• Disease
  • Mast
  • Mast Cells
  • Nicholas Arthur Soter

    Prominent publications by Nicholas Arthur Soter

    KOL Index score: 10391

    To investigate the functional heterogeneity of mouse mast cells, we extracted and purified cutaneous and peritoneal mast cells from 10- to 18-week-old BALB/c mice and compared their responses to secretagogues. Cutaneous mast cells (CMC) were extracted from mouse ears after digestion with hyaluronidase and collagenase in MEM containing 25% fetal calf serum and purified on a discontinuous Percoll gradient. The histamine content of cells obtained from the 30/40% interface was 1.0 +/- 0.1 ...

    Also Ranks for: Mast Cells |  histamine release |  cmc pmc |  calcium cell |  balb mice
    KOL Index score: 10042

    In two randomized, double-blind, multicenter studies, a total of 631 adult patients with moderate to severe atopic dermatitis applied tacrolimus ointment (0.03% or 0.1%) or vehicle twice daily for up to 12 weeks. The mean percent body surface area (%BSA) affected at baseline was 45%, and 56% of patients had severe atopic dermatitis. As previously reported, these studies showed that tacrolimus ointment was superior to vehicle for all efficacy parameters measured. This report focuses on ...

    Also Ranks for: Tacrolimus Ointment |  atopic dermatitis |  patients vehicle |  skin burning |  common adverse events
    KOL Index score: 9332

    The buttock skin of clinically normal human subjects was subjected to approximately 2.5 minimal erythema doses of ultraviolet A irradiation. Deep red erythema developed during irradiation, faded slightly within the next few hours, increased to maximum intensity between 9-15 h, and decreased gradually thereafter although still persisting strongly at 48 h. Suction blister exudates were obtained at 0, 5, 9, 15, 24, and 48 h after irradiation as well as suction blister exudates from a ...

    Also Ranks for: Arachidonic Acid |  increased concentrations |  human skin |  uva irradiation |  control levels
    KOL Index score: 9287

    To better define the inflammatory infiltrates and kinetics of mediator release during the cutaneous late-phase reaction (LPR), we examined skin biopsies at 8 h, and skin chamber cell counts and mediator release for 12 h after antigen challenge. Compared with the control sites, the antigen-stimulated biopsy sites contained 14 times as many basophils (P less than 0.01) and six times as many eosinophils (P less than 0.001) with one to two fold more mononuclear cells (P less than 0.03) and ...

    Also Ranks for: Mediator Release |  delayed hypersensitivity |  eosinophils basophils |  mononuclear cells |  cutaneous late
    KOL Index score: 9191

    Sera from 29 patients with biopsy-proven idiopathic active cutaneous necrotizing venulitis (CNV) were examined for immune complexes by serum complement levels, Clq binding, and ADCC inhibition. For comparison these studies were also performed in patients with systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA). Most of the patients with CNV, SLE, and RA have evidence of circulating immune complexes at a time during which they have active disease. Patients with CNV tend to ...

    Also Ranks for: Immune Complexes |  patients vasculitis |  rheumatoid arthritis |  clq binding |  serum complement
    KOL Index score: 8870

    BACKGROUND: Cetirizine and astemizole have been shown to be safe and effective in the treatment of patients with chronic idiopathic urticaria. Cetirizine brings about clinical benefit more rapidly.

    OBJECTIVE: The purpose of this study was to compare the efficacy of single daily doses of cetirizine and astemizole in relieving the symptoms of chronic idiopathic urticaria, with particular emphasis on the commencement of action.

    METHODS: Patients with chronic idiopathic urticaria were ...

    Also Ranks for: Chronic Idiopathic Urticaria |  4 weeks |  astemizole cetirizine |  symptom severity |  drug administration
    KOL Index score: 8261

    The local effects of intracutaneous injections into humans of 1-3 nmol of five products of arachidonic acid metabolism, leukotrienes (LT) C4, D4, E4, and B4 from the 5-lipoxygenase pathways and prostaglandin (PG) D2 from the cyclooxygenase pathway, were assessed clinically and histologically. In equimolar concentrations, LTC4, LTD4, and LTE4, elicited erythema and wheal formation, in which a wheal with central pallor was present up to 2 hr, and the erythema persisted as long as 6 hr. ...

    Also Ranks for: Synthetic Leukotrienes |  local effects |  human skin |  arachidonic acid metabolism |  cyclooxygenase pathway
    KOL Index score: 8222

    Profiles of serum complement components were studied in patients with necrotizing angiitis (vasculitis) of the skin and concomitant rheumatoid arthritis, Sjögren's syndrome, or systemic lupus erythematosus. In patients with either rheumatoid arthritis or Sjögren's syndrome, the early components—C1, C4, and C2—were depressed. When cryoglobulins containing mainly IgG and IgM were present in the patients with Sjögren's syndrome, there was further preferential reduction of C4 and C2 in serum ...

    Also Ranks for: Necrotizing Angiitis |  patients rheumatoid arthritis |  early components |  sjögrens syndrome |  lupus erythematosus
    KOL Index score: 8150

    BACKGROUND: In patients with psoriasis and human immunodeficiency virus type 1 (HIV-1) infection, therapeutic options may be limited by their potential immunosuppressive effects. UVB radiation can activate HIV-1 gene expression in transgenic mice and in vitro. It is not known whether this viral activation leads to a clinically significant effect or if these findings can be extrapolated to humans.

