• Disease
  • Amphetamine
  • Amphetamine Withdrawal
  • Kenneth J Renner

    Prominent publications by Kenneth J Renner

    KOL Index score: 14223

    Decreases in serotonergic activity in the central nucleus of the amygdala reduce responses to stressors, suggesting an important role for serotonin in this region of the amygdala in stress reactivity. However, it is not known whether exposure to stressors actually increases serotonin release in the central nucleus of the amygdala. The current experiment tested the hypothesis that restraint stress increases extracellular serotonin within the central nucleus of the amygdala and adjacent ...

    Also Ranks for: Central Nucleus |  restraint stress |  serotonin release |  releasing factor |  receptors corticotropin
    KOL Index score: 13075

    Interactions between central corticotropin-releasing factor (CRF) and serotonergic systems are believed to be important for mediating fear and anxiety behaviors. Recently we demonstrated that infusions of CRF into the rat dorsal raphe nucleus result in a delayed increase in serotonin release within the medial prefrontal cortex that coincided with a reduction in fear behavior. The current studies were designed to study the CRF receptor mechanisms and pathways involved in this serotonergic ...

    Also Ranks for: Dorsal Raphe |  type 2 |  spraguedawley receptors |  central nucleus |  releasing factor
    KOL Index score: 12566

    Acute amphetamine administration activates monoaminergic pathways and increases systemic corticosterone, both of which influence anxiety states and adult dentate gyrus neurogenesis. Chronic amphetamine increases anxiety states in rats when measured at 24 h and at 2 weeks of withdrawal. However, the effects of chronic amphetamine exposure and withdrawal on long term anxiety-like behavior and adult neurogenesis in the dentate gyrus are unknown. Adult male rats were administered amphetamine ...

    Also Ranks for: Dentate Gyrus |  chronic amphetamine |  anxiety states |  adult neurogenesis |  weeks withdrawal
    KOL Index score: 12374

    Withdrawal from amphetamine increases anxiety and reduces the ability to cope with stress, which are factors that are believed to contribute to drug relapse. Stress-induced serotonergic transmission in the central nucleus of the amygdala is associated with anxiety states and fear. Conversely, stress-induced increases in ventral hippocampal serotonin (5-HT) levels have been linked to coping mechanisms. The goal of this study was to investigate the neurobiological changes induced by ...

    Also Ranks for: Amphetamine Withdrawal |  ventral hippocampus |  central amygdala |  5ht levels |  glucocorticoid receptors
    KOL Index score: 12187

    Corticotropin-releasing factor (CRF) is a neurohormone that mediates stress, anxiety, and affects serotonergic activity. Studies have shown that CRF has dose-dependent opposing effects on serotonergic activity. This effect has been hypothesized to be differentially mediated by CRF(1) and CRF(2) receptors in the dorsal raphé nucleus. We directly tested this hypothesis by using in vivo microdialysis to determine the effects of CRF and CRF receptor antagonists in the dorsal raphé nucleus on ...

    Also Ranks for: Nucleus Accumbens |  serotonin release |  2 receptors |  releasing factor |  serotonergic activity
    KOL Index score: 12115

    Withdrawal from amphetamine is associated with increased anxiety and sensitivity to stressors which are thought to contribute to relapse. Rats undergoing amphetamine withdrawal fail to exhibit stress-induced increases in serotonin (5-HT) release in the ventral hippocampus and show heightened anxiety-like behaviors. Therefore, we tested the hypothesis that reducing 5-HT levels in the ventral hippocampus is a causal mechanism in increasing anxiety-like behaviors during amphetamine ...

    Also Ranks for: Ventral Hippocampus |  amphetamine withdrawal |  anxiety behavior |  5 ht |  male rats
    KOL Index score: 11684

    Central serotonergic neurons have been implicated in numerous animal behaviors and psychiatric disorders, but the molecular mechanisms underlying their development are not well understood. Here we generated Lmx1b (LIM homeobox transcription factor 1 beta) conditional knock-out mice (Lmx1b(f/f/p)) in which Lmx1b was only deleted in Pet1 (pheochromocytoma 12 ETS factor-1)-expressing 5-HT neurons. In Lmx1b(f/f/p) mice, the initial generation of central 5-HT neurons appeared normal. However, ...

