 | DEBBIE RITCHIE |
Prominent publications by DEBBIE RITCHIE
OBJECTIVES: We prospectively sought evidence-based criteria that distinguished between seizures and syncope.
BACKGROUND: Loss of consciousness is usually due to either seizures or syncope. There are no evidence-based historical diagnostic criteria that distinguish them.
METHODS: A total of 671 patients with loss of consciousness completed a 118-item historical questionnaire. Data sets were complete for all subjects. The data set was randomly divided into two equal groups. The ...
| Also Ranks for: Seizures Syncope | historical criteria | loss consciousness | specificity surveys | point scores |
INTRODUCTION: Vasovagal syncope is common, often recurrent, and reduces quality of life. No therapies have proven useful to improve quality of life in adequately designed randomized clinical trials. Beta-blockers have mixed evidence for effectiveness in preventing syncope.
METHODS: The Prevention of Syncope Trial was a randomized, placebo-controlled, double-blind, multinational, clinical trial that tested the hypothesis that metoprolol improves quality of life in adult patients with ...
| Also Ranks for: Quality Life | metoprolol patients | vasovagal syncope | clinical trial | 6 12 |
Fludrocortisone for the Prevention of Vasovagal Syncope A Randomized, Placebo-Controlled Trial
[ PUBLICATION ]
BACKGROUND: There is limited evidence whether being on fludrocortisone prevents vasovagal syncope.
OBJECTIVES: The authors sought to determine whether treatment with fludrocortisone reduces the proportion of patients with recurrent vasovagal syncope by at least 40%, representing a pre-specified minimal clinically important relative risk reduction.
METHODS: The multicenter POST 2 (Prevention of Syncope Trial 2) was a randomized, placebo-controlled, double-blind trial that assessed the ...
| Also Ranks for: Vasovagal Syncope | controlled trial | limited evidence | randomized placebo | female fludrocortisone |
BACKGROUND: Previous studies that assessed the effects of beta-blockers in preventing vasovagal syncope provided mixed results. Our goal was to determine whether treatment with metoprolol reduces the risk of syncope in patients with vasovagal syncope.
METHODS AND RESULTS: The multicenter Prevention of Syncope Trial (POST) was a randomized, placebo-controlled, double-blind, trial designed to assess the effects of metoprolol in vasovagal syncope over a 1-year treatment period. Two ...
| Also Ranks for: Syncope Patients | vasovagal tilt | test treatment | matching placebo | outcome measure |
AIMS: Our goal was to develop historical criteria for the diagnosis of vasovagal syncope.
METHODS AND RESULTS: We administered a 118-item historical questionnaire to 418 patients with syncope and no apparent structural heart disease. The prevalence of each item was compared between patients with positive tilt tests and those with syncope of other, known causes. The contributions of symptoms to diagnoses were estimated with logistic regression, point scores were developed, and the scores ...
| Also Ranks for: Vasovagal Syncope | decision rule | male medical | point score | historical criteria |
INTRODUCTION: Understanding whether vasovagal syncope is a lifelong disorder might shed insight into its physiology and affect management strategies. Accordingly, we determined the age of the first syncopal spell in adult patients who sought care for syncope.
METHODS AND RESULTS: Patients were 42 +/- 18 years old with 64% women. They had had a median 8 syncope spells (interquartile range [IQR]: 4, 20) with a median frequency of 1.0 syncopal spells per year. The range of syncopal spells ...
| Also Ranks for: Vasovagal Syncope | patients 40 years | age onset | syncopal spells | median frequency |
Syncope and Structural Heart Disease: Historical Criteria for Vasovagal Syncope and Ventricular Tachycardia
[ PUBLICATION ]
INTRODUCTION: to develop evidence-based criteria that distinguish syncope due to ventricular tachycardia (VT) from vasovagal syncope (VVS) in patients with structural heart disease (SHD).