    OBJECTIVE: This study was performed to evaluate the safety of UVB light treatment in ...

    Also Ranks for: Uvb Phototherapy |  hiv infection |  patients psoriasis |  syndrome adult |  transgenic mice
    KOL Index score: 7716

    To evaluate further the interactions of C5a and mast cells in cutaneous inflammation, the ability of human native C5a (nC5a) (10 to 500 ng/ml) and human recombinant C5a (rC5a) (10 ng/ml to 100 ng/ml) to induce histamine release from purified BALB/c cutaneous mast cells (CMC) and peritoneal mast cells (PMC) was analyzed. It was found that nC5a induced histamine release from CMC but not from PMC, with a maximal net release at 250 ng/ml nC5a (22.8 +/- 2.6%). Kinetic experiments demonstrated ...

    Also Ranks for: Mast Cells |  murine model |  histamine release |  vivo studies |  c5a induced
    KOL Index score: 7421

    Patients with idiopathic acquired cold-induced urticaria were evaluated for the release of the preformed mast-cell mediators of immediate-type hypersensitivity during a study in which one arm was immersed in ice water while the other arm remained as a control. Blood specimens were obtained from each arm serially over a one-hour interval, and serum speciments were assessed for histamine, eosinophil chemotactic factor of anaphylaxis, and complement components. Levels of histamine and ...

    Also Ranks for: Cold Urticaria |  chemotactic factor |  histamine release |  mast cell |  control arm
    KOL Index score: 7327

    BACKGROUND: Although photosensitivity disorders have been well described, their incidence in a referral institution had not been studied.

    OBJECTIVE: The purpose of this study was to evaluate the incidence of photosensitivity disorders, including photocontact dermatitis, in an academic medical center.

    METHODS: The results of the assessment of 203 consecutive patients, all of whom had phototests, referred for the evaluation of photosensitivity disorders during a 7.3-year period were ...

    Also Ranks for: Photoallergic Dermatitis |  photosensitivity disorders |  antimicrobial agents |  polymorphous light eruption |  positive reactions
    KOL Index score: 6879

    BACKGROUND: There is a paucity of investigation on which to base the treatment of chronic urticaria after a patient fails maximum therapy with antihistamines. One prospective, open-label, uncontrolled study suggested that mycophenolate mofetil may be a successful second-line therapy.

    OBJECTIVE: We sought to evaluate the efficacy and safety of mycophenolate mofetil in 19 patients with autoimmune and chronic idiopathic urticaria.

    METHODS: In a retrospective chart review, records of ...

    Also Ranks for: Mycophenolate Mofetil |  idiopathic urticaria |  autoimmune chronic |  retrospective studies |  immunosuppressive agents


    Nicholas Arthur Soter: Influence Statistics

    Sample of concepts for which Nicholas Arthur Soter is among the top experts in the world.
    Concept World rank
    actinic dermatitis #1
    product inquiries #1
    contact urticating hairs #1
    purpuric papule #1
    angioedema 20 #1
    reactions medications #1
    langerhans uva #1
    cadyounger women #1
    methylene bis‐benzotriazolyl #1
    hairs moth parts #1
    inflammatory response position #1
    biology mast cell #1
    moth parts extracts #1
    ichthyosis recognized #1
    individuals urticaria #1
    recognized skin #1
    local heat urticaria #1
    hypersensitivity role #1
    neutrophilic leukocytes circulation #1
    extracts moth parts #1
    cell venules #1
    perivenular infiltrate lymphocytes #1
    balb mice cimetidine #1
    cutaneous wheals #1
    urticating hairs #1
    photosensitivity majority #1
    neutrophilic leukocytes model #1
    skin mild form #1
    moth parts histamine #1
    venulitis #1
    traditional h1 antihistamines #1
    degrees hypogranulation #1
    review fentichlor #1
    enhancement cimetidine #1
    1micron plasticembedded sections #1
    mastocytosis birth #1
    arthralgias vasculitis #1
    greater thanexpected #1
    normal complement hypocomplementemia #1
    pharmacologic state #1
    normal minimal #1
    child chlorophenols dermatitis #1
    lichenoid drug eruption #1

    Key People For Mast Cells

    Top KOLs in the world
    Stephen Joseph Galli
    mast cells stem cell factor inbred balb mice
    Dean Darrel Metcalfe
    mast cells bone marrow stem cell factor
    Mindy M Tsai
    mast cells stem cell factor cell activation
    K Frank Austen
    mast cells leukotriene c4 chondroitin sulfate
    Lawrence B Schwartz
    mast cells tryptase levels hypereosinophilic syndrome
    Theoharis Constantin Theoharides
    mast cells interstitial cystitis acute stress

    Nicholas Arthur Soter:Expert Impact

    Concepts for whichNicholas Arthur Soterhas direct influence:Mast cells,  Chronic actinic dermatitis,  Atopic dermatitis,  Uvb phototherapy,  Mast cell,  Visible light,  Mycophenolate mofetil,  Actinic dermatitis.

    Nicholas Arthur Soter:KOL impact

    Concepts related to the work of other authors for whichfor which Nicholas Arthur Soter has influence:Atopic dermatitis,  Mast cells,  Leukotriene b4,  Chronic urticaria,  Psoriatic arthritis,  Histamine release,  Human skin.



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    The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, NY, USA | The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York. | The Ronald O. Perel