 | Michael C StaceyShow email addressDivision of Vascular Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada | School of Medicine, University of Western Australia, Crawley, Western ... |
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Michael C Stacey:Expert Impact
Concepts for whichMichael C Staceyhas direct influence:Arterial disease,Wound fluid,Growth factors,Chronic venous disease,Calf muscle function,Chronic wounds,Leg ulcers,Peripheral arterial disease.
Michael C Stacey:KOL impact
Concepts related to the work of other authors for whichfor which Michael C Stacey has influence:Wound healing,Venous leg ulcers,Growth factors,Compression therapy,Varicose veins.
KOL Resume for Michael C Stacey
| Year | |
|---|---|
| 2021 | Division of Vascular Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada |
| 2019 | School of Medicine, University of Western Australia, Crawley, Western Australia, Australia Departments of Surgery, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada. Electronic address: Department of Surgery, McMaster University, Hamilton, Ontario, Canada |
| 2018 | Faculty of Health and Medical Sciences, University of Western Australia, Crawley, Perth, Western Australia, Australia Division of Vascular Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada. |
| 2017 | University of Western Australia Department of Surgery Crawley, Australia |
| 2013 | Fremantle Hospital, The University of Western Australia Department of Surgery Fremantle Australia |
| 2012 | School of Surgery, Fremantle Hospital, University of Western Australia, Fremantle, Australia |
| 2011 | MC Stacey, DS, FRACS, Fremantle Hospital, The University of Western Australia, Fremantle, Western Australia, Australia |
| 2010 | School of Surgery, University of Western Australia, Perth, Australia |
| 2009 | Fremantle Hospital, Fremantle, Western Australia, Australia |
| 2008 | MC Stacey, DS, School of Surgery and Pathology, The University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia |
| 2007 | School of Surgery and Pathology, The University of Western Australia, Fremantle Hospital, Fremantle, Australia |
| 2006 | Department of Surgery, University of Western Australia, Freemantle Hospital, Australia; School of Surgery and Pathology, University of Western Australia, Fremantle Hospital, Fremantle, WA, Australia |
| 2005 | The University Department of Surgery, Fremantle Hospital, Fremantle, Western Australia 6160, Australia Departments of Surgery St. Thomas' Hospital, London, UK |
| 2004 | Elizabeth A. Ayello is a clinical associate professor and senior adviser for the John A. Hartford Institute of Geriatric Nursing in the division of nursing at New York University in New York, N.Y. Caroline Dowsett is a nurse-consultant and lecturer in wound care at South Bank University in London, United Kingdom. Gregory S. Schultz is a professor in the department of obstetrics and gynecology at the University of Florida in Gainesville. R. Gary Sibbald is associate professor of medicine and director of continuing education in the department of medicine at the University of Toronto in Toronto, Ontario, and director of the dermatology day care and wound healing clinic at Sunnybrook and Women's College Health Sciences Centre in Toronto. Vincent Falanga is professor of dermatology and biochemistry at Boston (Mass.) University School of Medicine and chairman of the department of dermatology at the Roger Williams Medical Center in Providence, R.I. Keith Harding is professor of rehabilitation medicine at the University of Wales College of Medicine in Cardiff, Wales, United Kingdom. Marco Romanelli is a consultant dermatologist in the department of dermatology and head of the wound healing service at Azienda Ospedaliera Pisana and the University of Pisa in Pisa, Italy. Michael Stacey is associate professor of surgery at Fremantle Hospital in Western Australia. Luc Téot is associate professor of plastic surgery at Montpelier University in France. Wolfgang Vanscheidt is professor of dermatology at Rheintalklinik Astoria-Privatkliniken in Bad Krozingen, Germany. University Department of Surgery, Fremantle Hospital, Fremantle, WA. |