METHODS AND RESULTS: one hundred and thirty-four patients with syncope and SHD completed a 118-item questionnaire and underwent noninvasive and invasive diagnostic assessments in a prospective cohort study. The contributions of symptoms to diagnoses were estimated with logistic regression and a point ...
| Also Ranks for: Ventricular Tachycardia | syncope patients | structural heart disease | historical criteria | 35 years |
INTRODUCTION: accurate selection of patients for vasovagal syncope studies requires strong risk stratification and knowledge of the natural history of syncope. We aimed to test the hypothesis that recent history of vasovagal syncope compared to distant history better predicts subsequent recurrence of syncope.
METHODS AND RESULTS: in all, 208 subjects with a positive tilt test and ≥ 3 lifetime syncope spells were followed for 1 year. Syncope episodes in the preceding year and total ...
| Also Ranks for: Vasovagal Syncope | preceding year | tilt test | risk stratification | 22 2 |
The development and preliminary validation of a scale measuring the impact of syncope on quality of life
[ PUBLICATION ]
AIMS: To develop a brief syncope-specific measure of health-related quality of life.
METHODS AND RESULTS: One hundred and fourteen patients with syncope completed a 48-item questionnaire derived from a generic measure of quality of life (the EQ-5D), the Syncope Functional Status Questionnaire, a depression scale (the CES-D) and historical symptoms. From these, clinical impact methodology was used to derive 12-item Impact of Syncope on Quality of Life (ISQL). The ISQL correlated with the ...
| Also Ranks for: Quality Life | impact syncope | convergent validity | female health | frequency spells |
Dissection of long-range heart rate variability Controlled induction of prognostic measures by activity in the laboratory
[ PUBLICATION ]
OBJECTIVES: We sought to determine whether the long-range measures of heart rate variability (HRV)--the standard deviation of sequential 5-min heart period mean values (SDANN) and the heart period spectral amplitude in the ultra-low frequency band <0.0033 Hz (ULF)--had their origins partly in physical activity.
BACKGROUND: The SDANN and ULF are prognostic HRV factors whose physiologic origins are obscure. Their discontinuous presence throughout the day suggested that they arise from ...
| Also Ranks for: Heart Rate | prognostic measures | physical activity | 00001 ulf | ventricular dysfunction |
Reduced quality of life and greater psychological distress in vasovagal syncope patients compared to healthy individuals
[ PUBLICATION ]
BACKGROUND: Vasovagal syncope (VVS) patients have a reduced health-related quality of life (HRQoL). There are limited data comparing HRQoL and psychological profile in VVS patients and healthy individuals. We tested the hypothesis that VVS patients have greater impairment in both HRQoL and psychological profile compared to healthy nonfainting individuals, and that both outcome measures are negatively correlated for VVS patients.
METHODS: The RAND 36-Item Health Survey (RAND36), global ...
| Also Ranks for: Vvs Patients | healthy participants | vasovagal syncope | quality life | depression anxiety |
BACKGROUND: Recurrent vasovagal syncope is common, responds poorly to treatment, and causes physical trauma and poor quality of life. Midodrine prevents hypotension and syncope during tilt tests in patients with vasovagal syncope.
OBJECTIVE: To determine whether midodrine can prevent vasovagal syncope in usual clinical conditions.
DESIGN: Randomized, double-blind, placebo-controlled clinical trial. (ClinicalTrials.gov: NCT01456481).
SETTING: 25 university hospitals in Canada, the United ...
| Also Ranks for: Vasovagal Syncope | male midodrine | patients recurrent | controlled clinical |
Randomized Pragmatic Trial of Pacemaker Versus Implantable Cardiac Monitor in Syncope and Bifascicular Block
[ PUBLICATION ]
Objectives In this study, the authors tested whether a strategy of empiric permanent pacing reduces major composite events more effectively than acting on the results of an implantable cardiac monitor (ICM). Background Syncope may be caused by intermittent complete heart block in patients with bifascicular heart block, but competing diagnoses coexist. Whether empiric permanent pacing or acting on investigative results provides best care is unknown. Methods This was a multinational, ...
