• Disease
  • Ischemic
  • Ischemic Stroke
  • Ru Tai Hui

    Prominent publications by Ru Tai Hui

    KOL Index score: 14851

    BACKGROUND: The relationship between dietary glycemic index, glycemic load and risk of coronary heart disease (CHD), stroke, and stroke-related mortality is inconsistent.

    METHODS: We systematically searched the MEDLINE, EMBASE, and Science Citation Index Expanded databases using glycemic index, glycemic load, and cardiovascular disease and reference lists of retrieved articles up to April 30, 2012. We included prospective studies with glycemic index and glycemic load as the exposure and ...

    Also Ranks for: Dietary Glycemic |  stroke mortality |  coronary heart disease |  chd risk |  sex factors
    KOL Index score: 13656

    BACKGROUND: Recent studies on genome-wide association have identified common variants on chromosome 9p21 associated with coronary artery disease (CAD). Given that ischemic stroke and CAD share several aspects of etiology and pathogenesis, we investigated the association of variants on chromosome 9p21 with ischemic stroke and CAD in the Chinese Han population by capturing the majority of diversity in this locus using haplotype-tagging single-nucleotide polymorphisms.


    Also Ranks for: Ischemic Stroke |  coronary artery |  chinese population |  chromosome 9p21 |  disease cad
    KOL Index score: 13444

    BACKGROUND: The haplotypes in the gene vitamin K epoxide reductase complex subunit 1 (VKORC1) have been found to affect warfarin dose response through effects on the formation of reduced-form vitamin K, a cofactor for gamma-carboxylation of vitamin K-dependent proteins, which is involved in the coagulation cascade and has a potential impact on atherosclerosis. We hypothesized that VKORC1-dependent effects on the coagulation cascade and atherosclerosis would contribute to susceptibility ...

    Also Ranks for: Coronary Heart Disease |  aortic dissection |  vkorc1 haplotypes |  risk stroke |  vitamin epoxide
    KOL Index score: 13101

    Cytochrome P450 arachidonic acid (AA) epoxygenase metabolites, the epoxyeicosatrienoic acids (EETs), dilate arteries via hyperpolarization of smooth muscle cells and also have nonvasodilatory effects within the vasculature. The present study investigated the angiogenic effects of endogenous and exogenous EETs and the relevant signaling mechanisms involved. Bovine aortic endothelial cells (BAECs) were incubated with synthetic EETs or infected with recombinant adeno-associated viruses ...

    Also Ranks for: Signaling Pathways |  endothelial cell |  protein kinase |  epoxygenase metabolites |  arachidonic acid
    KOL Index score: 12866

    In Syrian hamster embryo (SHE) fibroblasts, epidermal growth factor receptor (EGFR) tyrosine kinase activity regulates the metabolism of endogenous linoleic acid to (13S)-hydroperoxyoctadecadienoic acid (13S)-HPODE). (13S)-HPODE stimulates EGF-dependent mitogenesis in a SHE cell phenotype, which expresses tumor suppressor genes (supB+), but was not effective in a variant that does not express these suppressor genes (supB-). In the present study, we have investigated the potential effects ...

    Also Ranks for: Linoleic Acid |  growth factor |  supb cells |  syrian hamster |  egf egfr
    KOL Index score: 12224

    BACKGROUND AND PURPOSE: It is still controversial whether elevated plasma homocysteine and the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene are risk factors for stroke. The aim of the present study was to investigate the association between the 2 factors and stroke in Chinese in a large case-control study.

    METHODS: We recruited 1823 stroke patients (807 cerebral thrombosis, 513 lacunar infarction, 503 intracerebral hemorrhage) and 1832 controls. Total plasma ...

    Also Ranks for: C677t Polymorphism |  plasma homocysteine |  thrombotic stroke |  reductase gene |  mutational analysis
    KOL Index score: 11971

    NEDD4L is involved in the regulation of plasma volume and blood pressure by controlling cell surface expression of the kidney epithelial Na(+) channel. Previously, the cryptic splice variant rs4149601(G/A) A allele of NEDD4L, generating isoform I, was estimated to decrease blood pressure by downregulating Na(+) reabsorption. However, a recent functional study showed that isoform I should lead to abnormal Na(+) reabsorption increases by antagonistically downregulating epithelial Na(+) ...

    Also Ranks for: Orthostatic Hypotension |  antihypertensive response |  functional variant |  blood pressure |  nedd4l hypertension
    KOL Index score: 11966

    Our study aimed to explore whether left ventricular hypertrophy (LVH), abnormal LV geometry and relative wall thickness (RWT) are associated with an increased risk of stroke in a hypertensive Chinese population. This study included 462 stroke patients and 3808 non-stroke hypertensive patients. LVH was diagnosed using the criteria of LV mass ⩾49.2 g m−2.7 for men and 46.7 g m−2.7 for women. A partition value of 0.43 was used for RWT. LV geometric patterns (normal, concentric remodeling, ...

    Also Ranks for: Ventricular Hypertrophy |  risk factors stroke |  adjusted 95 |  relative wall |  lv geometry
    KOL Index score: 11724

    PURPOSE: Protein kinase plays an essential role in controlling cardiac growth and hypertrophic remodeling. The cardiac troponin I-interacting kinase (TNNI3K), a novel cardiac specific kinase, is associated with cardiomyocyte hypertrophy. However, the precise function of TNNI3K in regulating cardiac remodeling has remained controversial.

    METHODS AND RESULTS: In a rat model of cardiac hypertrophy generated by transverse aortic constriction, myocardial TNNI3K expression was significantly ...

