Prominent publications by Shelley N Chou

KOL Index score: 10274

✓ In vitro experiments were performed to determine the contractile activity of human serum and cerebrospinal fluid on the canine basilar artery. The majority of contractile activity in these CSF samples, which were collected 2 to 7 days following a subarachnoid hemorrhage, was proven to be due to serotonin. Serotonin was capable of producing a prolonged contraction of the artery depending on its activity. Methylsergide reversibly blocked the artery's response to serotonin and caused a ...

Known for Contractile Activity |  Basilar Artery |  Cerebral Arterial Spasm |  Subarachnoid Hemorrhage |  Human Serum
KOL Index score: 7684

In vitro experiments were performed with a small volume chamber to determine the contractile activity of various vasoactive agents on human basilar and anterior cerebral arteries. Cumulative log-dose response curves were obtained for most of the agents tested including serotonin and three different prostaglandins; many of these curves were found to be similar to curves previously obtained with canine cerebral arteries. It was concluded from these similarities that canine cerebral ...

Known for Cerebral Arteries |  Contractile Activity |  Human Basilar |  Arterial Spasm |  Vasoactive Agents
KOL Index score: 7250

✓ In vivo experiments in dogs demonstrated that physiological concentrations of serotonin, when injected intracisternally, caused cerebral arterial spasm that lasted for at least 3 hours. Comparable spasm was produced by the injection of blood containing approximately the same amount of serotonin. Phenoxybenzamine reversed both the spasm produced by pure serotonin and that produced by blood. A hypothesis of the etiology of cerebral arterial spasm is proposed based on the experimental ...

Known for Cerebral Arterial Spasm |  Injection Blood |  3 Hours |  Basilar Artery |  Ischemic Attack
KOL Index score: 7157

Stimulating electrodes were placed on the terminal branches of the pelvic nerves to the urinary bladder and the pudendal nerve to the sphincters in seven Rhesus monkeys and two chimpanzees. The proximity of the electrodes to these structures assured organ specificity. Evoked responses produced by stimulation of these terminal nerve branches were recorded in the fascicles and rootlets of the lower thoracic, lumbar, and sacral nerve roots. During identical stimulating and recording ...

Known for Urinary Bladder |  Higher Primates |  Rhesus Monkey |  Evoked Responses |  Pelvic Nerves
KOL Index score: 6805

The clinical outcome of our first 40 patients (six with transient ischemic attacks, 22 with mild ischemic infarctions, and 12 with moderate ischemic infarctions) treated with a superficial temporal artery-middle cerebral artery anastomosis was analyzed. All cerebral ischemias or infarctions occurred in the internal carotid artery distribution. An independent neurologist observer recorded the patients preoperative and postoperative medical and neurological histories and objective ...

Known for Cerebral Artery |  Superficial Temporal |  Internal Carotid |  40 Patients |  Postoperative Angiograms
KOL Index score: 6767

Stimulating electrodes were placed on the terminal branches of the pudendal nerve to the external urethral and external anal sphincters. The proximity of the electrodes to the sphincters assured organ specificity. Evoked responses produced by stimulation of these terminal nerve branches were recorded in the fascicles and rootlets of the lower thoracic, lumbar, and sacral nerve roots. By this method, the segmental spinal cord origin of the innervation of the external urethral and anal ...

Known for External Anal |  Pudendal Nerve |  Rhesus Monkey |  Urinary Bladder |  Terminal Branches
KOL Index score: 6370

The efficacy of cerebral revascularization by anastomosis of the superficial temporal artery (STA) to the middle cerebral artery (MCA), performed 4 and 24 hours after a regional MCA infarction had been produced by combined occlusion of the MCA and internal carotid artery, was tested in 12 dogs. To control possible intercurrent variables, seven other dogs remained untreated and five had a sham operation. Clinical and pathological changes were recorded and analyzed. An incidence of 85% ...

Known for Cerebral Revascularization |  Untreated Control |  24 Hours |  Infarction Animals |  Combined Occlusion
KOL Index score: 6348

In vitro experiments were performed using a small volume chamber to study serotonin-induced contractions of the canine basilar artery. Temperature was found to have a profound effect on the artery's response to serotonin. Raising the temperature to 40 degrees C (104 degrees F) increased the maximum response by 20% and lowering the temperature by 10 degrees C caused a 40% reduction in the maximum contraction. Cumulative log-dose response curves for analogues of serotonin demonstrated a ...

Known for Canine Basilar Artery |  Vitro Effects |  Cerebral Arterial Spasm |  Extracellular Calcium |  Induced Contractions
KOL Index score: 5233

✓ This report presents 18 cases of lipoma of the spinal cord or cauda equina, four of which were unassociated with congenital anomalies of the spine and 14 with such anomalies. Review of the literature shows that unassociated cases are rare, with only 100 cases reported, while those associated with congenital anomalies are more common. The patients ranged in age from 2 months to 5 years. Fourteen patients had external evidence of an abnormality in the form of a mass or dimple over the ...

Known for Spinal Cord |  Cauda Equina |  Subtotal Removal |  5 Years |  Cases Lipoma
KOL Index score: 5207

✓ This report describes a technique of differential sacral rhizotomy for the treatment of neurogenic bladder dysfunction, particularly symptoms of frequency, urgency, and incontinence due to detrusor hyperreflexia. Under cystometric control, the sacral nerve roots are stimulated and anesthetized to determine the correct roots for section. Under magnification, cutting a few but not all of the fascicles in one or two roots increases bladder capacity while preserving detrusor reflex and ...

