• Flecainide Acetate
    • Anthony W Nathan
    • Anthony W Nathan: Influence Statistics

      Anthony W Nathan

      Anthony W Nathan

      Department of Cardiology, First Floor, Dominion House, 60 Bartholomew Close, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK | Department of Cardiology, Bart's ...

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      Anthony W Nathan:Expert Impact

      Concepts for whichAnthony W Nathanhas direct influence:Flecainide acetate,Proarrhythmic effects,Sinus node,Cardiac arrhythmias,Ventricular pacing,Pretibial myxoedema,Catheter inversion,Cardiac transplantation.

      Anthony W Nathan:KOL impact

      Concepts related to the work of other authors for whichfor which Anthony W Nathan has influence:Ventricular tachycardia,Atrial fibrillation,Catheter ablation,Sinus rhythm,Flecainide acetate,Cardiac pacing,Radiation exposure.

      KOL Resume for Anthony W Nathan


      Department of Cardiology, First Floor, Dominion House, 60 Bartholomew Close, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK


      Department of Cardiology, Bart's and The London NHS Trust, London, United Kingdom

      The Heart Hospital, University College London Hospitals NHS Trust, London, UK


      Department of Cardiology, St Bartholomew's Hospital, London EC1A 7BE, UK


      St Bartholomew's Hospital, London.

      British Pacing and Electrophysiology Group, Royal Brompton National Heart and Lung Hospital, London SW3 6NP


      From The Newark Beth Israel Medical Center, Newark, New Jersey

      St. Bartholomew's Hospital, United Kingdom


      Departments of Medical Electronics and Cardiology, St. Bartholomew s Hospital, London, United Kingdom

      From the Department of Cardiology, St. Bartholomew's Hospital, London, England, and the Department of Cardiology, Royal North Shore Hospital, Sydney, Australia

      Department of Cardiology, St. Bartholomew's Hospital, the Department of Cardiology, Brompton Hospital


      Department of Cardiology, St. Bartholomew's Hospital, West Smithfield, London, England


      Department of Cardiology, St. Bartholomew's Hospital London, England


      Department of Cardiology, St. Bartholomew's Hospital, London, England


      Department of Cardiology, St. Bartholomew’s Hospital, West Smith-field, EC1A 7BE, London, England

      St Bartholomew's Hospital, London


      Department of Cardiology, St. Bartholomew's Hospital London, England.

      From St. Bartholomew's Hospital, London, England


      From the Department of Cardiology, St. Bartholomew's Hospital, West Smithfield, London, England


      St.Bartholomew's Hospital, London, England

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      Sample of concepts for which Anthony W Nathan is among the top experts in the world.
      Concept World rank
      flecainide acetate review #1
      oral flecainide recurrence #2
      pathological tachycardia limitations #2
      severe progressive exophthalmos #2
      common dose flecainide #2
      flecainide duration #2
      unwanted arrhythmias #2
      antiarrhythmic drugs size #2
      distinction pathological tachycardia #2
      organ culture plasma #2
      tachycardia reversion #2
      unwanted effects 14 #2
      intermedics intertach patients #2
      13 proarrhythmic effects #2
      longterm management problems #2
      immunoglobulins plasma samples #2
      wolffparkinsonwhite syndrome flecainide #2
      pathological tachycardia #2
      studies abnormal immunoglobulins #2
      complete control arrhythmias #2
      qrs ddd #2
      management cardiac humans #2
      reversion pacemaker #2
      arrhythmia substrate mechanisms #2
      flecainide flecainide humans #2
      heart graves #2
      initial arrhythmia strategy #2
      limitations new device #2
      20 patient population #2
      diminished studies #2
      flecainide treatment episodes #2
      tachycardia tachycardia computerassisted #2
      plasmapheresis exophthalmos #2
      tachycardia years #2
      anomalous abnormal tissue #3
      sensed intracardiac potential #3
      gpd analysis phase #3
      reversion pacemakers #3
      intravenous flecainide acetate #3
      pacemaker algorithms #3
      electrogram gpd #3
      flecainide administration refractoriness #3
      revised method strauss #3
      pacemaker bartholomews hospital #3
      mechanisms proarrhythmic effects #3
      myxedema plasmapheresis #3
      automatic tachycardia diagnosis #3
      preset coupling time #3
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      Prominent publications by Anthony W Nathan

      KOL-Index: 12499

      Intravenous flecainide acetate was administered to 33 patients undergoing routine electrophysiologic study: 18 patients had a direct accessory atrioventricular (AV) pathway and 15 patients had functional longitudinal A-H dissociation (dual A-H pathways). Flecainide was given to 14 patients during sustained AV reentrant tachycardia and to 9 patients during sustained intra-AV nodal reentrant tachycardia. AV reentrant tachycardia was successfully terminated in 12 of 14 patients. Tachycardia ...

      Known for Flecainide Acetate | Accessory Pathway | Patients Tachycardia | Electrophysiologic Effects | Anterograde Retrograde
      KOL-Index: 10411

      AIMS: The efficacy of transvenous Cryoablation (Cryo), for the treatment of atrioventricular nodal re-entry tachycardia (AVNRT), when compared with radiofrequency (RF) ablation, requires further investigation.

      METHODS AND RESULTS: We sought to compare the acute- and follow-up results of 71 cases each of Cryo and RF for AVNRT using a retrospective matched case-control study design and aimed at identifying patient and procedural factors that may predict success with each strategy. Primary ...

      Known for Radiofrequency Ablation | Atrioventricular Nodal | Cryo Avnrt | Recurrence Rate | Entrant Tachycardia
      KOL-Index: 8624

      INTRODUCTION: The aim of this prospective randomized study was to compare the routine use of electroanatomic imaging (CARTO) with that of conventional fluoroscopically guided activation mapping (conventional) in an unselected population referred for catheter ablation. We sought to compare the two approaches with respect to procedure outcome and duration, radiation exposure, and cost.

      METHODS AND RESULTS: All patients undergoing catheter ablation (with the exception of complete AV nodal ...

      Known for Catheter Ablation | Procedure Duration | Supraventricular Tachycardia | Fluoroscopy Time | Radiation Exposure
      KOL-Index: 8024

      Thirteen patients suffering from reentrant supraventricular tachycardia have undergone implantation of a scanning extrastimulus pacemaker. This pacemaker is fully implanted and automatic, and it requires no external control device to activate or control it. The pacemaker is activated when tachycardia occurs. After four cycles an extrastimulus is induced with a preset coupling time from a sensed intracardiac potential, and every four cycles thereafter a further extrastimulus occurs, but ...

      Known for Termination Tachycardia | Scanning Pacemaker | Implantation Patients | Implantable Automatic | Coupling Intervals
      KOL-Index: 7843

      The function of both the denervated donor and innervated recipient sinus nodes of 14 asymptomatic cardiac transplant recipients was assessed. Tests of sinoatrial function were performed in 14 donor and 10 recipient atria. The mean spontaneous cycle length of the recipient atria was significantly longer than that of the donor atria (944 +/- 246 versus 663 +/- 158 ms, p less than 0.01). Donor sinus node recovery time was prolonged in four patients (greater than 2,500 ms in two) and ...

      Known for Cardiac Transplantation | Recipient Atria | Recovery Time | Sinus Node | Heart Rate
      KOL-Index: 7089

      Flecainide acetate, a new potent class I antiarrhythmic agent, was given to 152 patients (46 orally and 106 intravenously) over a period of 22 months. Seven patients developed proarrhythmic effects. The only conduction abnormalities induced were PR interval prolongation and QRS complex widening, and no patient developed significant sinus bradyarrhythmias; patients with known serious abnormalities of impulse generation or conduction were excluded from this study. Five patients developed ...

      Known for Proarrhythmic Effects | Flecainide Acetate | Antiarrhythmic Agent | Patients Ventricular Tachycardia | Ventricular Arrhythmias
      KOL-Index: 6371

      The acute electrophysiologic effects of i.v. flecainide acetate (2 mg/kg body weight) were assessed in 71 patients undergoing electrophysiologic study. Ten patients underwent investigation for sinus node dysfunction. Sinus cycle length shortened slightly, from 980 +/- 292 to 931 +/- 276 ms (p less than 0.01). Uncorrected or corrected sinus node recovery times or sinoatrial conduction time (according to the methods of Strauss and Narula) did not change in 6 patients with normal sinus node ...

      Known for Flecainide Acetate | Electrophysiologic Effects | Sinus Node Function | Acute Termination | Accessory Pathway
      KOL-Index: 6318

      Pacemaker recognition of pathological tachycardia relies on heart rate analysis. This can lead to misdiagnosis when sinus tachycardia exceeds the preset tachycardia response trigger rate. We have explored a method for automatic tachycardia diagnosis by analysis of bipolar endocardial electrogram morphology. Electrograms were recorded from 11 patients (pts) during sinus rhythm and during a total of 20 abnormal rhythms: retrograde atrial depolarization from ventricular pacing in six ...

