• Disease
  • Sildenafil
  • Sildenafil Citrate
  • Patricia Guhring

    Prominent publications by Patricia Guhring

    KOL Index score: 11446

    PURPOSE: Erectile dysfunction is a recognized complication of radiation therapy for prostate cancer. Sildenafil citrate is a well-known management strategy for erectile dysfunction that has been found to be efficacious across a wide spectrum of comorbidities, including post-radiation erectile dysfunction. We defined the efficacy of sildenafil citrate in patients with erectile dysfunction following radiation therapy for prostate cancer and assessed the impact of the interval after ...

    Also Ranks for: Radiation Therapy |  sildenafil citrate |  erectile dysfunction |  prostate cancer |  androgen deprivation
    KOL Index score: 10872

    INTRODUCTION: Sildenafil citrate is an effective and well-tolerated oral erectogenic medication. Through phosphodiesterase type 5 (PDE5) inhibition, it induces relaxation in penile smooth muscle, resulting in erection. Due to its mild affinity for other PDE enzymes, it may cause smooth muscle relaxation in a number of other organs. Recent data suggest an association between erectile dysfunction (ED) and lower urinary tract symptoms (LUTS). Anecdotally some patients cite improvement in ...

    Also Ranks for: Sildenafil Citrate |  erectile dysfunction |  ipss score |  improvement luts |  urinary tract
    KOL Index score: 8914

    PURPOSE: Penile prosthetic surgery is associated with satisfaction rates >90% for the general penile implant population. It is suggested that satisfaction rates may be lower in certain populations. This study was undertaken to define potential predictors of satisfaction.

    METHODS: Patients undergoing penile prosthesis surgery completed the International Index of Erectile Function (IIEF) prior to surgery, and the IIEF and Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) ...

    Also Ranks for: Penile Prosthesis Surgery |  satisfaction rates |  patient age |  erectile function |  general implant population
    KOL Index score: 7649

    OBJECTIVES: To define the impact of intralesional verapamil injection therapy on penile deformity in men with Peyronie's disease.

    METHODS: Patients underwent a total of 6 intralesional injections of verapamil. Penile deformity was assessed at baseline and 3 months after the last intralesional injection of verapamil during penile erection after the administration of intracavernosal medication. Measurement was recorded using a goniometer at maximum penile rigidity. Endpoints included ...

    Also Ranks for: Intralesional Verapamil |  penile deformity |  peyronies disease |  patient age |  injection therapy
    KOL Index score: 7621

    INTRODUCTION: Orgasmic pain is an infrequently reported but distressing problem for the patients who experience it. No consensus exists as to its etiology however bladder neck/pelvic floor spasm may play a role. This analysis was conducted to assess the effect of the alpha-blocking medication, tamsulosin on post-orgasmic pain.

    METHODS: In a prospective, non-placebo controlled study, patients with orgasmic pain were interviewed and administered tamsulosin 0.4 mg po qhs for at least 4 ...

    Also Ranks for: Orgasmic Pain |  tamsulosin treatment |  radical prostatectomy |  erectile function |  outcome measures
    KOL Index score: 7298

    AIM: Peyronie's disease (PD) may be treated in a medical or surgical fashion. Factors involved in the decision of which treatment to choose include duration of disease and magnitude of penile deformity. Curvature can be measured using at-home photography (AHP), vacuum erection device (VED), or intracavernosal injection (ICI). This study was undertaken to determine the concordance between the three methods of deformity assessment. Patients were also questioned regarding the presence of ...

    Also Ranks for: Penile Curvature |  erectile dysfunction |  intracavernosal injection |  peyronies disease |  vacuum erection
    KOL Index score: 7018

    INTRODUCTION: Peyronie's disease (PD) is usually seen in men in their fifth decade of life.

    AIM: In this study, we investigated the characteristics of the disease in young men.

    MAIN OUTCOME MEASURES: The demographics, clinical features, and associated comorbidities of the patients with PD were retrospectively reviewed.

