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Xiaoying Jia: Influence Statistics

Xiaoying Jia

Xiaoying Jia

Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA | Authors' Affiliations: 1Dana-Farber Cancer Institute, 2Department of Pathology, Brigham ...

Xiaoying Jia: Expert Impact

Concepts for which Xiaoying Jia has direct influence: Wm cells , Waldenstrom macroglobulinemia , Multiple myeloma , Mm cells , Bone marrow , Migration adhesion , Waldenstrom macroglobulinemia wm .

Xiaoying Jia: KOL impact

Concepts related to the work of other authors for which for which Xiaoying Jia has influence: Multiple myeloma , Bone marrow , Waldenström macroglobulinemia , Mm cells , Stem cell , Proteasome inhibitors , Cxcr4 expression .

KOL Resume for Xiaoying Jia

Year
2010

Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA

Authors' Affiliations: 1Dana-Farber Cancer Institute, 2Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 3Community Hospital of Monterey Peninsula, Monterey, California; 4Center for Cancer Research, National Cancer Institute, Bethesda, Maryland; and 5Keryx Biopharmaceuticals, Inc., New York, New York

2009

Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA

2008

Bing Center for Waldenstrom’s Macroglobulinemia, Dana‐Farber Cancer Institute, Boston, MA, USA

Kirsch Laboratory for Waldenstrom's Macroglobulinemia, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA

2007

Dana-Farber Cancer Institute, Boston, MA;

Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA

2006

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA

Service des Maladies du Sang and Laboratoire d’Immunologie, CHRU, Lille, France

Prominent publications by Xiaoying Jia

KOL-Index: 16765 . The interaction of multiple myeloma (MM) cells with their microenvironment in the bone marrow (BM) provides a protective environment and resistance to therapeutic agents. We hypothesized that disruption of the interaction of MM cells with their BM milieu would lead to their sensitization to therapeutic agents such as bortezomib, melphalan, doxorubicin, and dexamethasone. We report that the ...
Known for Mm Cells | Bone Marrow | Messenger Rna | Small Interfering Receptors
KOL-Index: 12845 . The interaction of multiple myeloma (MM) cells with the bone marrow (BM) milieu plays a crucial role in MM pathogenesis. Stromal cell-derived factor-1 (SDF1) regulates homing of MM cells to the BM. In this study, we examined the role of RhoA and Rac1 GTPases in SDF1-induced adhesion and chemotaxis of MM. We found that both RhoA and Rac1 play key roles in SDF1-induced adhesion of MM cells ...
Known for Mm Cells | Cell Adhesion | Multiple Myeloma | Rac1 Gtp
KOL-Index: 12074 . PURPOSE: The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (mTOR) pathway and the heat shock protein family are up-regulated in multiple myeloma and are both regulators of the cyclin D/retinoblastoma pathway, a critical pathway in multiple myeloma. Inhibitors of mTOR and HSP90 protein have showed in vitro and in vivo single-agent activity in multiple myeloma. Our ...
Known for Multiple Myeloma | Rapamycin Inhibitor | Mammalian Target | 17 Aag
KOL-Index: 11672 . Waldenstrom macroglobulinemia (WM) is an incurable low-grade lymphoplasmacytic lymphoma. We demonstrate up-regulated Akt activity in WM, and that Akt down-regulation by Akt knockdown and the inhibitor perifosine leads to significant inhibition of proliferation and induction of apoptosis in WM cells in vitro, but not in normal donor peripheral blood and hematopoietic progenitors. ...
Known for Waldenstrom Macroglobulinemia | Akt Pathway | Wm Cells | Inhibitor Perifosine
KOL-Index: 10516 . Multilevel genetic characterization of Waldenström macroglobulinemia (WM) is required to improve our understanding of the underlying molecular changes that lead to the initiation and progression of this disease. We performed microRNA-expression profiling of bone marrow-derived CD19(+) WM cells, compared with their normal cellular counterparts and validated data by quantitative ...
Known for Microrna Expression | Waldenström Macroglobulinemia | Wm Cells | Protein Kinase
KOL-Index: 10437 . Waldenstrom macroglobulinemia (WM) is characterized by widespread involvement of the bone marrow at the time of diagnosis, implying continuous homing of WM cells into the marrow. The mechanisms by which trafficking of the malignant cells into the bone marrow has not been previously elucidated. In this study, we show that WM cells express high levels of chemokine and adhesion receptors, ...
Known for Wm Cells | Cxcr4 Vla4 | Migration Adhesion | Waldenstrom Macroglobulinemia
KOL-Index: 10247 . The mechanisms by which multiple myeloma (MM) cells migrate and home to the bone marrow are not well understood. In this study, we sought to determine the effect of the chemokine SDF-1 (CXCL12) and its receptor CXCR4 on the migration and homing of MM cells. We demonstrated that CXCR4 is differentially expressed at high levels in the peripheral blood and is down-regulated in the bone marrow ...
Known for Multiple Myeloma | Mm Cells | Cxcr4 Migration | Bone Marrow
KOL-Index: 9449 . Waldenström macroglobulinemia (WM) is an incurable lymphoplasmacytic lymphoma with limited options of therapy. Protein kinase Cbeta (PKCbeta) regulates cell survival and growth in many B-cell malignancies. In this study, we demonstrate up-regulation of PKCbeta protein in WM using protein array techniques and immunohistochemistry. Enzastaurin, a PKCbeta inhibitor, blocked PKCbeta activity ...
Known for Waldenström Macroglobulinemia | Protein Kinase | Wm Cells | Inhibitor Enzastaurin
KOL-Index: 8871 . PURPOSE: We hypothesized that targeting both Akt and heat shock protein (HSP) 90 would induce cytotoxic activity against multiple myeloma (MM) cells and target the bone marrow (BM) microenvironment to inhibit angiogenesis, osteoclast formation, as well as migration and adhesion of MM cells. EXPERIMENTAL DESIGN: MM cell lines were incubated with perifosine (5 and 10 micromol/L) and ...
Known for Multiple Myeloma | Bone Marrow | Heat Shock Protein | Mm Cells
KOL-Index: 8303 . Detailed genomic studies have shown that cytogenetic abnormalities contribute to multiple myeloma (MM) pathogenesis and disease progression. Nevertheless, little is known about the characteristics of MM at the epigenetic level and specifically how microRNAs regulate MM progression in the context of the bone marrow milieu. Therefore, we performed microRNA expression profiling of bone marrow ...
Known for Multiple Myeloma | Tumor Proliferation | Mm Cells | Neoplastic Humans
KOL-Index: 7717 . PURPOSE: Resveratrol (3,4',5-tri-hydroxy-trans-stilbene) is an antioxidant constituent of a wide variety of plant species including grapes. It has gained considerable attention because of its anticancer properties, as shown in solid and hematologic malignancies. Whether resveratrol could inhibit proliferation or induce cytotoxicity in Waldenström's macroglobulinemia (WM) was ...
Known for Cells Resveratrol | Waldenströms Macroglobulinemia | Cell Proliferation | Western Blot
KOL-Index: 7527 . Waldenström macroglobulinemia (WM) is an incurable low-grade B-cell lymphoma characterized by high protein turnover. We dissected the biologic role of the proteasome in WM using 2 proteasome inhibitors, NPI-0052 and bortezomib. We found that NPI-0052 inhibited proliferation and induced apoptosis in WM cells, and that the combination of NPI-0052 and bortezomib induced synergistic ...
Known for Dual Targeting | Wm Cells | Waldenström Macroglobulinemia | Proteasome Inhibitors
KOL-Index: 7499 . Waldenström macroglobulinemia (WM) cells present with increased expression of microRNA-206 (miRNA-206) and reduced expression of miRNA-9*. Predicted miRNA-206- and -9*-targeted genes include histone deacetylases (HDACs) and histone acetyl transferases (HATs), indicating that these miRNAs may play a role in regulating histone acetylation. We were able to demonstrate that primary WM cells ...
Known for Histone Acetylation | Wm Cells | Waldenström Macroglobulinemia | Aberrant Expression
KOL-Index: 7092 . PURPOSE: Waldenstrom macroglobulinemia is a lymphoplasmacytic lymphoma characterized by widespread involvement of the bone marrow. Despite different options of therapy, Waldenstrom macroglobulinemia is still incurable. Src tyrosine kinase has been shown to play a central role in the regulation of a variety of biological processes, such as cell proliferation, migration, adhesion, and ...
Known for Waldenstrom Macroglobulinemia | Tyrosine Kinase | Migration Adhesion | Cell Cycle
KOL-Index: 6838 . Waldenstrom macroglobulinemia (WM) is an incurable low-grade lymphoma characterized by bone marrow (BM) involvement of IgM secreting lymphoplasmacytic cells. The induction of unfolded protein response (UPR) genes ("physiologic" UPR) enables cells to differentiate into professional secretory cells capable of production of high amounts of endoplasmic reticulum (ER)-processed proteins, such ...
Known for Endoplasmic Reticulum | Wm Cells | Waldenstrom Macroglobulinemia | Bone Marrow

Key People For Wm Cells

Top KOLs in the world
#1
Steven Peter Treon
waldenström macroglobulinemia consultancy funding patients wm
#2
Kenneth Carl Anderson
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#3
Irene M Ghobrial
multiple myeloma board directors advisory committees
#4
Xavier Leleu
consultancy honoraria multiple myeloma board directors
#5
Morie Abraham A Gertz
multiple myeloma consultancy funding stem cell
#6
Rafael Fonseca
multiple myeloma consultancy funding situ hybridization
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Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA | Authors' Affiliations: 1Dana-Farber Cancer Institute, 2Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 3Community Hospital of Monter