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  • Visual Acuity
  • Charles Stephen Foster

    Prominent publications by Charles Stephen Foster

    KOL Index score: 20590

    PURPOSE: Conjunctival fibrosis due to excessive accumulation of collagens is an important histologic feature in ocular cicatricial pemphigoid (OCP). Studies have suggested a role of transforming growth factor (TGF)-beta1 in conjunctival fibrosis in patients with OCP. Connective tissue growth factor (CTGF) is an important downstream mediator of TGF-beta1-induced collagen synthesis. CTGF usually acts synergistically with TGF-beta1 during the process of fibrosis in various organs. Hence, ...

    Also Ranks for: Growth Factor |  patients ocp |  ocular cicatricial pemphigoid |  conjunctival fibrosis |  expression ctgf
    KOL Index score: 19814

    PURPOSE: Submucosal fibrosis due to excessive accumulation of collagens is an important histologic feature in the pathogenesis of ocular cicatricial pemphigoid (OCP). Heat shock protein 47 (HSP47), a collagen-binding protein, plays an important role in the biosynthesis of procollagens. In the present study, we examined the role of HSP47 in conjunctival scarring in patients with OCP.

    METHODS: Biopsy specimens of the conjunctiva of 15 patients with OCP and 5 normal subjects were studied ...

    Also Ranks for: Conjunctival Scarring |  patients ocp |  heat shock |  ocular cicatricial pemphigoid |  expression hsp47
    KOL Index score: 16803

    PURPOSE: To evaluate the efficacy and safety of the fluocinolone acetonide (Retisert) implant compared with the dexamethasone (Ozurdex) implant in patients with noninfectious uveitis.

    DESIGN: Comparative case series.

    STUDY PARTICIPANTS: Twenty-seven eyes received either the fluocinolone acetonide (FA) (n=16) or dexamethasone (n=11) implant.

    METHODS: Chart review of patients at the Massachusetts Eye Research and Surgery Institution (MERSI) was done and patients were selected and matched ...

    Also Ranks for: Fluocinolone Acetonide |  intravitreal implants |  cataract progression |  dexamethasone ozurdex |  noninfectious uveitis
    KOL Index score: 16377

    OBJECTIVE: To evaluate the demographic characteristics, clinical features, ocular complications, and disease associations of patients with scleritis and episcleritis; as well as to delineate the risk factors for decreased vision in patients with scleritis.

    DESIGN: Retrospective case series.

    PARTICIPANTS: Five hundred patients with scleritis and 85 patients with episcleritis.

    METHODS: The electronic health records of 500 patients with scleritis and 85 patients with episcleritis seen at 2 ...

    Also Ranks for: Patients Scleritis |  ocular complications |  clinical characteristics |  anterior uveitis |  large cohort
    KOL Index score: 14712

    OBJECTIVE: To investigate the levels of matrix metalloproteinases (MMPs), myeloperoxidase (MPO), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in tears of patients with Stevens-Johnson syndrome (SJS) and ocular cicatricial pemphigoid (OCP).

    DESIGN: Prospective, noninterventional cohort study.

    PARTICIPANTS: Four SJS patients (7 eyes), 19 OCP patients (37 eyes), and 20 healthy controls who underwent phacoemulsification (40 eyes).

    METHODS: Tear washes were collected from all patients ...

    Also Ranks for: Mmp8 Mpo |  ocular cicatricial pemphigoid |  johnson syndrome |  timp1 sjs |  ocp patients
    KOL Index score: 14546

    OBJECTIVE: To evaluate the safety and efficacy of Ahmed glaucoma valve implantation for the management of glaucoma associated with chronic uveitis.

    DESIGN: Retrospective, noncomparative case series.

    PARTICIPANTS: Nineteen patients (21 eyes) with chronic uveitis underwent Ahmed glaucoma valve implantation for uncontrolled glaucoma between 1995 and 1998.

