• Disease
  • Wm
  • Wm Cells
  • Xiaoying Jia

    Prominent publications by Xiaoying Jia

    KOL Index score: 16765

    The interaction of multiple myeloma (MM) cells with their microenvironment in the bone marrow (BM) provides a protective environment and resistance to therapeutic agents. We hypothesized that disruption of the interaction of MM cells with their BM milieu would lead to their sensitization to therapeutic agents such as bortezomib, melphalan, doxorubicin, and dexamethasone. We report that the CXCR4 inhibitor AMD3100 induces disruption of the interaction of MM cells with the BM reflected by ...

    Also Ranks for: Mm Cells |  bone marrow |  messenger rna |  small interfering receptors |  multiple myeloma
    KOL Index score: 12845

    The interaction of multiple myeloma (MM) cells with the bone marrow (BM) milieu plays a crucial role in MM pathogenesis. Stromal cell-derived factor-1 (SDF1) regulates homing of MM cells to the BM. In this study, we examined the role of RhoA and Rac1 GTPases in SDF1-induced adhesion and chemotaxis of MM. We found that both RhoA and Rac1 play key roles in SDF1-induced adhesion of MM cells to BM stromal cells, whereas RhoA was involved in chemotaxis and motility. Furthermore, both ROCK and ...

    Also Ranks for: Mm Cells |  cell adhesion |  multiple myeloma |  rac1 gtp |  bone marrow bm
    KOL Index score: 12074

    PURPOSE: The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (mTOR) pathway and the heat shock protein family are up-regulated in multiple myeloma and are both regulators of the cyclin D/retinoblastoma pathway, a critical pathway in multiple myeloma. Inhibitors of mTOR and HSP90 protein have showed in vitro and in vivo single-agent activity in multiple myeloma. Our objective was to determine the effects of the mTOR inhibitor rapamycin and the HSP90 inhibitor ...

    Also Ranks for: Multiple Myeloma |  rapamycin inhibitor |  mammalian target |  17 aag |  protein kinases
    KOL Index score: 11672

    Waldenstrom macroglobulinemia (WM) is an incurable low-grade lymphoplasmacytic lymphoma. We demonstrate up-regulated Akt activity in WM, and that Akt down-regulation by Akt knockdown and the inhibitor perifosine leads to significant inhibition of proliferation and induction of apoptosis in WM cells in vitro, but not in normal donor peripheral blood and hematopoietic progenitors. Importantly, down-regulation of Akt induced cytotoxicity of WM cells in the bone marrow microenvironment (BMM) ...

    Also Ranks for: Waldenstrom Macroglobulinemia |  akt pathway |  wm cells |  inhibitor perifosine |  cell survival
    KOL Index score: 10516

    Multilevel genetic characterization of Waldenström macroglobulinemia (WM) is required to improve our understanding of the underlying molecular changes that lead to the initiation and progression of this disease. We performed microRNA-expression profiling of bone marrow-derived CD19(+) WM cells, compared with their normal cellular counterparts and validated data by quantitative reverse-transcription-polymerase chain reaction (qRT-PCR). We identified a WM-specific microRNA signature ...

    Also Ranks for: Microrna Expression |  waldenström macroglobulinemia |  wm cells |  protein kinase |  therapeutic agents
    KOL Index score: 10437

    Waldenstrom macroglobulinemia (WM) is characterized by widespread involvement of the bone marrow at the time of diagnosis, implying continuous homing of WM cells into the marrow. The mechanisms by which trafficking of the malignant cells into the bone marrow has not been previously elucidated. In this study, we show that WM cells express high levels of chemokine and adhesion receptors, including CXCR4 and VLA-4. We showed that CXCR4 was essential for the migration and trans-endothelial ...

    Also Ranks for: Wm Cells |  cxcr4 vla4 |  migration adhesion |  waldenstrom macroglobulinemia |  bone marrow
    KOL Index score: 10247

    The mechanisms by which multiple myeloma (MM) cells migrate and home to the bone marrow are not well understood. In this study, we sought to determine the effect of the chemokine SDF-1 (CXCL12) and its receptor CXCR4 on the migration and homing of MM cells. We demonstrated that CXCR4 is differentially expressed at high levels in the peripheral blood and is down-regulated in the bone marrow in response to high levels of SDF-1. SDF-1 induced motility, internalization, and cytoskeletal ...

