• Disease
  • Germ
  • Germ Cell
  • Dieter Harms

    Prominent publications by Dieter Harms

    KOL Index score: 13048

    The WT1 gene, located on chromosome 11p13, is mutated in a low number of Wilms tumors (WTs). Germ-line mutations in the WT1 gene are found in patients with bilateral WT and/or associated genital tract malformations (GU). We have identified 19 hemizygous WT1 gene mutations/deletions in 64 patient samples. The histology of the tumors with mutations was stromal-predominant in 13, triphasic in 3, blastemal-predominant in 1, and unknown in 2 cases. Thirteen of 21 patients with ...

    Also Ranks for: Wt1 Gene |  wilms tumors |  mutations patients |  predominant histology |  germ mutation
    KOL Index score: 13002

    Yolk sac tumors are the most frequent kind of malignant pediatric germ cell tumor and may have a fundamentally different pathogenesis than adult germ cell tumors. Since few cytogenetic studies have been performed so far, in situ hybridization was applied to interphase cell nuclei of seven gonadal yolk sac tumors of childhood in routine paraffin-embedded tissue sections. The panel of chromosome-specific DNA probes was selected on the basis of their relevance in adult germ cell tumors and ...

    Also Ranks for: Chromosome Aberrations |  paraffin sections |  sac tumors |  germ cell |  situ hybridization
    KOL Index score: 12747

    Primary mediastinal germ cell tumors (M-GCTs) represent a heterogeneous group of tumors that varies with regard to age at presentation, histologic differentiation, and outcome. We retrospectively analyzed archival tissue samples of mediastinal mature and immature teratomas (n = 15) and malignant nonseminomatous M-GCTs (n = 20) with comparative genomic hybridization (CGH). The aim of this study was to define distinct genetic subgroups of M-GCT among the pediatric cohort that may differ in ...

    Also Ranks for: Germ Cell |  genetic analysis |  children gain |  klinefelter syndrome |  mediastinal neoplasms
    KOL Index score: 12339

    A new WHO classification of renal cell carcinoma has been introduced in 2004. This classification includes the recently described renal cell carcinomas with the ASPL-TFE3 gene fusion and carcinomas with a PRCC-TFE3 gene fusion. Collectively, these tumors have been termed Xp11.2 or TFE3 translocation carcinomas, which primarily occur in children and young adults. To further study the characteristics of renal cell carcinoma in young patients and to determine their genetic background, 41 ...

    Also Ranks for: Renal Cell |  young patients |  new classification |  tfe3 gene |  translocation carcinomas
    KOL Index score: 11677

    BACKGROUND: The Cooperative Ewing Sarcoma Study (CESS 86), conducted by the German Society of Pediatric Oncology and Hematology (GPOH), was planned on the basis of the results of the preceding CESS 81 study. The prognostic significance of tumor volume in localized Ewing sarcoma of bone was well documented in the CESS 81 trial. As a consequence, the treatment intensity was adapted to volume in the follow-up CESS 86 trial: the four-drug combination used in CESS 81 was amended for patients ...

    Also Ranks for: Tumor Volume |  localized ewing sarcoma |  prognostic factor |  cess 86 |  adapted treatment
    KOL Index score: 11258

    PURPOSE: Cooperative Ewing's Sarcoma Study (CESS) 86 aimed at improving event-free survival (EFS) in patients with high-risk localized Ewing tumor of bone.

    PATIENTS AND METHODS: We analyzed 301 patients recruited from January 1986 to July 1991 (60% male; median age 15 years). Tumors of volume >100 mL and/or at central-axis sites qualified patients for "high risk" (HR, n = 241), and small extremity lesions for "standard risk" (SR, n = 52). Standard-risk patients received 12 courses of ...

    Also Ranks for: Ewing Tumor |  adjuvant child child |  bone patients |  sarcoma study |  cess 86
    KOL Index score: 10938

    PURPOSE: To evaluate children and adolescents with primary mediastinal teratoma and malignant germ cell tumors (GCTs).

