 | Steffen Naegel |
Prominent publications by Steffen Naegel
Erenumab in highly therapy-refractory migraine patients: First German real-world evidence
[ PUBLICATION ]
BackgroundCalcitonin gene related peptide (CGRP) monoclonal antibodies (mAB) are the first specific migraine prophylactic medication. Erenumab is the only CGRP mAB targeting the CGRP receptor. Clinical data regarding efficacy and tolerability of erenumab in highly therapy-refractory patients are not available, yet, although many patients treated with CGRP mAB under real world conditions can be considered as highly therapy-refractory.MethodsClinical routine data of highly ...
| Also Ranks for: Migraine Patients | 3 months | gene peptide | monoclonal antibodies | cgrp receptor |
Patient-conducted anodal transcranial direct current stimulation of the motor cortex alleviates pain in trigeminal neuralgia
[ PUBLICATION ]
BACKGROUND: Transcranial direct current stimulation (tDCS) of the primary motor cortex has been shown to modulate pain and trigeminal nociceptive processing.
METHODS: Ten patients with classical trigeminal neuralgia (TN) were stimulated daily for 20 minutes over two weeks using anodal (1 mA) or sham tDCS over the primary motor cortex (M1) in a randomized double-blind cross-over design. Primary outcome variable was pain intensity on a verbal rating scale (VRS 0-10). VRS and attack ...
| Also Ranks for: Trigeminal Neuralgia | current stimulation | transcranial direct | primary motor cortex | pain intensity |
Trigeminal neuralgia (TN) is supposedly caused by an ectatic blood vessel affecting the trigeminal nerve at the root entry zone of the brain stem. Recent evidence suggests an additional central component within trigeminal pain-processing in the pathophysiology of TN. Therefore, we aimed to identify specific brain regions possibly associated with the development or maintenance of TN using magnetic resonance imaging (MRI) voxel-based morphometry (VBM). Sixty patients with classical TN were ...
| Also Ranks for: Chronic Pain | trigeminal neuralgia | gray matter | volume reduction | patients healthy controls |
BACKGROUND: Vestibular migraine affects 1% of the general population, and 30%-50% of all migraine patients describe occasionally associated vertigo or dizziness. We aimed to identify brain regions altered in vestibular migraine in order to evaluate the connection between migraine and the vestibular system.
METHODS: Seventeen patients with definite vestibular migraine were compared to 17 controls using magnetic resonance imaging-based voxel-based morphometry.
RESULTS: We found grey matter ...
| Also Ranks for: Vestibular Migraine | gm volume | brain regions | disease duration | grey matter |
BACKGROUND: The combination of vertigo, dizziness and balance disturbance with migraine is called vestibular migraine. Although it is estimated that up to 1% of the population suffers from this disease, it is still widely unknown and often underdiagnosed. Recently, the International Headache Society and the Báràny Society published the first joint document with mutually accepted diagnostic criteria for vestibular migraine.
METHOD: This review summarizes current knowledge on vestibular ...
| Also Ranks for: Vestibular Migraine | differential diagnosis | clinical presentation | vertigo dizziness | therapeutic recommendations |
Cluster headache (CH) is characterized by recurrent episodes of excruciatingly painful, unilateral headache attacks typically accompanied by trigeminal autonomic symptoms. Due to its rhythm with alternating episodes of pain and no-pain, it is an excellent model to investigate whether structural brain changes detected by magnetic resonance based voxel-based-morphometry (VBM) reflect the cause of the disease, may be a consequence of the underlying disease other than pain, or may simply be ...
| Also Ranks for: Cluster Headache | cortical plasticity | magnetic resonance | temporal lobe | structural brain |
BACKGROUND: Hypnic headache (HH) is a rare primary headache disorder that is characterized by exclusively sleep-related headache attacks. Because of its low prevalence, clinical features and therapeutic options are widely unknown or under discussion.
METHODS: Twenty patients with HH were examined and interviewed using a standardized questionnaire in regard to their clinical characteristics and effective treatment regimens. Data were evaluated according to current International Headache ...
| Also Ranks for: Hypnic Headache | therapeutic options | clinical characteristics | primary humans | low prevalence |
BACKGROUND: Persistent postural perceptual dizziness (PPPD) is the most common vestibular syndrome in middle-aged patients. Multisensory maladjustment involving alterations of sensory response pattern including vestibular, visual and motion stimuli is thought to be a key pathophysiological correlate of this disorder.
OBJECTIVE: We aimed to identify regional gray matter changes in PPPD patients that might be involved in the underlying pathophysiology of this disorder.
METHODS: 42 PPPD ...
| Also Ranks for: Gray Matter | pppd patients | perceptual dizziness | persistent postural | visual cortex |
BACKGROUND: Central facilitation of trigeminal pain processing and deficient habituation was observed in different headache and facial pain disorders. This overactivation seems to be primarily associated with chronic pain states.
OBJECTIVE: To investigate the function of the trigeminal nociceptive system in patients with hypnic headache (HH).
METHODS: Fifteen HH patients according International Classification of Headache Disorders II criteria and 15 age- and gender-matched healthy ...
| Also Ranks for: Hypnic Headache | nociceptive blink reflex | central facilitation | primary humans | evoked potentials |
Topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference
[ PUBLICATION ]
Migraine is a very common disorder characterized by the combination of typical headache with associated autonomic symptoms and/or the presence of aura. Considerable advances have been made in recent years to understand the pathophysiology of migraine, which has led to improved treatment options for the acute migraine attack as well as migraine prophylaxis. Unfortunately, preventive treatment is often insufficient to decrease migraine frequency substantially or is not well tolerated. ...
| Also Ranks for: Patient Preference | treatment migraine | efficacy safety | trials topiramate | frequency tolerated |
OBJECTIVE: To investigate whether central facilitation of trigeminal pain processing is part of the pathophysiology of cluster headache (CH).