    Also Ranks for: Central Serotonergic Neurons |  knockout mice |  expression lmx1b |  locomotor activity |  stages development
    KOL Index score: 11322

    The effects of the serotonin neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), on serotonin1 (5-HT1) and 5-HT2 receptors were investigated using the high degree of resolution provided by quantitative autoradiography in an effort to determine the synaptic location of these receptors. 5,7-DHT treatment resulted in a decrease in 5-HT1 binding in the dentate gyrus and CA3c/4 of the anterior hippocampus and in the dorsal raphe nucleus, whereas no changes were observed in the posterior hippocampus ...

    Also Ranks for: Quantitative Autoradiography |  central nervous |  5ht2 receptors |  5 ht1 |  dorsal raphe
    KOL Index score: 10528

    Social stress in adolescence is correlated with emergence of psychopathologies during early adulthood. In this study, the authors investigated the impact of social defeat stress during mid-adolescence on adult male brain and behavior. Adolescent male Sprague-Dawley rats were exposed to repeated social defeat for 5 days while controls were placed in a novel empty cage. When exposed to defeat-associated cues as adults, previously defeated rats showed increased risk assessment and ...

    Also Ranks for: Limbic Monoamines |  male rats |  social defeat |  anxiety behavior |  stress psychological
    KOL Index score: 9930

    Microdissection techniques were utilized to measure the activity of choline acetyltransferase (ChAT) (enzyme responsible for synthesis of acetylcholine) in individual basal forebrain nuclei of aged (24 month) and young (4 month) male and female rats. Small but consistent decreases in the activity of ChAT in aged rats were found, and the location of the changes was dependent on the sex of the rat. Aged female rats showed approximately 30% lower ChAT and 40% lower acetylcholinesterase ...

    Also Ranks for: Basal Forebrain |  activity chat |  choline acetyltransferase |  aged rats |  age dependent
    KOL Index score: 9843

    To assess whether the brain's monoaminergic and/or corticotropin-releasing factor (CRF) systems may be involved in mediating the appetite-suppressing effects of high environmental ammonia levels, we exposed rainbow trout to one of four NH4Cl treatments (0, 500, 750, 1000 micromol l(-1)) for 24 or 96 h and monitored changes in food intake, brain serotonin (5-HT) and dopamine (DA) activity, CRF and urotensin I (UI) mRNA levels, and plasma cortisol levels. Food intake decreased in a ...

    Also Ranks for: Ammonia Exposure |  rainbow trout |  food intake |  suppressing effects |  mrna levels
    KOL Index score: 9462

    Stress induced by early life social isolation leads to long-lasting alterations in stress responses and serotonergic activity. Corticotropin-releasing factor (CRF) is a neurotransmitter that mediates stress responses and alters serotonergic activity. We tested the hypothesis that the stress of early life isolation enhances responses to CRF in adulthood by determining the effect of CRF infusions into the dorsal raphe nucleus (dRN) on 5-HT release in the nucleus accumbens (NAc) of adult ...

    Also Ranks for: Adult Rats |  social isolation |  nucleus accumbens |  early life |  spraguedawley receptors
    KOL Index score: 9460

    Rapid activation of central serotonergic systems occurs in response to the social stress of aggression in dominant lizards. The most rapid expression of serotonergic activity occurs in nucleus accumbens, hippocampus and brainstem. To compare previously measured responses induced by social stressors with those provoked by physical stress, serotonergic activity was examined following restraint stress (handling) and forced physical exertion. After handling, some male Anolis carolinensis ...