    Also Ranks for: Multiple Myeloma |  mm cells |  cxcr4 migration |  bone marrow |  inbred nod mice
    KOL Index score: 9449

    Waldenström macroglobulinemia (WM) is an incurable lymphoplasmacytic lymphoma with limited options of therapy. Protein kinase Cbeta (PKCbeta) regulates cell survival and growth in many B-cell malignancies. In this study, we demonstrate up-regulation of PKCbeta protein in WM using protein array techniques and immunohistochemistry. Enzastaurin, a PKCbeta inhibitor, blocked PKCbeta activity and induced a significant decrease of proliferation at 48 hours in WM cell lines (IC(50), 2.5-10 ...

    Also Ranks for: Waldenström Macroglobulinemia |  protein kinase |  wm cells |  inhibitor enzastaurin |  48 hours
    KOL Index score: 8871

    PURPOSE: We hypothesized that targeting both Akt and heat shock protein (HSP) 90 would induce cytotoxic activity against multiple myeloma (MM) cells and target the bone marrow (BM) microenvironment to inhibit angiogenesis, osteoclast formation, as well as migration and adhesion of MM cells.

    EXPERIMENTAL DESIGN: MM cell lines were incubated with perifosine (5 and 10 micromol/L) and 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG; 50 and 100 nmol/L) alone and in ...

    Also Ranks for: Multiple Myeloma |  bone marrow |  heat shock protein |  mm cells |  tumor growth
    KOL Index score: 8303

    Detailed genomic studies have shown that cytogenetic abnormalities contribute to multiple myeloma (MM) pathogenesis and disease progression. Nevertheless, little is known about the characteristics of MM at the epigenetic level and specifically how microRNAs regulate MM progression in the context of the bone marrow milieu. Therefore, we performed microRNA expression profiling of bone marrow derived CD138(+) MM cells versus their normal cellular counterparts and validated data by qRT-PCR. ...

    Also Ranks for: Multiple Myeloma |  tumor proliferation |  mm cells |  neoplastic humans |  scid micrornas
    KOL Index score: 7717

    PURPOSE: Resveratrol (3,4',5-tri-hydroxy-trans-stilbene) is an antioxidant constituent of a wide variety of plant species including grapes. It has gained considerable attention because of its anticancer properties, as shown in solid and hematologic malignancies. Whether resveratrol could inhibit proliferation or induce cytotoxicity in Waldenström's macroglobulinemia (WM) was investigated.

    EXPERIMENTAL DESIGN: We studied resveratrol-induced inhibition of proliferation and induction of ...

    Also Ranks for: Cells Resveratrol |  waldenströms macroglobulinemia |  cell proliferation |  western blot |  anticancer properties
    KOL Index score: 7527

    Waldenström macroglobulinemia (WM) is an incurable low-grade B-cell lymphoma characterized by high protein turnover. We dissected the biologic role of the proteasome in WM using 2 proteasome inhibitors, NPI-0052 and bortezomib. We found that NPI-0052 inhibited proliferation and induced apoptosis in WM cells, and that the combination of NPI-0052 and bortezomib induced synergistic cytotoxicity in WM cells, leading to inhibition of nuclear translocation of p65NF-kappaB and synergistic ...

    Also Ranks for: Dual Targeting |  wm cells |  waldenström macroglobulinemia |  proteasome inhibitors |  akt pathway
    KOL Index score: 7499

    Waldenström macroglobulinemia (WM) cells present with increased expression of microRNA-206 (miRNA-206) and reduced expression of miRNA-9*. Predicted miRNA-206- and -9*-targeted genes include histone deacetylases (HDACs) and histone acetyl transferases (HATs), indicating that these miRNAs may play a role in regulating histone acetylation. We were able to demonstrate that primary WM cells are characterized by unbalanced expression of HDACs and HATs, responsible for decreased acetylated ...

