Diane M. Bless

Diane M. Bless

From The Division Of Otolaryngology–head And Neck Surgery. Department Of Surgery, University Of Wisconsin Medical School, Madison, Wisconsin. This Study Was Supported By Grant ...

Direct Impact

Concepts for which Diane M Bless has direct influence:

vocal fold
spasmodic dysphonia
glottic insufficiency
hepatocyte growth factor
voice disorders
lamina propria
injectable collagen

External impact

Concepts related to the work of other authors for which Diane M Bless has influence:

laryngeal carcinoma
hepatocyte growth factor
vocal folds
rat larynx
soleus muscle
bone marrow
neuromuscular junctions

Prominent publications by Diane M. Bless

KOL-Index: 22 OBJECTIVES/HYPOTHESIS: Regenerative properties of age-associated changes in the intrinsic laryngeal muscles following injury are unclear. The purpose of this study was to investigate the regenerative properties of the thyroarytenoid (TA) muscle in an aging rat model. The hypothesis was that following myotoxic injury, old animals would exhibit a decrease in mitotic activities of muscle ...
KOL-Index: 20 Botulinum neurotoxin (BoNT) injection into the thyroarytenoid (TA) muscle is a commonly performed medical intervention for adductor spasmodic dysphonia. The mechanism of action of BoNT at the neuromuscular junction is well understood, however, aside from reports focused on myosin heavy chain isoform abundance, there is a paucity of data addressing the effects of therapeutic BoNT injection on ...
Known for
Therapeutic Bont Injection | Maldi-Ms | Unilateral Muscle Bont | 2-D Sds-Page
KOL-Index: 19 Vocal fold fibrotic scar is characterized by fibrosis of the lamina propria and epithelium, and is difficult to treat. Hepatocyte growth factor (HGF) has antifibrotic activity and has received attention as a possible therapeutic alternative to treat fibrosis. In this study, in order to clarify whether HGF can be involved in vocal fold scarring, we examined the existence of HGF and its ...
Known for
Activity Hgf | Reepithelialization | Therapeutic Alternative | Injured Vocal Folds
KOL-Index: 17 Vocal fold scarring remains a therapeutic challenge. Hepatocyte growth factor (HGF) has strong antifibrotic activity and has proved to have therapeutic potential in restoration of scar tissues such as liver cirrhosis and lung fibrosis. The present study aimed to clarify the effects of HGF injection into scarred vocal folds in a canine model. Canine vocal folds were stripped unilaterally and ...
Known for
Cultured Autologous Normal Vocal | Collagen Sham | Considerable Potential | Scarring Vibratory
KOL-Index: 16 OBJECTIVES: To characterize the acute and chronic cellular effects of botulinum toxin (BT) injection into rat laryngeal muscles. A complete characterization of these effects is important because patients with focal dystonias of the head and neck are commonly treated with BT injection. Further, potential muscular changes in the larynx must be carefully delineated owing to the critical ...
Known for
Proliferative Response | Mitotically Active Nuclei | Injection Rat | Brdu-Labeled Cells
KOL-Index: 16 OBJECTIVE: The purpose of the study was to evaluate the inter-judge and intra-judge reliability of raters using the Voice-Vibratory Assessment with Laryngeal Imaging (VALI) rating form that was developed for assessing videostroboscopy and high-speed videoendoscopic (HSV) recordings. SUBJECTS AND METHODS: Nine speech-language pathologists with an average of 12.8 years of experience with ...
Known for
Current Form | Nonvibratory Portion | Vertical Level | Phase Closure
KOL-Index: 16 To examine whether personality has causal, concomitant, or outcome status in common voice disorders, a vocally normal control group and 4 groups with voice disorders--functional dysphonia (FD), vocal nodules (VN), spasmodic dysphonia (SD), and unilateral vocal fold paralysis (UVFP)--were compared using the Multidimensional Personality Questionnaire (MPQ). Univariate and discriminant analyses ...
Known for
Groups Voice | Multidimensional Personality Questionnaire | Unilateral Vocal Fold Paralysis | Lower-Trait
KOL-Index: 15 OBJECTIVES/HYPOTHESIS: The purpose of this study was to compare the clinical effectiveness of type I thyroplasty, injection laryngoplasty, and graft implantation for the treatment of vocal fold scar and pathologic sulcus vocalis. STUDY DESIGN: Prospective, multi-arm, quasi-experimental research design. METHODS: Twenty-eight patients with newly diagnosed vocal fold scar and/or pathologic ...
Known for
Improvement Vocal | Reduced Voice Handicap | 18 Months Posttreatment | Laryngoplasty Graft
KOL-Index: 15 OBJECTIVE: The primary goal of this study was to evaluate a nonlinear dynamic approach to the acoustic analysis of dysphonia associated with vocal fold scar and sulcus vocalis. STUDY DESIGN: Case-control study. METHODS: Acoustic voice samples from scar/sulcus patients and age-/sex-matched controls were analyzed using correlation dimension (D2) and phase plots, time-domain based perturbation ...
Known for
Acoustic Dysphonia | Bifurcations | Time-Domain Algorithms | Nonlinear Dynamic Approach
KOL-Index: 15 BACKGROUND/OBJECTIVES: When the lamina propria of the vocal fold is replaced by fibrosis after wound healing, it is difficult to restore an appropriate viscoelasticity of the vocal fold. To treat fibrotic scarring, material that reduces collagen deposition and increases soft amorphous substances, such as hyaluronic acid, is required. The potential use of hepatocyte growth factor (HGF) is ...
Known for
Fibrotic Scarring | Supernatants Culture | Production Transforming | Excessive Fibronectin

From the Division of Otolaryngology–Head and Neck Surgery. Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin. This study was supported by grant R01 DC4428 from the National Institute on Deafness and Other Communication

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