| Also Ranks for: Bifascicular Block | cardiac monitor | empiric permanent pacing | 33 months | compared icm |
Quality of life improves in vasovagal syncope patients after clinical trial enrollment regardless of fainting in follow-up
[ PUBLICATION ]
BACKGROUND: Frequent syncope is linked to poorer health-related quality of life (HRQoL). Recurrent syncope has been observed to reduce in all groups after seeing a syncope expert and enrolling in a clinical trial. It is unknown if HRQoL improves with this reduction in syncope recurrence.
OBJECTIVES: We examined the change in HRQoL over time in vasovagal syncope (VVS) patients seen by a syncope expert and enrolled in a trial. We also explored whether change differed with treatment or the ...
| Also Ranks for: Syncope Patients | quality life | clinical trial | 12 months | health survey |
INTRODUCTION: Vasovagal syncope is common and distressing. One important symptom is presyncope, but there are no clinimetric measures of this. We developed the Calgary Presyncope Form (CPF) and used it to test whether metoprolol reduces presyncope in a randomized trial.
METHODS: The CPF captures the frequency, duration, and severity of presyncope. We administered it to participants in the Prevention of Syncope Trial (POST), a randomized clinical trial that tested the hypothesis that ...
| Also Ranks for: Syncope Presyncope | patients metoprolol | clinical trial | observation period |
DEBBIE RITCHIE: Influence Statistics
| Concept | World rank |
|---|---|
| faints median | #2 |
| 77 likelihoods | #3 |
| signaling vasovagal | #3 |
| 00035 year | #3 |
| 82 fainters | #3 |
| alleles syncope | #3 |
| international accident data | #3 |
| slc6a4 promoter alleles | #3 |
| fainted driving | #3 |
| alleles decreased syncope | #3 |
| likelihoods females | #3 |
| syncope likelihoods | #3 |
| 47 syncope likelihoods | #3 |
| risk vasovagal syncope | #3 |
| lifetime vasovagal | #3 |
| likelihoods syncope | #3 |
| placebo ≤1 | #3 |
| sexspecific serotonin signaling | #3 |
| fainted total | #3 |
| 00035 personyear | #3 |
| decreased syncope males | #3 |
| kindreds vasovagal | #3 |
| post syncope | #3 |
| death 00035 | #3 |
| faints patients | #3 |
| year accident data | #3 |
| females gg males | #3 |
| vvs patients depression | #4 |
| biomarkers vasovagal syncope | #4 |
| syncope expert | #4 |
| baseline spell | #4 |
| enrollment vvs | #4 |
| 0001 vvs | #4 |
| syncope events syncope | #4 |
| vvs patients time | #4 |
| participants vvs | #4 |
| sibutramine vasovagal syncope | #4 |
| referral‐based population | #4 |
| endothelin1 copeptin | #4 |
| baseline spell frequency | #4 |
| faints randomization | #4 |
| syncope preceding year | #4 |
| healthy nonfainting individuals | #4 |
| nonfainting individuals | #4 |
| enrollment fainting | #4 |
| distress vasovagal | #4 |
| strong risk stratification | #4 |
| optimal statistical significance | #4 |
| fainting follow | #4 |
| profile vvs | #4 |
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Key People For Vasovagal Syncope
DEBBIE RITCHIE:Expert Impact
Concepts for whichDEBBIE RITCHIEhas direct influence:Vasovagal syncope, Vvs patients, Patients vasovagal syncope, Syncope trial, Ventricular tachycardia, Syncope vasovagal, Bifascicular block, Syncope patients.
DEBBIE RITCHIE:KOL impact
Concepts related to the work of other authors for whichfor which DEBBIE RITCHIE has influence:Vasovagal syncope, Transient loss, Heart rate variability, Orthostatic intolerance, Differential diagnosis, Physical examination, Epileptic seizures.
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