    Also Ranks for: Histone Acetylation |  wm cells |  waldenström macroglobulinemia |  aberrant expression |  apoptosis autophagy
    KOL Index score: 7092

    PURPOSE: Waldenstrom macroglobulinemia is a lymphoplasmacytic lymphoma characterized by widespread involvement of the bone marrow. Despite different options of therapy, Waldenstrom macroglobulinemia is still incurable. Src tyrosine kinase has been shown to play a central role in the regulation of a variety of biological processes, such as cell proliferation, migration, adhesion, and survival in solid tumors. We sought to determine whether the protein tyrosine kinase Src regulates ...

    Also Ranks for: Waldenstrom Macroglobulinemia |  tyrosine kinase |  migration adhesion |  cell cycle |  bone marrow
    KOL Index score: 6838

    Waldenstrom macroglobulinemia (WM) is an incurable low-grade lymphoma characterized by bone marrow (BM) involvement of IgM secreting lymphoplasmacytic cells. The induction of unfolded protein response (UPR) genes ("physiologic" UPR) enables cells to differentiate into professional secretory cells capable of production of high amounts of endoplasmic reticulum (ER)-processed proteins, such as immunoglobulins. Ultimately, the initially cytoprotective UPR triggers an apoptotic cascade if ER ...

    Also Ranks for: Endoplasmic Reticulum |  wm cells |  waldenstrom macroglobulinemia |  bone marrow |  unfolded protein response


    Xiaoying Jia: Influence Statistics

    Sample of concepts for which Xiaoying Jia is among the top experts in the world.
    Concept World rank
    evaluation perifosine #4
    migration adhesion #4
    activity waldenstrom #4
    cells perifosine #5
    homing wm #5
    amd3100 inhibited #5
    migration wm #5
    identified wm #5
    agents wm #5
    homing waldenstrom #6
    cxcr4 wm cells #6
    adhesion wm #6
    incurable low #6
    cxcr4 inhibitor amd3100 #6
    survival waldenstrom macroglobulinemia #6
    physiologic upr #7
    sdf1induced adhesion chemotaxis #7
    simvastatin waldenstrom #7
    sdf1induced polymerization #7
    cd19 wm #7
    upr wm #7
    wm cells tunicamycin #7
    rac1 mm cells #7
    physiologic upr machinery #7
    stress inducer agents #7
    wm simvastatin #7
    gtpases mm #7
    gtpases sdf1 #7
    rac1 gtpases #7
    rhoa scid multiple #7
    lines bcwm1 #7
    apoptosis waldenstrom macroglobulinemia #7
    major differential roles #7
    hmg‐coa inhibitor #7
    tunicamycin waldenstrom #7
    stromal cells rhoa #7
    mapk 18 #7
    wm boronic #7
    chemotaxis multiple myeloma #7
    proapoptotic terminal upr #7
    wm tunicamycin #7
    mm rhoa #7
    macroglobulinemia boronic #7
    cytotoxicity wm #7
    sdf1induced adhesion #7
    tunicamycin stress inducer #7
    secretion waldenstrom #7
    primary bm cd19 #7

    Key People For Wm Cells

    Top KOLs in the world
    Steven Peter Treon
    waldenström macroglobulinemia consultancy funding patients wm
    Kenneth Carl Anderson
    multiple myeloma mm cells board directors
    Irene M Ghobrial
    multiple myeloma board directors advisory committees
    Xavier Leleu
    consultancy honoraria multiple myeloma board directors
    Morie Abraham A Gertz
    multiple myeloma consultancy funding stem cell
    Rafael Fonseca
    multiple myeloma consultancy funding situ hybridization
    Select a search phrase   wm cells

    Xiaoying Jia:Expert Impact

    Concepts for whichXiaoying Jiahas direct influence:Wm cells,  Waldenstrom macroglobulinemia,  Multiple myeloma,  Mm cells,  Bone marrow,  Migration adhesion,  Waldenstrom macroglobulinemia wm,  Therapeutic agents.

    Xiaoying Jia:KOL impact

    Concepts related to the work of other authors for whichfor which Xiaoying Jia has influence:Multiple myeloma,  Bone marrow,  Waldenström macroglobulinemia,  Mm cells,  Stem cell,  Proteasome inhibitors,  Cxcr4 expression.



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    Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA | Authors' Affiliations: 1Dana-Farber Cancer Institute, 2Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 3Community Hospital of Monter