Prominent publications by Blair Anderson Jobe

KOL Index score: 17974

BACKGROUND & AIMS: The goal of treatment for Barrett's esophagus (BE) with dysplasia is complete eradication of intestinal metaplasia (CEIM). The long-term durability of CEIM has not been well characterized, so the frequency and duration of surveillance are unclear. We report results from a 5-year follow-up analysis of patients with BE and dysplasia treated by radiofrequency ablation (RFA) in the randomized controlled Ablation of Intestinal Metaplasia Containing Dysplasia (AIM) ...

Also Ranks for: Intestinal Metaplasia |  complete eradication |  ceim patients |  dysplasia recurrence |  ablation rfa
KOL Index score: 14890

BACKGROUND & AIMS: Radiofrequency ablation (RFA) can eradicate dysplasia and intestinal metaplasia in patients with dysplastic Barrett's esophagus (BE), and reduce rates of esophageal adenocarcinoma. We assessed long-term rates of eradication, durability of neosquamous epithelium, disease progression, and safety of RFA in patients with dysplastic BE.

METHODS: We performed a randomized trial of 127 subjects with dysplastic BE; after cross-over subjects were included, 119 received RFA. ...

Also Ranks for: Dysplasia Intestinal Metaplasia |  radiofrequency ablation |  rfa patients |  2 years |  esophageal adenocarcinoma
KOL Index score: 13159

OBJECTIVE: To determine whether the presence of laryngopharyngeal reflux symptoms is associated with the presence of esophageal adenocarcinoma (EAC).

BACKGROUND: Most patients diagnosed with EAC have incurable disease at the time of detection. The majority of these patients are unaware of the presence of Barrett's esophagus prior to cancer diagnosis and many do not report typical symptoms of gastroesophageal reflux disease (GERD). This suggests that the current GERD symptom-based ...

Also Ranks for: Reflux Symptoms |  barretts esophagus |  esophageal adenocarcinoma eac |  patients gerd |  chronic cough
KOL Index score: 12808

BACKGROUND: Barrett's esophagus, a condition of intestinal metaplasia of the esophagus, is associated with an increased risk of esophageal adenocarcinoma. We assessed whether endoscopic radiofrequency ablation could eradicate dysplastic Barrett's esophagus and decrease the rate of neoplastic progression.

METHODS: In a multicenter, sham-controlled trial, we randomly assigned 127 patients with dysplastic Barrett's esophagus in a 2:1 ratio to receive either radiofrequency ablation (ablation ...

Also Ranks for: Radiofrequency Ablation |  complete eradication dysplasia |  intestinal metaplasia |  dysplastic barretts esophagus |  neoplastic progression
KOL Index score: 12308

Idiopathic pulmonary fibrosis (IPF) is a diffuse fibrotic lung disease of unknown etiology. The association between IPF and gastroesophageal reflux disease (GERD) has been suggested. The objective of this study was to determine the prevalence of GERD and assess the proximity of reflux events in patients with histologically proven IPF using hypopharyngeal multichannel intraluminal impedance (HMII). This is a retrospective review of prospectively collected data from patients with ...

Also Ranks for: Pulmonary Fibrosis |  gastroesophageal reflux disease |  patients ipf |  multichannel intraluminal |  hmii lpr
KOL Index score: 12192

Background:Adipose tissue is a primary in vivo site of inflammation in obesity. Excess visceral adipose tissue (VAT), when compared to subcutaneous adipose tissue (SAT), imparts an increased risk of obesity-related comorbidities and mortality, and exhibits differences in inflammation. Defining depot-specific differences in inflammatory function may reveal underlying mechanisms of adipose-tissue-based inflammation.Methods:Stromovascular cell fractions (SVFs) from VAT and SAT from obese ...

Also Ranks for: Nk Cells |  adipose tissue |  inflammatory mediators |  vat sat |  ifnγ inflammation
KOL Index score: 11811

OBJECTIVE: Complications of anastomotic healing are a common source of morbidity and mortality after esophagogastrostomy. The delay phenomenon is seen when a skin flap is partially devascularized in a staged procedure prior to its definitive placement, resulting in increased blood flow at the time of grafting. This effect may be applied to esophagogastrectomy, potentially reducing anastomotic complications.

SUMMARY BACKGROUND DATA: The purpose of this investigation was to apply the delay ...

Also Ranks for: Blood Flow |  delay phenomenon |  anastomotic healing |  gastric fundus |  underwent ligation
KOL Index score: 11706

Background: A disparity exists between the incidence of accessory spleens reported in the open (15–30%) versus the laparoscopic (0–12%) literature. This disparity implies that a percentage of laparoscopic patients will require a reoperation for accessory splenectomy. We present our experience with the laparoscopic management of accessory spleens discovered after primary splenectomy for idiopathic thrombocytopenic purpura (ITP).Methods: Seventeen patients who underwent primary splenectomy ...

