Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias: Influence Statistics

Expert Impact

Concepts for which they have has direct influence: Cerebellar ataxias , Cerebellar ataxia , Consensus paper , Mediated cerebellar , Immune mediated , Cerebellar type , Systemic lupus erythematosus .

Key People For Cerebellar Ataxias

Top KOLs in the world
#1
Thomas Klockgether
spinocerebellar ataxia type multiple sclerosis friedreich ataxia
#2
Ludger Schöls
spinocerebellar ataxia type friedreich ataxia spastic paraplegia
#3
Alexandra Dürr
huntington disease cerebellar ataxia spastic paraplegia
#4
Alexis Brice
parkinson disease cerebellar ataxia age onset
#5
Massimo Pandolfo
friedreich ataxia frataxin deficiency sticky dna
#6
Mario‐Ubaldo Manto
cerebellar ataxias motor cortex essential tremor

Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias

Abstract

. In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia associated with anti-GAD antibodies, the cerebellar type of Hashimoto's encephalopathy, primary autoimmune cerebellar ataxia, gluten ataxia, Miller Fisher syndrome, ataxia associated with systemic lupus erythematosus, and paraneoplastic cerebellar degeneration. Humoral mechanisms, cell-mediated immunity, inflammation, and vascular injuries contribute to the cerebellar deficits in immune-mediated cerebellar ataxias.