• Disease
  • Willebrand
  • Willebrand Factor
  • Pier Mannuccio Mannuccio Mannucci

    Prominent publications by Pier Mannuccio Mannuccio Mannucci

    KOL Index score: 20840

    BACKGROUND: Point mutations in the factor V gene (factor V Leiden) and the prothrombin gene (the substitution of A for G at position 20210) are the most common causes of inherited thrombophilia. Whether or not factor V Leiden increases the risk of recurrent deep venous thrombosis is controversial, and there is no information on the risk of recurrence among carriers of both mutations.

    METHODS: We studied a retrospective cohort of 624 patients who were referred for a first episode of deep ...

    Also Ranks for: Prothrombin Mutation |  heterozygous carriers |  venous thrombosis |  factor leiden |  recurrent deep
    KOL Index score: 17661

    BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal.

    METHODS: We performed two mendelian randomisation analyses. ...

    Also Ranks for: Myocardial Infarction |  hdl cholesterol |  genetic score |  1 increase |  reduced risk
    KOL Index score: 16248

    Venous thromboembolism is a rare but threatening complication of pregnancy. Little conclusive information is available on the actual risk of venous thromboembolism during pregnancy or puerperium in women with inherited thrombophilia, particularly in carriers of factor V Leiden and of the G20210A prothrombin gene mutation. To determine the pregnancy-related and puerperium-related risk of venous thromboembolism in women with inherited thrombophilia, we performed a case-control study on 119 ...

    Also Ranks for: Inherited Thrombophilia |  venous thromboembolism |  pregnancy puerperium |  protein deficiency |  factor leiden
    KOL Index score: 15843

    BACKGROUND: The blood coagulation system is activated in the acute phase of unstable angina and acute myocardial infarction. However, it remains unclear whether augmented function of the hemostatic mechanism serves only as a marker of the acute thrombotic episode or whether a hypercoagulable state persists for a prolonged period after clinical stabilization.

    METHODS AND RESULTS: We prospectively measured the plasma concentrations of prothrombin fragment 1 + 2 (F1 + 2) and fibrinopeptide ...

    Also Ranks for: Unstable Angina |  myocardial infarction |  f1 patients |  6 months |  persistent activation
    KOL Index score: 15212

    1-Deamino-8-D-arginine vasopressin (DDAVP, desmopressin), a synthetic analog of the antidiuretic hormone L-arginine vasopressin, improves hemostasis parameters in cirrhotic patients. Hence its use in combination with a vasoactive drug such as terlipressin might improve the performance of this drug in controlling variceal bleeding. The aim of this trial was to compare the efficacy of desmopressin plus terlipressin with that of terlipressin alone in controlling acute variceal hemorrhage. ...

    Also Ranks for: Cirrhotic Patients |  acute variceal hemorrhage |  terlipressin treatment |  combination esophageal |  variceal bleeding
    KOL Index score: 13865

    INTRODUCTION: Current guidelines for ischemic stroke prevention in atrial fibrillation or flutter (AFF) recommend Vitamin K antagonists (VKAs) for patients at high-intermediate risk and aspirin for those at intermediate-low risk. The cost-effectiveness of these treatments was demonstrated also in elderly patients. However, there are several reports that emphasize the underuse of pharmacological prophylaxis of cardio-embolism in patients with AFF in different health care settings.

    AIMS: ...

    Also Ranks for: Elderly Patients |  internal medicine |  antithrombotic therapy |  atrial fibrillation |  adherence guidelines
    KOL Index score: 13758

    Autoantibodies neutralizing human ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type 1 motif), the metalloprotease that physiologically cleaves von Willebrand factor, are a major cause of severe deficiency of the protease and of acquired thrombotic thrombocytopenic purpura (TTP). We evaluated prevalence of anti-ADAMTS13 antibodies in 59 patients with thrombotic microangiopathies (TMAs) and in 160 patients with immunologic or thrombocytopenic diseases different ...

    Also Ranks for: Thrombotic Microangiopathies |  adamts13 autoantibodies |  antibodies patients |  immunoglobulin igg |  ttp elisa
    KOL Index score: 13691

    BACKGROUND: Particulate air pollution has been linked to heart disease and stroke, possibly resulting from enhanced coagulation and arterial thrombosis. Whether particulate air pollution exposure is related to venous thrombosis is unknown.

    METHODS: We examined the association of exposure to particulate matter of less than 10 microm in aerodynamic diameter (PM10) with deep vein thrombosis (DVT) risk in 870 patients and 1210 controls from the Lombardy region in Italy, who were examined ...

