• Allergies
  • Allergies Kols

    Prominent publications by Alain TAIEB

    KOL Index score: 15300

    Trichothiodystrophy (TTD) is a rare, autosomal recessive disorder characterized by sulfur-deficient brittle hair and nails, mental retardation, impaired sexual development, and ichthyosis. Photosensitivity has been reported in approximately 50% of the cases, but no skin cancer is associated with TTD. Virtually all photosensitive TTD patients have a deficiency in the nucleotide excision repair (NER) of UV-induced DNA damage that is indistinguishable from that of xeroderma pigmentosum (XP) ...

    Also Ranks for: Repair Transcription |  xp ttd |  mental retardation |  subunits tfiih |  cockayne syndrome
    KOL Index score: 13357

    BACKGROUND: Interleukin (IL)-13 plays a key role in type 2 inflammation and is an emerging pathogenic mediator in atopic dermatitis (AD).

    OBJECTIVE: We investigated the efficacy and safety of lebrikizumab, an IL-13 monoclonal antibody, as an add-on to topical corticosteroid (TCS) treatment.

    METHODS: A randomized, placebo-controlled, double-blind, phase 2 study. Adults with moderate-to-severe AD were required to use TCS twice daily and then randomized (1:1:1:1) to lebrikizumab 125 mg ...

    Also Ranks for: Atopic Dermatitis |  topical corticosteroids |  efficacy safety |  12 weeks |  monoclonal antibody
    KOL Index score: 13355

    BACKGROUND: Vehicle-controlled studies have demonstrated the efficacy and safety of tacrolimus ointment in the treatment of patients with atopic dermatitis (AD).

    OBJECTIVE: This study was undertaken to compare 0.03% and 0.1% tacrolimus ointment with 1% hydrocortisone acetate ointment in children 2 to 15 years of age with moderate-to-severe AD.

    METHODS: Treatment was twice daily to affected areas for 3 weeks in this multicenter, randomized, double-blind, parallel-group study. The primary ...

    Also Ranks for: Tacrolimus Ointment |  hydrocortisone acetate |  atopic dermatitis |  003 01 |  efficacy safety
    KOL Index score: 12304

    OBJECTIVE: In 1940 Kasabach and Merritt described an infant with a vascular anomaly, extensive purpura, and thrombocytopenia; they called his lesion "capillary hemangioma." Hemangioma is a benign tumor that grows in infancy and is characterized by proliferation of endothelial cells and regression during childhood. Although Kasabach-Merritt syndrome (KMS) is frequently mentioned as a possible complication of hemangioma, our experience suggests that the anatomic vascular lesion underlying ...

    Also Ranks for: Hemangioma Infancy |  merritt syndrome |  22 patients |  vascular lesion |  endothelial cells
    KOL Index score: 12228

    BACKGROUND: Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune diseases.

    METHODS: To identify generalized vitiligo susceptibility loci, we conducted a genomewide association study. We genotyped 579,146 single-nucleotide polymorphisms (SNPs) in 1514 patients with generalized vitiligo who were of European-derived white (CEU) ancestry and compared ...

    Also Ranks for: Generalized Vitiligo |  susceptibility loci |  autoimmune diseases |  patchy depigmentation |  melanocyte loss
    KOL Index score: 12167

    Netherton syndrome is a severe autosomal recessive skin disorder characterized by congenital erythroderma, a specific hair-shaft abnormality, and atopic manifestations with high IgE levels. Recently, we identified SPINK5, which encodes the serine protease inhibitor Kazal-type 5 protein (LEKTI), as the defective gene in Netherton syndrome. Here we describe the intron-exon organization of the gene and characterize the SPINK5 mutations in patients from 21 families of different geographic ...

    Also Ranks for: Spink5 Mutations |  netherton syndrome |  disease expression |  ichthyosiform erythroderma |  peptidase inhibitor
    KOL Index score: 11528

    We have hypothesised that melanocytes disappear in vitiligo because they are weakly attached to the epidermal basal membrane (melanocytorrhagy). In the epidermis, attachment of melanocytes to collagen IV is mediated through DDR1, which is under the control of CCN3. DDR1 genetic variants have been associated with vitiligo in patients of different ethnic origin. In vitro studies have shown that inhibition of CCN3 induces the detachment of melanocytes. We have studied in parallel the ...

    Also Ranks for: Vitiligo Skin |  ccn3 expression |  receptor protein |  melanocyte adhesion |  discoidin domain
    KOL Index score: 11132

    BACKGROUND: The diagnosis of atopic dermatitis (AD) is made using evaluated clinical criteria. Management of AD must consider the symptomatic variability of the disease.

    METHODS: EADV eczema task force developed its guideline for atopic dermatitis diagnosis and treatment based on literature review and repeated consenting group discussions.

    RESULTS AND DISCUSSION: Basic therapy relies on hydrating topical treatment and avoidance of specific and unspecific provocation factors. ...

    Also Ranks for: Atopic Dermatitis |  topical treatment |  selected cases |  task force |  eadv eczema
    KOL Index score: 11013

    The human XPB DNA helicase is a subunit of the DNA repair/basal transcription factor TFIIH, involved in early steps of the nucleotide excision repair pathway. Two distinct clinical phenotypes, xeroderma pigmentosum associated with Cockayne's syndrome (XP/CS) and trichothiodystrophy (TTD), can be due to mutations in the XPB gene. In the present work, we studied cellular DNA repair properties of skin fibro-blasts from two patients mutated in the XPB gene: an XP/CS patient cell (XPCS2BA) ...

