remnants and this antibody has been suggested as a useful immunohistochemical marker of mesonephric lesions in the female genital tract. Calretinin has also been shown to be positive in mesonephric lesions. In this study the specificity of these two ...

Also Ranks for: Mesonephric Lesions |  endometrial stroma |  cd10 positivity |  endometrioid adenocarcinomas |  uterine corpus
KOL Index score: 20318

Uterine smooth muscle tumors (SMTs) are usually recognized on the basis of their routine morphologic features; however, their distinction from endometrial stromal tumors (ESTs), the second most common mesenchymal tumor of the uterus, is sometimes problematic. Histone deacetylases (HDACs) were originally identified as nuclear enzymes regulating histone acetylation. We have recently shown that in normal human tissues, HDAC8 is exclusively expressed in the cytoplasm of cells showing smooth ...

Also Ranks for: Smooth Muscle |  mesenchymal tumors |  histone deacetylase |  8 hdac8 |  tumor uterine
KOL Index score: 18960

The expression of desmin, h-caldesmon, calponin, CD10, CD34, CD99, inhibin, and keratin (AE1/3-Cam 5.2) was studied in 10 conventional leiomyomas, 9 highly cellular leiomyomas, 9 epithelioid smooth muscle tumors, 9 leiomyosarcomas, 10 endometrial stromal tumors (4 with smooth muscle metaplasia), and 7 uterine tumors resembling ovarian sex cord tumors (UTROSCTs). c-kit expression was tested in 10 endometrial stromal tumors, 7 UTROSCTs, and 9 leiomyosarcomas. Desmin was positive in almost ...

Also Ranks for: Smooth Muscle |  endometrial stromal |  immunohistochemical analysis |  desmin hcaldesmon |  cd10 cd34
KOL Index score: 18037

Sertoli-Leydig cell tumors are characterized by the presence of somatic DICER1 hotspot mutations. In this study, we sought to define the association between DICER1 hotspot mutations and different morphologic subtypes of ovarian Sertoli-Leydig cell tumors. Furthermore, we aimed to assess whether DICER1 hotspot mutations occur in other ovarian sex cord-stromal tumors, testicular sex cord-stromal tumors, or other female genital tract tumors with rhabdomyosarcomatous differentiation. We ...

Also Ranks for: Dicer1 Hotspot Mutations |  stromal tumors |  sex cord |  ovarian sertoli |  leydig cell
KOL Index score: 17713

Sex cord-stromal tumors (SCSTs) of the ovary are relatively uncommon tumors. Diagnosis of SCST rests primarily on the histomorphology of these tumors, and tumors with an atypical or unconventional appearance can pose diagnostic challenges. Previously, we had identified FOXL2 (402C→G) mutation as being characteristic of adult granulosa cell tumors (aGCTs). However, molecular screening for this mutation is not always possible and adds time and cost to the diagnostic process. In this study, ...

Also Ranks for: Stromal Tumors |  foxl2 mutation |  sex cord |  calretinin immunostaining |  protein forkhead
KOL Index score: 16356

Aspects of immunohistochemistry (IHC), which are useful in the diagnosis of ovarian tumors (mostly neoplasms but also a few tumor-like lesions), are discussed. The topic is first approached by considering the different growth patterns and cell types that may be encountered. Then a few other specific situations in which IHC may assist are reviewed. Selected findings largely, or only, of academic interest are also mentioned. One of the most common situations in which IHC may aid is in the ...

Also Ranks for: Ovarian Tumors |  diagnostic aid |  tumor diagnosis |  endometrioid carcinoma |  inhibin calretinin
KOL Index score: 16326

Gonadal sex cord-stromal tumors contain some of the most morphologically interesting neoplasms of the gonads and these lead to many important issues in differential diagnosis. The pathology of these tumors is reviewed with emphasis on new information, similarities and differences in the two gonads, and diagnostic problems. Sertoli cell tumors occur in both gonads being more common in the testis where they usually exhibit a lobular pattern of hollow or solid tubules. In the ovary, tubular ...

