Prominent publications by David W Ellison

KOL Index score: 18954

INTRODUCTION: We performed a genomic study in lung adenocarcinoma cases with discordant anaplastic lymphoma receptor tyrosine kinase gene (ALK) status by fluorescent in situ hybridization (FISH) and immunohistochemical (IHC) analysis.

METHODS: DNA from formalin-fixed paraffin-embedded tissues of 16 discordant (four FISH-positive/IHC-negative and 12 FISH-negative/IHC-positive) cases by Vysis ALK Break Apart FISH and ALK IHC testing (ALK1 clone) were subjected to whole gene capture and ...

Known for Lung Adenocarcinoma |  Fish Ihc |  Alk Gene |  Situ Hybridization |  Positive Cases
KOL Index score: 16751

Medulloblastoma is heterogeneous, being characterized by molecular subgroups that demonstrate distinct gene expression profiles. Activation of the WNT or SHH signaling pathway characterizes two of these molecular subgroups, the former associated with low-risk disease and the latter potentially targeted by novel SHH pathway inhibitors. This manuscript reports the validation of a novel diagnostic immunohistochemical method to distinguish SHH, WNT, and non-SHH/WNT tumors and details their ...

Known for Molecular Subgroups |  Wnt Shh |  Proteins Signal |  Immunohistochemical Markers |  Factors Disease
KOL Index score: 15882

Low-grade neuroepithelial tumors (LGNTs) are diverse CNS tumors presenting in children and young adults, often with a history of epilepsy. While the genetic profiles of common LGNTs, such as the pilocytic astrocytoma and ‘adult-type’ diffuse gliomas, are largely established, those of uncommon LGNTs remain to be defined. In this study, we have used massively parallel sequencing and various targeted molecular genetic approaches to study alterations in 91 LGNTs, mostly from children but ...

Known for Genetic Alterations |  Neuroepithelial Tumors |  Braf Fgfr1 |  Angiocentric Gliomas |  Fibroblast Growth Factor
KOL Index score: 15592

CONTEXT: Neuroblastoma is diagnosed over a wide age range from birth through young adulthood, and older age at diagnosis is associated with a decline in survivability.

OBJECTIVE: To identify genetic mutations that are associated with age at diagnosis in patients with metastatic neuroblastoma.

DESIGN, SETTING, AND PATIENTS: Whole genome sequencing was performed on DNA from diagnostic tumors and their matched germlines from 40 patients with metastatic neuroblastoma obtained between 1987 ...

Known for Genetic Mutations |  Tumors Patients |  Situ Hybridization |  Age Diagnosis |  Atrx Gene
KOL Index score: 15221

BACKGROUND: Young children with medulloblastoma have a poor overall survival compared with older children, due to use of radiation-sparing therapy in young children. Radiotherapy is omitted or reduced in these young patients to spare them from debilitating long-term side-effects. We aimed to estimate event-free survival and define the molecular characteristics associated with progression-free survival in young patients with medulloblastoma using a risk-stratified treatment strategy ...

Known for Young Children |  Chemotherapy Patients |  Adapted Therapy |  Adjuvant Child |  Methylation Profiling
KOL Index score: 13752

Cancer stem cells are remarkably similar to normal stem cells: both self-renew, are multipotent and express common surface markers, for example, prominin 1 (PROM1, also called CD133). What remains unclear is whether cancer stem cells are the direct progeny of mutated stem cells or more mature cells that reacquire stem cell properties during tumour formation. Answering this question will require knowledge of whether normal stem cells are susceptible to cancer-causing mutations; however, ...

Known for Stem Cells |  Neoplastic Transformation |  Small Intestinal |  Tumour Formation |  Cell Lineage
KOL Index score: 13729

BACKGROUND: Over half of childhood intracranial ependymomas occur in children younger than 5 years. As an adjuvant treatment, radiotherapy can be effective, but has the potential to damage the child's developing nervous system at a crucial time-with a resultant reduction in IQ and cognitive impairment, endocrinopathy, and risk of second malignancy. We aimed to assess the role of a primary chemotherapy strategy in avoiding or delaying radiotherapy in children younger than 3 years with ...

Known for Intracranial Ependymoma |  Radiotherapy Children |  5 Years |  Metastatic Disease |  Adjuvant Child Child
KOL Index score: 11740

OBJECTIVE: Tumours of the choroid plexus are rare tumours of neuro-ectodermal origin, accounting for less than 1% of all intracranial tumours. Most cases present in children less than 2 years of age. While choroid plexus carcinomas (CPC) are reported to have an extremely poor prognosis, choroid plexus papillomas (CPP) are generally regarded as benign tumours with a very favourable long-term outcome. Management dilemmas are associated with the choice of surgical procedure, tumour ...