    INTERVENTION: All patients had their uveitis controlled before surgery via immunomodulatory therapy. Ahmed glaucoma valve implantation ...

    Also Ranks for: Valve Implantation |  ahmed glaucoma |  chronic uveitis |  intraocular pressure |  visual acuity
    KOL Index score: 14463

    PURPOSE: To evaluate the outcomes of treatment with mycophenolate mofetil in patients with scleritis and uveitis refractory to or intolerant of methotrexate.

    DESIGN: Retrospective noncomparative case series.

    PARTICIPANTS: Eighty-five patients with scleritis and/or uveitis who failed with or did not tolerate methotrexate and were subsequently treated with mycophenolate mofetil between 1998 and 2006.

    METHODS: We reviewed medical records of patients who were treated with mycophenolate ...

    Also Ranks for: Mycophenolate Mofetil |  patients scleritis |  inflammation control |  uveitis methotrexate |  treatment failure
    KOL Index score: 13390

    OBJECTIVE: To evaluate the safety and efficacy of 2 doses of dexamethasone intravitreal implant (DEX implant) for treatment of noninfectious intermediate or posterior uveitis.

    METHODS: In this 26-week trial, eyes with noninfectious intermediate or posterior uveitis were randomized to a single treatment with a 0.7-mg DEX implant (n = 77), 0.35-mg DEX implant (n = 76), or sham procedure (n = 76).

    MAIN OUTCOME MEASURE: The main outcome measure was the proportion of eyes with a vitreous haze ...

    Also Ranks for: Noninfectious Intermediate |  dexamethasone intravitreal |  dex implant |  posterior uveitis |  vitreous haze score
    KOL Index score: 12238

    PURPOSE: Two multicenter studies compared the efficacy and safety of rimexolone 1% ophthalmic suspension (Vexol 1%, Alcon) and 1% prednisolone acetate (Pred Forte, Allergan).

    METHODS: Patients with acute uveitis, recurrent iridocyclitis, or chronic uveitis treatable by topical corticosteroid were enrolled. Treatment regimen was one or two drops every hour during Week 1, every two hours during Week 2, four times a day during Week 3, and once a day for the last three days. Efficacy and ...

    Also Ranks for: Rimexolone 1 |  efficacy safety |  ophthalmic suspension |  treatment uveitis |  anterior chamber
    KOL Index score: 11821

    Interleukin-17A (IL-17A) is elaborated by the T helper 17 (T(H)17) subset of T(H) cells and exhibits potent proinflammatory properties in animal models of autoimmunity, including collagen-induced arthritis, experimental autoimmune encephalomyelitis, and experimental autoimmune uveitis. To determine whether IL-17A mediates human inflammatory diseases, we investigated the efficacy and safety of AIN457, a human antibody to IL-17A, in patients with psoriasis, rheumatoid arthritis, and ...

    Also Ranks for: Rheumatoid Arthritis |  patients psoriasis |  monoclonal antibodies |  human antibody |  animal models
    KOL Index score: 11545

    PURPOSE: To report the outcomes of combined phacoemulsification and pars plana vitrectomy (PPV) to restore visual acuity in patients with cataract and posterior segment involvement secondary to chronic uveitis.

    SETTING: Ocular Immunology and Uveitis Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.

    METHODS: This study comprised 34 patients (20 women, 14 men; 36 eyes) with posterior segment involvement secondary to chronic uveitis who had ...

    Also Ranks for: Chronic Uveitis |  plana vitrectomy |  visual acuity |  combined phacoemulsification |  patients cataract
    KOL Index score: 11453

    PURPOSE: To evaluate the outcome of treatment with methotrexate for noninfectious ocular inflammation.

    DESIGN: Retrospective cohort study.

    PARTICIPANTS: Patients with noninfectious ocular inflammation managed at 4 tertiary ocular inflammation clinics in the United States observed to add methotrexate as a single, noncorticosteroid immunosuppressive agent to their treatment regimen, between 1979 and 2007, inclusive.