Also Ranks for: Sex Cord |  stromal tumors |  cell tumor |  annular tubules |  neoplasms sertoli
KOL Index score: 16276

The classification of appendiceal mucinous tumors is controversial and terminology used for them inconsistent, particularly when they lack overtly malignant features but are associated with extra-appendiceal spread. We reviewed 107 appendiceal mucinous neoplasms and classified them as low-grade appendiceal mucinous neoplasm (LAMN) (n = 88), mucinous adenocarcinomas (MACAs) (n = 16), or discordant (n = 3) based on architectural and cytologic features. LAMNs were characterized by a villous ...

Also Ranks for: Appendiceal Mucinous |  patients lamns |  peritoneal tumor |  lamn maca |  low grade
KOL Index score: 15111

PURPOSE: Following a thorough Phase I/II study, we evaluated by a Phase III trial high versus conventional dose external beam irradiation as mono-therapy for patients with Stage T3-T4 prostate cancer. Patient outcome following standard dose radiotherapy or following a 12.5% increase in total dose to 75.6 Cobalt Gray Equivalent (CGE) using a conformal perineal proton boost was compared for local tumor control, disease-free survival, and overall survival.


Also Ranks for: Conventional Dose |  conformal protons |  local control |  prostate cancer |  differentiated tumors
KOL Index score: 15012

A heterogeneous spectrum of epithelial alterations and atypical lesions affect the squamous epithelium of penile mucosal anatomical compartments. Analogous to other genital sites, the terminology utilized to define the lesions is variable. The few pathologic studies of penile precancerous lesions are mostly related to carcinoma in situ and human papilloma virus (HPV), and the information on low-grade atypical lesions is limited. The objective of this study was to comprehensively describe ...

Also Ranks for: Squamous Cell |  epithelial lesions |  invasive penile |  warty basaloid |  situ carcinoma
KOL Index score: 14843

A group of investigators have proposed that the presence of micropapillary or cribriform patterns within ovarian serous tumors diagnosed as borderline according to World Health Organization (WHO) criteria identifies a subset of these neoplasms that are apt to be associated with invasive peritoneal implants and therefore should be designated as "micropapillary carcinoma." The authors of the current article identified 40 serous borderline tumors that showed one or both of these patterns, ...

Also Ranks for: Cribriform Patterns |  borderline tumors |  ovarian serous |  invasive peritoneal implants |  5 years
KOL Index score: 14600

Distinguishing primary ovarian carcinoma, particularly endometrioid and mucinous subtypes, from metastatic colorectal carcinoma to the ovary is often difficult on histologic examination alone. Recently, three immunohistochemical markers CDX2, a homeobox gene encoding an intestine-specific transcription factor; α-methylacyl-CoA racemase (AMACR/P504S), a mitochondrial and peroxisomal enzyme with fairly restricted expression in selective tumors and β-catenin, an adenomatous polyposis coli ...

Also Ranks for: Ovarian Tumors |  colonic adenocarcinoma |  metastatic colorectal |  immunohistochemical markers |  expression cdx2
KOL Index score: 14401

The morphology of urothelial carcinomas, particularly when poorly differentiated or in metastatic sites, is not distinctive and overlaps significantly with other poorly differentiated nonurothelial carcinomas. Currently, there is no widely used single marker or panel of markers to confirm urothelial origin. We evaluated a panel consisting of antibodies to uroplakin III (UROIII), thrombomodulin (THR), high molecular weight cytokeratin (HMWCK), and cytokeratin 20 (CK20) in a wide range of ...

Also Ranks for: Uroplakin Iii |  urothelial origin |  tumor carcinoma |  transitional cell |  potential utility

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Robert H Young:Expert Impact

Concepts for whichRobert H Younghas direct influence:Urinary bladder,  Ovarian tumors,  Differential diagnosis,  Cell tumor,  Cell carcinoma,  Stromal tumors,  Uterine cervix,  Cell tumors.

Robert H Young:KOL impact

Concepts related to the work of other authors for whichfor which Robert H Young has influence:Urinary bladder,  Prostate cancer,  Cell carcinoma,  Uterine cervix,  Differential diagnosis,  Ovarian neoplasms,  Fallopian tube.



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From the James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (Boyraz, Watkins, Oliva, Young). | The James Homer Wright Pathology Laboratories, Massachusetts