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    • Urofacial Syndrome
    • Adrian Spencer Woolf
    • Adrian Spencer Woolf: Influence Statistics

      Adrian Spencer Woolf

      Adrian Spencer Woolf

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      Royal Manchester Children’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom | Division of Cell ...

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      Adrian Spencer Woolf:Expert Impact

      Concepts for whichAdrian Spencer Woolfhas direct influence:Urofacial syndrome,Urinary tract,Organ culture,Growth factor,Cell turnover,Fraser syndrome,Vesicoureteric reflux,Persistent cloaca.

      Adrian Spencer Woolf:KOL impact

      Concepts related to the work of other authors for whichfor which Adrian Spencer Woolf has influence:Urinary tract,Kidney disease,Vesicoureteral reflux,Biedl syndrome,Growth factor,Congenital anomalies,Diabetic nephropathy.

      KOL Resume for Adrian Spencer Woolf

      Year
      2022

      Royal Manchester Children’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

      Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Michael Smith Building, Oxford Road, M13 9PT, Manchester, UK

      2021

      School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, M13 9PT UK

      Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.

      2020

      Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK

      Division of Cell Matrix Biology and Regenerative Medicine, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester, Manchester, United Kingdom

      2019

      School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, United Kingdom

      Department of Paediatric Nephrology, Royal Manchester Children’s Hospital, Manchester University National Health Service Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK

      2018

      Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

      2017

      Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Central Manchester Foundation Trust, Manchester, UK

      2016

      Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre and the Royal Manchester Children's and St Mary's Hospitals, Manchester, UK

      2015

      Department of Paediatric Nephrology, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester Academic Health Science Centre (MAHSC), Manchester, UK

      Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom;

      2014

      Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre and the Royal Manchester Children’s and St Mary’s Hospitals, Manchester, United Kingdom;

      2013

      Institute of Human Development, University of Manchester and the Royal Manchester Children’s Hospital, Manchester, United Kingdom

      Centre for Paediatrics Child Health, University of Manchester, Michael Smith Building, Oxford Road, M13 9PT, Manchester, UK

      2012

      Developmental and Regenerative Medicine Research Group, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT UK

      School of Biomedicine, University of Manchester and the Royal Manchester Children's Hospital, Manchester M13 9PT, United Kingdom

      2011

      University of Manchester, Oxford Road, Manchester, UK.

      2010

      Professor and Chief of Pediatric Urology, Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland

      Department of Paediatrics, Central Manchester Foundation National Health Service (NHS) Trust and Regenerative Medicine Research Group, School of Biomedicine, University of Manchester, Manchester M13 9WL, UK

      University of Manchester and Manchester Children’s Hospital, Manchester, England

      2009

      Nephro-Urology Unit, UCL Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK

      UCL Institute of Child Health, University College, London, United Kingdom;

      2008

      Nephro-Urology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

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      Sample of concepts for which Adrian Spencer Woolf is among the top experts in the world.
      Concept World rank
      bilobed organ #1
      diseases term #1
      mutations hpse2 #1
      bold conceptual package #1
      embryonic mouse ureters #1
      adpkd cysts endothelium #1
      microarray interrogation molecules #1
      humans hepatocyte nuclear #1
      13 cases hypertension #1
      mutations renal malformations #1
      obstructioninduced stretch #1
      critical steps hpscs #1
      satellite dispersal #1
      urachal urethral ligation #1
      maternal diet programs #1
      pcm1 ofd1 #1
      dysplastic cyst formation #1
      detrusor proliferation #1
      vegf adpkd #1
      symptoms postnatal screening #1
      renal tract development #1
      syndrome hpse2 #1
      human renal dysplasia #1
      tshz3 mutations #1
      urethral bladder disease #1
      mutations tshz2 #1
      leaky glomeruli #1
      podocyte epithelia #1
      ecm blastocoelar protein #1
      metanephros embryonic #1
      9 urethral obstruction #1
      kidneys likelihood ratio #1
      metanephric epithelia #1
      sham controls catheters #1
      permissive 37 degrees #1
      ovine bladder #1
      e15 apoptosis #1
      incubation medium sensitivity #1
      epidemiology congenital boo #1
      urinary bladder disease #1
      desmin proliferating #1
      regressive step #1
      23 mm tubes #1
      kspcs #1
      streptozotocin stzinduced dm #1
      embryonic organ #1
      kidney maturation #1
      gdnf initiation #1
      tie1 lacz #1
      winyard #1
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      Prominent publications by Adrian Spencer Woolf

      KOL-Index: 13083

      Development of epithelial organs requires co-ordinated interactions between epithelial and mesenchymal tissues. Studies using null mutant mice have indicated that the ret receptor and its ligand, glial cell line-derived neurotrophic factor (GDNF), are crucial for initiation of development of the metanephric kidney. However, the role of this signalling system in other branching organs has not been analysed. Here we describe expression studies of ret, GDNF, and a co-receptor for GDNF ...

