Billie‐Jo M. Kerns

Billie‐Jo M. Kerns

Becton Dickinson Cellular Imaging Systems, San Jose, California University Of Texas, M. D. Anderson Cancer Center, Houston, Texas

Direct Impact

Concepts for which Billie‐Jo M Kerns has direct influence:

breast cancer
dna ploidy
acne keloidalis
quantitative image
p53 overexpression
prognostic significance
tyrosine phosphatase

External impact

Concepts related to the work of other authors for which Billie‐Jo M Kerns has influence:

breast cancer
monoclonal antibody
b-cell malignancies
athymic mice
bone marrow
estrogen receptor
growth factor

Prominent publications by Billie‐Jo M. Kerns

KOL-Index: 30 DNA ploidy has been shown to have prognostic value in adenocarcinoma of the prostate. While occasional benign lesions of the prostate may be associated with a DNA aneuploid status, most aneuploid epithelial proliferations of the prostate are carcinomas. Because of the relationship between aneuploidy and malignancy, DNA ploidy analysis might improve detection of adenocarcinoma in small ...
Known for
Initial Histologic Diagnosis | Resultant Dna Ploidy | Adenocarcinoma Prostate | Subsequent Pathologic Follow-Up
KOL-Index: 21 A murine monoclonal antibody designated 4B5 was raised against the high molecular weight fraction of pooled sputum from patients with non-small cell lung cancer (NSCLC). Immunohistochemical staining indicated that 4B5 binds to histologically normal bronchial epithelium distant from tumor in 72% (39 of 54) of patients with NSCLC, but it binds to the primary cancer in only 13% (7 of 54) of the ...
Known for
4b5 Molecular | Nsclc Binds
KOL-Index: 20 Neuroblastoma, a tumor of the sympathetic nervous system, is one of the most common solid malignancies in infants and represents 7% of all cases of childhood cancer outside of the central nervous system. Thirty-five samples of neuroblastoma from 31 patients were obtained from Duke University Medical Center between 1979 and 1991 and studied to determine the relative prognostic value of a ...
Known for
Survival Neuroblastoma | Mib-1-Proliferation | Neu Egfr | Studied Stage
KOL-Index: 20 The quantitation of estrogen and progesterone receptors (ER and PgR) has become the standard of care in the evaluation of patients with primary breast carcinoma. It has been demonstrated that ER and PgR detected by immunohistochemical methods in formalin-fixed paraffin-embedded tissue can be quantified by computerized image analysis. In this study, ER and PgR levels were determined by using ...
Known for
Dcc Image | Prognostic Stratification | Automated Immunohistochemistry | Method Pgr
KOL-Index: 14 Monoclonal antibodies (MAbs) and immunoconjugates reactive with different antigens expressed by neoplastic cells can inhibit tumor growth. Use of these agents in combination with one another or with chemotherapy can exert additive or synergistic cytotoxicity against tumor cells. An augmented therapeutic activity with favorable therapeutic index might be attained when coexpression is observed ...
Known for
Additive Synergistic Cytotoxicity | 5 Recurrent | 10 Stage Iii | 19 Ovarian Cancers
KOL-Index: 14 BACKGROUND AND OBJECTIVES: The monoclonal antibody MIB-1 is an immunohistochemical marker reacting most strongly with cells in late S phase, G2, and M portions of the cell cycle. This antibody, reactive in formalin-fixed, paraffin-embedded tissue, allows the quantitation of a proliferation index (PI) in both current clinical cases and archival material using a computerized image analyzer ...
Known for
Immunohistochemistry Aih | Quantitation Mib-1 | Significance Late | Expression Months
KOL-Index: 13 Traditionally, estrogen and progesterone receptor levels have been determined by biochemical ligandbinding assays, but more recently immunohistochemical techniques have become available. They have gained popularity due to their low cost, smaller sample size requirements, and direct visualization capability of reaction location. Several antibody clones are commercially available and ...
Known for
Progesterone Antibody | Abbott Park | Premenopausal Status | Cas Zootm
KOL-Index: 12 OBJECTIVE: Our purpose was to determine whether protein tyrosine phosphatase 1B is overexpressed in ovarian cancers, possibly altering the balance of intracellular tyrosine phosphorylation. STUDY DESIGN: The expression of protein tyrosine phosphatase 1B was assayed in frozen sections from 54 human ovarian carcinomas and seven normal ovaries by immunochemical staining with monoclonal antibody ...
Known for
Increased Protein Tyrosine Phosphatase | 1b Messenger | Intracellular Tyrosine Phosphorylation | Normal Ovarian Epithelium
KOL-Index: 12 The distinction between the keratoacanthoma (KA) and the squamous cell carcinoma (SCC) can sometimes be difficult on the basis of histologic and clinical criteria. The possible diagnostic significance of DNA ploidy initiated the present study evaluating the DNA ploidy in paraffin-embedded tissue sections of 7 KA and 15 SCC, and fresh frozen tissue touch preparations of 15 of the same cases ...
Known for
7 Ka | Considerable Overlap | 16 22 | Image Paraffin
KOL-Index: 12 Previous studies have suggested that overexpression of HER-2/neu oncogene occurs in 15-40% of breast cancers and that overexpression is associated with poor prognosis. In the present report, we have used an immunohistochemical technique involving a monoclonal antibody specifically reactive with the external domain of HER-2/neu to study expression of HER-2/neu in frozen sections of normal ...
Known for
Primary Therapy | Frozen Sections | Second-Look Laparotomy | 50 68

Becton Dickinson Cellular Imaging Systems, San Jose, California University of Texas, M. D. Anderson Cancer Center, Houston, Texas

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