Prominent publications by Luc JSM Teppema

KOL Index score: 11843

In this study, Fos immunohistochemistry was used to map brainstem neuronal pathways activated during hypercapnia and hypoxia. Conscious rats were exposed to six different gas mixtures: (a) air; (b) 8% CO2 in air; (c) 10% CO2 in air; (d) 15% CO2 in air; (e) 15% CO2 + 60% O2, balance N2; (f) 9% O2, balance N2. Double-staining was performed to show the presence of tyrosine hydroxylase. Hypercapnia, in a dose-dependent way caused Fos expression in the following areas: caudal nucleus tractus ...

Known for Hypoxia Hypercapnia |  Rat Brainstem |  Fos Expression |  Labeled Cells |  Co2 Air
KOL Index score: 11327

BACKGROUND: The effect of a single nucleotide polymorphism of the mu-opioid receptor at nucleotide position 118 (OPRM1:c.118A>G) was investigated on morphine-6-glucuronide (M6G)-induced analgesia and respiratory depression in a group of healthy volunteers.

METHODS: Sixteen subjects of either sex received 0.4 mg/kg (n = 8) or 0.6 mg/kg M6G (n = 8). At regular time intervals, the isocapnic acute hypoxic ventilatory response, pain tolerance (derived from a transcutaneous electrical acute ...

Known for Respiratory Depression |  Genetic Receptors |  Opioid Receptor |  Analgesia Analgesics |  Nucleotide Position
KOL Index score: 11299

BACKGROUND: Respiratory depression is a serious side effect of anesthetics and opioids. The authors examined the influence of the combined administration of sevoflurane and alfentanil on ventilatory control, heart rate (HR), and Bispectral Index (BIS) in healthy volunteers.

METHODS: Step decreases in end-tidal partial pressure of oxygen from normoxia into hypoxia (approximately 50 mmHg) at constant end-tidal partial pressure of carbon dioxide (approximately 48 mmHg) were performed in ...

Known for Response Surface Modeling |  Cardiorespiratory Control |  Opioid Anesthetics |  Respiratory Depression |  Carbon Dioxide
KOL Index score: 11042

BACKGROUND: The involvement of the mu-opioid receptor (muOR) system in the control of breathing, anesthetic potency, and morphine- and anesthesia-induced respiratory depression was investigated in mice lacking the muOR.

METHODS: Experiments were performed in mice lacking exon 2 of the muOR gene (muOR-/-) and their wild-type littermates (muOR+/+). The influence of saline, morphine, naloxone, and sevoflurane on respiration was measured using a whole body plethysmographic method during air ...

Known for Knockout Mice |  Opioid Anesthetics |  Morphine Naloxone |  Carbon Dioxide |  Respiration Sevoflurane
KOL Index score: 10906

BACKGROUND: Human breathing is regulated by feedback and feed-forward control mechanisms, allowing a strict matching between metabolic needs and the uptake of oxygen in the lungs. The most important control mechanism, the metabolic ventilatory control system, is fine-tuned by two sets of chemoreceptors, the peripheral chemoreceptors in the carotid bodies (located in the bifurcation of the common carotid arteries) and the central CO2 chemoreceptors in the ventral medulla. Animal data ...

Known for Central Chemoreceptors |  Carotid Body |  Co2 Sensitivity |  Ventilatory Control |  Response Hypoxia
KOL Index score: 10575

BACKGROUND: Mitochondrial succinate dehydrogenase (SDH) is a component of both the tricarboxylic acid cycle and the electron transport chain. Mutations of SDHD, the first protein of intermediary metabolism shown to be involved in tumorigenesis, lead to the human tumors paraganglioma (PGL) and pheochromocytoma (PC). SDHD is remarkable in showing an 'imprinted' tumor suppressor phenotype. Mutations of SDHD show a very high penetrance in man and we postulated that knockout of Sdhd would ...

Known for Paraganglioma Pheochromocytoma |  Mutations Sdhd |  Tumor Development |  Mice Knockout |  Succinate Dehydrogenase
KOL Index score: 10231

BACKGROUND: The objective of this investigation was to examine the ability of the opioid antagonist naloxone to reverse respiratory depression produced by the mu-opioid analgesic, buprenorphine, in healthy volunteers. The studies were designed in light of the claims that buprenorphine is relatively resistant to the effects of naloxone.

METHODS: In a first attempt, the effect of an intravenous bolus dose of 0.8 mg naloxone was assessed on 0.2 mg buprenorphine-induced respiratory ...

Known for Respiratory Depression |  Naloxone Reversal |  Buprenorphine Dose |  Continuous Infusion |  Receptors Opioid
KOL Index score: 10204

BACKGROUND: Animal and human studies indicate the existence of important sex-related differences in opioid-mediated behavior. In this study the authors examined the influence of morphine on experimentally induced pain in healthy male and female volunteers.

METHODS: Young healthy men and women (10 of each sex) received intravenous morphine (bolus 0.1-mg/kg dose followed by an infusion of 0.030 mg. kg-1. h-1 for 1 h). Pain threshold and pain tolerance in response to a gradual increase in ...

Known for Morphine Analgesia |  Pain Threshold |  Intravenous Injections |  Stimulus Intensity |  Data Sex Differences
KOL Index score: 9886

BACKGROUND: Morphine-6-glucuronide (M6G) is a metabolite of morphine with potent analgesic properties. The influence of M6G on respiratory and antinociceptive responses was investigated in mice lacking the micro -opioid receptor (MOR) and compared with morphine.