Known for Choroid Plexus |  Cpc Cpp |  Adjuvant Therapy |  6 Months |  Median Followup
KOL Index score: 11460

PURPOSE: CNS tumors are the most common second primary neoplasm (SPN) observed after childhood cancer in Britain, but the relationship of risk to doses of previous radiotherapy and chemotherapy is uncertain.

METHODS: The British Childhood Cancer Survivor Study is a national, population-based, cohort study of 17,980 individuals surviving at least 5 years after diagnosis of childhood cancer. Linkage to national, population-based cancer registries identified 247 SPNs of the CNS. Cohort and ...

Known for Cns Tumors |  Childhood Cancer |  Risk Meningioma |  Radiationinduced Neoplasms |  Dose Radiation
KOL Index score: 11362

Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies from several groups around the world demonstrated that medulloblastoma is not one disease but comprises a collection of distinct molecular subgroups. However, all these studies reported on different numbers of subgroups. The current consensus is that there are only four core subgroups, which should be termed WNT, SHH, Group 3 and Group 4. Based on this, we performed a meta-analysis of all molecular ...

Known for 4 Medulloblastomas |  Molecular Subgroups |  Clinical Data |  Genetic Aberrations |  Wnt Shh
KOL Index score: 11165

BACKGROUND: Radiotherapy is an effective adjuvant treatment for brain tumours arising in very young children, but it has the potential to damage the child's developing nervous system at a crucial time - with a resultant reduction in IQ leading to cognitive impairment, associated endocrinopathy and risk of second malignancy. We aimed to assess the role of a primary chemotherapy strategy in avoiding or delaying radiotherapy in children younger than 3 years with malignant brain tumours ...

Known for 3 Years |  Patients Medulloblastoma |  Young Children |  Early Childhood |  Brain Tumours


David W Ellison: Influence Statistics

Sample of concepts for which David W Ellison is among the top experts in the world.
Concept World rank
improved outcome prediction #1
immunohistochemistry additional testing #1
19 ependymoma #1
distant failure rt1 #1
multiple s100 #1
supratentorial posterior #1
27 medulloblastomas cgh #1
dipgs recurrent alterations #1
59 fibrillary astrocytoma #1
patients relapsed ependymoma #1
sjyc07 csi #1
pxa epxas #1
spinal medullary ependymomas #1
development cerebral neoplasms #1
nct00278252 #1
bmi1 smoa1 #1
recognition geneticohistological entity #1
nadph substantia #1
worse p0003 #1
mmb myc amplification #1
h3k27me3 tumor growth #1
ptch1 exon1a #1
pathologists ependymomas #1
muj591 staging #1
epigenetic regulation medulloblastoma #1
relapsed ependymoma children #1
children intracranial aa #1
children dnmb mben #1
95ci 1q gain #1
cytologic measures #1
9 ependymoma #1
adolescent confirmed #1
cns9702 data validation #1
cns9102 #1
retained ini1 #1
patients psma imaging #1
case extraneural metastasis #1
rad54l cpcs #1
cmb efs #1
genetic abnormalities ependymomas #1
image features work #1
dipg adipg #1
nucleopositive #1
mutations chromothripsis #1
pineal sites #1
ffp csi #1
hgg erlotinib #1
poorer efs p0003 #1
12 participants str #1
events pediatric cancer #1

Key People For Astrocytic Tumours

Top KOLs in the world
David N Louis
allelic loss central nervous situ hybridization
Paul Kleihues
p53 mutations secondary glioblastomas dna methylation
Guido Reifenberger
mgmt promoter methylation central nervous malignant gliomas
Bernd Walter Scheithauer
pituitary adenomas central nervous situ hybridization
Vincent Peter Collins
human pair cell lines electron microscopy
Otmar Dieter Wiestler
central nervous temporal lobe epilepsy cell lines

David W Ellison:Expert Impact

Concepts for whichDavid W Ellisonhas direct influence:Astrocytic tumours,  Central nervous,  Young children,  Situ hybridization.

David W Ellison:KOL impact

Concepts related to the work of other authors for whichfor which David W Ellison has influence:Brain tumors,  Central nervous,  Stem cells,  Gene expression,  Cell proliferation,  Quinolinic acid,  Glioma patients.



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Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA | Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA | Department of Pathology, St. Jude Children’s Research Hospital, Memphi

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