      Known for Electrogram Morphology | Sinus Rhythm | Ventricular Tachycardia Patients | Heart Rate Analysis | Automatic Recognition
      KOL-Index: 5700

      The long-term characteristics of the right ventricular outflow tract have been assessed as an alternative permanent pacing site to the right ventricular apex. Thirty-three consecutive patients requiring ventricular pacing were randomized to be paced from one of the two sites. Pacing was performed using a screw-in lead, and a programmable pacemaker was used to facilitate threshold testing. There was no significant difference in the lead positioning time or any acute implant measurement ...

      Known for Outflow Tract | Long‐term Follow‐up | Pacing Site | Ventricular Apex | Pacemaker Artificial
      KOL-Index: 5699

      Sotalol and propranolol were administered both intravenously and orally in conventional equipotent beta-blocking doses to 8 patients with permanent programmable ventricular pacemakers to study their effects on ventricular repolarization. Sotalol prolonged the QT interval by 6.5% (430 to 455 ms) after intravenous administration (p less than 0.01) and by up to 11.5% (430 to 483 ms) after 4 weeks of oral treatment (p less than 0.001). This was entirely due to prolongation of the JT ...

      Known for Ventricular Repolarization | Qt Prolongation | Chronic Treatment | Acute Administration | Class Iii Activity
      KOL-Index: 5536

      OBJECTIVE: To determine whether ventricular arrhythmia related to nocturnal hypoxaemia during Cheyne-Stokes respiration (CSR) explains the observation that CSR is an independent marker of death in heart failure.

      DESIGN: Prospective, observational study.

      PATIENTS: 101 patients at high risk of clinical serious ventricular arrhythmia fitted with an implantable cardioverter-defibrillator (ICD).

      MEASUREMENTS: Patients were studied at baseline for CSR during sleep. Arrhythmia requiring device ...

      Known for Stokes Respiration | Cardiac Defibrillators | Heart Failure | Death Sudden | Nocturnal Ventricular
      KOL-Index: 5328

      Flecainide acetate depresses both the upstroke of the intracellular action potential and the rate of diastolic depolarisation in isolated tissue preparations of atrial myocardium. It produces no consistent effect on action potential duration. Predictably, in the human heart, studied by clinical cardiac electrophysiological techniques, conduction velocity through atrial myocardium, the atrioventricular (AV) node and anomalous tissue is depressed following flecainide administration. ...

      Known for Flecainide Acetate | Atrial Tachycardia | Supraventricular Arrhythmias | Small Proportion | Atrioventricular Node
      KOL-Index: 4853

      A patient with Graves's disease with acute progressive exophthalmos and pretibial myxoedema was treated twice with plasmapheresis. Two weeks after the first treatment the symptoms recurred, but 20 weeks after the second treatment the exophthalmos was much improved and the pretibial myxoedema had disappeared. Analysis of sequential serum IgG concentrations and the thyroid-stimulating immunoglobulin index suggested that the two conditions were caused by specific IgGs. The results suggest ...

      Known for Pretibial Myxoedema | Successful Treatment | Leg Dermatoses | Graves Disease | Plasmapheresis Patient

      Catheter Inversion:

      KOL-Index: 4320

      Cure of typical atrial flutter (AFL) by catheter ablation to produce bidirectional block across the tricuspid annulus-inferior vena cava isthmus (IS) is highly effective, but failures may occur. We describe a technique that may allow creation of bidirectional block where a conventional strategy has failed. AFL ablation was performed using the conventional approach with a mapping/ablation (ablation) catheter introduced via the right femoral vein (RFV) to create a line of bidirectional ...

      Known for Catheter Inversion | Vena Cava | Bidirectional Block | Conventional Strategy | Atrial Flutter
      KOL-Index: 4241

      Twenty consecutive patients with paroxysmal intra A-V nodal or atrio-ventricular tachycardia had a new tachycardia reversion pacing modality evaluated during routine electrophysiological study. The pacing was controlled by a micropressor interfaced with a stimulator connected to a right atrial pacing electrode. On detection of tachycardia the first pacing cycle interval is equal to the tachycardia cycle length minus a decrement value D. Each subsequent pacing cycle is further reduced by ...

      Known for Atrial Pacing | Artificial Tachycardia | Unwanted Arrhythmias | Heart Ventricles | Evaluation Studies

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      Department of Cardiology, First Floor, Dominion House, 60 Bartholomew Close, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK | Department of Cardiology, Bart's and The London NHS Trust, London, United Kingdom | Department of Cardiolog

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