METHODS: Sixty-six patients with CH (18 episodic CH inside bout, 28 episodic CH outside bout, 20 chronic CH) according to the International Classification of Headache Disorders-II classification, as well as 30 healthy controls, were investigated in a case-control study using simultaneous recordings of the nociceptive blink reflex (nBR) and ...
| Also Ranks for: Cluster Headache | trigeminal nociception | patients episodic | 20 chronic | international classification |
BACKGROUND: Hypnic headache (HH) is a rare primary headache disorder characterized by strictly sleep-related headache attacks. Most patients are over the age of 50 and usually awake at the same time at night with dull bilateral head pain. The pathophysiology of this headache disorder is still enigmatic but association with rapid eye movement (REM) sleep and sleep-disordered breathing (SDB) has been suggested.
METHODS: Six patients with HH according to the current International ...
| Also Ranks for: Hypnic Headache | rem sleep | disorders primary | attacks patients | pathophysiology adult |
BACKGROUND: Hypnic headache (HH) is a rare primary headache disorder that is characterised by strictly sleep-related headache attacks.
PURPOSE: Because of the low prevalence of this headache disorder, disease information is mainly based on case reports and small case series. This review summarises current knowledge on HH in regard to clinical presentation, pathophysiology, symptomatic causes and therapeutic options.
METHOD: We review all reported HH cases since its first description in ...
| Also Ranks for: Hypnic Headache | primary humans | therapeutic options | case reports | clinical presentation |
Polarity-specific modulation of pain processing by transcranial direct current stimulation – a blinded longitudinal fMRI study
[ PUBLICATION ]
BackgroundTo enrich the hitherto insufficient understanding regarding the mechanisms of action of transcranial direct current stimulation (tDCS) in pain disorders, we investigated its modulating effects on cerebral pain processing using functional magnetic resonance imaging (fMRI).MethodsThirteen right-handed healthy participants received 20 min of 1.5 mA tDCS applied over the primary motor cortex thrice and under three different stimulation pattern (1.anodal-tDCS, 2.cathodal-tDCS, and ...
| Also Ranks for: Pain Processing | direct current | stimulation tdcs | motor cortex | dorsolateral prefrontal |
OBJECTIVE: Hypnic headache (HH) is a rare primary headache disorder characterized by strictly nocturnal headache attacks that mostly occur at the same time at night. The pathophysiology of this disease is poorly understood, but hypothalamic involvement was suspected as the hypothalamus represents the cerebral management center of sleep regulation and pain control.
METHODS: Fourteen patients with HH and 14 age-matched and gender-matched healthy controls were investigated using magnetic ...
| Also Ranks for: Hypnic Headache | gray matter | posterior hypothalamus | primary humans | hypothalamic involvement |
Steffen Naegel: Influence Statistics
| Concept | World rank |
|---|---|
| reduction medication overuse | #2 |
| medication overuse therapy | #2 |
| highly selected erenumab | #2 |
| previous prophylaxis treatments | #2 |
| therapy erenumab | #2 |
| migraine fgf21 | #3 |
| growthfactor 21 fgf21 | #3 |
| gdf15 migraine | #3 |
| 27587 pg | #3 |
| mannwhitney test bmi | #3 |
| growthdifferentiationfactor | #3 |
| erenumab therapy | #3 |
| gdf15 migraine patients | #3 |
| gdf15 detected | #3 |
| 50665 ± | #3 |
| motion sickness rotation | #4 |
| báránysociety | #4 |
| sickness vm | #4 |
| sleeprelated headache attacks | #4 |
| chair shielded | #4 |
| posterior hypothalamus works | #4 |
| headache character conclusions | #4 |
| sensitized rotatory | #4 |
| investigated sitting | #4 |
| electrophysiology studies effectiveness | #4 |
| symptomatic headache types | #4 |
| decades cerebral imaging | #4 |
| background hypnic headache | #4 |
| structural multiple structures | #4 |
| data cerebral imaging | #4 |
| sickness rating scale | #4 |
| rotation vm patients | #4 |
| cerebral imaging investigation | #4 |
| strictly sleep | #4 |
| vm patients hc | #4 |
| pathophysiology hypnic | #4 |
| primary humans purpose | #4 |
| shielded visual | #4 |
| pathophysiology hypnic headache | #4 |
| attack frequency reduction | #5 |
| anodal weeks | #5 |
| conducted anodal | #5 |
| occasionally vertigo | #5 |
| onset instant chronification | #5 |
| image interpretation vestibular | #5 |
| slowly increasing velocity | #5 |
| grey matter pathophysiology | #5 |
| pain stimuli terms | #5 |
| motorized rotary chair | #5 |
| attack frequency tdcs | #5 |
Key People For Vestibular Migraine
Steffen Naegel:Expert Impact
Concepts for whichSteffen Naegelhas direct influence:Vestibular migraine, Hypnic headache, Cluster headache, Nociceptive blink reflex, Gray matter, Pain processing, Migraine patients, Chronic migraine.
Steffen Naegel:KOL impact
Concepts related to the work of other authors for whichfor which Steffen Naegel has influence:Vestibular migraine, Cluster headache, Trigeminal neuralgia, Chronic pain, Gray matter, Functional connectivity, Patients vm.
Tools
Is this your profile? Claim your profile Copy URL Embed Link to your profile |