    PATIENTS AND METHODS: Forty-seven patients from the German nontesticular GCT studies were analyzed (median age, 2.5 years; range, neonate to 17 years). Teratoma (n = 21) were resected, and no adjuvant treatment was given. Malignant GCTs (n = 26) were treated with cisplatin-based chemotherapy and resection. Three of 26 patients underwent radiotherapy.

    RESULTS: In all ...

    Also Ranks for: Primary Mediastinal |  malignant gcts |  cell tumors |  children adolescents |  beta subunit
    KOL Index score: 10871

    PURPOSE: The goal of the second German Soft Tissue Sarcoma Study CWS-86 (1985 to 1990) was to improve the prognosis in children and adolescents with soft tissue sarcoma by means of a clinical trial comprising intensive chemotherapy and risk-adapted local therapy.

    PATIENTS AND METHODS: There were 372 eligible patients. A staging system based on the postsurgical extent of disease was used. Chemotherapy consisted of vincristine, dactinomycin, doxorubicin, and ifosfamide. Radiotherapy was ...

    Also Ranks for: Soft Tissue Sarcoma |  stage iii |  combined chemotherapy |  5 years |  clinical trial
    KOL Index score: 10561

    To evaluate the results of the two-stage anatomic correction of simple transposition of the great arteries the size, distensibility, and histologic characteristics of the anatomic pulmonary root, which arises from the anatomic left ventricle and which we termed the functional aortic root after anatomic correction, were determined in seven patients before and twice after anatomic correction (mean 43 and 671 days) and the results were compared with those in normal control subjects. The ...

    Also Ranks for: Anatomic Correction |  great arteries |  aortic root |  simple transposition |  size distensibility
    KOL Index score: 10505

    BACKGROUND: The SIOP Nephroblastoma therapeutic protocols include a period of preoperative chemotherapy followed by nephrectomy and a period of postoperative chemotherapy. From the outset, identification of low-risk groups has been an aim of the SIOP Nephroblastoma Trials and Studies. Now that 90% of children with Wilms tumor can be cured, attention is even more focused on the identification of patients who could benefit from less aggressive postoperative therapy, thus minimizing the ...

    Also Ranks for: Preoperative Chemotherapy |  wilms tumor |  international society |  kidney neoplasms |  paediatric oncology
    KOL Index score: 10401

    PURPOSE: During recent years, more intensified systemic and local treatment regimens have increased the 5-year survival figures in localized Ewing's sarcoma to more than 60%. There is, however, concern about the risk of second malignancies (SM) in long-term survivors. We have analyzed the second malignancies in patients treated in the German Ewing's Sarcoma Studies CESS 81 and CESS 86.

    MATERIALS AND METHODS: From January 1981 through June 1991, 674 patients were registered in the two ...

    Also Ranks for: 10 Years |  local therapy |  malignancies patients |  ewings sarcoma |  treatment ewing
    KOL Index score: 10366

    The previous International Society of Paediatric Oncology (SIOP) trials and studies recognized three prognostic groups of renal tumors of childhood: low risk, intermediate risk, and high risk tumors, which were further defined in the SIOP (Stockholm) Working Classification of Renal Tumors of Childhood (1994). The results of the latest SIOP Trials and Studies showed that certain histological features which remain after preoperative chemotherapy, such as blastema, are of prognostic ...

    Also Ranks for: Renal Tumors |  paediatric oncology |  preoperative chemotherapy |  international society |  prognostic significance
    KOL Index score: 10093

    PURPOSE: To evaluate a multimodal approach including surgery and cisplatinum chemotherapy for treatment of children with malignant sacrococcygeal germ cell tumors (GCT) and to compare adjuvant and neoadjuvant strategies in advanced tumors.

