Prominent publications by Diane M Bless

KOL Index score: 15251

BACKGROUND/OBJECTIVES: When the lamina propria of the vocal fold is replaced by fibrosis after wound healing, it is difficult to restore an appropriate viscoelasticity of the vocal fold. To treat fibrotic scarring, material that reduces collagen deposition and increases soft amorphous substances, such as hyaluronic acid, is required. The potential use of hepatocyte growth factor (HGF) is intriguing. In this study, the authors examined canine vocal fold fibroblasts to determine how HGF ...

Known for Growth Factor |  Extracellular Matrix |  Vocal Fold |  Collagen Type |  Hyaluronic Acid
KOL Index score: 12729

OBJECTIVES/HYPOTHESIS: Vocal fold scarring disrupts the layer structure of the vocal fold lamina propria that is essential for optimal mucosal vibration. Prevention of vocal fold scarring remains challenging. Hepatocyte growth factor (HGF) has strong antifibrotic activity. The authors' previous studies have found that HGF stimulates hyaluronic acid production and suppresses collagen production from vocal fold fibroblasts, suggesting that HGF has therapeutic potential in prevention of ...

Known for Vocal Fold Scarring |  Rabbit Model |  Hepatocyte Growth |  Hgf Treated |  Wound Healing
KOL Index score: 10244

Vocal fold scarring remains a therapeutic challenge. Hepatocyte growth factor (HGF) has strong antifibrotic activity and has proved to have therapeutic potential in restoration of scar tissues such as liver cirrhosis and lung fibrosis. The present study aimed to clarify the effects of HGF injection into scarred vocal folds in a canine model. Canine vocal folds were stripped unilaterally and treated with intracordal injection of saline solution (sham group), HGF (HGF group), or HGF with ...

Known for Canine Model |  Vocal Fold Scarring |  Growth Factor |  Hgf Sham |  Therapeutic Potential
KOL Index score: 9820

OBJECTIVES: Vocal fold scarring is the major cause of voice disorders after voice surgery or laryngeal trauma. The role of inflammatory factors in vocal fold wound healing and fibrosis has not been adequately investigated. Scarless wound healing has been associated with decreased inflammatory responses. To understand scar formation and develop reliable treatments, it is necessary to control extracellular matrix production and inflammation. Thus, we examined the inflammation profile and ...

Known for Scar Formation |  72 Hours |  Vocal Folds |  Inflammatory Response |  Messenger Rats
KOL Index score: 8850

OBJECTIVES/HYPOTHESIS: It has been reported that in aged vocal folds, dense collagen deposition takes place and hyaluronic acid decreases in the lamina propria, which are thought to contribute to the vocal problems occurring with age (presbyphonia). To restore aged vocal folds to their younger state, it seems crucial to address these age-related lamina propria changes. Intervention that might increase hyaluronic acid and decrease collagen would appear to be a potentially useful approach. ...

Known for Growth Factor |  Aging Voice |  Therapeutic Potential |  Hyaluronic Acid |  Aged Vocal
KOL Index score: 8683

PURPOSE: To develop and evaluate a rat excised larynx model for the measurement of acoustic, aerodynamic, and vocal fold vibratory changes resulting from vocal fold scar.

METHOD: Twenty-four 4-month-old male Sprague-Dawley rats were assigned to 1 of 4 experimental groups: chronic vocal fold scar, chronic vocal fold scar treated with 100-ng basic fibroblast growth factor (bFGF), chronic vocal fold scar treated with saline (sham treatment), and unscarred untreated control. Following tissue ...

Known for Vocal Fold |  Excised Larynx |  Vibratory Amplitude |  Collagen Type |  Bfgf Treated
KOL Index score: 8562

OBJECTIVES/HYPOTHESIS: The objective was to measure the level of hyaluronan during the first 15 days after vocal fold biopsy in a rabbit model.

STUDY DESIGN: Experimental, nonrandomized prospective study.

METHODS: Twenty-eight rabbits underwent unilateral vocal fold biopsy. The contralateral vocal fold was preserved as a control sample. On days 3, 5, 10, and 15 after biopsy, hyaluronan levels in the injured and normal vocal folds were measured immunohistologically and with an ELISA ...

Known for Vocal Fold |  3 5 |  Rabbit Model |  Objectives Hypothesis |  Wound Repair
KOL Index score: 8330

The purpose of the current study was to assess the histologic and rheologic properties of the scarred vocal fold lamina propria during a chronic phase of wound repair in a rabbit model. Eighteen rabbit larynges were scarred using a procedure that involved stripping the vocal fold lamina propria down to the thyroarytenoid muscle, using 3-mm microforceps. The approximate dimension of injury to the vocal fold was 3 x 1.5 x 0.5 mm [length x width x depth]. At 6 months postoperatively, ...

Known for Rabbit Model |  Vocal Fold |  6 Months |  Hyaluronic Acid |  Wound Repair
KOL Index score: 8276

OBJECTIVE: To examine the expressions of fibronectin and other adhesion molecules on the scarred vocal folds in a short- and long-term animal model.

STUDY DESIGN: Animal model.

METHODS: Six beagles' vocal folds were stripped unilaterally and left untreated. After wounding the vocal folds were harvested from three dogs at 2 months and three dogs at 6 months. The untouched vocal fold was used as a control, and the stripped vocal fold as scarred. Subsequently, the expressions of ...

Known for Vocal Folds |  6 Months |  Deposition Collagen |  Animal Model |  Lamina Propria
KOL Index score: 8274

OBJECTIVES: The purpose of this study was to quantify disorder-specific signature kinematic disturbances of vibratory motion in adductor spasmodic dysphonia (AdSD) and muscle tension dysphonia (MTD), in voice disturbances of a severe nature, with the use of high-speed digital imaging (HSDI). A secondary hypothesis of the study was to investigate the sensitivity and specificity of the signature kinematic features obtained from HSDI, in differentiating between AdSD and MTD.


