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Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder: Influence Statistics

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Thomas Christian Südhof
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Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder

Abstract

. The SNP rs2251214 of the SYT1 gene was recently associated with externalizing phenotypes, including ADHD and cocaine use disorder (CUD). Here, we investigated whether SYT1-rs2251214 could also be implicated with cognitive performance variations among women with CUD. Results showed that G homozygous (n = 146) have lower cognitive performance in the Stroop, Trail Making and Matrix Reasoning tests compared with A-allele carriers (n = 64), suggesting that rs2251214 may influence the severity of cognitive impairments in CUD.