    METHODS: The findings were compared between men with the disease who were under 40 years of age with those over 40 years. Statistical analyses were conducted to define ...

    Also Ranks for: 40 Years |  disease diabetes |  clinical characteristics |  patients age |  outcome measures
    KOL Index score: 6877

    INTRODUCTION: As a vascular test, dynamic infusion cavernosometry (DIC) has lost popularity, and in the urologic community, penile duplex Doppler ultrasound (DUS) has become the sole test to investigate a vascular etiology of erectile dysfunction. Vasoactive agent redosing has been shown to increase the accuracy of DUS.

    AIM: To define the erectile hemodynamics in men with previously diagnosed venous leak on DUS.

    METHODS: Prospective data were collected on patients who (i) had been given ...

    Also Ranks for: Venous Leak |  false diagnosis |  erectile hemodynamics |  arterial insufficiency |  systolic velocity
    KOL Index score: 6451

    INTRODUCTION: Intracavernosal injection therapy (ICI) is a well-established second-line therapy used in the treatment of erectile dysfunction (ED). Controversy exists as to whether oral phosphodiesterase type 5 inhibitors (PDE5i) or injection therapy lead to higher satisfaction.

    AIM: This study addressed ICI satisfaction in a modern cohort of patients in the PDE5i era.

    METHODS: Patients on ICI for at least 6 months were included in our study. Patients were administered the International ...

    Also Ranks for: Injection Therapy |  patients ici |  5 inhibitors |  erectile function |  multivariate analysis
    KOL Index score: 6424

    Study Type--Therapy (outcomes research) Level of Evidence 2b. What's known on the subject? and What does the study add? Intracavernosal injection (ICI) therapy is an important treatment option for erectile dysfunction. However, high discontinuation rates have been reported for ICI therapy, and a risk of priapism has long been a concern. There has never been a large sample study performed with multivariate analysis to characterise outcomes of ICI therapy. The present paper reviews ICI ...

    Also Ranks for: Intracavernosal Injection |  ici therapy |  discontinuation rates |  5 inhibitors |  multivariate analysis
    KOL Index score: 6210

    OBJECTIVE: To define the ability of the International Index of Erectile Function (IIEF) to differentiate between organic and psychogenic erectile dysfunction (ED).

    PATIENTS AND METHODS: Patients presenting for the evaluation and treatment of ED who had penile duplex Doppler ultrasonography (DUS) completed the IIEF questionnaire. Accepted ranges of the IIEF EF domain were used to grade baseline severity (severe, moderate and mild < or =11, 11-17, 18-25, respectively). Accepted criteria ...

    Also Ranks for: Erectile Function |  venous leak |  radical prostatectomy |  illness surveys |  organic psychogenic
    KOL Index score: 6024

    PURPOSE: Little information exists on the natural history of PD. We defined the course of PD in a group of men with this condition who received no treatment.

    MATERIALS AND METHODS: The study population comprised patients with PD who presented within 6 months of disease onset, had no medical treatment and were followed until at least 12 months after disease onset. At baseline and followup penile abnormality was determined following intracavernous injection and by measurement at maximum ...

    Also Ranks for: Curvature Baseline |  12 months |  medical treatment |  intracavernous injection |  penile length
    KOL Index score: 5330

    OBJECTIVE: To assess whether mannose receptor assays can predict fertilization outcome in vitro.

    DESIGN: A prospective, double-blind study of the mannose receptor properties of spermatozoa.

    SETTING: Assisted human reproduction program at a university hospital.

    PATIENT(S): Partners of 140 consecutive women undergoing their first in vitro fertilization cycle.

    INTERVENTION(S): Motile sperm populations were tested for surface receptors for mannose by measuring their ability to bind ...

    Also Ranks for: Mannose Receptor |  vitro fertilization |  sperm binding |  mannosylated albumin |  140 consecutive women
    KOL Index score: 5281

    INTRODUCTION: For the practicing clinician, appreciating Peyronie's disease (PD) significant negative psychological impact is apparent. Despite this, there exists not a single study using validated instruments assessing this issue.

