Prominent publications by Annette M Hartmann

KOL Index score: 8211

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. ...

Also Ranks for: Biological Insights |  schizophrenia genes |  genetic loci |  glutamatergic neurotransmission |  common alleles
KOL Index score: 7027

Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

Also Ranks for: Rare Coding Variants |  innate immunity |  amino acid |  alzheimers disease |  plcg2 abi3
KOL Index score: 6120

Susceptibility to schizophrenia is inversely correlated with general cognitive ability at both the phenotypic and the genetic level. Paradoxically, a modest but consistent positive genetic correlation has been reported between schizophrenia and educational attainment, despite the strong positive genetic correlation between cognitive ability and educational attainment. Here we leverage published genome-wide association studies (GWASs) in cognitive ability, education, and schizophrenia to ...

Also Ranks for: Cognitive Ability |  educational attainment |  association analysis |  subsets variants |  neurodevelopmental disorders
KOL Index score: 5221

BACKGROUND: A long-standing epidemiological puzzle is the reduced rate of rheumatoid arthritis (RA) in those with schizophrenia (SZ) and vice versa. Traditional epidemiological approaches to determine if this negative association is underpinned by genetic factors would test for reduced rates of one disorder in relatives of the other, but sufficiently powered data sets are difficult to achieve. The genomics era presents an alternative paradigm for investigating the genetic relationship ...

Also Ranks for: Rheumatoid Arthritis |  genetic factors |  negative association |  genome wide |  single nucleotide
KOL Index score: 4358

The CNV analysis group of the Psychiatric Genomic Consortium analyzes a large schizophrenia cohort to examine genomic copy number variants (CNVs) and disease risk. They find an enrichment of CNV burden in cases versus controls and identify 8 genome-wide significant loci as well as novel suggestive loci conferring either risk or protection to schizophrenia.

Also Ranks for: Wide Study |  copy variants schizophrenia |  cnv burden |  genetic loci |  41321 subjects
KOL Index score: 3576

Michael O'Donovan and colleagues present a genome-wide association study of schizophrenia in 479 cases and 2,937 controls, followed by replication in several cohorts. They report evidence for association for a susceptibility allele near ZNF804A.

Also Ranks for: Evidence Association |  loci schizophrenia |  479 cases |  follow studies |  genome wide
KOL Index score: 1787

General cognitive function is a prominent human trait associated with many important life outcomes


, including longevity


. The substantial heritability of general cognitive function is known to be polygenic, but it has had little explication in terms of the contributing genetic variants


. Here, we combined cognitive and genetic data from the CHARGE ...

Also Ranks for: Cognitive Function |  brain structure |  uk biobank |  independent samples |  genetic variants
KOL Index score: 643


Schizophrenia (SCZ) and bipolar disorder (BD) are highly heritable disorders that share a significant proportion of common risk variation. Understanding the genetic factors underlying the specific symptoms of these disorders will be crucial for improving diagnosis, intervention and treatment. In case-control data consisting of 53,555 cases (20,129 BD, 33,426 SCZ) and 54,065 controls, we identified 114 genome-wide significant loci (GWS) when ...

Also Ranks for: Bipolar Disorder

Key People For General Cognitive Function

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Annette M Hartmann:Expert Impact

Concepts for whichAnnette M Hartmannhas direct influence:General cognitive function,  Negative association,  Rare coding variants,  Education schizophrenia,  Cognitive ability education,  Bipolar disorder,  Biological insights,  Genetic loci.

Annette M Hartmann:KOL impact

Concepts related to the work of other authors for whichfor which Annette M Hartmann has influence:Bipolar disorder,  Gene expression,  Polygenic risk,  Genome wide,  Dna methylation,  Alzheimer disease,  Schizophrenia patients.



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Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle 06108, Germany. | Department of Psychiatry, University of Halle, Halle, Germany | Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany | Depa