Prominent publications by Aristotle N Voineskos

KOL Index score: 16783

OBJECTIVE: Neurodevelopmental disorders (NDDs) (attention deficit hyperactivity disorder [ADHD], autism spectrum disorder [ASD], and obsessive-compulsive disorder [OCD]) share genetic vulnerability and symptom domains. The authors present direct comparison of structural brain circuitry in children and adolescents with NDDs and control subjects and examine brain circuit-behavior relationships across NDDs using dimensional measures related to each disorder.

METHOD: Diffusion imaging and ...

Also Ranks for: White Matter |  asd adhd |  autism spectrum |  fractional anisotropy |  diffusion tensor
KOL Index score: 15872

CONTEXT: Highly significant elevations in regional brain monoamine oxidase A (MAO-A) binding were recently reported during major depressive episodes (MDEs) of major depressive disorder (MDD). The relationship between MAO-A levels and selective serotonin reuptake inhibitor (SSRI) treatment, recovery, and recurrence in MDD is unknown.

OBJECTIVES: To determine whether brain MAO-A binding changes after SSRI treatment, whether brain MAO-A binding normalizes in subjects with MDD in recovery, ...

Also Ranks for: Brain Monoamine |  major depressive disorder |  mde mdd |  mao binding |  female gyrus
KOL Index score: 13898

IMPORTANCE: A major obstacle to the identification of the neurobiological correlates of schizophrenia is the substantial clinical heterogeneity present in this disorder. Dividing schizophrenia into "deficit" and "nondeficit" subtypes may reduce heterogeneity and facilitate identification of neurobiological markers of disease.

OBJECTIVE: To determine whether patients with deficit schizophrenia differ from patients with nondeficit schizophrenia and healthy controls in neuroimaging-based ...

Also Ranks for: Deficit Subtype |  patients schizophrenia |  white matter tracts |  cortical thickness |  neuroimaging evidence
KOL Index score: 13668

Importance: Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood.

Objective: To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), ...

Also Ranks for: Cortical Thickness |  psychiatric disorders |  bipolar disorder |  virtual histology |  interregional profiles
KOL Index score: 13047

INTRODUCTION: Advances in image segmentation of magnetic resonance images (MRI) have demonstrated that multi-atlas approaches improve segmentation over regular atlas-based approaches. These approaches often rely on a large number of manually segmented atlases (e.g. 30-80) that take significant time and expertise to produce. We present an algorithm, MAGeT-Brain (Multiple Automatically Generated Templates), for the automatic segmentation of the hippocampus that minimises the number of ...

Also Ranks for: Atlas Segmentation |  maget brain |  automatically generated |  automated methods |  aged 80
KOL Index score: 12873

Importance: Psychotic depression is a severely disabling and potentially lethal disorder. Little is known about the efficacy and tolerability of continuing antipsychotic medication for patients with psychotic depression in remission.

Objective: To determine the clinical effects of continuing antipsychotic medication once an episode of psychotic depression has responded to combination treatment with an antidepressant and antipsychotic agent.

Design, Setting, and Participants: Thirty-six ...

Also Ranks for: Psychotic Depression |  olanzapine placebo |  relapse patients |  depressive disorder |  participants randomized
KOL Index score: 12710

OBJECTIVES: The current novel coronavirus disease of 2019 (COVID-19) pandemic presents a time-sensitive opportunity to rapidly enhance our knowledge about the impacts of public health crises on youth mental health, substance use, and well-being. This study examines youth mental health and substance use during the pandemic period.

METHODS: A cross-sectional survey was conducted with 622 youth participants across existing clinical and community cohorts. Using the National Institute of ...

Also Ranks for: Mental Health |  community sample |  youth pandemic |  impacts covid19 |  substance disorders
KOL Index score: 11603

BACKGROUND: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group.

METHODS: The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; ...

Also Ranks for: Individuals Schizophrenia |  cortical brain |  imaging genetics |  enhancing neuro |  enigma consortium
KOL Index score: 11329

CONTEXT: The brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) polymorphism may predict the risk of Alzheimer disease (AD). However, genetic association studies of the BDNF gene with AD have produced equivocal results. Imaging-genetics strategies may clarify the manner in which BDNF gene variation predicts the risk of AD via characterization of its effects on at-risk structures or neural networks susceptible in this disorder.

OBJECTIVE: To determine whether the BDNF Val66Met ...

