Jorge J. Castillo

Jorge J. Castillo

Division Of Hematology And Oncology, The Warren Alpert Medical School, The Miriam Hospital, The Leonard And Adele R. Decof Comprehensive Cancer Center, 164 Summit Ave, ...

Direct Impact

Concepts for which Jorge J Castillo has direct influence:

waldenström macroglobulinemia
mutated myd88
latin america
plasmablastic lymphoma
speakers bureau
btk cys481
advisory committees

External impact

Concepts related to the work of other authors for which Jorge J Castillo has influence:

waldenström macroglobulinemia
advisory committees
entitys board
speakers bureau
latin america
plasmablastic lymphoma
mutated myd88

Prominent publications by Jorge J. Castillo

KOL-Index: 140 Multiple myeloma is a malignant neoplasm of plasma cells that accumulate in bone marrow, leading to bone destruction and marrow failure. This manuscript discusses the management of patients with solitary plasmacytoma, smoldering multiple myeloma, and newly diagnosed multiple myeloma.
Known for
Newly Diagnosed Myeloma | Plasma Cells | Manuscript
KOL-Index: 116 En diciembre de 2019 se detectó por primera vez en China la existencia del SARS-CoV2, causante de la enfermedad COVID-19. El virus rápidamente se propagó por Europa y Asia, tardándose un par de meses antes de llegar a América Latina. Se ha demostrado que los pacientes que desarrollan una enfermedad severa y que tienen mayor riesgo de mortalidad por COVID-19 son aquellos con edades avanzadas ...
Known for
Grupo | Consenso | Profesionales | Tratamiento Cáncer
KOL-Index: 116 Opinion statementThere are multiple treatment options in patients with Waldenström macroglobulinemia, including chemotherapy, monoclonal antibodies, proteasome inhibitors, and covalent Bruton tyrosine kinase (BTK) inhibitors. The choice of therapy should take into account the patient’s clinical presentation, comorbidities, and preferences. A thorough discussion should take place to outline ...
Known for
Chemoimmunotherapy Proteasome | Macroglobulinemia | Frontline Relapsed | Waldenström
KOL-Index: 109 Next-generation sequencing has revealed recurring somatic mutations in Waldenström macroglobulinemia (WM), including MYD88 (95%-97%), CXCR4 (30%-40%), ARID1A (17%), and CD79B (8%-15%). Deletions involving chromosome 6q are common in patients with mutated MYD88 and include genes that modulate NFKB, BCL2, Bruton tyrosine kinase (BTK), and apoptosis. Patients with wild-type MYD88 WM show an ...
Known for
Wild-Type Myd88 Wm | Cxcr4 Mutations | 8-15 | Btk Inhibitor Ibrutinib
KOL-Index: 90 Anaplastic lymphoma kinase-positive (ALK+) large B-cell lymphoma (LBCL) is a rare CD20-negative aggressive lymphoma. Given its rarity, data on ALK + LBCL are scarce and limited to case reports and small case series. Our systematic review included 184 unique cases published in the literature and shows that ALK + LBCL can affect individuals at any age, has a male predominance and is not ...
Known for
Bob-1 | Erk Pathways | Plcg2 | 184 Unique
KOL-Index: 81 Adult T-cell leukemia/lymphoma (ATLL) is a largely incurable disease. Cutaneous involvement is common and could be first symptom of the disease. We analyzed 169 patients with ATLL of whom 63 had cutaneous involvement. Cutaneous involvement was found in 48, 27, 17, and 60% of acute, lymphomatous, chronic and smoldering ATLL cases, respectively. Eight cases had primary cutaneous tumoral ...
Known for
Involvement Leukemia | Lymphoma Atll | Survival Compared
KOL-Index: 77 The human endometrium is unique among adult tissues. Its functions are modulated by numerous hormones and mediators. The aim of this study was to evaluate the suitability of human endometrial explants for studying functional effects of chemicals and drugs on gene expression biomarkers. Endometrial tissues were obtained by aspiration curettage and cultivated for up to 24 h. Relative mRNA ...
Known for
Deep Responses | Age ≥65 | Ibrutinib | Bruton Tyrosine Kinase Btk
KOL-Index: 77 Neutropenia is a common reason for hematology consultations in the inpatient and outpatient settings and is defined as an absolute neutrophil count less than 1500 cells/μL. Neutropenia varies in severity, with more profound neutropenia being associated with higher rates of infections and infection-related deaths. The causes for neutropenia are diverse and include congenital and acquired ...
KOL-Index: 67 Waldenström macroglobulinaemia (WM) is a rare and incurable lymphoma. Given that the survival of WM patients can be prolonged, our objective was to describe trends in overall survival (OS) and analyse competing risks of death in patients with WM. The analysis included 5784 patients diagnosed with WM between 1991 and 2010 from the Surveillance, Epidemiology and End Results (SEER) database. ...
Known for
1991 2000 | Epidemiology Database | Macroglobulinaemia | 0·66 0·79
KOL-Index: 66 Introduction: Waldenström macroglobulinemia (WM) is a rare subtype of non-Hodgkin lymphoma characterized by the presence of IgM-secreting clonal lymphocytes, plasma cells, and lymphoplasmacytic cells. Many well-established treatment options are available for patients with WM. However, a unique array of side effects may occur in patients during therapy related to the underlying disease, as ...
Known for
Toxicity Waldenström | Macroglobulinemia | Effects Occur

Division of Hematology and Oncology, The Warren Alpert Medical School, The Miriam Hospital, The Leonard and Adele R. Decof Comprehensive Cancer Center, 164 Summit Ave, Providence, RI 02906, USA

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