Prominent publications by Yosuke Kakisaka

KOL Index score: 10219

PURPOSE: To investigate the utility of magnetic source imaging (MSI) and ictal single photon emission computed tomography (SPECT), each compared with intracranial electroencephalography (EEG) (ICEEG), to localize the epileptogenic zone (EZ) and predict epilepsy surgery outcome in patients with nonlesional neocortical focal epilepsy.

METHODS: Studied were 14 consecutive patients with nonlesional neocortical epilepsy who underwent presurgical evaluation including ICEEG, positive MSI, and ...

Also Ranks for: Ictal Spect |  intracranial eeg |  magnetic source imaging |  epilepsy surgery |  presurgical evaluation
KOL Index score: 8628

Although previous studies have investigated the sensitivity of electroencephalography (EEG) and magnetoencephalography (MEG) to detect spikes by comparing simultaneous recordings, there are no published reports that focus on the relationship between spike dipole orientation or sensitivity of scalp EEG/MEG and the “gold standard” of intracranial recording (stereotactic EEG). We evaluated two patients with focal epilepsy; one with lateral temporal focus and the other with insular focus. ...

Also Ranks for: Insular Epilepsy |  scalp eeg |  simultaneous recordings |  magnetoencephalography male |  cerebral cortex
KOL Index score: 8416

See Bear and Kirsch (doi:10.1093/aww248) for a scientific commentary on this article. Magnetoencephalography and stereo-electroencephalography are often necessary in the course of the non-invasive and invasive presurgical evaluation of challenging patients with medically intractable focal epilepsies. In this study, we aim to examine the significance of magnetoencephalography dipole clusters and their relationship to stereo-electroencephalography findings, area of surgical resection, and ...

Also Ranks for: Epilepsy Surgery |  stereo electroencephalography |  patients magnetoencephalography |  dipole clusters |  surgical resection
KOL Index score: 8413

BACKGROUND: Acceptance of disability (AOD) is a key concept in rehabilitation psychology that enhances psychosocial adjustment of individuals with disability. However, the impact of AOD on well-being has never been examined for patients with epilepsy. The present study investigated whether AOD affects quality of life (QOL) in patients with epilepsy in the presence of other multiple aspects of epilepsy based on the biopsychosocial model.

METHODS: We retrospectively reviewed 151 ...

Also Ranks for: Patients Epilepsy |  disability aod |  quality life |  comprehensive assessment |  reported questionnaires
KOL Index score: 8329

OBJECTIVE: MRI-negative (MRI-) pharmacoresistant focal epilepsy (PFE) patients are most challenging for epilepsy surgical management. This study utilizes a voxel-based MRI postprocessing technique, implemented using a morphometric analysis program (MAP), aiming to facilitate detection of subtle focal cortical dysplasia (FCD) in MRI- patients. Furthermore, the study examines the concordance between MAP-identified regions and localization from magnetic source imaging (MSI).


Also Ranks for: Magnetic Source |  mri postprocessing |  patients map |  surgical outcome |  detection rate
KOL Index score: 7294

OBJECTIVE: To investigate the connectivity associated with the reorganized language network in patients with temporal lobe epilepsy (TLE) using cortico-cortical evoked potential (CCEP), which reveals the brain networks.

METHODS: Six patients with intractable TLE who underwent chronic intracranial electrode placement and revealed an atypical distribution of posterior language areas (Wernicke's areas) were studied. Alternating 1 Hz electrical stimuli were delivered to the anterior language ...

Also Ranks for: Temporal Lobe |  cortical evoked |  posterior language area |  ccep responses |  brain networks
KOL Index score: 7185

BACKGROUND: Myelin-oligodendrocyte glycoprotein and aquaporin-4 have been extensively analyzed as targets for humoral immune reactions in central nervous system (CNS) demyelinating diseases, and the results indicated a possible role of these antibodies in the pathogenesis of various demyelinating diseases.

OBJECTIVE: To investigate the antibody titer levels against myelin-oligodendrocyte glycoprotein and aquaporin-4 in pediatric patients with inflammatory CNS disorders, and to evaluate ...

Also Ranks for: Oligodendrocyte Glycoprotein |  japanese children |  central nervous |  demyelinating diseases |  anti myelin
KOL Index score: 6980

OBJECTIVE: We hypothesized that high frequency oscillations (HFOs) are differently suppressed during rapid eye movement sleep (REM) between epileptogenic and less epileptogenic cortices, and that the suppressive effect can serve as a specific marker of epileptogenicity.

METHODS: Intracranial electroencephalography (EEG) was recorded in 13 patients with drug-resistant epilepsy. HFOs between 80 and 200Hz were semi-automatically detected from total 15-min EEG epochs each for REM and slow ...

Also Ranks for: Frequency Oscillations |  rapid eye movement |  sws rem |  surgical resection |  13 patients
KOL Index score: 6864

OBJECTIVE: To investigate the utility of magnetic source imaging (MSI) for localizing the epileptogenic zone (EZ) and predicting epilepsy surgery outcome in non-lesional neocortical focal epilepsy (NLNE) patients.