| 2003 | University of Western Australia Department of Surgery, Fremantle Hospital, Fremantle, Western Australia 6160, Australia A/Professor |
| 2002 | University of Western Australia, Fremantle. |
| 2001 | University Department of Surgery, Fremantle Hospital, Fremantle, Western Australia, Australia |
| 2000 | University Department of Surgery, Fremantle Hospital, PO Box 480, Fremantle, WA 6160, Australia |
| 1999 | From the Department of Surgerya, University of Western Australia, Fremantle, Australia; Institute for Wound Healingb, University of Florida College of Medicine, Gainesville, FL; Orlando Regional Medical Centerc, Orlando, FL; Pfizer Pharmaceuticals Ltdd, Sandwich, and Strangeways Laboratorye, Cambridge, United Kingdom. Department of Surgery, The University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia |
| 1998 | The University of Western Australia, Department of Surgery, Fremantle Hospital, Fremantle, Western Australia |
| 1997 | Fremantle, Australia |
| 1996 | University Department of Surgery, Fremantle Hospital, Fremantle, Western Australia Australia Fremantle Hospital, Fremantle, WA |
| 1995 | Department of Surgery (PC), Nepean Hospital, Sydney; Department of Surgery (GMF), Westmead Hospital, Sydney; and University Department of Surgery (MCS), Fremantle Hospital, Western Australia, Australia. |
| 1994 | University Department of Surgery, Fremantle Hospital, Western Australia |
| 1993 | University of Western Australia, Nedlands and Fremantle, and the Office of Research, National Center for Toxicological Research Departments of Pharmacology and Surgery Jefferson |
| 1992 | The University Department of Surgery, Fremantle Hospital, Western Australia, Australia University Department of Surgery, Fremantle Hospital, Alma Street, Fremantle, WA, 6160 |
| 1989 | Department of Surgery, St Thomas' Hospital Medical School, St. Thomas' Hospital, London, SE1 UK |
| 1986 | Department of Surgery, St Thomas' Hospital, London SE1 7EH, UK. |
| 1982 | Queen Elizabeth II Medical Centre, Nedlands, WA, 6009 |
| Concept | World rank |
|---|---|
| factors chronic ulceration | #1 |
| apg differences | #1 |
| apg measurements | #1 |
| effectiveness polidocanol | #1 |
| rater reliability raters | #1 |
| apg test | #1 |
| 239 limbs | #1 |
| limbs arterial | #1 |
| wound leg | #1 |
| calf gaiter | #1 |
| venous ulcers time | #1 |
| time point ultrasonography | #1 |
| surgery fremantle hospital | #1 |
| gaiter positions | #1 |
| heal growth | #1 |
| 10 tests visit | #1 |
| impair wound granulation | #1 |
| effectiveness sclerosant | #1 |
| tumor necrosis factoralphawere | #1 |
| time calf muscle | #1 |
| chronic ulceration leg | #1 |
| adjacent skin factors | #1 |
| vlu healing status | #1 |
| directed chronic | #1 |
| test wound healing | #1 |
| polidocanol varicose | #1 |
| polidocanol std | #1 |
| duplex scan evaluation | #1 |
| tnfalpha bioactivity relative | #1 |
| nct02845466 | #1 |
| ulceration median | #1 |
| topical autologous platelet | #1 |
| reported polidocanol | #1 |
| chronic leg frequency | #1 |
| impregnated stockingette | #1 |
| healing chronic | #1 |
| 2448 ulcers | #1 |
| poor calf muscle | #1 |
| ulcers urokinase | #1 |
| alginate dressing patients | #1 |
| base healing wounds | #1 |
| activators venous | #1 |
| pa ulcer | #1 |
| growth factors concept | #1 |
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Prominent publications by Michael C Stacey
Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors
[ PUBLICATION ]
To assess the differences in proteolytic activity of acute and chronic wound environments, wound fluids were collected from acute surgical wounds (22 samples) and chronic wounds (25 samples) of various etiologies, including mixed vessel disease ulcers, decubiti and diabetic foot ulcers. Matrix metalloproteinase (MMP) activity measured using the Azocoll assay was significantly elevated by 30 fold in chronic wounds (median 22.8 microg MMP Eq/ml) compared to acute wounds (median 0.76 microg ...