      Known for Ureteric Bud | Glial Cell | Neurotrophic Factor | Gdnf Development | Wolffian Duct
      KOL-Index: 12514

      Renal parenchymal disease after urinary tract infection (UTI) has been associated with the development of hypertension and renal functional impairment. A systematic literature review and meta-analysis was performed to determine how effectively the finding of primary vesicoureteric reflux (VUR) on micturating cystography (MCU) in children hospitalized with UTI predicted renal parenchymal disease on (99m)Technetium-dimercaptosuccinic acid ((99m)Tc-DMSA) scintigraphy. Medline, Embase, and ...

      Known for Renal Damage | Vesicoureteric Reflux | Urinary Tract Infection | Children Uti | Likelihood Ratio
      KOL-Index: 11462

      Several lines of evidence suggest that hepatocyte growth factor/scatter factor (HGF/SF), a soluble protein secreted by embryo fibroblasts and several fibroblast lines, may elicit morphogenesis in adjacent epithelial cells. We investigated the role of HGF/SF and its membrane receptor, the product of the c-met protooncogene, in the early development of the metanephric kidney. At the inception of the mouse metanephros at embryonic day 11, HGF/SF was expressed in the mesenchyme, while met ...

      Known for Early Development | Renal Mesenchyme | Hepatocyte Growth | Scatter Factor | Transgenic Microscopy
      KOL-Index: 11145

      Fraser syndrome (OMIM 219000) is a multisystem malformation usually comprising cryptophthalmos, syndactyly and renal defects1. Here we report autozygosity mapping and show that the locus FS1 at chromosome 4q21 is associated with Fraser syndrome, although the condition is genetically heterogeneous. Mutation analysis identified five frameshift mutations in FRAS1, which encodes one member of a family of novel proteins related to an extracellular matrix (ECM) blastocoelar protein found in ...

      Known for Fraser Syndrome | Extracellular Matrix | Blebbed Phenotype | Mutations Fras1 | Inbred Strains Mice
      KOL-Index: 11088

      Mutations in hepatocyte nuclear factor 1B (HNF1B), which is a transcription factor expressed in tissues including renal epithelia, associate with abnormal renal development. While studying renal phenotypes of children with HNF1B mutations, we identified a teenager who presented with tetany and hypomagnesemia. We retrospectively reviewed radiographic and laboratory data for all patients from a single center who had been screened for an HNF1B mutation. We found heterozygous mutations in 21 ...

      Known for Hnf1b Mutations | Renal Magnesium | Nuclear Factor | Chronic Kidney Disease | 1 Beta
      KOL-Index: 10544

      A critical role for Tie1, an orphan endothelial receptor, in blood vessel morphogenesis has emerged from mutant mouse studies. Moreover, it was recently demonstrated that certain angiopoietin (Ang) family members can activate Tie1. We report here that Ang1 induces Tie1 phosphorylation in endothelial cells. Tie1 phosphorylation was, however, Tie2 dependent because 1) Ang1 failed to induce Tie1 phosphorylation when Tie2 was down-regulated in endothelial cells; 2) Tie1 phosphorylation was ...

      Known for Receptor Tie1 | Cell Survival | Tie2 Ang1 | Enzyme Activation | Kinase Activity
      KOL-Index: 10327

      Autosomal dominant polycystic kidney disease (ADPKD) in children is sometimes considered to be a benign condition, with morbidity manifesting in adulthood. Therefore, diagnostic screening of children at risk is controversial. The aim of our study was to to compare the manifestations of ADPKD in children diagnosed by postnatal ultrasound (US) screening versus those presenting with symptoms. This was a retrospective chart review of children with ADPKD assessed in a single centre between ...

      Known for Children Adpkd | Kidney Disease | Diagnostic Screening | Benign Condition | Postnatal Ultrasound
      KOL-Index: 10313

      BACKGROUND: In rats, offspring born to mothers supplied low protein diets during pregnancy have fewer glomeruli than normal. We hypothesized that such nephron deficits are associated with altered cell turnover in the metanephros, the embryonic precursor of the adult kidney.

      METHODS: Wistar rats were supplied with one of three isocaloric diets from day 0 of pregnancy: control (18% protein) or low protein (9% or 6%) diets. All had a normal chow after birth. Groups were compared by ...

