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An immunohistochemical study of glucagonoma conducted on the metastatic lymph nodes from a patient with recurrent metastatic glucagonoma: Report of a case: Influence Statistics

Expert Impact

Concepts for which they have has direct influence: Report case , Pancreatic neoplasms , Glucagonoma humans , Immunohistochemistry lymphatic , Lymphatic metastasis , Nodes patient , Lymph nodes .

Key People For Report Case

Top KOLs in the world
#1
Christopher D M FLETCHER†
soft tissue situ hybridization fibrous histiocytoma
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Juan Rosai
papillary carcinoma lymph nodes sinus histiocytosis
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Bernd Walter Scheithauer
pituitary adenomas central nervous situ hybridization
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Markku M A Miettinen
gastrointestinal stromal tumors differential diagnosis epithelioid sarcoma
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Sharon Whelan Weiss
soft tissue situ hybridization synovial sarcoma
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Franz M Enzinger
synovial sarcoma soft tissue malignant fibrous histiocytoma

An immunohistochemical study of glucagonoma conducted on the metastatic lymph nodes from a patient with recurrent metastatic glucagonoma: Report of a case

Abstract

. In this report, we briefly present the case of a 67-year-old woman who developed recurrent glucagonoma with lymph node metastasis. An immunohistochemical study of the metastatic tumor revealed immunoreactivity of glucagon and protein kinase C (PKC)-α, -β, and -γ in the tumor cells, two types of which were seen by electron microscopy. One type had abundant secretory granules and mitochondria, while the other had few granules and mitochondria. Some granules were similar to typical A cell granules and others were atypical. An immunoelectron microscopic demonstration revealed PKC-α, -β, and -γ immunostaining in the cytoplasm of all the tumor cells, while some secretory granules had PKC immunostaining, and others had no immunostaining. Thus, it appears that metastatic glucagonoma and its associated granules are composed of two types of mature and immature cells or granules. As immunoreactivity of PKC-α and -γ was found in the tumor cells, but not in the normal A cells of the islets of Langerhans, the PKC subspecies α and γ, which are not present in normal pancreatic A cells, may exist in human glucagonoma cells.