    METHODS: Participants were identified from the Systemic Immunosuppressive ...

    Also Ranks for: Inflammatory Diseases |  child child |  6 months |  1 year |  outcome measures
    KOL Index score: 11409

    Epidermolysis bullosa acquisita (EBA) is a chronic, uncommon, sub-epidermal blistering disease involving the skin and mucous membranes that heals with scar formation and milia. Collagens, matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are important components that play an essential role(s) in matrix remodeling during scar formation. However, the possible involvement of these components in EBA-induced scarring is not yet known. In the present study, ...

    Also Ranks for: Conjunctival Fibroblasts |  bullosa acquisita eba |  mmps timps |  increased expression |  collagen hsp47


    Charles Stephen Foster: Influence Statistics

    Sample of concepts for which Charles Stephen Foster is among the top experts in the world.
    Concept World rank
    eyes noninfectious uveitis #1
    lysates ocp sera #1
    stepladder approach #1
    vitritis retinal vasculitis #1
    birdshot chorioretinitis lesions #1
    scleritis risk factors #1
    alkali burning ulcers #1
    bsrc treatment #1
    vitreous haze grading #1
    hsk incidence #1
    immunomodulatory therapy #1
    rtx rituximab time #1
    uveitis surgery #1
    systemic immunosuppression treatment #1
    patients serpiginous #1
    autoimmune uveitis mmf #1
    retinochoroidopathy #1
    anterior intermediate uveitis #1
    idiopathic scleritis patients #1
    cataract 2 #1
    recurrent nodular scleritis #1
    saids patients #1
    hlab27associated chronic uveitis #1
    chronic keratoconjunctivitis #1
    classic immunomodulation #1
    hsp47 conjunctival scarring #1
    lirentelimab treatment #1
    organ eye #1
    tdr allergic conjunctivitis #1
    patients scleritis #1
    scleritis episcleritis #1
    uveitis time #1
    bilateral uveitis #1
    hsr hsv #1
    hypotony patient #1
    ivta ivb groups #1
    dexamethasone intravitreal implants #1
    uveitis purpose #1
    interleukin 1 components #1
    patients conjunctiva #1
    bromfenac ivb #1
    autoimmune disease eau #1
    egp437 #1
    acyclovir followup #1
    conjunctival biopsy #1
    prednisolone acetate 1 #1
    lirentelimab severe #1
    eye initial #1
    reliability ommp #1
    immunisation hsv1 keratitis #1

    Key People For Visual Acuity

    Top KOLs in the world
    Paul A Mitchell
    visual impairment diabetic retinopathy cataract surgery
    Ronald E Klein
    diabetic retinopathy beaver dam atherosclerosis risk
    Frederick L III Ferris
    diabetic retinopathy visual acuity macular edema
    Neil M Bressler
    visual acuity diabetic macular edema choroidal neovascularization
    Barbara E K Klein
    diabetic retinopathy beaver dam blood pressure
    Wong Tien Yin Wong
    diabetic retinopathy blood pressure retinal vascular caliber

    Charles Stephen Foster:Expert Impact

    Concepts for whichCharles Stephen Fosterhas direct influence:Visual acuity,  Ocular cicatricial pemphigoid,  Cataract surgery,  Ocular inflammation,  Anterior uveitis,  Noninfectious uveitis,  Cicatricial pemphigoid,  Rheumatoid arthritis.

    Charles Stephen Foster:KOL impact

    Concepts related to the work of other authors for whichfor which Charles Stephen Foster has influence:Visual acuity,  Macular edema,  Ocular surface,  Cataract surgery,  Dry eye,  Rheumatoid arthritis,  Anterior uveitis.



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    Ocular Immunology & Uveitis Foundation, Waltham, MA, USA | Department of Ophthalmology, Harvard Medical School, Boston, MA, USA | Massachussetts Eye Research and Surgery Institution, Waltham, MA, USA | Massachusetts Eye Research & Surgery Institution