Also Ranks for: Alzheimer Disease |  val66met polymorphism |  neurotrophic factor |  bdnf gene |  white matter tracts
KOL Index score: 11146

OBJECTIVE: Life expectancy in individuals with schizophrenia continues to increase. It is not clear whether cognitive deficits associated with schizophrenia remain as strong predictors of function in older and younger individuals. Thus, we assessed the relationship between cognition and functional competence in individuals with schizophrenia across 7 decades of life.

METHODS: We analyzed data obtained in 232 community-dwelling participants with schizophrenia (age range: 19-79 years). ...

Also Ranks for: Functional Competence |  schizophrenia cognition |  negative symptoms |  age education |  cognitive deficits
KOL Index score: 10830

Post-mortem studies have demonstrated alterations in superficial white matter (SWM) in schizophrenia patients. Diffusion tensor imaging (DTI) can be used to assess SWM in vivo, and compare SWM fractional anisotropy (FA) in schizophrenia patients vs healthy controls. The assessment of SWM in vivo also provides an opportunity to identify novel neural correlates of cognitive performance, and potential cognitive impairment in schizophrenia patients. Forty-four patients with schizophrenia and ...

Also Ranks for: Cognitive Performance |  superficial white matter |  schizophrenia patients |  frontal lobe |  diffusion tensor imaging
KOL Index score: 10659

Schizophrenia (SCZ) and obsessive-compulsive disorder (OCD) are psychiatric disorders with abnormalities in white matter structure. These disorders share high comorbidity and family history of OCD is a risk factor for SCZ which suggests some shared neurobiology. White matter was examined using diffusion tensor imaging in relativity large samples of SCZ (N = 48), OCD (N = 38) and non-psychiatric controls (N = 45). Fractional anisotropy (FA) was calculated and tract based spatial ...

Also Ranks for: White Matter |  scz ocd |  compulsive disorder |  imaging diffusion |  fractional anisotropy
KOL Index score: 10042

The hippocampus is a neuroanatomical structure that has been widely studied in the context of learning, memory, stress, and neurodegeneration. Neuroanatomically, the hippocampus is subdivided into several subfields with intricate morphologies and complex three-dimensional relationships. Recent studies have demonstrated that the identification of different subfields is possible with high-resolution and -contrast image volumes acquired using ex vivo specimens in a small bore 9.4 T scanner ...

Also Ranks for: Hippocampal Subfields |  magnetic resonance |  artistic atlases |  resolution 3 |  limited availability
KOL Index score: 9656

IMPORTANCE: The clinical heterogeneity of schizophrenia has hindered neurobiological investigations aimed at identifying neural correlates of the disorder.

OBJECTIVE: To identify network-based biomarkers across the spectrum of impairment present in schizophrenia by separately evaluating individuals with deficit and nondeficit subtypes of this disorder.

DESIGN, SETTING, AND PARTICIPANTS: A university hospital network-based neuroimaging study was conducted between February 1, 2007, and ...

Also Ranks for: Patients Schizophrenia |  deficit subtype |  bipolar disorder |  frontal lobe |  compared healthy
KOL Index score: 9479

In healthy adult individuals, late life is a dynamic time of change with respect to the microstructural integrity of white matter tracts. Yet, elderly individuals are generally excluded from diffusion tensor imaging studies in schizophrenia. Therefore, we examined microstructural integrity of frontotemporal and interhemispheric white matter tracts in schizophrenia across the adult lifespan. Diffusion tensor imaging data from 25 younger schizophrenic patients (< or = 55 years), 25 younger ...

Also Ranks for: Patients Schizophrenia |  diffusion tensor |  microstructural integrity |  fractional anisotropy |  cingulum bundle

Key People For White Matter

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Aristotle N Voineskos:Expert Impact

Concepts for whichAristotle N Voineskoshas direct influence:White matter,  Thought spot,  Psychotic depression,  Cortical thickness,  Schizophrenia spectrum disorders,  Tardive dyskinesia,  Brain structure,  General cognitive function.

Aristotle N Voineskos:KOL impact

Concepts related to the work of other authors for whichfor which Aristotle N Voineskos has influence:White matter,  Bipolar disorder,  Mental health,  Cortical thickness,  Patients schizophrenia,  Corpus callosum,  Negative symptoms.



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Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Ontario, Canada | Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada | Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto,