KOL | Sara ZarnegarDepartment of Molecular Genetics and Cell Biology, Department of Medicine, and, Department of Human Genetics, The University of Chicago, Chicago, Illinois, USA. | Department ... |
KOL Resume for Sara Zarnegar
| Year | |
|---|---|
| 2004 | Department of Molecular Genetics and Cell Biology, Department of Medicine, and, Department of Human Genetics, The University of Chicago, Chicago, Illinois, USA. |
Sara Zarnegar: Influence Statistics
| Concept | World rank |
|---|---|
| sarcoglycannull alleles | #6 |
| extrinsic vascular spasm | #6 |
| spasm transgenes | #6 |
| permeability sarcoglycans | #6 |
| background sarcoglycan | #6 |
| vascular spasm spasm | #6 |
| spasm restoration | #6 |
| tissue damage spasm | #6 |
| sarcoglycan background | #6 |
| sarcoglycannull mice | #6 |
| cardiomyocyte sarcoglycan | #6 |
| smooth muscle sarcoglycan | #6 |
| cardiac focal degeneration | #6 |
| sarcoglycans spasm | #6 |
| zeta sarcoglycan | #7 |
| sarcoglycans verapamil | #8 |
| gammasarcoglycandeficient mice | #8 |
| degeneration sarcoglycan | #8 |
| 1149 279 | #8 |
| gamma sarcoglycan hearts | #8 |
| perturbation sarcoglycan complex | #8 |
| microvascular filling defects | #8 |
| spasm arises | #8 |
| gammasarcoglycan mutant mice | #8 |
| transgene rescue strategy | #8 |
| vasospasm promotes | #8 |
| zetasarcoglycan | #9 |
| cardiac focal | #9 |
| vasospasm cytoskeletal | #10 |
| infarctlike pattern | #13 |
| echocardiography verapamil | #14 |
| sarcoglycan zeta | #15 |
| restoration cardiomyocyte | #16 |
| extrinsic vascular | #20 |
| cardiomyopathic progression | #22 |
| secondary vasospasm | #23 |
| sarcoglycan mutant | #23 |
| membrane sarcoglycan | #24 |
| promotes cardiomyopathy | #27 |
| restoration smooth | #27 |
| 016 data | #31 |
| sarcoglycan gene mutations | #32 |
| mechanism spasm | #33 |
| alleles mechanism | #36 |
| vasospasm vascular | #38 |
| complementary fibrosis | #41 |
| cardiac degeneration | #46 |
| damage alleles | #46 |
| muscle sarcoglycan | #48 |
| vascular spasm | #50 |
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Prominent publications by Sara Zarnegar
Smooth muscle cell–extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy
[ PUBLICATION ]
Vascular spasm is a poorly understood but critical biomedical process because it can acutely reduce blood supply and tissue oxygenation. Cardiomyopathy in mice lacking gamma-sarcoglycan or delta-sarcoglycan is characterized by focal damage. In the heart, sarcoglycan gene mutations produce regional defects in membrane permeability and focal degeneration, and it was hypothesized that vascular spasm was responsible for this focal necrosis. Supporting this notion, vascular spasm was noted in ...
| Known for Smooth Muscle | Vascular Spasm | Cardiac Myocytes | Sarcoglycan Complex | Mice Mice |
Genetic defects in the plasma membrane-associated sarcoglycan complex produce cardiomyopathy characterized by focal degeneration. The infarct-like pattern of cardiac degeneration has led to the hypothesis that coronary artery vasospasm underlies cardiomyopathy in this disorder. We evaluated the coronary vasculature of gamma-sarcoglycan mutant mice and found microvascular filling defects consistent with arterial vasospasm. However, the vascular smooth muscle sarcoglycan complex was intact ...
| Known for Sarcoglycan Complex | Smooth Muscle | Coronary Artery | Verapamil Treatment | Cytoskeletal Proteins |
Key People For Vascular Spasm
Sara Zarnegar:Expert Impact
Concepts for whichSara Zarnegarhas direct influence:Vascular spasm, Muscular dystrophy, Sarcoglycan complex, Cardiomyopathy progression, Cardiac myocytes, Extrinsic vascular spasm, Smooth muscle cell, Secondary vasospasm.
Sara Zarnegar:KOL impact
Concepts related to the work of other authors for whichfor which Sara Zarnegar has influence:Muscular dystrophy, Sarcoglycan complex, Mdx mice, Dilated cardiomyopathy, Vascular spasm, Abnormal nuclear envelopes, Cardiac fibrosis.
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