Known for Differential Sacral Rhizotomy |  Neurogenic Bladder |  Preliminary Report |  Topic Female Humans |  Detrusor Hyperreflexia
KOL Index score: 5165

Fifteen infants and children, 11 of whom had clinical brain death and four of whom were comatose, were evaluated with the radionuclide bolus study and electroencephalography. Clinical criteria for brain death included: (1) absence of spontaneous respirations, (2) absence of cephalic reflexes, and (3) unresponsiveness. Results demonstrated complete correlation among clinical examination, EEG, and radionuclide study in 79% of cases. An approach to the evaluation of the infant or child with ...

Known for Brain Death |  Infants Children |  Clinical Criteria |  Radionuclide Bolus |  Cephalic Reflexes
KOL Index score: 4945

✓ Brain injury was created in anesthetized dogs by the inflation and subsequent deflation of an epidural balloon. Animals in which intracranial pressure (ICP) increased to 40 torr within 3 hours after balloon removal were included in a randomized treatment protocol that included three treatment groups. Group I (control animals) received no additional treatment. Group II animals received 40 mg/kg pentobarbital initially, plus hourly doses. Group III animals received sufficient sodium ...

Known for Intracranial Pressure Icp |  Pressure Brain |  Epidural Balloon |  Barbiturate Treatment |  3 Hours
KOL Index score: 4920

Quantitation of the concentration of immunoproteins in serum, and cystic fluids from six patients (three with cerebral astrocytoma and three with cerebellar hemangioblastoma) has been determined. The values for total protein, albumin, immunoproteins IgG, IgA, and IgM, and C3C (complement) in cyst fluid more closely correspond to serum than to cerebrospinal fluid values. Values for cyst fluid, cerebrospinal fluid, and serum were determined using albumin ratios in order to compare relative ...

Known for Cyst Fluid |  Brain Tumor |  Cerebellar Neoplasms |  Total Protein |  Humans Immunoglobulin
KOL Index score: 4672

The authors present the results of a controlled, randomized study of alterations in spinal cord blood flow, CO2 responsiveness, and autoregulation following experimental spinal cord injury in cats. Permanent paraplegia is shown to be associated with persistent hyperemia, loss of CO2 responsiveness, and impaired autoregulation in the white matter at the injury site. Probable mechanisms underlying these changes in spinal cord vasomotor control are discussed. Marked similarities between ...

Known for White Matter |  Spinal Cord |  Co2 Responsiveness |  Vascular Responses |  Injury Site


Shelley N Chou: Influence Statistics

Sample of concepts for which Shelley N Chou is among the top experts in the world.
Concept World rank
maximum contraction analogues #1
magnesium serotonininduced contractions #1
serotonin extracellular calcium #1
klippelfeil syndrome children #1
profound arterys response #1
large nonphysiological #1
arterys response temperature #1
contrast serotonininduced contractions #1
abscesses accounted #2
physiological concentrations serotonin #2
spasm pure serotonin #2
vasoactive agents agents #2
hangman publication accidents #2
experience neurogenic bladder #2
methylsergide phenoxybenzamine #2
basilar arterys response #2
serotonin prolonged contraction #2
vivo intracisternal production #2
arterys response contraction #2
cephalic reflexes #2
arterys response #2
adhesive neuropathological #2
intracisternal production #2
large dosedependent contractions #2
experimental entire study #2
pertinent correlation #2
angiography diagnostic tests #2
vivo intracisternal #2
comparable spasm injection #2
basilar artery phenoxybenzamine #2
brain scan electroencephalography #2
diagnostic tests drainage #2
activity methylsergide #2
phenoxybenzamine ✓ #2
meningocele paraplegia #2
similarities cerebral arteries #2
prolonged contraction artery #2
reversal phenoxybenzamine #2
✓ eightysix patients #2
✓ vivo experiments #2
minnesota fatalities #2
comparable spasm #2
blocked basilar #2
pure serotonin blood #2
subarachnoid hemorrhage serotonin #2
treatment increasing mortality #2
vertebral vessels neck #2
blood reversal #2
isotope encephalometry review #2
patients refined rhizotomy #3

Key People For Urinary Bladder

Top KOLs in the world
William Chet De Groat
spinal cord urinary bladder micturition reflex
Alan J Wein
urinary bladder prostate cancer smooth muscle
Karl‐Erik Andersson
smooth muscle urinary bladder nitric oxide
Harry W Herr
bladder cancer radical cystectomy transurethral resection
Leifeng Cheng
prostate cancer urinary bladder urothelial carcinoma
Johnathan I Jonathan
prostate cancer gleason score needle biopsy

Shelley N Chou:Expert Impact

Concepts for whichShelley N Chouhas direct influence:Urinary bladder,  Cerebral arterial spasm,  Spinal cord,  Cauda equina,  Cerebral revascularization,  Intracranial lesions,  Brain abscess,  Brain death.

Shelley N Chou:KOL impact

Concepts related to the work of other authors for whichfor which Shelley N Chou has influence:Brain death,  Spinal cord,  Subarachnoid hemorrhage,  Cerebral vasospasm,  Vertebral artery,  Arteriovenous malformations,  Electrical stimulation.



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Department of Neurosurgery, University of Minnesota (SDM, GLR, SNC), and Division of Neurosurgery (SDM, GLR), and Department of Radiology (DY), Hennepin County Medical Center, Minneapolis, Minnesota, and Department of Neurosurgery (MSB), University o

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