• Disease
  • White
  • White Muscle
  • Peter W Hochachka

    Prominent publications by Peter W Hochachka

    KOL Index score: 11261

    1. The properties of fructose diphosphatase from the liver of rainbow trout (Salmo gairdnerii) were examined over the physiological temperature range of the organism. 2. Saturation curves for substrate (fructose 1,6-diphosphate) and a cofactor (Mg(2+)) are sigmoidal, and Hill plots of the results suggest a minimum of two interacting fructose 1,6-diphosphate sites and two interacting Mg(2+) sites per molecule of enzyme. 3. Mn(2+)-saturation curves are hyperbolic, and the K(a) for Mn(2+), ...

    Also Ranks for: Fructose Diphosphatase |  enzyme activity |  mg2 mn2 |  hill plots |  higher concentrations
    KOL Index score: 10808

    We develop a unifying theory of hypoxia tolerance based on information from two cell level models (brain cortical cells and isolated hepatocytes) from the highly anoxia tolerant aquatic turtle and from other more hypoxia sensitive systems. We propose that the response of hypoxia tolerant systems to oxygen lack occurs in two phases (defense and rescue). The first lines of defense against hypoxia include a balanced suppression of ATP-demand and ATP-supply pathways; this regulation ...

    Also Ranks for: Oxygen Lack |  hypoxia tolerance |  unifying theory |  translational arrest |  metabolic defense
    KOL Index score: 10772

    During the last half century or more, studies of diving physiology and biochemistry made great progress in mechanistically explaining the basic diving response of aquatic mammals and birds. Key components of the diving response (apnea, bradycardia, peripheral vasoconstriction, redistribution of cardiac output) were found in essentially all species analyzed and were generally taken to be biological adaptations. By the mid 1970s, this approach to unravelling the diving response had run ...

    Also Ranks for: Diving Response |  pinnipeds studies |  conceptual stasis |  bradycardia peripheral vasoconstriction |  aquatic mammals
    KOL Index score: 10229

    Alanopine dehydrogenase (alanopine: NAD oxidoreductase) was purified from the adductor muscle of the Japanese oyster, Crassostrea gigas Thunberg. This enzyme catalyzes the reductive imination between pyruvate and alanine, or glycine, utilizing NADH as coenzyme, producing 2,2′-iminodipropionic acid (alanopine), or 2-methyliminodiacetic acid (strombine). The enzyme can be readily purified to a specific activity of 700 units/mg protein. The molecular weight was 47000 ± 4000 when measured by ...

    Also Ranks for: Alanopine Dehydrogenase |  crassostrea gigas |  alanine glycine |  adductor muscle |  enzyme substrates
    KOL Index score: 9444

    The term homeostasis traditionally refers to the maintenance of a relatively constant internal milieu in the face of changing environmental conditions or changing physiological function. Tissues such as skeletal and cardiac muscles must sustain very large-scale changes in ATP turnover rate during equally large changes in work. In many skeletal muscles, these changes can exceed 100-fold. In unique biological circumstances (for example, during periods of oxygen limitation, vasoconstriction ...

    Also Ranks for: Atp Turnover |  skeletal muscles |  cellular metabolism |  muscle contraction |  metabolic homeostasis
    KOL Index score: 9268

    We investigated structural characteristics for high O2 flux in hummingbird flight muscle, i.e. the most O2 demanding skeletal muscle per unit tissue mass among vertebrates. Pectoralis and supracoracoideus muscles of 3-4 g hummingbirds (Selaphorus rufus) were perfusion fixed in situ, processed for electron microscopy and analyzed by morphometry. Small fiber size (group mean +/- SE, 201 +/- 14 microns 2 at 2.1 microns sarcomere length), large capillary length per fiber volume (8947 +/- 869 ...

    Also Ranks for: Mitochondrial Density |  fiber geometry |  hummingbird flight |  animal male mitochondria |  o2 flux
    KOL Index score: 9224

    The present study was conducted to investigate the potential role of changes in the apparent K(m) for ADP and in the functional coupling of the creatine (Cr) kinase (CK) system (CK efficiency) in explaining the tighter integration of ATP supply and demand after exercise training. Mitochondrial function was assessed in saponin-skinned fibers from the soleus and the deep red portion of the medial gastrocnemius isolated from trained (T; treadmill running, 5 days/wk, 4 wk) and control (C) ...

    Also Ranks for: Mitochondrial Function |  muscle fibers |  endurance training |  dry wt1 |  atp supply
    KOL Index score: 9201

    In heart and red muscle of dogfish (Squalus acanthias), the maximal activities of the fatty acid catabolizing enzyme carnitine palmitoyltransferase (CPT) are less than 5% the rate in the same tissues of teleosts (carp, Cyprinus carpio; trout, Salmo gairdneri). CPT activities in these tissues of hagfish (Eptatretus stouti) are approximately 10% the rate in teleosts. However, the maximal activities of the beta-oxidation enzyme beta-hydroxyacyl-CoA dehydrogenase (HOAD) in dogfish red muscle ...

    Also Ranks for: Fatty Acids |  mitochondria muscle |  maximal activities |  acid oxidation |  squalus acanthias
    KOL Index score: 8997

    Organisms vary widely in their tolerance to conditions of limiting oxygen supply to their cells and tissues. A unifying framework of hypoxia tolerance is now available that is based on information from cell-level models from highly anoxia-tolerant species, such as the aquatic turtle, and from other more hypoxia-sensitive systems. The response of hypoxia-tolerant systems to oxygen lack occurs in two (defense and rescue) phases. The first lines of defense against hypoxia include a drastic, ...

