• Ventral Hippocampus
    • Serotonin In The Ventral...
    • Serotonin in the ventral hippocampus modulates anxiety-like behavior during amphetamine withdrawal: Influence Statistics

      Expert Impact

      Concepts for whichthey havehas direct influence:Ventral hippocampus,Amphetamine withdrawal,Anxiety behavior,Anxietylike behavior,Withdrawal amphetamine,5 ht,Serotonin 5,5ht levels.

      Key People For Ventral Hippocampus

      Top KOLs in the world
      Joram Feldon
      latent inhibition nucleus accumbens ventral hippocampus
      Edvard Ingjald Moser
      grid cells entorhinal cortex spatial learning
      Michael S Fanselow
      fear conditioning dorsal hippocampus basolateral amygdala
      Benjamin K Yee
      prepulse inhibition glycine transporter ventral hippocampus
      Menno P Witter
      entorhinal cortex hippocampal formation grid cells
      John Nicholas P Rawlins
      hippocampal lesions systemic inflammation tg2576 mice

      Serotonin in the ventral hippocampus modulates anxiety-like behavior during amphetamine withdrawal


      Withdrawal from amphetamine is associated with increased anxiety and sensitivity to stressors which are thought to contribute to relapse. Rats undergoing amphetamine withdrawal fail to exhibit stress-induced increases in serotonin (5-HT) release in the ventral hippocampus and show heightened anxiety-like behaviors. Therefore, we tested the hypothesis that reducing 5-HT levels in the ventral hippocampus is a causal mechanism in increasing anxiety-like behaviors during amphetamine withdrawal. First, we tested whether reducing 5-HT levels in the ventral hippocampus directly increases anxiety behavior. Male rats were bilaterally infused with 5,7-dihydroxytryptamine (5,7-DHT) into the ventral hippocampus, which produced a 83% decrease in ventral hippocampus 5-HT content, and were tested on the elevated plus maze (EPM) for anxiety-like behavior. Reducing ventral hippocampus 5-HT levels decreased the time spent in the open arms of the maze, suggesting that diminished ventral hippocampus 5-HT levels increases anxiety-like behavior. Next, we tested whether increasing 5-HT levels in the ventral hippocampus reverses anxiety behavior exhibited by rats undergoing amphetamine withdrawal. Rats were treated daily with either amphetamine (2.5-mg/kg, i.p.) or saline for 2weeks, and at 2weeks withdrawal, were infused with the selective serotonin reuptake inhibitor paroxetine (0.5μM) bilaterally into the ventral hippocampus and tested for anxiety-like behavior on the EPM. Rats pre-treated with amphetamine exhibited increased anxiety-like behavior on the EPM. This effect was reversed by ventral hippocampus infusion of paroxetine. Our results suggest that 5-HT levels in the ventral hippocampus are critical for regulating anxiety behavior. Increasing 5-HT levels during withdrawal may be an effective strategy for reducing anxiety-induced drug relapse.

      Sign-in to see all concepts, it's free!


    Download on the App StoreGet it on Google Play

    Copyright © 2023 Key Opinion Leaders, LLC.