    PATIENTS AND METHODS: Between 1983 and 1995, 71 patients with malignant sacrococcygeal GCT were prospectively enrolled onto the German protocols for nontesticular GCT Maligne Keimzelltumoren 83/86 and 89. Five patients who received no chemotherapy (n = ...

    Also Ranks for: Germ Cell |  tumor resection |  malignant sacrococcygeal |  male neoplasms |  71 patients
    KOL Index score: 9726

    Clinical data and tumor histology of 37 patients with advanced and/or metastatic hepatoblastoma (32 stage III and 5 stage IV) treated according to the protocol of the German Cooperative Pediatric Liver Tumor Study HB-89 from 1988 to 1992 were studied for prognostic factors. Twenty-three patients (73%) were free of tumor 9 months to 5 years (median, 36 months) after treatment, whereas 4 experienced progressive disease, 7 had local relapse, and 3 had recurrent metastases. None of 2 ...

    Also Ranks for: Liver Tumor |  advanced hepatoblastoma |  complete resection |  combined chemotherapy |  5 years


    Dieter Harms: Influence Statistics

    Sample of concepts for which Dieter Harms is among the top experts in the world.
    Concept World rank
    doxorubicin ipa #1
    hepatoblastomas low proliferation #1
    pattern hyalinizing #1
    study siop trials #1
    subtype brms #1
    cases jxg #1
    rare histologic features #1
    liver carcinoma involvement #1
    cytometry histologic patterns #1
    clonality juvenile xanthogranuloma #1
    wilms tumor nephroblastomas #1
    115 neuroblastomas #1
    nonviable tumor #1
    tumours newborn #1
    diploid tumors prognosis #1
    stromal–predominant histology #1
    viable stage presence #1
    childhood report #1
    xanthogranuloma antigens #1
    bösartige tumoren kindesalter #1
    nephroblastomas neoplasms #1
    beta subunit yst #1
    methodsrt pcr analysis #1
    rare tumors tumors #1
    general htert transcription #1
    aberrations testicular #1
    special staining immunohistochemistry #1
    14 vaginal rms #1
    polypoid rms #1
    hyalinizing pattern #1
    sarcomatous wilms tumour #1
    low proliferation 7 #1
    primary metastases chemotherapy #1
    aberrations paraffin #1
    rms spindle #1
    difference image cytometry #1
    tumours hyalinizing #1
    histology favorable #1
    adolescence rare tumors #1
    teratoma complete #1
    yst tumours #1
    gonadal yolk #1
    skin rms #1
    tumoren kindesalters #1
    17 months symptoms #1
    extragonadal yolk #1
    comparatively frequent tumors #1
    11 brms #1
    initial serumafp values #1
    vimentin abdominal #1

    Key People For Germ Cell

    Top KOLs in the world
    Lawrence Henry Einhorn
    germ cell testicular cancer indiana university
    George J Bosl
    germ cell clinical stage lymph node
    Bokemeyer Bokemeyer
    germ cell testicular cancer elderly patients
    Sophie Dorothea Fosså
    testicular cancer germ cell late effects
    Leendert H J Looijenga
    germ cell sex development situ hybridization
    Jan Wolter Adriaan Oosterhuis
    germ cell situ hybridization sex development

    Dieter Harms:Expert Impact

    Concepts for whichDieter Harmshas direct influence:Germ cell,  Wt1 mutations,  Anatomic correction,  Wilms tumor,  Mesoblastic nephroma,  Cell tumors.

    Dieter Harms:KOL impact

    Concepts related to the work of other authors for whichfor which Dieter Harms has influence:Germ cell,  Ewing sarcoma,  Wilms tumor,  Soft tissue,  Juvenile xanthogranuloma,  Situ hybridization,  Differential diagnosis.



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    Department of Pathology, University of Kiel, 24105 Kiel, Germany;, d.harms@online.de | Kiel Paediatric Tumor Registry, Dept. of Paediatric Pathology, University of Kiel, Kiel, Germany. | Department of Pediatric Pathology, Christian Albrechts Universi