METHODS: Data from 18 consecutive patients with NLNE who underwent presurgical evaluation including intracranial electroencephalography (ICEEG) and MSI were studied. Follow-up after epilepsy surgery was ≥24 months. Intracranial electroencephalography and MSI results were ...

Also Ranks for: Iceeg Msi |  magnetic source imaging |  neocortical epilepsy |  presurgical evaluation |  epileptogenic zone
KOL Index score: 6744

Kawasaki Disease (KD) is acute, febrile, multisystem vasculitis of early childhood, the detailed mechanism of which is still unclear. Skin symptoms occur in KD, such as edema of the hands and feet with subsequent desquamation and redness at the inoculation site of bacillus Calmette-Guerin (BCG). The change at the BCG inoculation site has been considered as a specific feature of KD, although its mechanism is not fully understood. We present an 11-month-old boy who developed fever with ...

Also Ranks for: Kawasaki Disease |  inoculation site |  specific feature |  bacillus calmetteguerin |  6 human
KOL Index score: 6031

OBJECTIVE: To clarify whether the presence and timing of peri-ictal heart rate (HR) change is a seizure lateralizing sign in patients with mesial temporal lobe epilepsy (mTLE).

METHODS: Long-term video EEGs were retrospectively reviewed in 21 patients, 7 men and 14 women aged 13 to 67 years, diagnosed as mTLE with MRI lesions in the mesial temporal structures (hippocampal sclerosis in 20 cases, amygdala hypertrophy in 1 case). Seventy-seven partial seizures without secondary ...

Also Ranks for: Earlier Tachycardia |  temporal lobe |  9 patients |  heart rate |  electroencephalography epilepsy
KOL Index score: 5426

West syndrome, which is narrowly defined as infantile spasms that occur in clusters and hypsarrhythmia on EEG, is the most common early-onset epileptic encephalopathy (EOEE). Patients with West syndrome may have clear etiologies, including perinatal events, infections, gross chromosomal abnormalities, or cases followed by other EOEEs. However, the genetic etiology of most cases of West syndrome remains unexplained. DNA from 18 patients with unexplained West syndrome was subjected to ...

Also Ranks for: West Syndrome |  pathogenic variants |  infantile spasms |  wholeexome sequencing |  genetic etiology
KOL Index score: 5325

PURPOSES: The aims of the study were to evaluate the detectability of focal leading activity in three cases of West syndrome having focal abnormal activity on EEG by comparing subtraction ictal images and raw ictal images, and to interpret the results in 16 cases.

METHODS: Subtraction images were constructed using iNeurostat (revision 2).

RESULTS: In three cases with focal abnormal activity on EEG, subtraction ictal images reflected the EEG findings; in contrast, raw ictal images did ...

Also Ranks for: West Syndrome |  subtraction ictal |  subcortical structures |  infantile tomography |  single photon
KOL Index score: 5124

OBJECTIVES: To evaluate the agreement between magnetoencephalography (MEG) and intracranial electroencephalography (ICEEG) results, to determine the characteristics that lead to concordance, and to assess how these factors relate to favorable epilepsy surgery outcome.

MATERIALS: This retrospective study reviewed 50 patients who had positive MEG findings and ICEEG recordings between 2008 and 2010. The anatomical concordance between MEG and ICEEG recordings, the features of the MEG focus, ...

Also Ranks for: Intracranial Eeg |  epileptogenic zone |  epilepsy surgery |  surgical resection |  50 patients
KOL Index score: 5040

Abdominal migraine is one subcategory of migraine-related syndromes. Migraine is sometimes associated with facial ecchymosis, which may be accounted for by trigeminovascular activation. However, the precise mechanism of this concurrence remains unknown. Here, we describe a 9-year-old girl, who presented ecchymosis of the legs and buttock associated with recurrent, severe, non-localized midline abdominal pain. The patient has positive family history of migraine. Investigations during an ...

Also Ranks for: Abdominal Migraine |  headache disorders |  facial ecchymosis |  precise mechanism |  receptor agonists

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Yosuke Kakisaka:Expert Impact

Concepts for whichYosuke Kakisakahas direct influence:West syndrome,  Focal epilepsy,  Abdominal migraine,  Epileptic seizures,  Magnetic source imaging,  Ictal spect,  3p deletion syndrome,  Temporal lobe.

Yosuke Kakisaka:KOL impact

Concepts related to the work of other authors for whichfor which Yosuke Kakisaka has influence:Epilepsy surgery,  Epileptogenic zone,  Presurgical evaluation,  Focal cortical dysplasia,  Abdominal migraine,  Ictal spect,  Kawasaki disease.



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Department of Epileptology, Tohoku University Graduate School of Medicine, Japan. | Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. | Department of Epileptology, Tohoku University Graduate School of M