David L Page
Prominent publications by David L Page
To assess the importance of various risk factors for breast cancer in women with benign proliferative breast lesions, we reevaluated 10,366 consecutive breast biopsies performed in women who had presented at three Nashville hospitals. The median duration of follow-up was 17 years for 3303 women, 1925 of whom had proliferative disease. This sample contained 84.4 per cent of the patients originally selected for follow-up. Women having proliferative disease without atypical hyperplasia had ...
|Known for Breast Cancer | Risk Women | Nonproliferative Lesions | Proliferative Disease | Cent Patients|
Ductal Lavage for Detection of Cellular Atypia in Women at High Risk for Breast Cancer
[ PUBLICATION ]
BACKGROUND: Breast cancer originates in breast epithelium and is associated with progressive molecular and morphologic changes. Women with atypical breast ductal epithelial cells have an increased relative risk of breast cancer. In this study, ductal lavage, a new procedure for collecting ductal cells with a microcatheter, was compared with nipple aspiration with regard to safety, tolerability, and the ability to detect abnormal breast epithelial cells.
METHODS: Women at high risk for ...
|Known for Ductal Lavage | Breast Cancer | Cellular Atypia | Nipple Aspiration | Women Risk|
Pathogenesis of Paget's Disease: Epidermal Heregulin-α, Motility Factor, and the HER Receptor Family
[ PUBLICATION ]
BACKGROUND AND METHODS: In Paget's disease of the breast, the epidermis of the nipple is infiltrated by large neoplastic cells of glandular origin. It has been hypothesized that the spread of Paget cells through the nipple epidermis is induced by a motility factor that acts via the HER2/NEU receptor. To test this hypothesis, we characterized and purified a motility factor released by keratinocytes and identified its target receptors in specimens from patients with Paget's disease and in ...
|Known for Motility Factor | Her2 Neu | Paget Cells | Mammary Receptor | Nipple Epidermis|
Microglandular adenosis (MGA) is a well-recognized, if rare and incompletely characterized, entity in which carcinoma is rarely thought to develop. We report 17 cases in which patterns of adenoid cystic carcinoma (ACC) coexisted with MGA. Immunocharacterization with beta-catenin, E-cadherin, cytokeratins (AE1/AE3), epithelial membrane antigen, S-100 protein, smooth muscle actin, and vimentin was also performed. Most cases had areas of invasive ACC characterized by its defining dual-lumen ...
|Known for Microglandular Adenosis | Adenoid Cystic Carcinoma | Acc Breast | Mga Cases | S100 Protein|
Apocrine ductal carcinoma in situ of the breast: Histologic classification and expression of biologic markers
[ PUBLICATION ]
Apocrine ductal carcinoma in situ (ADCIS) has been called a special type of ductal carcinoma in situ (DCIS) because the histologic grading is considered difficult using the classification schemes that have been proposed for common DCIS. However, ADCIS encompasses a spectrum of lesions with different morphologic aspects ranging from minimally atypical to overtly malignant. To define a classification scheme for ADCIS, 35 cases (22 pure and 13 associated with invasive carcinoma) were ...
|Known for Ductal Carcinoma | Androgen Receptors | Situ Adcis | Breast Cell | Receptor Erbb2|
Lung cancer classification: The relationship of disease extent and cell type to survival in a clinical trials population
[ PUBLICATION ]
The staging and histologic cell type of patients in the Lung Cancer Study Group (LCSG) clinical trials program are reviewed and confirmed or resolved at the reference center for anatomic and pathologic classification of lung cancer. A high level of consistency in classification has been achieved through the use of criteria that minimize intraobserver variability. The data obtained from the review project have been used to characterize the relationship of disease extent and cell type to ...
|Known for Cell Type | Lung Cancer | Disease Extent | Patients Adenocarcinoma | Complete Resection|
Isolation of completely inactive plasma prorenin and its activation by kallikreins A possible new link between renin and kallikrein
[ PUBLICATION ]
Existing views on prorenin are conflicting and its physiological activation mechanism is not clear. In an attempt to obtain clearcut views on the molecular properties of prorenin in human plasma, the renin zymogen (prorenin) was separated from active renin by two steps of affinity chromatography and it was demonstrated that prorenin is a completely inactivate zymogen contrary to the existing information. Inactive prorenin has an apparent molecular of 56,000 contrary to 46,000-43,000 of ...
|Known for Plasma Prorenin | Completely Inactive | Active Renin | Enzyme Activation | Affinity Chromatography|
Myocardial Changes Associated with Cardiogenic Shock
[ PUBLICATION ]
The amount of left ventricular myocardium destroyed by recent and old infarcts in patients with acute myocardial infarction with and without cardiogenic shock was compared in hearts obtained at autopsy. All 20 patients with, and only one of 14 without, shock had lost 40 per cent or more of the left ventricle. The remainder lost 35 per cent or less. These results indicate that cardiogenic shock is associated with extensive loss of left ventricular myocardium due to new and frequently old ...
