• Disease
  • Dna
  • Dna Ploidy
  • Billie‐jo M Kerns

    Prominent publications by Billie‐Jo M Kerns

    KOL Index score: 11562

    OBJECTIVE: Overexpression of the p53 and HER-2/neu oncogenes are the two most common genetic abnormalities associated with breast cancer. Shorter survival time has been reported in patients with tumors with p53 or HER-2/neu. This report analyzes a retrospective cohort of early stage breast cancers for both oncogenes and relates overexpression to clinicopathologic parameters and survival.

    METHODS: Immunostaining for p53 and HER-2/neu was performed on 230 paraffin-embedded specimens of ...

    Also Ranks for: Her2 Neu |  stage breast |  overexpression p53 |  positive staining |  gene amplification
    KOL Index score: 11446

    BACKGROUND: Several molecular-genetic alterations in endometrial cancers, including aneuploidy and aberrant expression of p53 and HER-2/neu, have been associated with poor prognosis. To determine the importance of molecular-genetic factors relative to more traditional surgical-pathologic prognostic factors, a multivariable analysis was performed.

    METHODS: Immunohistochemical staining for p53, HER-2/neu, estrogen receptor, progesterone receptor, and epidermal growth factor receptor was ...

    Also Ranks for: Dna Ploidy |  multivariable analysis |  estrogen receptors |  her2 neu |  endometrial cancer
    KOL Index score: 10927

    To investigate epidermal growth factor receptor (EGFr) presence in the prostate, monoclonal antibody (clone EGFR1) immunohistochemical examination of radical prostatectomy specimens was performed (n = 37). All prostatic specimens contained benign prostatic hyperplasia (BPH) and/or dysplasia (prostatic intraepithelial neoplasia or PIN), as well as prostatic carcinoma (CaP). Areas of dysplasia were further categorized as to the basal cell layer and the luminal cell area. BPH, PIN, and CaP ...

    Also Ranks for: Pin Cap |  basal cells |  egfr immunoreactivity |  prostatic tissues |  growth factor
    KOL Index score: 9949

    BACKGROUND: Tumors of borderline malignancy are still a controversial subgroup of ovarian neoplasms. The expression of several cell regulatory proteins was studied to characterize the molecular phenotype of these tumors, and to compare them with their benign and malignant counterparts.

    METHODS: Specimens from 22 patients with tumors of borderline malignancy (11 serous and 11 mucinous tumors), 12 patients with benign tumors, and 16 patients with invasive ovarian carcinomas were evaluated ...

    Also Ranks for: Borderline Tumors |  egfr expression |  her2 neu |  ovarian neoplasms |  protein tyrosine
    KOL Index score: 9695

    DNA ploidy has been shown to have prognostic value in adenocarcinoma of the prostate. While occasional benign lesions of the prostate may be associated with a DNA aneuploid status, most aneuploid epithelial proliferations of the prostate are carcinomas. Because of the relationship between aneuploidy and malignancy, DNA ploidy analysis might improve detection of adenocarcinoma in small core-needle biopsy specimens. In this study, DNA ploidy analysis was performed on 186 fresh core ...

    Also Ranks for: Dna Ploidy |  core biopsy |  diagnosis malignancy |  adenocarcinoma prostate |  sensitivity specificity
    KOL Index score: 8561

    The quantitation of estrogen and progesterone receptors (ER and PgR) has become the standard of care in the evaluation of patients with primary breast carcinoma. It has been demonstrated that ER and PgR detected by immunohistochemical methods in formalin-fixed paraffin-embedded tissue can be quantified by computerized image analysis. In this study, ER and PgR levels were determined by using an automated immunochemistry stainer (Ventana ES 320) and an image analyzer (CAS 200) in a series ...

    Also Ranks for: Breast Carcinoma |  estrogen receptors |  dcc method |  progesterone receptor |  image analysis
    KOL Index score: 7961

    OBJECTIVE: To determine the utility of measuring the tumor proliferation index as a prognostic marker in patients with non-small-cell lung cancer.