    Also Ranks for: Serotonergic Activity |  nucleus accumbens |  physical stress |  locus ceruleus |  medial amygdala
    KOL Index score: 9460

    In the rat dorsomedial hypothalamus (DMH), serotonin (5-HT) concentrations are altered rapidly in response to acute stressors. The mechanism for rapid changes in 5-HT concentrations in the DMH is not clear. We hypothesize that the mechanism involves corticosteroid-induced alterations in the uptake of 5-HT from extracellular fluid through the action of corticosterone-sensitive organic cation transporters (OCTs). To determine if OCTs affect the clearance of 5-HT from the extracellular ...

    Also Ranks for: Medial Hypothalamus |  organic cation |  5 ht |  extracellular fluid |  behavioral responses
    KOL Index score: 9307

    The role of GABAergic neurons in activating female sexual behavior and possible mechanisms for GABAergic effects on behavior were examined in female rats. First, effects of the ovarian hormones estrogen and progesterone (P), at doses which promote lordosis, on levels and turnover/activity of GABA, were examined in brain areas which regulate lordosis. Utilizing AOAA, an inhibitor of GABA degradation, the accumulation rate of GABA (turnover/activity) was assessed in ovariectomized (Ovx), ...

    Also Ranks for: Female Rats |  gabaergic neurons |  estrogen progesterone |  gaba vmn |  sexual behavior


    Kenneth J Renner: Influence Statistics

    Sample of concepts for which Kenneth J Renner is among the top experts in the world.
    Concept World rank
    overflow poa #1
    differentiates rapid #1
    differing fighting strategies #1
    norepinephrine pigmentation #1
    rapid responses restraint #1
    restrained dominants #1
    promotion neuronal plasticity #1
    lower levels rats #1
    ht vertebrates #1
    albinism reduced sleep #1
    mtbi induction #1
    brain monoamine detection #1
    colony behavior selforganization #1
    432 protein spots #1
    beetle parental behavior #1
    cpu voltammetric signals #1
    current studies size #1
    losers interactions #1
    nac isolationreared animals #1
    initial size discrepancies #1
    eyespots noradrenergic turnover #1
    regional temporal separation #1
    adolescent defeat experience #1
    exertion handling #1
    pigmentation sleep #1
    receptor antagonism raphé #1
    crf dorsal #1
    stressors serotonergic #1
    icv corticotropin #1
    amphetamine treatment neurogenesis #1
    male stalkeyed fly #1
    completely dark conditions #1
    adult infralimbic mpfc #1
    5ht life events #1
    brains restrained dominants #1
    mcg vivo microdialysis #1
    frog embryos paternal #1
    cck8s generation #1
    albinism sleep loss #1
    5ht overflow rats #1
    dispersal nest site #1
    amphetamine contribute #1
    vhipp oct3 #1
    vta anolis #1
    puromycin poa #1
    mcg treatment #1
    higher raphé #1
    withdrawal dentate gyrus #1

    Key People For Amphetamine Withdrawal

    Top KOLs in the world
    George F Koob
    nucleus accumbens animal models drug addiction
    Athina Markou
    nicotine withdrawal brain reward function wistar receptors
    Larry Kokkinidis
    acoustic startle locomotor activity electrical stimulation
    Manit Srisurapanont
    alcohol dependence major depressive disorder amphetamine withdrawal
    Alasdair M Barr
    antipsychotic drugs insulin resistance psychotic symptoms
    Robert J Barrett
    drug discrimination training dose electroconvulsive shock

    Kenneth J Renner:Expert Impact

    Concepts for whichKenneth J Rennerhas direct influence:Amphetamine withdrawal,  Serotonergic activity,  Ventral hippocampus,  Central nucleus,  Serotonin release,  Opponent recognition,  Monoamine levels,  Chronic amphetamine.

    Kenneth J Renner:KOL impact

    Concepts related to the work of other authors for whichfor which Kenneth J Renner has influence:Social defeat,  Male rats,  Nucleus accumbens,  Sexual behavior,  Physical activity,  Rainbow trout,  5 ht.



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    Department of Biology, University of South Dakota, Vermillion, SD 57069 USA | Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069 USA | Department of Biology, Univers