Benjamin Aaron Alman

Benjamin Aaron Alman

Department Of Orthopaedic Surgery, Duke University, Duke University Medical Center, Room 2888, 200 Trent Drive, Durham, North Carolina, 27710, United States

Direct Impact

Concepts for which Benjamin Aaron Alman has direct influence:

aggressive fibromatosis
desmoid tumors
fracture repair
duchenne muscular dystrophy
adynamic bone
growth plate
acute infection

External impact

Concepts related to the work of other authors for which Benjamin Aaron Alman has influence:

aggressive fibromatosis
vertebral malformations
fracture healing
desmoid tumors
tumor growth
indian hedgehog
tissue amino acid profiles

Prominent publications by Benjamin Aaron Alman

KOL-Index: 90 Desmoid tumors, or aggressive fibromatosis, are rare, locally infiltrative neoplasms caused by mutations that activate β-catenin. Although these tumors do not metastasize, they are difficult to manage due to variability in tumor presentation and behavior. A variety of treatment options exist, including surgery, radiotherapy, chemotherapy, hormone therapy, isolated limb perfusion, ...
Known for
Therapy Desmoid
KOL-Index: 53 Purpose of reviewEnchondroma is a common cartilage benign tumor that develops from dysregulation of chondrocyte terminal differentiation during growth plate development. Here we provide an overview of recent progress in understanding causative mutations for enchondroma, dysregulated signaling and metabolic pathways in enchondroma, and the progression from enchondroma to malignant ...
Known for
Signaling Metabolic Pathways | Metabolic Enzymes Isocitrate Dehydrogenase | Enchondromatosis Growth Plate | Differentiation Enchondroma
KOL-Index: 46 Vertebral malformations contribute substantially to the pathophysiology of kyphosis and scoliosis, common health problems associated with back and neck pain, disability, cosmetic disfigurement, and functional distress. This review explores (1) recent advances in the understanding of the molecular embryology underlying vertebral development and relevance to elucidation of etiologies of ...
Known for
Understanding Molecular | Congenital Vertebral
KOL-Index: 42 Sarcomas are mesenchymal cancers, which, in many cases, have distinctive molecular features. Limb-sparing surgery delivered at specialised sarcoma centres as part of a multidisciplinary approach has become the standard treatment for most patients and usually provides excellent local control. Preoperative treatment with chemotherapy is most common for patients with bone sarcomas. The ideal ...
Known for
Sarcomas Targeting
KOL-Index: 35 Abstract Cancer precision medicine implies identification of tumor-specific vulnerabilities associated with defined oncogenic pathways. Desmoid tumors are soft-tissue neoplasms strictly driven by Wnt signaling network hyperactivation. Despite this clearly defined genetic etiology and the strict and unique implication of the Wnt/β-catenin pathway, no specific molecular targets for these ...
Known for
Vivo Ezh2 | Sid Genetic | Vulnerabilities Crispr | Genes Desmoid
KOL-Index: 35
Known for
Reflections | Competency-Based Education
KOL-Index: 34 The replacement of articular cartilage through transplantation of chondrogenic cells or preformed cartilage tissue represents a potential new avenue for the treatment of degenerative joint diseases. Although many studies have described differentiation of human pluripotent stem cells (hPSCs) to the chondrogenic lineage, the generation of chondrocytes able to produce stable articular cartilage ...
Known for
Stable Articular | Hpsc Derived | Chondrocytes Pluripotent
KOL-Index: 33 A coordinated, multidisciplinary approach to care is essential for optimum management of the primary manifestations and secondary complications of Duchenne muscular dystrophy (DMD). Contemporary care has been shaped by the availability of more sensitive diagnostic techniques and the earlier use of therapeutic interventions, which have the potential to improve patients' duration and quality ...
Known for
Long-Term Glucocorticoid | Therapeutic Interventions | Genetic Molecular Therapies | Sensitive Diagnostic Techniques
KOL-Index: 31 The cell of origin for most mesenchymal tumors is unclear. One cell type that contributes to this lineages is the pericyte, a cell expressing Ng2/Cspg4. Using lineage tracing, we demonstrated that bone and soft tissue sarcomas driven by the deletion of the Trp53 tumor suppressor, or desmoid tumors driven by a mutation in Apc, can derive from cells expressing Ng2/Cspg4. Deletion of the Trp53 ...
Known for
Bone Soft Tissue Sarcomas | Tumors Catenin | Ng2 Cspg4 | Trp53 Tumor Suppressor
KOL-Index: 31 BACKGROUND: Little is known about the mechanisms and treatment of radiation-induced inhibition of craniofacial bone growth. In an earlier study, the radioprotector amifostine (WR-2721) administered to rabbits before irradiation radioprotected cultured orbitozygomatic complex periosteal osteoblast-like cells. This study assessed the effects of amifostine and its active metabolite on the ...
Known for
10 Wr-1065 | Mouse Calvarial Osteoblast-Like Cells | Effects Radioprotection | Osteoblastic Phenotype Genes

Department of Orthopaedic Surgery, Duke University, Duke University Medical Center, Room 2888, 200 Trent Drive, Durham, North Carolina, 27710, United States

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