• Disease
  • Voluntary
  • Voluntary Intake
  • Jean Pierre Lhuintre

    Prominent publications by Jean Pierre Lhuintre

    KOL Index score: 8831

    Adult male Long Evans were selected as ethanol preferring rats (DR) during 28 days. After this period, they were daily IP injected during 14 days with one of the next drugs: diazepam 1 mg.kg-1, alprazolam 1 mg.kg-1 (benzodiazepines), progabide 25 mg. kg-1 (GABA A and B agonist), nipecotic acid 150 mg.kg-1 (GABA uptake inhibitor), muscimol 0.2 mg.kg-1 (GABA A agonist), AOAA 10 mg.kg-1 (GABA decarboxylase inhibitor), baclofen 3 mg.kg-1 (GABA B agonist), or NaCl 0.9% (1 ml/200 g). During ...

    Also Ranks for: Ethanol Intake |  gaba transmission |  rats receptors |  benzodiazepine receptor |  free choice
    KOL Index score: 6853

    Ethanol preferring rats were selected and showed a constant voluntary intake of a 12 percent ethanol solution during 14 days (about 5 g/kg body weight daily). Analysis of 3H serotonin uptake by striatal synaptosomes showed that steady state 3H serotonin synaptosomal levels were lower in alcohol preferring rats. Grouping these rats (5 per cage) reduced both voluntary intake of ethanol and synaptosomal 3H serotonin uptake. Furthermore, blocking the serotonin uptake by clomipramine 5 mg X ...

    Also Ranks for: Voluntary Intake |  serotonin uptake |  ethanol rats |  striatal synaptosomes |  synaptosomal 3h
    KOL Index score: 6837

    The effects of some derivatives of homotaurine (3 APS), the well known GABA agonist, were tested on the voluntary intake of ethanol by rats. Spontaneously ethanol drinking rats (DR) were selected and had a constant voluntary intake of ethanol by rats. Spontaneously ethanol drinking rats (DR) were selected and had a constant voluntary intake of a 12% ethanol solution (VIE) during 14 days (about 5 g/kg body weight daily). Calcium acetylhomotaurine (0.26 and 0.52 mmol/kg daily IP) ...

    Also Ranks for: Voluntary Intake |  ethanol rats |  gaba receptors |  calcium acetylhomotaurine |  alcohol drinking
    KOL Index score: 6269

    After they had been weaned off alcohol in hospital 85 severe alcoholics (above 200 g alcohol/day) were included in a double-blind study of calcium bis acetyl homotaurine (Ca AOTA, 25 mg/kg/day), a new gamma-aminobutyric acid agonist, versus placebo. Patients were treated as outpatients during the 3-month study. The only other treatment that patients received was meprobamate, 800 to 1200 mg/day, in the first month. The criterion for success was abstinence at 3 months (with normal ...

    Also Ranks for: Weaned Alcoholics |  acetyl homotaurine |  prevent relapse |  placebo patients |  acamprosate adult
    KOL Index score: 4836

    The kinetic parameters of 3H-paroxetine binding and 3H-serotonin uptake were studied in platelets of alcoholic patients. There was no difference between alcoholic and non alcoholic subjects in 3H-paroxetine binding. When binding and 3H-serotonin uptake were studied, in the same plasma of the same subjects, the Vmax of serotonin uptake was increased in alcoholics. The data confirm the involvement of serotonin uptake system in alcohol dependence and suggest that serotonin uptake and ...

    Also Ranks for: Serotonin Uptake |  alcoholic patients |  paroxetine binding |  platelets 3h |  alcohol dependence
    KOL Index score: 4391

    The kinetics of 3H serotonin platelet uptake were studied in alcoholics and former alcoholics to see whether differences found between alcohol-preferring and non-preferring rats could be reproduced in man. Three groups of patients were studied: 10 dependent alcoholics on admission for treatment; 10 dependent alcoholics after 20 days of treatment; 8 former dependent alcoholics, abstinent for 1-11 years. Controls were non-alcoholics, matched for age and sex. The Km for 3H serotonin uptake ...