| Known for Chronic Wound | Healing Acute | Epidermal Growth Factor | Leg Ulcers | Nonparametric Tissue Inhibitor |
Levels of Tumor Necrosis Factor-α (TNF-α) and Soluble TNF Receptors in Chronic Venous Leg Ulcers – Correlations to Healing Status
[ PUBLICATION ]
This study tested the hypothesis that excessive tumor necrosis factor-alpha (TNF-alpha) levels in chronic venous leg ulcers are associated with impaired healing. TNF-alpha was measured by two enzyme-linked immunosorbent assays and a bioassay (KYM-1D4) in paired wound fluid samples collected during the nonhealing and healing phases from 21 human patients with venous leg ulcers. Soluble TNF receptor levels (p55 and p75) were also measured. The levels of immunoreactive TNF-alpha were ...
| Known for Tumor Necrosis | Wound Fluid | Healing Status | Venous Leg Ulcers | Tnf Alpha |
Objective: To evaluate the complications of polidocanol and compare its effectiveness and complications with sodium tetradecyl sulphate (STD) and hypertonic saline. Design: A single-arm prospective study of polidocanol complications and its effectiveness as a sclerosant. This was compared with each investigator's previous experience with other sclerosing agents. Setting: Multiple investigators in both private practices and hospital settings. Patients: Patients had either varicose ...
| Known for Complications Polidocanol | Hypertonic Saline | Effectiveness Sclerotherapy | Investigators Previous Experience | Varicose Veins |
Induction of MMP‐1, MMP‐3 and TIMP‐1 in normal dermal fibroblasts by chronic venous leg ulcer wound fluid*
[ PUBLICATION ]
In the wound bed of chronic venous leg ulcers, an imbalance of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) may cause excessive proteolysis and impair wound granulation. Soluble mediators in the wound environment may be responsible for this imbalance. The in vitro effect of wound fluid from venous leg ulcers on dermal fibroblast production of MMP-1, MMP-3 and TIMP-1 was compared with the effect of acute wound fluid from two different sources: fluid ...
| Known for Wound Fluid | Venous Leg | Dermal Fibroblasts | 1 Matrix Metalloproteinase | Tissue Inhibitor |
The healing process in acute wounds has been extensively studied and the knowledge derived from these studies has often been extrapolated to the care of chronic wounds, on the assumption that nonhealing chronic wounds were simply aberrations of the normal tissue repair process. However, this approach is less than satisfactory, as the chronic wound healing process differs in many important respects from that seen in acute wounds. In chronic wounds, the orderly sequence of events seen in ...
| Known for Wound Bed Preparation | Systematic Approach | Healing Process | Acute Chronic | Therapeutic Measures |
The cause of impaired healing in chronic leg ulcers is not known. However, recent attempts to modify the healing process have focused on adding growth factors to stimulate healing and have failed to produce dramatic improvements in healing. This study used a unique model of chronic wound healing in humans to obtain wound fluid samples from chronic venous leg ulcers that had changed from a nonhealing to a healing phase. These samples were used to assess cytokine and growth factor levels, ...
| Known for Healing Chronic | Cytokine Levels | Growth Factor | Wound Fluid | Leg Ulcers |
Cytokines and growth factors in keratinocytes and sweat glands in chronic venous leg ulcers. An immunohistochemical study
[ PUBLICATION ]
The role of growth factors and cytokines in the impaired healing of chronic leg ulcers remains uncertain. The aim of this study was to determine whether changes in the amount and location of cytokines and growth factors may be associated with impaired healing in chronic leg ulcers. Biopsies from leg ulcers of 21 patients and from normal skin of nine healthy volunteers were examined immunohistochemically for selected growth factors and cytokines. Greater staining intensity was found in ...