    Also Ranks for: Xpb Gene |  dna repair |  xp ttd |  xeroderma pigmentosum |  cockayne syndrome
    KOL Index score: 10820

    BACKGROUND: Few therapeutic alternatives currently exist in the treatment of papulopustular rosacea (PPR).

    OBJECTIVES: To demonstrate superiority of once-daily ivermectin 1% cream (IVM 1%) once daily vs. twice-daily metronidazole (MTZ 0·75%) cream, regarding percentage reduction of inflammatory lesions in subjects with moderate to severe PPR.

    METHODS: In this Phase 3, investigator-blinded, randomized, parallel-group study, subjects received IVM 1% once daily, or MTZ 0·75% twice daily ...

    Also Ranks for: Inflammatory Lesions |  ivermectin 1 |  cream ivm |  papulopustular rosacea |  efficacy assessments
    KOL Index score: 10442

    BACKGROUND: Dermatological surgery is a relatively new and expanding subspecialty within dermatology. Little information is available about complications in this kind of surgery in the European setting.

    OBJECTIVES: The aim of this study was to assess the incidence of anaesthetic, haemorrhagic and infectious complications in dermatological surgery and to highlight the factors associated with these complications.

    METHODS: Data were collected prospectively over a 3-month period for all ...

    Also Ranks for: Dermatological Surgery |  surgical procedures |  infectious complications |  study incidence |  independent factors
    KOL Index score: 9964

    CONTEXT: Heterozygous GNAS inactivating mutations are known to induce pseudohypoparathyroidism type 1a when maternally inherited and pseudopseudohypoparathyroidism when paternally inherited. Progressive osseous heteroplasia (POH) is a rare disease of ectopic bone formation, and studies in different families have shown that POH is also caused by paternally inherited GNAS mutations.

    OBJECTIVE: Our purpose was to characterize parental origin of the mutated allele in de novo cases of POH and ...

    Also Ranks for: Progressive Osseous Heteroplasia |  gnas mutations |  parental origin |  pseudohypoparathyroidism type 1a |  mutated allele


    Alain TAIEB: Influence Statistics

    Sample of concepts for which Alain TAIEB is among the top experts in the world.
    Concept World rank
    overlapping hres #1
    vitiligo guidelines #1
    infants higher prevalence #1
    kc population #1
    dec 3rd #1
    study ccn3 #1
    irritant reaction aeroallergens #1
    cells reconstructed epidermis #1
    vmi melanin volume #1
    vitiligo tested #1
    skin hyperpigmentation disorders #1
    congenital nevi dermis #1
    gel bid #1
    transepidermal elimination melanocytes #1
    neonatal volkmann #1
    café wood #1
    atopic diathesis association #1
    patients ccn3 #1
    pigmentary systemic sclerosis #1
    adult patients monocytes #1
    ifag #1
    standard allergens children #1
    naevus atopicus #1
    hhnmd #1
    4 24 friction #1
    ecad melanocyte adhesiveness #1
    melanocytic loss #1
    successful short desensitization #1
    cancer disorders #1
    tfh type #1
    granuloma humans ifag #1
    lesional vitiligo skin #1
    positive apt controls #1
    european setting #1
    sunexposed areas hypopigmentation #1
    patients systemic metronidazole #1
    sv mixed vitiligo #1
    cosmetic agents #1
    cutaneous administration skin #1
    congenital nevi #1
    relapse infantile haemangiomas #1
    vitiligo core #1
    mesylate scleroderma #1
    antipd1 therapies vitiligo #1
    cd8 trm vitiligo #1
    onset generalized vitiligo #1
    flares tcs #1
    saves excellent correlation #1
    herpes infection sjs #1

    Key People For Atopic Dermatitis

    Top KOLs in the world
    Donald Y M Leung
    atopic dermatitis eczema herpeticum food allergy
    Thomas RM Bieber
    atopic dermatitis dendritic cells lupus erythematosus
    Jon M Hanifin
    atopic dermatitis eczema herpeticum histamine release
    Mark Boguniewicz
    atopic dermatitis eczema herpeticum tacrolimus ointment
    Hywel C G Williams
    atopic eczema cochrane skin basal cell carcinoma
    Johnannes Ring
    atopic eczema west germany histamine release

    Alain TAIEB:Expert Impact

    Concepts for whichAlain TAIEBhas direct influence:Atopic dermatitis,  Xeroderma pigmentosum,  Generalized vitiligo,  Nevus cells,  Longitudinal melanonychia,  Segmental vitiligo,  Atopic eczema.

    Alain TAIEB:KOL impact

    Concepts related to the work of other authors for whichfor which Alain TAIEB has influence:Atopic dermatitis,  Infantile hemangiomas,  Oxidative stress,  Oral propranolol,  Vascular anomalies,  Vitiligo patients,  Netherton syndrome.



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    BRIC, UMR 1312, Inserm, University Bordeaux, F-33076 Bordeaux, France;, priscilla.kaulanjan@gmail.com, (P.K.-C.);, ouch_sandra@hotmail.fr, (S.O.);, sorilla.prey@chu-bordeaux.fr, (S.P.);, muriel.cario-andre@u-bordeaux.fr, (M.C.);, christine.labreze@ch