    DESIGN: Immunostaining for the proliferation-associated antigen Ki-67, quantitated using computer-assisted image cytometry, was used to derive the tumor proliferation index for 61 fresh-frozen, banked specimens of non-small-cell lung cancer. DNA ploidy was measured concomitantly for all specimens. A median follow-up of 38 months was achieved ...

    Also Ranks for: Cell Lung |  prognostic significance |  tumor proliferation |  dna content |  patients small
    KOL Index score: 7070

    OBJECTIVE: Our purpose was to determine whether protein tyrosine phosphatase 1B is overexpressed in ovarian cancers, possibly altering the balance of intracellular tyrosine phosphorylation.

    STUDY DESIGN: The expression of protein tyrosine phosphatase 1B was assayed in frozen sections from 54 human ovarian carcinomas and seven normal ovaries by immunochemical staining with monoclonal antibody AE4-2J, which is specific for protein tyrosine phosphatase 1B. The expression of protein tyrosine ...

    Also Ranks for: Tyrosine Phosphatase |  ovarian cancers |  expression protein |  tumor cells |  growth regulation


    Billie‐Jo M Kerns: Influence Statistics

    Sample of concepts for which Billie‐Jo M Kerns is among the top experts in the world.
    Concept World rank
    acne keloidalis #1
    egfr basal cells #1
    areas cap #1
    pin luminal #1
    immunoreactivity bph tissues #1
    pin neoplasms receptor #1
    pin cap tissues #1
    bph basal #1
    acne keloidalis review #1
    cap egfr #1
    egfr bph #1
    egfr immunoreactivity areas #1
    pin basal cells #1
    immunoreactivity cap #1
    mib1 reacts #1
    immunoreactivity higher degree #1
    her2 neu immunoreactivity #1
    immunoreactivity egfr #1
    higher degree bph #1
    analysis quantitate #1
    early lesions inflammation #1
    differential immunoreactivity #1
    methods subfollicular destruction #1
    sebaceous glands etiology #1
    etiology acne keloidalis #1
    firm plaques nodules #1
    subfollicular destruction process #1
    immunoreactivity her2 #1
    cap immunoreactivity #1
    pin luminal cells #1
    egfr pin #1
    cap areas #1
    her2 neu p53 #1
    prostatic tissues egfr #1
    bph dysplasia #1
    examination early lesions #1
    cap tissues cap #1
    pin basal #1
    inflammation hair follicle #1
    pin egfr #1
    acne keloidalis centers #1
    expression p185c #1
    cerbb2 gene copy #1
    review acne keloidalis #1
    immunoreactivity bph #1
    immunoreactivity pin #1

    Key People For Dna Ploidy

    Top KOLs in the world
    David William Hedley
    pancreatic cancer flow cytometry tumor hypoxia
    Ian W Taylor
    cellular dna content flow cytometry cell cycle
    Michael Leonard Friedlander
    ovarian cancer maintenance olaparib brca1 genes
    Elizabeth A Musgrove
    breast cancer cyclin d1 cell cycle
    Catherine A Rugg
    transferrin receptor expression cellular dna content flow cytometry
    Bernhard Tribukait
    cell cycle flow cytometry ulcerative colitis

    Billie‐Jo M Kerns:Expert Impact

    Concepts for whichBillie‐Jo M Kernshas direct influence:Dna ploidy,  Image analysis,  Breast cancer,  Acne keloidalis,  Dna content,  Image cytometry,  Ovarian cancers,  Overexpression p53.

    Billie‐Jo M Kerns:KOL impact

    Concepts related to the work of other authors for whichfor which Billie‐Jo M Kerns has influence:Ovarian cancer,  P53 protein,  Her2 neu,  Situ hybridization,  Prognostic significance,  Breast carcinoma,  Cell lines.



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