• Disease
  • Extubation
  • Extubation Failure
  • Xiaojun Chen

    Prominent publications by Xiaojun Chen

    KOL Index score: 15526

    BACKGROUND: The management of latent Mycobacterium tuberculosis infection is a new priority action for the WHO End Tuberculosis (TB) Strategy. However, national guidelines on latent tuberculosis infection testing and treatment have not yet been developed in China. Here, we present the results from the 2-year follow-up of a study that aimed to track the development of active disease in individuals with latent tuberculosis infection, identify priority populations for latent infection ...

    Also Ranks for: Active Tuberculosis |  rural china |  latent infection |  100 personyears |  child child
    KOL Index score: 10398

    Mesenchymal stem cells (MSCs), which are poorly immunogenic and have potent immunosuppressive activities, have emerged as a promising candidate for cellular therapeutics for the treatment of disorders caused by abnormal immune responses. In this study we investigated whether human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) could ameliorate colitis in a trinitrobenzene sulfonic acid (TNBS)-induced colitis model. TNBS-treated colitic mice were infused with hUC-MSCs or ...

    Also Ranks for: Mesenchymal Stem |  umbilical cord |  huc mscs |  colitis colon |  sulfonic acid
    KOL Index score: 8865

    Ubiquitin ligases play important roles in immune regulation. The human RNF114 (RING finger protein 114), an ubiquitin ligase, was recently reported to be involved in immune response to double-stranded RNA in disease pathogenesis. Here, we identified a RNF114 homolog in Chinese sturgeon (Acipenser sinensis) and investigated its potential role in immune response. The full-length cDNA of Chinese sturgeon RNF114 (csRNF114) contains an open reading frame (ORF) of 681 nucleotides coding a ...

    Also Ranks for: Chinese Sturgeon |  ring finger protein |  signaling pathway |  immune response |  ubiquitin ligase
    KOL Index score: 8476

    Background: Tripartite motif-containing protein 11 (TRIM11) is one of the E3 ubiquitin ligases, which is upregulated in several human tumors. Meanwhile, the detailed function of TRIM11 remains unclear in breast cancer cells. Purpose: The purpose of the present study is to analyze the biological function of TRIM11 and identify its potential signaling pathway in breast cancer cells. Patients and methods: Thirty five pairs of breast cancer specimens and adjacent-matched noncancerous samples ...

    Also Ranks for: Breast Cancer |  biological function |  trim11 promotes |  signaling pathway |  rna interference
    KOL Index score: 7910

    In the past decades, hepatocellular carcinoma (HCC) has been receiving increased attention due to rising morbidity and mortality in both developing and developed countries. Koumine, one of the significant alkaloidal constituents of Gelsemium elegans Benth., has been regarded as a promising anti-inflammation, anxiolytic, and analgesic agent, as well as an anti-tumor agent. In the present study, we attempted to provide a novel mechanism by which koumine suppresses HCC cell proliferation. ...

    Also Ranks for: Hepatocellular Carcinoma |  cell proliferation |  ros production |  mapk signaling |  reactive oxygen species
    KOL Index score: 7737

    We have previously reported that the accumulation of IL-17-producing cells could mediate tumor protective immunity by promoting the migration of NK cells, T cells and dendritic cells in esophageal squamous cell carcinoma (ESCC) patients. However, there were no reports concerning the effect of IL-17A on tumor infiltrating B cells. In this study, we investigated the accumulation of CD20+ B cells in the ESCC tumor nests and further addressed the effect of IL-17A on the migration and ...

    Also Ranks for: Squamous Cell |  il17a migration |  carcinoma escc |  tumor protective immunity |  humans interleukin17
    KOL Index score: 7728

    Programmed cell death 4 (PDCD4) is a novel tumor suppressor, which is involved in the initiation and progression of cancers. However, the role of PDCD4 in hepatocellular carcinoma (HCC) has not been reported. The aim of this study was to investigate the molecular mechanism and clinical significance of PDCD4 inactivation in HCC.The mRNA levels of PDCD4 in HCC tissues and adjacent nontumor tissues were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR). Bisulfite ...

    Also Ranks for: Tumor Carcinoma |  methylation status |  programmed cell death |  suppressor gene |  regulation neoplastic
    KOL Index score: 7630

    Ovarian cancer is one of the common female malignant tumors. The early diagnosis and treatment of ovarian cancer has been a research hotspot. Therefore, we aimed to investigate the correlations between the levels of carbohydrate antigen 125 (CA125), human epididymis protein 4 (HE4), D-dimer (DDI), and fibrinogen degradation product (FDP) in patients with type II epithelial ovarian cancer.From January 2018 to January 2019, a total of 952 patients who underwent initial surgery for ...

    Also Ranks for: Ovarian Cancer |  he4 ca125 |  antigen carcinoma |  protein 2 |  wap disulfide
    KOL Index score: 7522

    Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is an autosomal dominant syndrome of eyelid malformations with (type I) or without (type II) associated premature ovarian failure. Multiple mutations in the exon and the putative core promoter region of FOXL2 gene encoding a putative forkhead transcription factor have been linked to this disease. To examine whether FOXL2 gene mutations contribute to BPES in the Chinese patient population, we screened 33 patients from 18 Chinese ...