|Known for Cardiogenic Shock | Ventricular Myocardium | 20 Patients | 35 Cent | Extensive Loss|
Excessive accumulation of fat in the interatrial septum, termed lipomatous hypertrophy of the interatrial septum, was found at postmortem examination in ten elderly patients. All patients had atrial arrhythmias. Seven patients had unusual arrhythmias including multifocal atrial tachycardia, wandering atrial pacemaker, paroxysmal atrial tachycardia, and sinus arrest, all of which proved refractory to therapy. In five patients an unusual “dome and dip” P-wave configuration was noted in ...
|Known for Atrial Arrhythmias | Lipomatous Hypertrophy | Heart Septum | Elderly Patients | Lipoma Male|
The tubular adenomas, lactating adenomas, and ectopic lactation- or gestation-associated benign lesions of the breast diagnosed during a 22-year period are reported. Forty-two breast adenomas (in 28 patients) that demonstrated lactational changes are reviewed, with special attention to classification and clinical presentation. Five ectopic lactating adenomas--three axillary or in the chest wall and two vulvar, the latter occurring in the same patient--were identified in three patients. ...
|Known for Ectopic Breast | Tubular Adenomas | Cytologic Features | Fine Needle Aspiration | Lactation Pregnancy|
IN CONTRAST to the X chromosome, little is known about the autosomal loci for various genetic traits. Recently Gerald et al1 and Bloom et al2 have presented suggestive evidence that the controlling formation of locus the α-chain of haptoglobin is situated on one end of a No. 13 chromosome. We have studied two patients with chromosome defects and dysgammaglobulinemia. One had a No. 18 ring chromosome, which is formed by breakage in both arms with reunion of the broken ends and loss of a ...
|Known for Partial Deletion | Iga Deficiency | Chromosome 18 | Karyotyping Male | Long Arm|
Since the recent acceptance of partial mastectomy (lumpectomy or segmentectomy) as equivalent to mastectomy for survival, design of the local management of breast cancers has centered around concerns of local recurrence. There has been wide acceptance of the tumorectomy or lumpectomy approach by most authors in North America, while in Italy, following the Milan trials, there has been a preference for a segmental or quadrantectomy approach. The latter preferentially includes more ductal ...
|Known for Situ Carcinoma | Dcis Nipple | Ductal Breast | Mastectomy Segmental | Neoplasm Recurrence|
Lipomatous hypertrophy of the cardiac interatrial septum: Its development and probable clinical significance
[ PUBLICATION ]
Interatrial fat deposits increase with advancing age.Atrial ectopic beats were present during life in a majority of patients with large amounts of fat in the interatrial septum. This atrial irritability may be the result of myocardial atrophy and fibrosis, which accompany the local deposition of large amounts of fat.
|Known for Interatrial Septum | Lipomatous Hypertrophy | Advancing Age | Clinical Significance | Female Heart|
A 3-year-old child with severe acute self-limited enterocolitis was found on rectal biopsy to be infected with the protozoal parasite Cryptosporidium. This organism is known to infect a variety of vertebrates, but this is the first report of infection by Cryptosporidium in a human being. Both light and electron microscopic findings in the rectal biopsy are reported. It is suggested, on the basis of the severity of the clinical symptoms, and on the pathological changes in the rectum, that ...
|Known for Infection Cryptosporidium | Child Preschool | Humans Protozoan | Rectal Biopsy | Variety Vertebrates|
David L Page: Influence Statistics
|pwave morphology indicator||#1|
|noncomedo dcis lesions||#1|
|women proliferative disease||#1|
|patients proliferative disease||#1|
|painful lumpy breasts||#1|
|cardiac cardiac autopsy||#1|
|risk great concern||#1|
|previous breast disease||#1|
|core biopsy subset||#1|
|subset core biopsy||#1|
|initial highrisk lesion||#1|
|patients unusual arrhythmias||#1|
|proliferative disease women||#1|
|paget disease scrotum||#1|
|invasive disease site||#1|
|summary human breast||#1|
|estimated magnitude studies||#1|
|fat interatrial septum||#1|
|menopause everincreasing numbers||#1|
|atypical cellular breast||#2|
|abnormal cells 6||#2|
|cardiac interatrial septum||#2|
|range nipple aspiration||#2|
|cellular atypia women||#2|
|ductal lavage median||#2|
|topic neoplasms terminology||#3|
|breast cancer hyperplasia||#3|
Key People For Breast Cancer
David L Page:Expert Impact
Concepts for whichDavid L Pagehas direct influence:Breast cancer, Proliferative disease, Motility factor, Ductal lavage, Cardiogenic shock, Cancer risk, Ductal carcinoma, Atypical hyperplasia.
David L Page:KOL impact
Concepts related to the work of other authors for whichfor which David L Page has influence:Breast cancer, Myocardial infarction, Ductal carcinoma, Cardiogenic shock, Infarct size, Atypical hyperplasia, Inactive renin.
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