| Known for Growth Factors | Leg Ulcers | Impaired Healing | Chronic Disease | Ulcer Wound |
The purpose of this study was to determine differences in iron and iron protein (ferritin and transferrin) levels in chronic venous ulcers and acute wounds. The deleterious effect of iron in free-radical-induced tissue damage was indirectly examined by assessing 8-isoprostane levels and antioxidant status in wound fluid samples. Wound fluid samples from chronic leg ulcers in nonhealing and healing phases and wound fluid from mastectomy wounds were assayed for ferritin, transferrin, total ...
| Known for Chronic Wounds | Wound Fluid | Ferritin Transferrin | Perls Staining | Leg Ulcers |
This study was undertaken to determine the relative prevalence of the factors causing chronic ulceration of the leg in the general population. Two hundred and fifty-nine patients with chronic ulceration of the leg were found on screening a Western Australian population of 238,000. (The prevalence of chronic ulceration of the leg was 1.1 per 1000 population.) Two hundred and forty-two of these patients (93%) with 286 chronically ulcerated limbs were fully assessed to determine the factors ...
| Known for Chronic Leg | Arterial Disease | Rheumatoid Arthritis | Ulcerated Limbs | 1000 Population |
Calf pump function in patients with healed venous ulcers is not improved by surgery to the communicating veins or by elastic stockings
[ PUBLICATION ]
Calf muscle pump function was assessed in 41 limbs after venous ulcers had healed. Treatment was then randomized either to ligation of incompetent lower leg communicating veins and ablation of incompetent superficial veins combined with permanent graduated compression elastic stockings, or to graduated compression elastic stockings only. Half volume refilling time (TV1/2) and relative expelled volume (EVrel) measured on foot volume plethysmography were used to assess calf muscle pump ...
| Known for Elastic Stockings | Venous Ulcers | Pump Function | 12 Months | Incompetent Superficial Veins |
OBJECTIVE: To evaluate the frequency of malignant ulcers in patients presenting with leg ulcers.
DESIGN: A descriptive study from data collected between July 1988 and June 1995 from 981 patients (2448 ulcers) attending a leg ulcer clinic.
SETTING: A specialised leg ulcer clinic at a tertiary teaching hospital.
SUBJECTS: 43 patients with 55 malignant skin lesions.
OUTCOME MEASURES: Tissue biopsies in ulcerated lesions that suggested malignancy or were not responding to appropriate ...
| Known for Leg Ulcers | Basal Cell Carcinoma | Malignant Lesions | Aged Skin | Ulcer Patients |
OBJECTIVE: To assess the effect of different dressings on venous ulcer healing.
DESIGN: A randomised clinical trial.
MATERIALS: Patients were randomised to treatment with one of three dressings: a zinc oxide impregnated bandage, a zinc oxide impregnated stockingette, or an alginate dressing. All patients were treated as outpatients and had compression bandaging with two minimal stretch bandages (Elastocrepe) and a stockingette (Tubigrip) to keep the bandages in place.
METHODS: One ...
| Known for Ulcer Healing | Venous Disease | Zinc Oxide | Alginate Dressing | Randomised Trial |
The aim of this study was to assess calf muscle function in patients with chronic venous disease and recently healed venous ulcers. Forty-nine consecutive patients with recently healed proven venous leg ulcers and 20 age- and sex-matched control subjects were entered into this study. Both patients and control subjects underwent duplex scan evaluation of their leg veins and isokinetic measurement for calf muscle strength and endurance. Calf muscle function was significantly impaired in ...
| Known for Calf Muscle Function | Chronic Venous | Muscle Strength | Leg Ulcers | Wound Healing |
Tissue and urokinase plasminogen activators in the environs of venous and ischaemic leg ulcers
[ PUBLICATION ]
Urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA) were assayed in biopsies from the base, edge and adjacent skin of ischaemic and venous ulcers using a functional bioimmunoassay and a standard immunoassay. Two series of 14 biopsies were examined: from seven venous and seven ischaemic ulcers in the first series, eight venous and six ischaemic in the second. It was found that tPA was detected in only four samples of ulcer edge using the bioimmunoassay and in no ...
| Known for Plasminogen Activator | Leg Ulcers | Ulcer Edge | Wound Healing | Skin Tissue |