    AIMS: To document the effect of PD on the psychosocial status of men.

    MAIN OUTCOME MEASURES: The Center for Epidemiological Studies Depression scale (CES-D) for evaluation of depression and the SF-36 for quality of life assessment.

    METHODS: Men (N = 92; 54 +/- ...

    Also Ranks for: Outcome Measures |  psychosocial status |  12 months |  validated instruments |  penile induration
    KOL Index score: 5115

    PROBLEM: To determine whether the results of the Acrobeads test, which measures the expression of the complement regulator molecule CD46 on the inner acrosomal membrane following the acrosome reaction, accurately identifies semen specimens that will exhibit reduced or failed fertilization following conventional IVF insemination.

    METHOD: The Acrobeads test was performed on semen specimens from 97 consecutive patients preparing to undergo an IVF cycle utilizing a standardized insemination ...

    Also Ranks for: Ivf Cycle |  acrosome reaction |  male lectins |  fertilization rate |  motile sperm populations


    Patricia Guhring: Influence Statistics

    Sample of concepts for which Patricia Guhring is among the top experts in the world.
    Concept World rank
    baseline intralesional injection #3
    success rates priapism #3
    failure ici therapy #3
    discontinuation rates rp #3
    rp note #3
    nonorganic respond #3
    penile deformity baseline #3
    rates undergone #3
    outcomes study type #3
    overt organic etiology #3
    outcomes nonorganic #3
    ici • patient #3
    priapism concern #3
    concern discontinuation rates #3
    study intracavernosal injection #3
    5 inhibitors ici #3
    pde5i consistently #3
    note rp #3
    baseline deformity assessment #3
    intracavernosal medication #3
    verapamil penile deformity #3
    concern discontinuation #3
    • note #3
    rates intracavernosal #3
    nonorganic respond pde5i #3
    pde5i lack #3
    rp patients ici #3
    consistently response pde5i #3
    recorded priapism #3
    ici therapy discontinuation #3
    6 intralesional injections #3
    medical management nonorganic #3
    • ici #3
    improvement penile deformity #3
    curvature stretched #3
    cesd evaluation #4
    induration personality #4
    stayed consistently #4
    48 cesd #4
    40 years 18 #4
    time diagnosis groups #4
    mhs stayed #4
    40 years 75 #4
    outcomes intracavernosal #4
    presentation distribution comorbidity #4
    validated instruments 48 #4
    mhs standardized #4
    22 pde5i #4
    40 years plaque #4
    evaluation cesd #4

    Key People For Sildenafil Citrate

    Top KOLs in the world
    Irwin S Goldstein
    erectile dysfunction smooth muscle sexual medicine
    Raymond C Rosen†
    erectile dysfunction sexual function premature ejaculation
    Ian H Osterloh
    erectile dysfunction sildenafil citrate spinal cord injury
    Harin Padma‐Nathan
    erectile dysfunction transurethral alprostadil sildenafil citrate
    Tom F Lue
    erectile dysfunction penile erection rat model
    Pierre A Wicker
    erectile dysfunction oral sildenafil clinical safety

    Patricia Guhring:Expert Impact

    Concepts for whichPatricia Guhringhas direct influence:Sildenafil citrate,  Venous leak,  Erectile dysfunction,  Erectile function,  Intralesional verapamil,  40 years,  Intracavernosal injection,  Penile prosthesis surgery.

    Patricia Guhring:KOL impact

    Concepts related to the work of other authors for whichfor which Patricia Guhring has influence:Erectile dysfunction,  Peyronies disease,  Penile curvature,  5 inhibitors,  Surgical treatment,  Radical prostatectomy,  Sexual function.



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    Sexual and Reproductive Medicine Program, Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. | Sexual & Reproductive Medicine Program, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, U