    Also Ranks for: Anoxia Tolerance |  expression proteins |  oxygen lack |  regulation hypoxia |  atp levels
    KOL Index score: 8990

    Phosphofructokinase (EC occurs in turtle heart at a specific activity of about 19 units per g wet weight; Mg2+ or Mn2+ can satisfy the divalent cation requirement; ATP, GTP, or ITP all can serve as phosphate donors for the reaction. Although the pH optimum for the enzyme is pH 7.5, the intracellular pH of the anoxic turtle heart, pH 6.8, was chosen for characterizing the enzyme. At this pH, turtle heart phosphofructokinase displays hyperbolic saturation kinetics with respect to ...

    Also Ranks for: Turtle Heart |  energy metabolism |  enzyme atp |  specific activity |  vertebrate facultative
    KOL Index score: 8928

    Citrate synthase occurs in two kinetically distinguishable forms, termed C and W in cold and warm acclimated trout, respectively. Oxalacetate and acetyl-CoA saturation curves for both enzymes are hyperbolic and do not show any substrate inhibition. The apparent Km values for the C form increase with temperature above 10°. At saturating (0.1 mm) levels of oxalacetate, the Km of acetyl-CoA is 0.05 mm at 10°, about one-fifth the value at 35°. At saturating levels of acetyl-CoA, the Km of ...

    Also Ranks for: Citrate Synthase |  trout liver |  enzyme variants |  atp inhibition |  low temperature
    KOL Index score: 8621

    1. The activity of glutamate dehydrogenase was measured in the tissues of the squid, Loligo pealeii. The enzyme occurs in high activity in digestive pouch, systemic heart, and all muscle tissues. 2. Glutamate dehydrogenase from mantle muscle is located intra-mitochondrially, has a molecular weight of 310,000, and is electrophoretically similar to the enzyme from all other squid tissues. 3. The enzyme from mantle muscle was purified 40-fold by elution from DEAE-cellulose and used for ...

    Also Ranks for: Glutamate Dehydrogenase |  amino acids |  mantle muscle |  energy production |  enzyme activity


    Peter W Hochachka: Influence Statistics

    Sample of concepts for which Peter W Hochachka is among the top experts in the world.
    Concept World rank
    thirtyfold greater affinity #1
    quechua brain #1
    varanus gouldi #1
    lung heart functions #1
    maximally activated work #1
    forms fold #1
    white muscle signs #1
    fructose 16 diphosphate #1
    ace cohort #1
    expression hypoxiasensitive genes #1
    glycolysis energy deficit #1
    ldh ldh hoad #1
    tissue carp #1
    allele frequencies quechua #1
    lungfish muscle glycogen #1
    oxaloacetate44 #1
    metabolic defense adaptations #1
    phosphoglycerate kinase muscle #1
    succinates turtles #1
    concentrations diphosphate saturation #1
    modest hypometabolism #1
    epo hypoxic response #1
    heart required glucose #1
    oxygen delivery signal #1
    muscles nautilus #1
    oxygen lack #1
    white muscles vertebrates #1
    hypometabolism skeletal muscles #1
    cycle pyruvate kinase #1
    shorterterm acclimatizations #1
    vivo respiration lactate #1
    kinase imp #1
    3°c absence #1
    marine poikilotherms #1
    caniformia diving #1
    atp 3 formation #1
    diving recovery cycles #1
    hypodermis fructose diphosphatase #1
    0·4–0·5 mm #1
    euthyroid state seals #1
    lowland lineages #1
    variation wing loading #1
    burnt muscle #1
    tolerant hepatocytes #1
    adaptations hypoxia sensing #1
    acetylcoa concentration decrease #1
    33 1020 atp #1
    amino acids glycolysis22 #1
    heart glycogen bodies #1
    regulation energy demand #1

    Key People For White Muscle

    Top KOLs in the world
    Ian Alistair Johnston
    atlantic salmon salmo salar muscle fibres
    Peter W Hochachka
    white muscle pyruvate kinase energy metabolism
    Geoffrey Goldspink
    skeletal muscle gene expression growth factor
    Thomas William MOON
    rainbow trout oncorhynchus mykiss anguilla rostrata
    quantitative histochemistry glucuronidase hydrolysis brain iii
    folin phenol reagent protein measurement tungsten compounds

    Peter W Hochachka:Expert Impact

    Concepts for whichPeter W Hochachkahas direct influence:White muscle,  Fructose diphosphatase,  Metabolic regulation,  Weddell seal,  Pyruvate kinase,  Atp turnover,  Skipjack tuna,  Energy metabolism.

    Peter W Hochachka:KOL impact

    Concepts related to the work of other authors for whichfor which Peter W Hochachka has influence:Skeletal muscle,  Metabolic rate,  Energy metabolism,  Rainbow trout,  Oxygen consumption,  Pyruvate kinase,  Chronic hypoxia.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Department of Zoology, University of British ColumbiaVancouver, BC, Canada | Department of Zoology, University of British Columbia, Vancouver, BC,Canada V6T 1Z4 | Department of Zoology, University of British Columbia, Vancouver, BC,Canada, V6T 1Z4 |