Known for Adductor Spasmodic Dysphonia |  Adsd Mtd |  Muscle Tension |  Vibratory Characteristics |  Digital Imaging
KOL Index score: 8267

OBJECTIVES: Inflammatory factors are key mediators of wound healing processes following injury, and their modulation may improve healing outcomes. The objective of this study was to characterize in vivo inflammatory factor and extracellular matrix (ECM) messenger RNA (mRNA) expression levels 1 hour after vocal fold injury.

METHODS: Five Sprague-Dawley rats were subjected to bilateral vocal fold injury, 5 rats were reserved as uninjured controls, and 1 rat was subjected to unilateral ...

Known for Vocal Fold |  Uninjured Controls |  Messenger Rats |  Extracellular Matrix |  Mrna Expression
KOL Index score: 8236

Hyaluronan (HYA) is considered to be a crucial factor in scarless wound healing and in maintaining tissue viscosity of the vocal fold lamina propria. In this study focusing on the effects of growth factors, we examined how HYA is produced and controlled in canine cultured vocal fold fibroblasts. Fibroblasts were taken from the lamina propria of the vocal folds of 8 dogs and cultured with and without growth factors. The production of HYA in the supernatant culture was quantitatively ...

Known for Growth Factors |  Vocal Fold |  Lamina Propria |  Tissue Viscosity |  Factor Transforming
KOL Index score: 8228

Vocal fold fibrotic scar is characterized by fibrosis of the lamina propria and epithelium, and is difficult to treat. Hepatocyte growth factor (HGF) has antifibrotic activity and has received attention as a possible therapeutic alternative to treat fibrosis. In this study, in order to clarify whether HGF can be involved in vocal fold scarring, we examined the existence of HGF and its receptor, c-Met, in rat vocal folds, and then the activity of HGF in rabbit injured vocal folds, using ...

Known for Hepatocyte Growth Factor |  Vocal Fold |  Lamina Propria |  Hgf Cmet |  Wound Healing
KOL Index score: 8172

OBJECTIVES: High-speed digital imaging (HSDI), unlike stroboscopy, is a frequency-independent visualization technique that provides detailed biomechanical assessment of vocal physiology due to increased temporal resolution. The purpose of this study was to investigate the clinical value of HSDI compared to that of stroboscopy across 3 disorder groups classified as epithelial, subepithelial, and neurologic disorders.

METHODS: Judgments of vibratory features of vocal fold edge, glottal ...

Known for Hsdi Data |  Digital Imaging |  Voice Disorders |  Glottal Closure |  Aged Stroboscopy
KOL Index score: 8108

Scarring of the vocal fold causes considerable dysphonia and presents significant treatment challenges. A rabbit model was developed to investigate the histologic ultrastructure and rheologic properties of the scarred vocal fold lamina propria. Eleven rabbit larynges were scarred by means of forcep biopsy. Sixty days postoperatively, the rabbits were sacrificed and their vocal folds were harvested. Histological analysis of the scarred and normal lamina propria was completed for collagen, ...

Known for Vocal Fold Scarring |  Lamina Propria |  Scarred Tissues |  Hyaluronic Acid |  Collagen Procollagen


Diane M Bless: Influence Statistics

Sample of concepts for which Diane M Bless is among the top experts in the world.
Concept World rank
ptp ocr #1
3dayold mf #1
optimal voice improvement #1
phonatory variables #1
incision middle region #1
peroral injection #1
lta regeneration #1
glottal measures #1
suture direction #1
digitized glottal measures #1
nyquist plot patterns #1
nonvibratory portion #1
effort toxin #1
hgf fbmf #1
treatment outcomes animals #1
3weekold 8monthold mfs #1
perceptually normal voices #1
airflow chink #1
mechanisms injectable collagen #1
type fbrs #1
speed laryngeal #1
muscle lta #1
injection thyroarytenoid #1
aerodynamic studies videostroboscopy #1
collagen treated larynges #1
analysis glottal characteristics #1
bfgftreated larynges #1
segmentation scheme #1
sham hgf #1
posterior cricoarytenoid differences #1
cellular composition density #1
regional undermining #1
cases uvp #1
highspeed laryngeal imaging #1
folds hyaluronic #1
arytenoid adduction procedures #1
confirming indications #1
fb hgf groups #1
collagenous fibers fibrils #1
echinacea vocal #1
elastin synthase #1
vibrating vocal folds #1

Key People For Vocal Fold

Top KOLs in the world
Ingo R Titze
vocal fold fundamental frequency phonation threshold pressure
Diane M Bless
vocal fold voice disorders hepatocyte growth factor
Charles N Ford
vocal fold spasmodic dysphonia botulinum toxin
Robert Thayer Sataloff
vocal fold hearing loss laryngopharyngeal reflux
Roger W Chan
vocal fold hyaluronic acid lamina propria
lamina propria voice disorders vocal folds

Diane M Bless:Expert Impact

Concepts for whichDiane M Blesshas direct influence:Vocal fold,  Vocal folds,  Hepatocyte growth factor,  Collagen type,  Glottic insufficiency,  Sulcus vocalis,  Injectable collagen,  Vocal fold scarring.

Diane M Bless:KOL impact

Concepts related to the work of other authors for whichfor which Diane M Bless has influence:Vocal fold,  Voice disorders,  Spasmodic dysphonia,  Botulinum toxin,  Fundamental frequency,  Wound healing,  Lamina propria.



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Department of Surgery Division of Otolaryngology, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin | Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison, Madison, WI, USA | Divisi

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