M. Zenatti

M. Zenatti

Service De Biochimie Médicale, Faculté De Médecine Pitié-Salpétrière, 91 Blvd De L'hôpital, 75634 Paris Cedex 13, France

Direct Impact

Concepts for which M Zenatti has direct influence:

adrenal carcinoma
aldosterone synthesis
mineralocorticoid pathway
kidney mitochondria
inhibitory agents
cyclosporine nephrotoxicity
oxidative phosphorylation chains

External impact

Concepts related to the work of other authors for which M Zenatti has influence:

adrenocortical carcinoma
energy metabolism
18 hydroxycorticosterone
adrenal toxicity
aldosterone synthesis
electron transport
mitochondria conversion

Prominent publications by M. Zenatti

KOL-Index: 26 The authors used incubated adrenal mitochondria to study the in vitro effect of suramin, an antiparasitic drug, on the transformation of corticosterone and 18-hydroxycorticosterone into aldosterone. The results show that, under conditions preserving membrane integrity, the "impermeance" of suramin meant that concentrations similar to the plasma-levels reached in treated patients induced only ...
Known for
Plasma-Levels | Extramitochondrial | Metabolic Intermediate Carriers | Incubated Adrenal Mitochondria
KOL-Index: 8 In order to find a biochemical marker to assist the physician in the difficult differential diagnosis between malignant and nonmalignant adrenal tumors, plasma levels of the mineralocorticosteroids (deoxycorticosterone, 18-hydroxydeoxycorticosterone, corticosterone, 18-hydroxycorticosterone, and aldosterone) were determined. The same method (RIA which is preceded by a crucial separation ...
Known for
Malignant Adrenocortical | Adrenal Tumors | Steroid Marker | Hypoaldosteronism Method
KOL-Index: 6 The authors review some current ideas concerning the role of 18-hydroxylated corticosteroids as mineralocorticoids themselves and as possible precursors of the principal mineralocorticoid, aldosterone. In particular, the physiological and pharmacological agents affecting their secretion are discussed together with a description of the methods used for their analysis in plasma in the ...
Known for
Biochemistry Pitié-Salpétrière | Physiological Pharmacological Agents | 18-Hydroxylated Corticosteroids | Inborn Errors
KOL-Index: 6 The authors incubated adrenal mitochondria to study the in vitro action of cortisol and testosterone on the transformation of corticosterone and 18-hydroxycorticosterone into aldosterone. The results show that cortisol at concentrations of 5 x 10(-6) and 10(-4) M inhibit the conversion of corticosterone into aldosterone by 23.6 to 90%; testosterone 5 x 10(-5) and 10(-4) M inhibit the ...
Known for
Functional Zonation | Adrenal Tumors | Hydroxylation Steps | Vitro Action
KOL-Index: 3 The action of verapamil, a calcium channel blocker, on the last step of aldosterone biosynthesis (transformation of 18-hydroxycorticosterone into aldosterone) was studied using duck adrenal mitochondria in the absence of regulatory factors. Results show that 10(-5) M verapamil inhibits the transformation of 18-hydroxycorticosterone into aldosterone by 52.8%. Moreover, our findings show that ...
Known for
11 Beta | Calcium Channel Blocker | Regulatory Verapamil | Duck Adrenal Mitochondria

Service de Biochimie Médicale, Faculté de Médecine Pitié-Salpétrière, 91 Blvd de l'Hôpital, 75634 Paris Cedex 13, France

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