James C Hogg: Influence Statistics

James C Hogg

James C Hogg

Research Center, St Pauls Hospital, Vancouver, BC, Canada | James Hogg Research Centre, University of British Columbia and St. Paul's Hospital, Vancouver, BC, Canada. | Centre ...

James C Hogg: Expert Impact

Concepts for which James C Hogg has direct influence: Bone marrow , Chronic obstructive , Polymorphonuclear leukocytes , Cigarette smoke , Small airways , Computed tomography , Pulmonary disease .

James C Hogg: KOL impact

Concepts related to the work of other authors for which for which James C Hogg has influence: Chronic obstructive , Pulmonary disease , Cigarette smoke , Copd patients , Lung function , Air pollution , Oxidative stress .

KOL Resume for James C Hogg

Year
2022

Research Center, St Pauls Hospital, Vancouver, BC, Canada

2021

Center for Heart Lung Innovation, University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, Canada.

Centre for Heart Lung Innovation, St Pauls Hospital, The University of British Columbia, Vancouver, BC, Canada

2020

Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada

2019

Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Center for Heart Lung Innovation, St. Paul’s Hospital, Vancouver, British Columbia, Canada

2018

Department of Pathology and Laboratory Medicine, University of British Columbia (UBC), Vancouver, British Columbia, Canada

1 Centre for Heart Lung Innovation, St. Paul's Hospital.

2017

6 University of British Columbia, Vancouver, British Columbia, Canada; and.

Centre for Heart Lung Innovation, St. Paul’s Hospital, Departments of Medicine, and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

2016

University of British Columbia James Hogg Research Centre, St. Paul's Hospital, Vancouver, British Columbia, Canada

2015

James Hogg Research Centre, University of British Columbia, Vancouver, Canada.

Departments of Medicine and Pathology and Laboratory Medicine, Centre for Heart Lung Innovation, Providence Heart-Lung Institute at St Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada

2014

UBC James Hogg Research Center and Institute for Heart and Lung Health, St Paul’s Hospital, Vancouver, BC V6Z 1Y6, Canada,

Center for Heart and Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada

2013

James Hogg Research Centre, The University of British Columbia, Vancouver, BC, Canada

2012

James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia and St Paul’s Hospital, Vancouver, Canada

University of British Columbia Research Laboratories, St Paul's Hospital, Vancouver, British Columbia.

2011

From the University of British Columbia James Hogg Research Centre, St. Paul's Hospital (J.E.M., R.Y., M.S., N.S., W.M.E., H.O.C., P.D.P., D.D.S., J.C.H.)

UBC James Hogg Research Centre, Heart and Lung Institute, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada

2010

UBC Department of Pathology, St. Paul's Hospital; Burrard Street, Vancouver, Canada

James Hogg iCAPTURE Research Centre, Providence Heart + Lung Institute, St Paul's Hospital; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia

2009

Department of Pathology and Laboratory Medicine, University of British Columbia and iCapture Center, St. Paul's Hospital, Vancouver, British Columbia V6Z 1Y6, Canada

2008

The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, University of British Columbia, Vancouver, Canada