    Also Ranks for: Alcohol Dependence |  biological marker |  vitro techniques |  serotonin uptake |  blood platelets
    KOL Index score: 3200

    3H-nipecotic acid (3H-NIP) binding to GABA uptake recognition sites was studied in the hippocampus of 3 groups of male, Long Evans rats: Group 1: ethanol-naive rats (ENR); Group II: ethanol-preferring rats (DR) and non-preferring rats (NDR), which had consumed about 5 g.kg-1.d-1 and 1 g-1.d-1 of alcohol respectively in the form of a 12% ethanol solution prior to 3H-NIP binding analysis; Group III: DR and NDR who had had no access to ethanol for 21 d after the initial exposure of ethanol ...

    Also Ranks for: Gaba Uptake |  hippocampus male |  aminobutyric acid |  affinity 3h
    KOL Index score: 2170

    Ethanol preferring and non preferring rats were selected. Ethanol preferring rats showed a constant voluntary intake of a 12% ethanol solution during 14 days (about 5 g/kg body weight daily) while the non preferring rats drank less than 1 g/kg body weight daily. Preferring rats were daily IP injected with 5 or 10 mg/kg of nomifensine, an inhibitor of dopamine uptake. Their intake of ethanol solution remained constant during the 14 days of treatment. Dopamine uptake into striatal ...

    Also Ranks for: Dopamine Uptake |  nomifensine rats |  alcohol drinking |  corpus striatum |  ethanol solution
    KOL Index score: 924
    Also Ranks for: Proctalgia Fugax |  diltiazem female humans


    Jean Pierre Lhuintre: Influence Statistics

    Sample of concepts for which Jean Pierre Lhuintre is among the top experts in the world.
    Concept World rank
    platelets kinetic parameters #1
    kinetic parameters platelets #1
    involvement serotonin uptake #1
    3hparoxetine binding plasma #1
    alcoholic patients platelets #1
    difference 3hparoxetine binding #1
    alcoholic patients difference #1
    platelets alcoholic patients #1
    serotonin uptake alcoholics #1
    ndr iii #4
    5 gkg1d1 #4
    bmax iii #4
    agonist aoaa #4
    ethanol intake modifies #4
    kd ndr #4
    3h nip #4
    ethanol intake ndr #4
    ndr bmax #4
    3hnip binding bmax #4
    1 ethanolnaive rats #4
    differences 3hnip binding #4
    intake ndr #4
    affinity 3hnip #4
    drugs 1 mgkg1 #4
    3hnip #4
    1 g1d1 #4
    intervention gaba receptors #4
    non‐preferring rats #4
    ndr ethanol #4
    mgkg1 alprazolam #4
    3hnip binding analysis #4
    2 groups iii #4
    iii ndr #4
    3hnip binding differences #4
    3hnip binding #4
    mgkg1 gaba #4
    non‐preferring #4
    alprazolam aminooxyacetic #4
    ethanol‐preferring #4
    aota placebo #5
    cage voluntary intake #5
    taurine gammaglutamyltransferase #5
    chemical housing stimulation #5
    placebo aota #5
    daily preferring #5
    7 patients aota #5
    ethanol synaptosomal 3h #5
    striatal receptors serotonin #5
    data striatal dopamine #5
    severe alcoholics alcohol #5

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    Jean Pierre Lhuintre:Expert Impact

    Concepts for whichJean Pierre Lhuintrehas direct influence:Voluntary intake,  Serotonin uptake,  Ethanol intake,  Ethanol rats,  Weaned alcoholics,  Alcohol intake,  Gaba transmission,  Alcoholic patients.

    Jean Pierre Lhuintre:KOL impact

    Concepts related to the work of other authors for whichfor which Jean Pierre Lhuintre has influence:Alcohol dependence,  Ethanol intake,  Gabab receptor,  Proctalgia fugax,  Nucleus accumbens,  Naltrexone acamprosate,  Serotonin uptake.



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    Pharmacochimie - U.F.R. de Médecine et Pharmacie -76803 Saint Etienne du Rouvray Cedex - France | Pharmacochimie, Faculty of Medicine of Rouen, BP 97, 76803 Saint‐Étienne‐du‐Rouvray, France | (GRAP), Groupe de recherche sur l'alcoolisme et sa prévent