    Also Ranks for: Cardiac Hypertrophy |  transgenic mice |  kinase tnni3 |  ctni phosphorylation |  heart failure
    KOL Index score: 11671

    BACKGROUND: At the APOE gene, encoding apolipoprotein E, genotypes of the ε2/ε3/ε4 alleles associated with higher LDL-cholesterol (LDL-C) levels are also associated with higher coronary risk. However, the association of APOE genotype with other cardiovascular biomarkers and risk of ischaemic stroke is less clear. We evaluated the association of APOE genotype with risk of ischaemic stroke and assessed whether the observed effect was consistent with the effects of APOE genotype on LDL-C or ...

    Also Ranks for: Apoe Genotype |  ischaemic stroke |  cardiovascular risk |  european ancestry |  ε2 ε4 95
    KOL Index score: 11662

    Ca2+ cycling plays a critical role in heart failure and lethal arrhythmias. As susceptibility to sudden cardiac death is considered to be a heritable trait in general population, we have therefore investigated whether potentially functional variants of genes encoding RyR2 (ryanodine receptor 2) and the L-type Ca2+ channel are related to the risk of ventricular arrhythmias and sudden cardiac death in CHF (chronic heart failure) in a case-control study. We found that the A allele of ...

    Also Ranks for: Heart Failure |  ventricular arrhythmias |  sudden cardiac |  patients chf |  rs3766871 ryr2
    KOL Index score: 11534

    BACKGROUND: The effect of isoflavone on endothelial function in postmenopausal women is controversial.

    OBJECTIVE: The objective of this study was to evaluate the effect of oral isoflavone supplementation on endothelial function, as measured by flow-mediated dilation (FMD), in postmenopausal women.

    DESIGN: A meta-analysis of randomized placebo-controlled trials was conducted to evaluate the effect of oral isoflavone supplementation on endothelial function in postmenopausal women. Trials ...

    Also Ranks for: Postmenopausal Women |  endothelial function |  isoflavone supplementation |  randomized placebo |  vascular female humans
    KOL Index score: 11446

    OBJECTIVES: Regulatory T (Treg) cells have been shown to play a protective role in experimental atherosclerosis. However, it is unclear whether Tregs can protect from rupture of vulnerable plaque in patients with atherosclerosis. Demethylation of the DNA encoding the transcription factor forkhead box P3 (FOXP3) was found to be essential for the stable maintenance of the suppressive properties of Tregs. We aimed to evaluate Treg levels in patients with acute coronary syndrome (ACS) using ...

    Also Ranks for: Patients Acs |  coronary artery disease |  treg cells |  methylation foxp3 |  peripheral blood


    Ru Tai Hui: Influence Statistics

    Sample of concepts for which Ru Tai Hui is among the top experts in the world.
    Concept World rank
    disease humans locus #1
    promoter angpt2 #1
    telomere attrition atherosclerosis #1
    p27 cdk2 mtor #1
    43 fchl families #1
    lvh camta2 #1
    aldosterone 4 prostaglandin #1
    ii–induced hypertension #1
    stroke lacunar infarction #1
    cardiac tuberous sclerosis #1
    protective chrysoeriol #1
    foxp3tsdr patients #1
    acute patients acute #1
    rs966221 #1
    male patients management #1
    association variant rs17168525 #1
    fast rhr normotensives #1
    rs1333049 cac #1
    thrombotic stroke #1
    control study stroke #1
    vivo c10orf97 #1
    taesm #1
    matrix aortic dissection #1
    rs2359612 #1
    al110200 proinflammatory #1
    mir451 cardiac hypertrophy #1
    gadd45b cardiomyocytes hypertrophy #1
    9176 ± #1
    macrophages mir216a #1
    q4 610 μg #1
    392 693 #1
    mir216a endothelial #1
    genes mendelian forms #1
    hcm fqrs #1
    normolipidemic families apolipoprotein #1
    association plin variants #1
    gg genotype rs901681 #1
    aspirin stroke recurrence #1
    association ace2 #1
    admission wbcc #1
    p0001 wnk4 rs9916754 #1
    novo gly716arg #1
    hcm akt473 #1
    mir216a smad7 expression #1
    mir221 heart failure #1
    normolipidemic members #1
    missense mutation motif #1
    intergenic polymorphisms oat1 #1
    proband2 father #1
    senescent pdl25 cells #1

    Key People For Ischemic Stroke

    Top KOLs in the world
    Ralph L Sacco
    ischemic stroke northern manhattan study carotid plaque
    Harold P Jr Adams
    ischemic stroke cerebral infarction subarachnoid hemorrhage
    José Biller
    ischemic stroke cerebral infarction neurologic complications
    Laurens Jaap Kappelle
    ischemic stroke type 2 diabetes cognitive impairment
    Geoffrey Alan Donnan
    ischemic stroke atrial fibrillation intracerebral haemorrhage
    Jeffrey L Saver
    acute ischemic stroke endovascular thrombectomy united states

    Ru Tai Hui:Expert Impact

    Concepts for whichRu Tai Huihas direct influence:Ischemic stroke,  Blood pressure,  Aortic dissection,  Hypertrophic cardiomyopathy,  Metabolic syndrome,  Chinese population,  Ventricular hypertrophy,  Resistant hypertension.

    Ru Tai Hui:KOL impact

    Concepts related to the work of other authors for whichfor which Ru Tai Hui has influence:Ischemic stroke,  Blood pressure,  Cardiovascular disease,  Heart failure,  Metabolic syndrome,  Hypertrophic cardiomyopathy,  Aortic dissection.



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    State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China | Department of Cardiology, Fuwai Hospital, Chinese Academ