Prominent publications by James C Hogg

KOL-Index: 15418 . BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation that is greater in patients with advanced disease. We asked whether there is a link between the severity of disease and the reduction in histone deacetylase (HDAC) activity in the peripheral lung tissue of patients with COPD of varying severity. HDAC is a key molecule in the repression ...
Known for Hdac Activity | Patients Copd | Lung Tissue | Chronic Obstructive Rna
KOL-Index: 14951 . Studies have shown that exposure to ambient particulate matter is related to an increased cardiopulmonary morbidity and mortality. The present study was designed to measure the effect of repeated exposure to urban air particles (PM10) on the rate of production and release of polymorphonuclear leukocytes (PMN) from the bone marrow into the peripheral blood. Rabbits exposed to PM10 (5 mg) ...
Known for Bone Marrow | Repeated Exposure | Particulate Air Pollution | Transit Time
KOL-Index: 14647 . RATIONALE: Patients with chronic obstructive pulmonary disease (COPD) show a poor response to corticosteroids. This has been linked to a reduction of histone deacetylase-2 as a result of oxidative stress and is reversed by theophylline. OBJECTIVES: To determine the role of phosphoinositide-3-kinase-delta (PI3K-δ) on the development of corticosteroid insensitivity in COPD and under ...
Known for Corticosteroid Insensitivity | Copd Theophylline | Chronic Obstructive | Pulmonary Disease
KOL-Index: 13684 . BACKGROUND: Although an eosinophilic infiltrate has been observed in the small airways of asthmatic individuals, the mechanisms responsible for cellular recruitment in the lung periphery remain to be clarified. Eotaxin and monocyte chemotactic protein (MCP)-4 are 2 eosinophil-associated chemokines shown to be upregulated at sites of allergic inflammation. However, their expression within ...
Known for Small Airways | Eotaxin Mcp4 | Mrna Expression | Monocyte Chemotactic
KOL-Index: 13479 . RATIONALE: Oxidative stress is a key contributor in chronic obstructive pulmonary disease (COPD) pathogenesis caused by cigarette smoking. NRF2, a redox-sensitive transcription factor, dissociates from its inhibitor, KEAP1, to induce antioxidant expression that inhibits oxidative stress. OBJECTIVES: To determine the link between severity of COPD, oxidative stress, and NRF2-dependent ...
Known for Obstructive Pulmonary | Positive Regulator | Nrf2 Protein | Copd Oxidative Stress
KOL-Index: 13405 . Exposure to ambient air pollution particles with a diameter of < 10 microm (PM(10)) has been associated with increased cardiopulmonary morbidity and mortality. We postulate that these adverse health effects are related to proinflammatory mediators produced in the lung and released into the circulation where they initiate a systemic inflammatory response. The present study was designed to ...
Known for Alveolar Macrophages | Epithelial Cells | Pm10 Exposure | Bone Marrow
KOL-Index: 13303 . OBJECTIVE: A hallmark of the systemic response to an inflammatory stimulus is the release of polymorphonuclear leukocytes (PMNs) from the bone marrow. This study was designed to measure the release of PMNs from the bone marrow and to determine their sequestration in the lung after an intravenous injection of either endotoxin (n = 5) or saline (n = 5). METHODS AND RESULTS: The thymidine ...
Known for Bone Marrow | Polymorphonuclear Leukocytes | Lung Microvessels | Brdulabeled Pmns
KOL-Index: 12945 . Studies from our laboratory have shown that chronic cigarette smoke exposure causes a neutrophilia associated with a shortening of the mean transit time of polymorphonuclear leukocytes (PMN) though the postmitotic pool of the marrow. The present study was designed to test the hypothesis that PMN newly released from bone marrow by smoke exposure preferentially sequestered in pulmonary ...
Known for Bone Marrow | Cigarette Smoking | Polymorphonuclear Leukocytes | Lung Microvessels
KOL-Index: 12839 . RATIONALE: Studies of excised lungs show that significant airway attrition in the "quiet" zone occurs early in chronic obstructive pulmonary disease (COPD). OBJECTIVES: To determine if the total number of airways quantified in vivo using computed tomography (CT) reflects early airway-related disease changes and is associated with lung function decline independent of emphysema in ...
Known for Computed Tomography | Chronic Obstructive | Total Airway Count | Pulmonary Disease
KOL-Index: 12678 . STUDY OBJECTIVE: To determine how the volume and severity of emphysema measured by CT morphometry (CTM) before and after lung volume reduction surgery (LVRS) relates to the functional status of patients after LVRS. DESIGN: A histologically validated CT algorithm was used to quantify the volume and severity of emphysema in 35 patients before and after LVRS: total lung volume (TLV), normal ...
Known for Lung Volume | Severe Emphysema | Patients Lvrs | Reduction Surgery
KOL-Index: 12167 . The cell adhesion molecule L-selectin is highly expressed on mature bone marrow polymorphonuclear leukocytes (PMN), and the release of these cells from the bone marrow could produce a population of circulating PMN expressing high levels of L-selectin. Because L-selectin initiates the interaction of PMN with activated endothelium, these cells could be important in the pathogenesis of ...
Known for Pmn Bone Marrow | Selectin Expression | Peripheral Blood | Cells Bone
KOL-Index: 12061 . Previous studies from our laboratory have shown that the expression of L-selectin on polymorphonuclear leukocytes (PMN) is higher in the bone marrow than in peripheral blood. The present study was designed to determine the location of this L-selectin loss as the PMN pass from the hematopoietic tissue into venous sinusoids of the bone marrow. Bone marrow and peripheral blood samples were ...
Known for Bone Marrow | Polymorphonuclear Leukocytes | Release Pmn | Lselectin Expression
KOL-Index: 12039 . Children with acute respiratory syncytial virus (RSV) bronchiolitis often develop sequelae of recurrent wheezing and asthma. To determine whether RSV persists within the lung after resolution of acute bronchiolitis, we examined the lungs of guinea pigs 60 days after intranasal inoculation with either human RSV (n = 10) or uninfected cell culture supernatant (n = 11). Evidence of viral ...
Known for Guinea Pigs | Respiratory Syncytial | Viral Bronchiolitis | Rsv Rtpcr
KOL-Index: 11851 . BACKGROUND: The major sites of obstruction in chronic obstructive pulmonary disease (COPD) are small airways (<2 mm in diameter). We wanted to determine whether there was a relationship between small-airway obstruction and emphysematous destruction in COPD. METHODS: We used multidetector computed tomography (CT) to compare the number of airways measuring 2.0 to 2.5 mm in 78 patients who ...
Known for Terminal Bronchioles | Airway Obstruction | Emphysematous Destruction | Obstructive Pulmonary
KOL-Index: 11622 . Epidemiologic studies have shown an association between exposure to ambient particulate air pollution <10 microm in diameter (PM(10)) and increased cardiovascular morbidity and mortality. We previously showed that PM(10) exposure causes progression of atherosclerosis in coronary arteries. We postulate that the recruitment of monocytes from the circulation into atherosclerotic lesions is a ...
Known for Atherosclerotic Plaques | Air Pollution | Particulate Matter | Progression Atherosclerosis

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Research Center, St Pauls Hospital, Vancouver, BC, Canada | James Hogg Research Centre, University of British Columbia and St. Paul's Hospital, Vancouver, BC, Canada. | Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Brit