Also Ranks for: Accessory Spleens |  patients laparoscopic splenectomy |  recurrent thrombocytopenia |  thrombocytopenic purpura |  operation time
KOL Index score: 11577

OBJECTIVE: To determine whether patients with Barrett esophagus who undergo antireflux surgery differ from medically treated patients in incidence of esophageal adenocarcinoma and probability of disease regression/progression.

SUMMARY BACKGROUND DATA: Barrett esophagus is a risk factor for the development of esophageal adenocarcinoma. A question exists as to whether antireflux surgery reduces this risk.

METHODS: Query of PubMed (1966 through October 2005) using predetermined search terms ...

Also Ranks for: Barrett Esophagus |  antireflux surgery |  incidence adenocarcinoma |  esophageal carcinogenesis |  progression regression
KOL Index score: 11257

Evidence suggests that patients with psychiatric illnesses may be more likely to experience a delay in diagnosis of coexisting cancer. The association between psychiatric illness and timely diagnosis and survival in patients with esophageal cancer has not been studied. The specific aim of this retrospective cohort study was to determine the impact of coexisting psychiatric illness on time to diagnosis, disease stage and survival in patients with esophageal cancer. All patients with a ...

Also Ranks for: Esophageal Cancer |  psychiatric illness |  mental disorders |  delayed diagnosis |  hazard ratio
KOL Index score: 11206

OBJECTIVE: Laparoscopic paraesophageal hernia repair (LPEHR) is associated with a high recurrence rate. Repair with synthetic mesh lowers recurrence but can cause dysphagia and visceral erosions. This trial was designed to study the value of a biologic prosthesis, small intestinal submucosa (SIS), in LPEHR.

METHODS: Patients undergoing LPEHR (n = 108) at 4 institutions were randomized to primary repair -1 degrees (n = 57) or primary repair buttressed with SIS (n = 51) using a ...

Also Ranks for: Biologic Prosthesis |  6 months |  recurrent hernia |  hiatal humans |  laparoscopic paraesophageal
KOL Index score: 11052

BACKGROUND: Gastroesophageal reflux disease (GERD) is common in patients with end-stage lung disease (ESLD). GERD may cause obliterative bronchiolitis after lung transplantation (LTx), represented by a decline in forced expiratory volume in 1 second (FEV(1)).

OBJECTIVES: To identify the patterns of reflux in patients with ESLD and to determine whether antireflux surgery (ARS) positively impacts lung function.

DESIGN: Retrospective review of prospectively collected data.

SETTING: Tertiary ...

Also Ranks for: Antireflux Surgery |  lung function |  reflux disease |  gerd patients |  pulmonary fibrosis
KOL Index score: 11048

IMPORTANCE: Chronic cough is a laryngeal symptom that can be caused by gastroesophageal reflux disease; however, treatment outcome has been difficult to predict because of the lack of an objective testing modality that accurately detects reflux-related cough.

OBJECTIVE: To define the patterns of reflux and assess the outcome of antireflux surgery (ARS) in patients with chronic cough who were selected using hypopharyngeal multichannel intraluminal impedance (HMII).

DESIGN: Review of ...

Also Ranks for: Chronic Cough |  antireflux surgery |  abnormal proximal exposure |  intraluminal impedance |  hypopharyngeal multichannel
KOL Index score: 9800

BACKGROUND: Colitis caused by Clostridium difficile is receiving increased attention as a nosocomial hospital-acquired infection.

METHODS: To determine the incidence of C difficile colitis in our facility and the relative proportion of patients dying from the colitis or requiring colectomy for it, we retrospectively reviewed 201 cases of colitis caused by C difficile from 1984 to 1994.

RESULTS: The incidence of C difficile colitis appears to be sharply increasing and is associated with ...

Also Ranks for: Difficile Colitis |  retrospective studies |  surgical patients |  child child |  antibacterial agents

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Blair Anderson Jobe:Expert Impact

Concepts for whichBlair Anderson Jobehas direct influence:Esophageal adenocarcinoma,  Esophageal cancer,  Antireflux surgery,  Barrett esophagus,  Esophageal manometry,  Electrical stimulation,  Esophageal preservation,  Gastric banding.

Blair Anderson Jobe:KOL impact

Concepts related to the work of other authors for whichfor which Blair Anderson Jobe has influence:Esophageal cancer,  Squamous cell,  Barrett esophagus,  Radiofrequency ablation,  Antireflux surgery,  Hiatal hernia,  Anastomotic leakage.



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