      Known for Mesenchymal Cells | Protein Restriction | Increased Apoptosis | Fewer Glomeruli | Rats Offspring
      KOL-Index: 10259

      Previous studies have demonstrated that hepatocyte growth factor/scatter factor (HGF/SF) is secreted by mesenchymal cells and that it elicits motility, morphogenesis and proliferation of epithelia expressing the met receptor. We now report that HGF/SF may act as an autocrine factor in fibromuscular renal mesangial cells. These cells mechanically support glomerular endothelia, control the rate of plasma ultrafiltration and are implicated in the pathogenesis of a variety of chronic renal ...

      Known for Mesangial Cells | Growth Factor | Hgf Mesangium Hepatocyte | Receptor Protein | Renal Glomerular
      KOL-Index: 10216

      BACKGROUND: Renal tract malformations are, on occasion, associated with uterine malformations. The transcription factor hepatocyte nuclear factor (HNF)-1beta is expressed from the earliest stages of development of the Wolffian duct, the mesonephros and metanephros, and the Müllerian ducts in the mouse. In adult mice HNF-1beta is expressed in the kidney tubules, collecting ducts, and in the oviducts and uterus in the female (Müllerian duct derivatives) and in the epididymis, vas deferens ...

      Known for Hnf1beta Mutations | Hepatocyte Nuclear | Genital Tract | Functioning Kidney | Müllerian Ducts
      KOL-Index: 10091

      Congenital anomalies of the kidney and urinary tract (CAKUT) include vesicoureteral reflux (VUR). VUR is a complex, genetically heterogeneous developmental disorder characterized by the retrograde flow of urine from the bladder into the ureter and is associated with reflux nephropathy, the cause of 15% of end-stage renal disease in children and young adults. We investigated a man with a de novo translocation, 46,X,t(Y;3)(p11;p12)dn, who exhibits multiple congenital abnormalities, ...

      Known for Vesicoureteral Reflux | Urinary Tract | Genetic Predisposition | Cakut Vur | Situ Hybridization
      KOL-Index: 10083

      The hepatocyte nuclear factor-1beta (HNF-1beta) transcription factor controls endoderm development. Human mutations cause early-onset diabetes mellitus and have recently been associated with dysplastic, hypoplastic, and glomerulocystic kidneys. A new kindred with this "renal cysts and diabetes" syndrome is described, and nephrogenic HNF-1beta expression is defined. The proband had congenital cystic kidneys: over the next 12 yr, his renal function was impaired, but he was normoglycemic. ...

      Known for Hepatocyte Nuclear | Renal Cysts | Gene Expression | Human Development | Factor 1
      KOL-Index: 9926

      The planar cell polarity (PCP) pathway, incorporating non-canonical Wnt signalling, controls embryonic convergent (CE) extension, polarized cell division and ciliary orientation. It also limits diameters of differentiating renal tubules, with mutation of certain components of the pathway causing cystic kidneys. Mutations in mouse Vangl genes encoding core PCP proteins cause neural tube defects (NTDs) and Vangl2 mutations also impair branching of embryonic mouse lung airways. Embryonic ...

      Known for Branching Morphogenesis | Cell Polarity | Gene Vangl2 | Pcp Pathway | Mutant Mice
      KOL-Index: 9828

      OBJECTIVES: To determine whether vascular endothelial growth factor A (VEGF) and its receptors are expressed during bladder development in mice when capillaries are forming, and whether exogenous VEGF might enhance the growth of endothelia and other types of bladder cells, using an embryonic organ-culture model.

      MATERIALS AND METHODS: Whole bladders from wild-type mice, at embryonic day (E) 14, were grown in serum-free organ culture in an air/5% CO2 atmosphere; some cultures were ...

      Known for Organ Culture | Endothelial Growth | Urinary Bladder | Exogenous Vegf | Smooth Muscle
      KOL-Index: 9651

      Familial glomerulocystic kidney disease (GCKD) is a dominantly inherited condition characterized by glomerular cysts and variable renal size and function; the molecular genetic etiology is unknown. Mutations in the gene encoding hepatocyte nuclear factor (HNF)-1beta have been associated with early-onset diabetes and nondiabetic renal disease-particularly renal cystic disease. We investigated a possible role for the HNF-1beta gene in four unrelated GCKD families and identified mutations ...

      Known for Hepatocyte Nuclear | Kidney Disease | Familial Hypoplastic | Hnf1beta Mutations | Earlyonset Diabetes

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      Royal Manchester Children’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom | Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Facult

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