    Also Ranks for: Foxl2 Gene |  epicanthus inversus |  polyalanine tract |  forkhead transcription |  sequence blepharophimosis
    KOL Index score: 7371

    BACKGROUND: MicroRNAs (miRNAs) play important roles in many important cellular processes and deregulation of miRNAs is linked to many human diseases including cancer. Although miR-424 has been demonstrated to inhibit progression of hepatocellular carcinoma (HCC), its expression level in serum samples and the potential clinical values remain unknown.

    MATERIALS AND METHODS: The expression level of miR-424 in the serum clinical samples from HCC patients and healthy volunteers were ...

    Also Ranks for: Hepatocellular Carcinoma |  serum mir424 |  hcc patients |  biomarkers tumor |  liver neoplasms
    KOL Index score: 7230

    BackgroundMidazolam has some potential in pain control of patients undergoing knee arthroscopy. However, the results remain controversial. We conduct a systematic review and meta-analysis to explore the effect of midazolam on pain control after knee arthroscopy.MethodsPubMed, EMbase, Web of science, EBSCO, and Cochrane library databases are systematically searched. Randomized controlled trials (RCTs) assessing the effect of midazolam on pain management after knee arthroscopy are ...

    Also Ranks for: Knee Arthroscopy |  pain control |  std md |  analgesic consumption |  systematic review metaanalysis
    KOL Index score: 7220

    Extubation failure is a complex and ongoing problem in the intensive care unit (ICU). It refers to the patients who require re-intubation after extubation (namely disconnection from mechanical ventilation). In these patients, extubation failure leads to severe risks associated with re-intubation and is associated with increased mortalities, longer stay in ICU and also higher health care costs. Many studies have been proposed to analyze the problem of extubation failure and identify ...

    Also Ranks for: Extubation Failure |  gradient boosting |  intensive unit |  mechanical ventilation |  feature analysis
    KOL Index score: 7124

    Background: Immune checkpoint inhibitors (ICIs) combined with chemotherapy have been applied as a first-line treatment for lung cancer, but consistent beneficial results have not been documented. Therefore, our meta-analysis aimed to evaluate the effectiveness and safety of combination therapy to promote its application.

    Methods: We searched electronic databases for studies that estimated the safety and efficacy of combined therapy. The objective response rate (ORR) and disease control ...

    Also Ranks for: Lung Cancer |  firstline treatment |  l1 inhibitors |  combined chemotherapy |  small cell
    KOL Index score: 7064

    Peritoneal fibrosis is a common complication of long-term peritoneal dialysis, and contributes to encapsulating peritoneal sclerosis and eventually peritoneal ultrafiltration failure, which restricts the wide application of peritoneal dialysis. Therefore, the prevention and treatment of peritoneal fibrosis is important to maintain peritoneal membrane integrity and prolong peritoneal dialysis treatment. Unfortunately, neither specific biomarkers nor effective therapies are available for ...

    Also Ranks for: Peritoneal Fibrosis |  body fluids |  dialysis patients |  common complication |  humans micrornas
    KOL Index score: 7009

    The versatile benefit effects of flavonoids lead some nutritionists to believe that they are micronutrients. However, excess intake of flavonoids may cause side effects. In this paper, the effects produced by a higher intake of rutin and baicalin on antioxidant status as well as trace minerals such as iron, copper and zinc in rat tissues were studied. When rats were fed a rutin or baicalin containing diet (1%) for 20 days, the body weight gain was lower than that of the control group. ...

    Also Ranks for: Rats Rutin |  lipid peroxidation |  catalase activity |  antioxidant status |  zinc copper


    Xiaojun Chen: Influence Statistics

    Sample of concepts for which Xiaojun Chen is among the top experts in the world.
    Concept World rank
    monotone ncp #1
    inexact uzawa methods #2

    Key People For Extubation Failure

    Top KOLs in the world
    Scott K Epstein
    mechanical ventilation extubation failure arm elevation
    Andrés Esteban
    mechanical ventilation septic shock respiratory distress
    Laurent Jean Brochard
    mechanical ventilation respiratory distress lung injury
    Ronald L Ciubotaru
    hospitalized patients mechanical ventilation failed extubation
    Inmaculada Alía
    mechanical ventilation spontaneous breathing accidental removal
    Antonio R Anzueto
    mechanical ventilation chronic obstructive copd exacerbations

    Xiaojun Chen:Expert Impact

    Concepts for whichXiaojun Chenhas direct influence:Extubation failure,  Knee arthroscopy,  Soluble fiber,  Peritoneal fibrosis,  Chinese sturgeon,  Foxl2 gene,  Fracture toughness,  Endometrial cancer.

    Xiaojun Chen:KOL impact

    Concepts related to the work of other authors for whichfor which Xiaojun Chen has influence:Cervical cancer,  Heat stress,  Nonsmooth equations,  Mesenchymal stem,  Inflammatory bowel disease,  Newton method,  Artificial intelligence.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, No. 419, Fangxie Road, 200011, Shanghai, People’s Republic of China | College of Computer Science and Software, Shenzhen University, 47890 Shenzhen, Guangdong, China, 518