    Also Ranks for: Particulate Air Pollution |  exposure pm10 |  deep vein thrombosis |  dvt risk |  year examination
    KOL Index score: 13493

    BACKGROUND: Idiopathic cerebral-vein thrombosis can cause serious neurologic disability. We evaluated risk factors for this disorder, including genetic risk factors (mutations in the genes encoding factor V and prothrombin) and nongenetic risk factors (such as the use of oral contraceptive agents). We compared the prevalence of these risk factors in 40 patients with cerebral-vein thrombosis, 80 patients with deep-vein thrombosis of the lower extremities, and 120 healthy controls. The ...

    Also Ranks for: Oral Contraceptives |  vein thrombosis |  factor gene |  risk cerebral |  mutation odds
    KOL Index score: 13243

    BACKGROUND: It is currently unclear whether or not cerebral venous thrombosis, such as splanchnic venous thrombosis, can be the first manifestation of an underlying myeloproliferative neoplasm.

    OBJECTIVE: To determine the prevalence of the JAK2 V617F mutation in patients with a first episode of cerebral venous thrombosis.

    PATIENTS: In this retrospective cohort study, patients with cerebral venous thrombosis were tested for the JAK2 V617F mutation and were followed until the development ...

    Also Ranks for: Cerebral Venous Thrombosis |  v617f mutation |  myeloproliferative neoplasm |  patients jak2 |  factors venous


    Pier Mannuccio Mannuccio Mannucci: Influence Statistics

    Sample of concepts for which Pier Mannuccio Mannuccio Mannucci is among the top experts in the world.
    Concept World rank
    val264met #1
    bleeding severe #1
    blood coagulation factors #1
    1983–1987 #1
    hiv infections hemophilia #1
    807c vwd #1
    familial dysfunction #1
    hemostatic functions #1
    hemophiliacs #1
    hemophilia humans hemophilia #1
    rco iu haemate #1
    factor viiirag #1
    q706 #1
    heat‐treatment step #1
    patients factor r506q #1
    baxter method standards #1
    hemophilia recombinant products #1
    fviii primates #1
    val88met #1
    reposi study #1
    comparison noc #1
    recombinant products #1
    rfviii inhibitors #1
    fviii subjects #1
    pdfviii products #1
    apc ratios patients #1
    convincing studies #1
    terlipressin desmopressin #1
    pdfviii #1
    antithrombin deficiency fpa #1
    r202w rvwf #1
    development alloantibodies #1
    desmopressin willebrand #1
    controls thromboplastins #1
    gammachain gene #1
    22 123 patients #1
    factor viii replacement #1
    hemostasis abnormalities #1
    female hemophilia #1
    patients fv leiden #1
    1deamino8darginine vasopressin #1
    plasma concentrates fviii #1
    vwd2m factor viii #1
    purity fviii products #1
    normal thrombin generation #1
    thrombophilia prothrombin 19911 #1
    appropriateness oac prescription #1
    vwf ricof #1
    endogenous factor viii #1
    vwd thrombocytopenia #1

    Key People For Willebrand Factor

    Top KOLs in the world
    Zaverio M Ruggeri
    willebrand factor platelet adhesion thrombus formation
    J Evan Sadler
    willebrand factor thrombotic thrombocytopenic plasma exchange
    Pier Mannuccio Mannuccio Mannucci
    willebrand factor venous thromboembolism myocardial infarction
    Dominique Meyer
    willebrand factor platelet adhesion type iia
    Jan J Sixma
    platelet adhesion willebrand factor flow conditions
    Denisa D Wagner
    willebrand factor endothelial cells deep vein thrombosis

    Pier Mannuccio Mannuccio Mannucci:Expert Impact

    Concepts for whichPier Mannuccio Mannuccio Mannuccihas direct influence:Willebrand factor,  Factor viii,  Willebrand disease,  Venous thromboembolism,  Myocardial infarction,  Plasma levels,  Thrombin generation,  Venous thrombosis.

    Pier Mannuccio Mannuccio Mannucci:KOL impact

    Concepts related to the work of other authors for whichfor which Pier Mannuccio Mannuccio Mannucci has influence:Willebrand factor,  Venous thromboembolism,  Air pollution,  Myocardial infarction,  Thrombin generation,  Cardiovascular disease,  Tranexamic acid.



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    Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy | Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre and Luigi Villa Foundation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy | Fonda