METHODS: Experiments were performed in mice lacking exon 2 of the MOR (n=18) and their wild type (WT) littermates (n=20). The influence of M6G and morphine on respiration was measured using whole body plethysmography during three ...

Known for M6g Morphine |  Opioid Receptor |  Body Plethysmography |  Carbon Dioxide |  Respiratory Depressant
KOL Index score: 9629

RATIONALE: Acute mountain sickness (AMS) may affect individuals who (rapidly) ascend to altitudes higher than 2,000-3,000 m. A more serious consequence of rapid ascent may be high-altitude pulmonary edema, a hydrostatic edema associated with increased pulmonary capillary pressures. Acetazolamide is effective against AMS, possibly by increasing ventilation and cerebral blood flow (CBF). In animals, it inhibits hypoxic pulmonary vasoconstriction.

OBJECTIVES: We examined the influence of ...

Known for Pulmonary Ventilation |  Acetazolamide Ams |  Isocapnic Hypoxia |  Rapid Ascent |  Acute Mountain Sickness
KOL Index score: 9428

Nitric oxide (NO) plays a pivotal role in the regulation of peripheral vascular tone. Its role in the regulation of cerebral vascular tone in humans remains to be elucidated. This study investigates the role of NO in hypoxia-induced cerebral vasodilatation in young healthy volunteers. The effect of the NO synthase inhibitor N(G)-monomethyl-L-arginine (L-NMMA) on the cerebral blood flow (CBF) was assessed during normoxia and during hypoxia (peripheral O(2) saturation 97 and 80%, ...

Known for Nitric Oxide |  Cbf Hypoxia |  Cerebral Vasodilation |  Magnetic Resonance |  Synthase Inhibitor
KOL Index score: 9352

We studied the effect of the antioxidants (AOX) ascorbic acid (2 g, I.V.) and alpha-tocopherol (200 mg, P.O.) on the depressant effect of subanaesthetic doses of halothane (0.11 % end-tidal concentration) on the acute isocapnic hypoxic ventilatory response (AHR), i.e. the ventilatory response upon inhalation of a hypoxic gas mixture for 3 min (leading to a haemoglobin saturation of 82 +/- 1.8 %) in healthy male volunteers. In the first set of protocols, two groups of eight subjects each ...

Known for Ventilatory Response |  Acute Hypoxic |  Ascorbic Acid |  Antioxidants Prevent |  Hypoxia Male
KOL Index score: 9228

BACKGROUND: There is evidence from animal studies suggesting the existence of a ceiling effect for buprenorphine-induced respiratory depression. To study whether an apparent ceiling effect exists for respiratory depression induced by buprenorphine, we compared the respiratory effects of buprenorphine and fentanyl in humans and rats.

METHODS: In healthy volunteers, the opioids were infused i.v. over 90 s and measurements of minute ventilation at a fixed end-tidal PCO2 of 7 kPa were ...

Known for Respiratory Effects |  Buprenorphine Fentanyl |  Minute Ventilation |  Rats Opioids |  7 Kpa


Luc JSM Teppema: Influence Statistics

Sample of concepts for which Luc JSM Teppema is among the top experts in the world.
Concept World rank
altitude duffin #1
anesthetics complex effects #1
plastic carotid bodies #1
study erythropoeitin #1
carotid bodyintact animals #1
increase pulmonary ventilation #1
erythropoeitin hvr #1
discovery reflexes #1
approaches preparations #1
hvr hcvr responses #1
to76 ± #1
higher doserange #1
entitled acetazolamide #1
breathing control functions #1
duffin letter #1
extracellular brainstem fluid #1
methazolamide phrenic #1
volatile anesthetics humans #1
lowered base #1
methazolamide pulmonary #1
placebo session increase #1
feedback male rabbits #1
co2 sensing perspective #1
nature combination #1
secondary rolloff #1
curtis smith #1
021 min1 kpa1 #1
highdose acetazolamide #1
dose acetazolamide #1
inhibitors cats #1
weakened respiratory #1
lowdose acetazolamide #1
cerebrovascular function altitude #1
acetazolamide underlying mechanisms #1
letter altitude #1
dose methazolamide #1
kg1 acetazolamide #1
reflexes additive interaction #1
effects methazolamide #1
co2mediated rise #1
032 min1 kpa1 #1

Key People For Respiratory Depression

Top KOLs in the world
Albert MD Dahan
respiratory depression ventilatory response epidural analgesia
Elise Y Sarton
respiratory depression acute pain ventilatory control
Luc JSM Teppema
respiratory depression ventilatory response carbonic anhydrase
Erik Olofsen
respiratory depression cardiac output surgical conditions
Leon P H J Aarts
cardiac output surgical conditions respiratory depression
Raymonda R Romberg
respiratory depression response surface modeling morphine analgesia

Luc JSM Teppema:Expert Impact

Concepts for whichLuc JSM Teppemahas direct influence:Respiratory depression,  Ventilatory control,  Ventilatory response,  Acute pain,  Naloxone reversal,  Carotid bodies,  Carbonic anhydrase,  Carbon dioxide.

Luc JSM Teppema:KOL impact

Concepts related to the work of other authors for whichfor which Luc JSM Teppema has influence:Respiratory depression,  Carotid body,  Chronic pain,  Ventilatory response,  Nitric oxide,  Carbonic anhydrase,  Transdermal buprenorphine.



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Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands | Anesthesiology, Leiden University Medical Center, Netherlands. | Department of Anaesthesiology, Leiden University Medical Centre, Leiden, The Netherlands | Depa

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